Article
Critical Care Medicine
Daisuke Kawakami, Shigeki Fujitani, Takeshi Morimoto, Hisashi Dote, Mumon Takita, Akihiro Takaba, Masaaki Hino, Michitaka Nakamura, Hiromasa Irie, Tomohiro Adachi, Mami Shibata, Jun Kataoka, Akira Korenaga, Tomoya Yamashita, Tomoya Okazaki, Masatoshi Okumura, Takefumi Tsunemitsu
Summary: This study identified the frequency of PICS impairments in ICU patients receiving mechanical ventilation at 6 months, finding that 64% of survivors had PICS, with 20% experiencing multiple PICS impairments. The occurrence of PICS was associated with a population with only mandatory education. Future research is needed to explore the MCID of SF-36 scores among ICU patients and standardize the definition of PICS.
Article
Health Care Sciences & Services
Nobuyuki Yotani, Daisuke Shinjo, Motohiro Kato, Kimikazu Matsumoto, Kiyohide Fushimi, Yoshiyuki Kizawa
Summary: The study found that children with hematologic malignancies are more likely to receive intensive EOLC compared to those with solid tumors, with younger age and shorter hospital stay potentially associated with intensive EOLC in these children.
BMC PALLIATIVE CARE
(2021)
Review
Pharmacology & Pharmacy
Pei Shang, Jiachun Feng, Wei Wu, Hong-Liang Zhang
Summary: Guillain-Barre syndrome (GBS) is an acute polyneuropathy characterized by acute flaccid paralysis, with current treatment options including immunotherapies and mechanical ventilation in the ICU setting which are largely empirical. This review emphasizes the importance of ICU care and treatment for severe GBS patients, summarizing the latest knowledge on pharmacological therapies and ICU management.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nursing
Louise Rose, Laura J. Allum, Laura Istanboulian, Craig Dale
Summary: The study identified 22 actionable processes important to prolonged ICU stay survivors and family members, categorized under physical recovery, patient psychological well-being, and family relations. The findings suggest the need for QI tools that standardize the delivery of these processes in clinical practice, highlighting the crucial role nurses can play in leading this effort.
JOURNAL OF ADVANCED NURSING
(2022)
Article
Critical Care Medicine
L. Imeen van der Wal, Chloe C. A. Grim, Michael R. del Prado, David J. van Westerloo, E. Christiaan Boerma, Hilda G. Rijnhart-de Jong, Auke C. Reidinga, Bert G. Loef, Pim L. J. van der Heiden, Marnix J. Sigtermans, Frederique Paulus, Alexander D. Cornet, Maurizio Loconte, F. Jeannette Schoonderbeek, Nicolette F. de Keizer, Ferishta Bakhshi-Raiez, Saskia Le Cessie, Ary Serpa Neto, Paolo Pelosi, Marcus J. Schultz, Hendrik J. F. Helmerhorst, Evert de Jonge
Summary: A low-oxygenation strategy did not result in a reduction of 28-day mortality compared with a high-oxygenation strategy in mechanically ventilated ICU patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Nicholas S. Hill, Gerard J. Criner, Richard D. Branson, Bartolome R. Celli, Neil R. MacIntyre, Amen Sergew
Summary: This document summarizes the work of the COPD Technical Expert Panel working group, making key recommendations for optimal access to noninvasive ventilation for patients with COPD. These recommendations include removal of overnight oximetry testing requirements, ability to initiate therapy using bilevel devices with backup rate capability, and increased duration of time to meet adherence criteria. Emphasis is placed on the need for adequate clinical support during initiation and maintenance of home noninvasive ventilation in such patients.
Article
Critical Care Medicine
Kyung Hun Nam, Jason Phua, Bin Du, Shinichiro Ohshimo, Hwa Jung Kim, Chae-Man Lim, Sheila Nainan Myatra, Nik Azman Bin Nik Adib, Yaseen M. Arabi, Ming-Cheng Chan, Mohammad Omar Faruq, Ike Sri Redjeki, Do Ngoc Son, Khalid Mahmood Khan Nafees, Dilshan Priyankara, Boonsong Patjanasoontorn, Jose Emmanuel Palo, Aidos Konkayev, Gentle Sunder Shrestha, Younsuck Koh
Summary: This study investigated the current practices of mechanical ventilation in Asian intensive care units. The results showed that low tidal volume ventilation and sufficient PEEP were underused in patients with ARDS, while intermediate tidal volumes were commonly used in patients without ARDS. Country income, age, and severity of illness were associated with mortality.
