Article
Multidisciplinary Sciences
Mauro Contini, Antonio Sarmento, Paola Gugliandolo, Alessandra Leonardi, Gianluigi Longinotti-Buitoni, Camilla Minella, Carlo Vignati, Massimo Mapelli, Andrea Aliverti, Piergiuseppe Agostoni
Summary: This study evaluated the ability of an innovative wearable system, X10X and X10Y, to detect and classify sleep apnea events without the use of a flowmeter. The results showed that these devices performed well in terms of respiratory signal quality, duration and classification of apneas, and identification of hypopneas. The devices were able to provide accurate grading of sleep respiratory disorders and can be considered as a type 3 sleep test device for screening tests.
Article
Critical Care Medicine
Jeremy E. Orr, Indu Ayappa, Danny J. Eckert, Jack L. Feldman, Chandra L. Jackson, Shahrokh Javaheri, Rami N. Khayat, Jennifer L. Martin, Reena Mehra, Matthew T. Naughton, Winfried J. Randerath, Scott A. Sands, Virend K. Somers, M. Safwan Badr
Summary: The international multidisciplinary group identified 11 specific research priorities regarding central sleep apnea (CSA) in heart failure patients, focusing on areas such as control of breathing, variability across individuals, examination techniques, treatment impact, and implementation strategies. Advancing care for patients with CSA in the context of heart failure will require progress in translational, epidemiological, and patient-centered outcome research. Priority should be given to targeted research to improve knowledge of CSA pathogenesis and treatment, given the increasing prevalence of heart failure and its substantial burden.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Sunil Sharma, Robert Stansbury, Benjamin Hackett, Henrik Fox
Summary: Obstructive sleep apnea (OSA) and pulmonary hypertension (PH) are known to be associated, with limited understanding of the relationship which appears to be bidirectional. Limited data suggests that treatment with continuous positive pressure therapy may be beneficial and reduce pulmonary pressure. Further research on the mechanisms of this relationship is important.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Michael Wester, Michael Arzt, Frederick Sinha, Lars Siegfried Maier, Simon Lebek
Summary: Heart failure with preserved ejection fraction (HFpEF) is a widespread disease with high morbidity and mortality, and sleep-disordered breathing (SDB) has been found to be closely associated with the development and progression of the obese HFpEF phenotype. Individualized therapeutic strategies and novel technologies like single-cell transcriptomics or CRISPR-Cas9 gene editing are needed to improve treatment outcomes.
Article
Clinical Neurology
Pi-Hung Tung, Meng-Jer Hsieh, Li-Pang Chuang, Shih-Wei Lin, Kuo-Chun Hung, Cheng-Hui Lu, Wen-Chen Lee, Han-Chung Hu, Ming-Shien Wen, Ning-Hung Chen
Summary: This study examined the diagnostic value of portable monitoring (PM) devices in detecting central sleep apnea (CSA) among patients with heart failure (HF). The results showed that the measurements obtained from PM devices were well-correlated with the standard polysomnography (PSG) results, and manual scoring was preferable to automated scoring.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Youmeng Wang, Christoph Schoebel, Thomas Penzel
Summary: Sleep apnea is a common chronic condition that can be classified as obstructive sleep apnea (OSA) or central sleep apnea (CSA). Patients with heart failure often have a combination of OSA and CSA, known as complex sleep apnea syndrome. This review examines different treatment options for OSA in heart failure patients, including surgical and non-surgical approaches, and discusses the potential positive and negative outcomes of these treatments. The review also provides references and suggestions for future research on CSA treatment options.
FRONTIERS IN MEDICINE
(2022)
Review
Critical Care Medicine
Salam Zeineddine, James A. Rowley, Susmita Chowdhuri
Summary: Sleep-disordered breathing (SDB) has significant cardiovascular and neurological effects, with supplemental oxygen therapy showing mixed results in improving oxygen saturation and apnea severity compared to positive airway pressure therapy. Further research is needed to clarify the optimal dose and duration of nocturnal supplemental oxygen (NSO) and its combination with PAP in improving cardiovascular, sleep, and cognitive outcomes in SDB patients.
Article
Medicine, General & Internal
Ryo Naito, Takatoshi Kasai, Koji Narui, Shin-Ichi Momomura
Summary: This study investigated the association between the frequency of central respiratory events coexisting with obstructive events and clinical outcomes in patients with heart failure (HF) and sleep apnea (SA). The results showed that the frequency of central respiratory events was an independent factor for all-cause death and hospitalization for HF in patients with HF and SA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Agnieszka Polecka, Natalia Olszewska, Lukasz Danielski, Ewa Olszewska
Summary: Obstructive sleep apnea is common in heart failure patients and can worsen their condition. Positive airway pressure treatment consistently improves sleep apnea index, ejection fraction, oxygen saturation, and quality of life. Recent studies suggest that certain medications may also impact sleep apnea outcomes through weight loss, improved metabolic profiles, and effects on upper airway muscles.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Shahrokh Javaheri, Sogol Javaheri
Summary: This review provides a comprehensive overview of the current knowledge of obstructive sleep apnea (OSA) and congestive heart failure (HF), including the pathophysiologic mechanisms, observational data, treatment options, and future research needs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Corrado Pelaia, Giuseppe Armentaro, Mara Volpentesta, Luana Mancuso, Sofia Miceli, Benedetto Caroleo, Maria Perticone, Raffaele Maio, Franco Arturi, Egidio Imbalzano, Francesco Andreozzi, Francesco Perticone, Giorgio Sesti, Angela Sciacqua
Summary: The research indicates that treatment with sac/val significantly improves cardiorespiratory performance in HFrEF patients with SA, integrating the positive impact of CPAP. Both CPAP and sac/val therapy may synergistically contribute to reducing the risks of cardiac and pulmonary complications in patients with HFrEF and SA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Ali Azarbarzin, Scott A. Sands, Magdy Younes, Luigi Taranto-Montemurro, Tamar Sofer, Daniel Vena, Raichel M. Alex, Sang-Wook Kim, Daniel J. Gottlieb, David P. White, Susan Redline, Andrew Wellman
Summary: The study suggests that obstructive sleep apnea patients with an elevated pulse-rate response may have increased risk of cardiovascular morbidity and mortality, especially in those with a significant hypoxic burden. This finding could be useful for risk stratification and patient selection in future clinical trials.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hui Gong, Xing Lyu, Lini Dong, Shengyu Tan, Shizhen Li, Jieting Peng, Yang Liu, Xiangyu Zhang
Summary: The severity of OSA is significantly associated with cardiac injury and remodeling in patients with DCM, potentially through altering autophagy levels. This study provides new clues for the treatment of heart failure caused by OSA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Microbiology
Olfat Khannous-Lleiffe, Jesse R. Willis, Ester Saus, Ignacio Cabrera-Aguilera, Isaac Almendros, Ramon Farre, David Gozal, Nuria Farre, Toni Gabaldon
Summary: Heart failure and sleep fragmentation are associated with inflammation and gut microbiota dysbiosis, with mouse experiments showing distinct changes in microbiome composition for both conditions, but combined treatment does not always have a synergistic effect.
Article
Clinical Neurology
Guoxin Zhang, Xiaoyun Zhao, Fang Zhao, Jin Tan, Qiang Zhang
Summary: Central sleep apnea (CSA) is often a part of severe sleep apnea hypopnea syndrome (SAHS), rather than occurring alone. This study investigated the clinical characteristics and polysomnography (PSG) parameters of CSA in patients with severe SAHS.
SLEEP AND BREATHING
(2023)