Article
Communication
Pier Luigi Parcu, Niccolo Innocenti, Chiara Carrozza
Summary: The development of 5G technology is expected to have a disruptive impact on various aspects, including the economy, geopolitics, and national security. An analysis of patents in the relevant fields reveals that the development of 5G is primarily dominated by a few countries globally, with Europe as a whole being a strong competitor alongside the US and Asia. This highlights the importance of strengthening cooperation within the EU.
TELECOMMUNICATIONS POLICY
(2022)
Review
Oncology
Sanjana Rajgopal, Kosuke Nakano, Leah M. Cook
Summary: Cancer is a complex and dynamic disease, and immune cells, especially neutrophils, play important roles in it. Immunotherapy has revolutionized cancer treatment, and neutrophils have the potential to become the next generation of immunotherapies. This article reviews current immunotherapy strategies, thoroughly discusses the roles of neutrophils in cancer, and explores novel neutrophil-targeted methods for treating cancer.
Article
Immunology
Nataliia Pavliuchenko, Iris Duric, Jarmila Kralova, Matej Fabisik, Frantisek Spoutil, Jan Prochazka, Petr Kasparek, Jana Pokorna, Tereza Skopcova, Radislav Sedlacek, Tomas Brdicka
Summary: This study demonstrates that PSTPIP2-bound PEST-PTPs and SHIP1 together control the IL-1 beta pathway. In addition, PEST-PTPs have unique roles in the control of reactive oxygen species and chemokine production.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Shuvasree SenGupta, Lauren E. Hein, Carole A. Parent
Summary: Neutrophils play a crucial role in tumor progression and metastasis by sensing and migrating towards chemotactic factors released in the tumor microenvironment. The molecular mechanisms of how cancer cells secrete mediators to recruit neutrophils and the signaling network integration among mediators need further exploration for developing effective therapeutic strategies in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Heidi Mathiessen, Sebastian Kjeldgaard-Nintemann, Carlota Marola Fernandez Gonzalez, Cyril Henard, Julie Algreen Reimer, Sara Vebaek Gelskov, Moonika Haahr Marana, Louise von Gersdorff Jorgensen
Summary: This study investigated the early immune responses in zebrafish larvae infected with the parasite Ichthyophthirius multifiliis. The results showed that the larvae exhibited mild inflammation upon infection, and the 12-day-old larvae were less susceptible compared to the 5-day-old larvae. Neutrophils and macrophages were attracted to the parasites and exhibited neutrophil extracellular traps (NETs) during the fight against the parasite. The parasite employed rotation as an immune evasive strategy, but occasionally, neutrophils and macrophages were able to kill the parasite. In conclusion, the zebrafish larvae responded with localized high activity from neutrophils and macrophages, but only displayed mild inflammation systemically.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Engineering, Biomedical
Daniil A. Vishnevskiy, Anastasiia S. Garanina, Anastasia A. Chernysheva, Vladimir P. Chekhonin, Victor A. Naumenko
Summary: The application of cell carriers for transporting nanodrugs to tumors, particularly neutrophils, shows great potential. However, several conceptual and technical issues need to be addressed for successful clinical translation of this technology.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Oncology
Yu-Gang Jiang, Mu-Yuan Ma, Jia-Jun Wu, Rong Ma, Xue-Hong Bai, Ren Zhao, Jin-Xi He, Yan-Yang Wang
Summary: This study aimed to investigate the prognostic factors in patients with thymoma who underwent radical resection and establish a nomogram to predict their prognosis. Smoking status and tumor size were identified as risk factors for progression-free survival (PFS), while high neutrophil count was an independent prognostic factor for overall survival (OS). The nomograms developed accurately predict PFS and OS rates at 5 and 10 years based on individual characteristics.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Cell Biology
Jessica L. Christenson, Michelle M. Williams, Jennifer K. Richer
Summary: The alveolar epithelium plays a significant role in the progression of metastatic cancer, not only influencing the site of metastasis within the lungs but also impacting metastatic progression through interactions with surrounding cells.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
News Item
Multidisciplinary Sciences
Dyani Lewis
Summary: Early in the pandemic, the World Health Organization wrongly stated that SARS-CoV-2 was not transmitted through the air, causing confusion and raising questions about the future handling of pandemics.