JOURNAL OF CRITICAL CARE
(2024)
Review
Multidisciplinary Sciences
Lichen Ouyang, Muqing Yu, Yan Zhu, Jie Gong
Summary: A systematic review of 40 studies involving 15320 COVID-19 patients revealed varying rates of IMV application in different continents, with higher mortality in patients treated with IMV compared to non-IMV respiratory support.
Review
Medicine, General & Internal
Shawn Sood, Hammad A. Ganatra, Francesca Perez Marques, Travis R. Langner
Summary: Mechanical ventilation is commonly used in pediatric intensive care units, especially for patients with respiratory failure. Despite the use of lung protective ventilation modes, complications still occur frequently, including atelectasis, post-extubation stridor, perioral tissue damage, pneumonia, mucus plugging, pneumothorax, pneumomediastinum, and ICU neuromyopathy. This review aims to discuss the risk factors, presentation, and management of complications associated with mechanical ventilation in pediatric patients.
FRONTIERS IN MEDICINE
(2023)
Article
Microbiology
Jolien Seinen, Rudolf Engelke, Mohammed R. Abdullah, Franziska Voss, Stephan Michalik, Vishnu M. Dhople, Willem Dieperink, Anne Marie G. A. de Smet, Uwe Voelker, Jan Maarten van Dijl, Frank Schmidt, Sven Hammerschmidt
Summary: Proteomic analysis of sputa from mechanically ventilated patients revealed distinct protein signatures related to antimicrobial activity, including elevated levels of antimicrobial host proteins, antibiotics, and S. pneumoniae-specific antibodies. Additionally, changes in sputum composition over time were observed in some patients. These findings suggest a potential novel tool for monitoring infection-related conditions in the lungs of ventilated patients.
Article
Nutrition & Dietetics
Cristina Cuerda, Ivan Sanchez Lopez, Carmen Gil Martinez, Maria Merino Viveros, Cristina Velasco, Vanessa Cevallos Penafiel, Maria Maiz Jimenez, Irene Gonzalo, Victor Gonzalez-Sanchez, Araceli Ramos Carrasco, Patricia Diaz Guardiola, Clara Marcuello Foncillas, M. A. Sampedro-Nunez, Marina Morato Martinez, Iciar Galicia, Naiara Modrono Mostoles, Maria Blanca Martinez-Barbeito, Laura Mola Reyes, Cristina Navea Aguilera, Loredana Arhip, Dolores Del Olmo Garcia, Mario Huelves Delgado, Emilia Cancer-Minchot, Maria Pastor Garcia, Beatriz Pelegrina-Cortes, Juana Olivar Roldan, Silmary Maichle, Begona Molina Bahena, Natalia Garcia Vazquez, Elena Atienza, Irene Hoyas Rodriguez, Angela Amengual Galbarte, Angela Morales, Ma A. Valero Zanuy, Pilar Matia-Martin, Carolina Knott, Alexander Agrifoglio Rotaeche, Andres Ortiz, Ma P. Gomez Montes, Mercedes Ramirez Ortiz, Marta Ruiz Aguado, Samara Palma Milla, Teresa Montoya Alvarez, Enrique Sanz Martinez, Marta Rodriguez De Codesal, Belen Quesada Bellver, Susana Aceituno, F. J. Perez-Sadaba, Julia Alvarez-Hernandez
Summary: This study describes the preliminary results of the ongoing NUTRICOVID study, which focuses on the nutritional and functional status and quality of life of adult COVID-19 survivors after ICU discharge. The preliminary analysis shows that COVID-19 survivors experience significant nutritional and functional impairment at hospital discharge, highlighting the importance of post-discharge nutritional management.
CLINICAL NUTRITION
(2022)
Article
Orthopedics
Sheetal Gandotra, D. Clark Files, Katherine L. Shields, Michael Berry, Rita N. Bakhru
Summary: The study found that physical activity levels increased as critically ill patients transitioned from ICU to hospital wards and back to the community, with significantly higher activity levels post-hospital discharge. Despite poor physical function scores at ICU and hospital discharge, there was moderate correlation with physical activity levels immediately upon return home.