Article
Ergonomics
Clemens Ohlert, Oliver Giering, Stefan Kirchner
Summary: Debates on digitalisation in Germany often mention "Industrie 4.0," which describes a seamless and technology-driven process led by manufacturing. However, empirical research shows that digitalisation processes are highly differentiated, and the adoption of digital technologies is closely related to organizational characteristics and technology types.
NEW TECHNOLOGY WORK AND EMPLOYMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Hui Qi, Hang Liu, Soni Savai Pullamsetti, Stefan Gunther, Carsten Kuenne, Ann Atzberger, Natascha Sommer, Stefan Hadzic, Andreas Gunther, Norbert Weissmann, Yonggang Zhou, Xuejun Yuan, Thomas Braun
Summary: The study discovered reduced histone modifications of H4K20me2/3 in COPD patients but not in PH patients dependent on SUV4-20H1 activity. Loss of Suv4-20h1 in cardiopulmonary progenitor cells caused a COPD/PH phenotype in mice, with characteristics including the formation of perivascular tertiary lymphoid tissue and goblet cell hyperplasia, hyperproliferation of smooth muscle cells/myofibroblasts, impaired alveolarization, and maturation defects of the microvasculature leading to massive right ventricular dilatation and premature death. Mechanistically, SUV4-20H1 represses the expression of the superoxide dismutase 3 gene, leading to increased hydrogen peroxide concentrations, causing vascular defects and impairing alveolarization.
Article
Mathematics, Applied
Tao You, Hailun Zhang, Ying Zhang, Qing Li, Peng Zhang, Mei Yang
Summary: The emergence and maintenance of cooperative behavior in groups is an important topic in game theory. Traditional networks with single mechanisms face challenges in analyzing the diversity of groups in society. Recent studies have shown the potential of multi-layer coupled network based evolutionary game theory in exploring the transmission of cooperative behavior between individuals. This study combines the game strategy of reinforcement learning with the traditional prisoner's dilemma strategy based on multiple coupled networks, enhancing the intelligent decision-making capability of group behaviors. Simulation of game evolution validates that cooperative behavior can be maintained by adjusting the group's ability with effective guidance.
APPLIED MATHEMATICS AND COMPUTATION
(2022)
Article
Oncology
Xuezhen Wang, Xiaoxia Li, Yufan Wu, Jinsheng Hong, Mingwei Zhang
Summary: This study found that tumor-associated neutrophils (TANs) and peripheral blood neutrophil levels before radiotherapy are prognostic markers for poor outcomes in patients with glioblastoma (GBM) classified according to CNS5. Increased TAN infiltration and peripheral blood neutrophil levels are associated with worse prognosis in GBM patients.
Article
Cell Biology
Pingping Nie, Weihong Zhang, Yan Meng, Moubin Lin, Fenghua Guo, Hui Zhang, Zhenzhu Tong, Meng Wang, Fan Chen, Liwei An, Yang Tang, Yi Han, Ruixian Yu, Wenjia Wang, Yuanzhi Xu, Linxin Wei, Zhaocai Zhou, Shi Jiao
Summary: Neutrophils, as an important component of tumor microenvironment, are poorly understood due to their spatiotemporal heterogeneity in tumorigenesis. In this study, tumor-specific neutrophils (tsNeus) were defined and characterized in gastric cancer (GC), revealing the essential role of YAP/TAZ-CD54 axis in tsNeus differentiation and antitumor activity. The relative amounts of CD54(+) tsNeus were found to be negatively associated with GC progression and positively associated with patient survival. Pharmacological enhancement of YAP activity selectively activated neutrophils to suppress refractory GC, providing a potential strategy for neutrophil-based antitumor therapeutics.
Article
Immunology
William D. S. Killgore, Sara A. Cloonan, Emily C. Taylor, Natalie S. Dailey
Summary: A survey of 1017 individuals in the U.S. during the COVID-19 vaccine campaign found that the majority were willing to get vaccinated, but some also expressed fear of the vaccine. Political ideology was identified as the most consistent predictor of willingness to be vaccinated and fear of the vaccine among participants.
Article
Immunology
Xintong Feng, Caiqi Zhao, Ling Li, Jingjing Feng, Wei He, Tianyun Shi, Na Li, Zhijun Jie, Xiao Su
Summary: PLZF interacts with GATA3 to restrain the differentiation of IL-4- and IL-5-producing T cells. iNKT cells with high PLZF expression are recruited to the lungs via CCL21-CCR7 signaling during the development of asthma tolerance.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Xintong Feng, Ling Li, Jingjing Feng, Wei He, Na Li, Tianyun Shi, Zhijun Jie, Xiao Su
Summary: Through experiments on mice and gene knockout methods, it was found that the vagus nerve, pulmonary C-fibers, and the Chrna7 gene play important roles in regulating asthma and asthma tolerance. This discovery may contribute to further research and treatment of asthma.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhao-wei Gao, Ling Li, Yuan-yuan Huang, Cai-qi Zhao, Shuang-jia Xue, Jie Chen, Zhong-zhou Yang, Jin-fu Xu, Xiao Su
Summary: The study revealed that vagal-alpha 7nAChR signaling can modulate lung inflammatory responses and may serve as a novel therapeutic target for treating lung inflammation during an influenza infection.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Yujiao Wu, Qianying Yu, Meng Zhang, Yao Zhou, Xiao Su, Min Wu, Jiajia Lv, Zhenwei Xia
Summary: HO-1 modulates asthmatic airway inflammation by releasing DCEVs from dendritic cells, which facilitates regulatory T cell differentiation, reduces inflammatory cell infiltration and mucus secretion.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Allergy
Yuying Huang, Xuezhen Li, Lin Zhu, Chunrong Huang, Wen Chen, Zhiyang Ling, SongLing Zhu, Xintong Feng, Chunyan Yi, Wangpeng Gu, Chenghua Yan, Jing Wang, Liyan Ma, Xiao Su, Ranran Dai, Guochao Shi, Bing Sun, Yaguang Zhang
Summary: The study discovered that by inhibiting thrombin, the maturation of IL-33 can be regulated, thus impacting ILC2s cells and treating lung inflammation.
Article
Biochemical Research Methods
Dalang Yu, Xiao Yang, Bixia Tang, Yi-Hsuan Pan, Jianing Yang, Guangya Duan, Junwei Zhu, Zi-Qian Hao, Hailong Mu, Long Dai, Wangjie Hu, Mochen Zhang, Ying Cui, Tong Jin, Cui-Ping Li, Lina Ma, Xiao Su, Guoqing Zhang, Wenming Zhao, Haipeng Li
Summary: Genomic epidemiology is crucial for studying the COVID-19 pandemic. The Coronavirus GenBrowser (CGB) is a tool that allows efficient analysis and visualization of SARS-CoV-2 genomic sequences, providing interactive operations and quick visualization modules for the study of evolution and transmission.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Immunology
Jing Wen, Xin Li, Qing-Xia Zhao, Xiao-Fan Yang, Meng-Li Wu, Qihong Yan, Junbiao Chang, Haikun Wang, Xia Jin, Xiao Su, Kai Deng, Ling Chen, Jian-Hua Wang
Summary: In this study, the researchers identified the Wnt downstream beta-catenin/TCF1 pathway as a crucial modulator for HIV-1 latency. Activation of this pathway with GSK3 inhibitors effectively promoted HIV-1 proviral DNA transcription and reactivated latency in CD4(+) T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Na Li, Tianyun Shi, Meng Zhang, Yanchao He, Jingjing Feng, Zhoufang Mei, Xiao Su, Zhijun Jie
Summary: Clarifying the pathogenesis of asthma and identifying the specific pathway underlying oral asthma tolerance (OT) is important. This study explores the effects of promyelocytic leukemia zinc finger (PLZF) on memory phenotypes in asthma and OT mouse models. The results suggest that PLZF may reduce memory cells and promote the establishment of OT.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Caixia Di, Yanshan Jiang, Lulu Li, Mengmeng Shi, Yinggang Zhu, Jing Zhang, Yuanlin Song, Xiao Su, Jieming Qu
Summary: Mesenchymal stem cells (MSCs) therapy attenuates LPS-induced acute lung injury and Pseudomonas aeruginosa (PA)-induced acute pneumonia, but the underlying molecular mechanisms are unclear. This study shows that PA-derived outer membrane vesicles (OMVs) induce mouse primary adipose tissue-derived mesenchymal stem cells (ASCs) to upregulate cyclic GMP-AMP synthase (cGAS) and express interleukin (IL)-7. Loss of cGAS-interferon (IFN)-beta axis abolishes the protective function of ASCs against PA-induced acute pneumonia. OMVs-delivered PA dsDNA activates cGAS-STING signaling pathway and increases IL-7 production via IFN-beta signaling in ASCs, which further amplifies IL-7 expression in lung epithelial cells.
Article
Medicine, Research & Experimental
Xiaoyan Chen, Cuiping Zhang, Tianchang Wei, Jie Chen, Ting Pan, Miao Li, Lu Wang, Juan Song, Cuicui Chen, Yan Zhang, Yuanlin Song, Xiao Su
Summary: In this study, it was found that activation of α7nAChR on AT2 cells promotes lung repair and regeneration by enhancing AT2 cell proliferation and differentiation into type I cells. The WNT7B signaling pathway was identified as essential for α7nAChR activation-mediated alveolar epithelial proliferation and differentiation. These findings provide a potential therapeutic target for acute lung injury.
Article
Virology
Shuting Song, Zhekai Lin, Caiqi Zhao, Jing Wen, Jie Chen, Shitao Xie, Huaxin Qi, Jianhua Wang, Xiao Su
Summary: This study reveals a previously unrecognized mechanism of neuromodulation in the pathogenesis of acute erythroleukemia. The vagal-mAChR4 signaling pathway promotes the disease by increasing erythroblast populations in the spleen and bone marrow.
Article
Integrative & Complementary Medicine
Cuiping Zhang, Xiaoyan Chen, Tianchang Wei, Juan Song, Xinjun Tang, Jing Bi, Cuicui Chen, Jian Zhou, Xiao Su, Yuanlin Song
Summary: The traditional Chinese medicine Xuebijing (XBJ) shows promise as a potential preventive agent for acute lung injury/acute respiratory distress syndrome (ALI/ARDS). An experimental study showed that pre-treatment with XBJ significantly reduced lung inflammation and increased the survival rate of ALI mice. XBJ achieved this by suppressing the production of TNF-alpha and protecting alveolar epithelial cells against gasdermin-E-mediated pyroptosis.
CHINESE JOURNAL OF NATURAL MEDICINES
(2023)
Article
Respiratory System
Wen-Wen Wang, Bei Mao, Yang Liu, Shu-Yi Gu, Hai-Wen Lu, Jiu-Wu Bai, Shuo Liang, Jia-Wei Yang, Jian-Xiong Li, Xiao Su, Hai-Yang Hu, Chen Wang, Jin-Fu Xu
Summary: This study utilized a multi-omics approach to identify differences in gut microbiota and metabolic profiles between bronchiectasis patients and healthy volunteers. It revealed the potential of gut microbiota as biomarkers for bronchiectasis.
RESPIRATORY RESEARCH
(2022)
Article
Virology
Zhihua Liu, Yawei Zhang, Mengli Cheng, Ningning Ge, Jiayi Shu, Zhiheng Xu, Xiao Su, Zhihua Kou, Yigang Tong, Chengfeng Qin, Xia Jin
Summary: A single mutation in the Zika virus envelope protein has been found to enhance its virulence and neurotropism, leading to severe neurological damage. This mutation also showed increased viral production and cytopathic effect in human neural astrocytes, indicating its potential neurotoxicity to the human brain.
Article
Microbiology
Shu-Ting Song, Meng-Li Wu, Hai-Jiao Zhang, Xiao Su, Jian-Hua Wang
Summary: Mast cells play a critical role in immune surveillance of pathogens, but their role and mechanisms in viral infection remain unclear.
FRONTIERS IN MICROBIOLOGY
(2022)