Article
Computer Science, Interdisciplinary Applications
Cong Zhou, J. Geoffrey Chase, Jennifer Knopp, Qianhui Sun, Merryn Tawhai, Knut Moller, Serge J. Heines, Dennis C. Bergmans, Geoffrey M. Shaw, Thomas Desaive
Summary: The study develops a digital clone model to predict lung mechanics in response to changes in mechanical ventilation, enabling personalised care. Results show that the virtual patient model accurately predicts patient-specific lung responses, guiding personalised and optimised mechanical ventilation therapy.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Cheng-Yang Chiang, Chou-Chin Lan, Chin-Hsuan Yang, Yi-Cheng Hou
Summary: Long-term respirator users need to be transferred to a respiratory care center for weaning. Malnutrition in critical care patients can lead to respiratory muscle mass reduction and decreased ventilatory capacity. This study suggests that improving nutritional status can help patients wean from respirators.
SCIENTIFIC REPORTS
(2023)
Article
Nursing
Carl -Johan Cederwall, Louise Rose, Silvana Naredi, Sepideh Olausson, Mona Ringdal
Summary: The study aimed to investigate care practices in Swedish intensive care units for patients requiring mechanical ventilation for >7 days. A national cross-sectional survey was conducted, receiving feedback from 77 units. The results showed that an individualized approach to ventilator weaning, with collaboration between physicians and nurses, was predominant. Early mobilization was prioritized in most units, but only a few used protocols. Nutritional protocols were widely adopted, but few units had dedicated dieticians.
INTENSIVE AND CRITICAL CARE NURSING
(2023)
Article
Gerontology
Heejung Jang, Fengyan Tang, Rachel A. Fusco, Rafael J. Engel, Steven M. Albert
Summary: The study found that co-parenting and custodial grandparents had higher all-cause mortality risk than grandparents who babysat occasionally, however, for custodial grandparents, the association was not significant once social relation variables were added to the model.
Article
Gerontology
Jessica Cheng, Lora E. Burke, Elizabeth M. Venditti, Susan M. Sereika, Nancy W. Glynn, Steven M. Albert, Anne B. Newman
Summary: This analysis examined the effectiveness of a community-based intervention in improving dietary habits. The intervention successfully shifted eating patterns and resulted in sustained improvements over 13 months. The use of a simple tool, Rate Your Plate, proved to be effective in assessing dietary changes.
JOURNAL OF APPLIED GERONTOLOGY
(2022)
Article
Clinical Neurology
Sneha Mantri, Lana M. Chahine, Karina Nabieva, Robert Feldman, Andrew Althouse, Benjamin Torsney, Steven M. Albert, Catherine Kopil, Connie Marras
Summary: Fatigue has a major impact on health-related quality of life in Parkinson's disease, especially in younger patients and those with more depressive symptoms.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Article
Gerontology
Raymond Van Cleve, Howard B. Degenholtz
Summary: This study examines the utilization of multiple services among older adults and explores the association between service use and level of disability and living arrangement.
JOURNAL OF APPLIED GERONTOLOGY
(2022)
Editorial Material
Geriatrics & Gerontology
Christine E. Bishop, Howard B. Degenholtz
INNOVATION IN AGING
(2022)
Article
Health Care Sciences & Services
Steven M. Albert, Polly McCracken, Thuy Bui, Janel Hanmer, Gary S. Fischer, Jaishree Hariharan, Alton Everette James
Summary: A cross-sectional survey found that the majority of patients support the inclusion of social needs information in medical records, but 20% of patients are uncomfortable with this practice. The survey also showed that individuals with more social needs are more cautious about including this information in electronic health records.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Gerontology
Tracy Chippendale, Steven M. Albert, Atiya Mahmood
Summary: The study found that the "Stroll Safe" program is effective in improving knowledge of outdoor fall risks and increasing safe strategy use for community mobility. This program fills a gap in outdoor fall prevention programs.
Article
Immunology
Chethan M. Puttarajappa, Amit D. Tevar, William Hoffman, Howard Degenholtz, Carrie A. Schinstock, Vikraman Gunabushanam, Adriana Zeevi, Qingyong Xu, Sundaram Hariharan
Summary: Virtual crossmatch is an alternative method for assessing HLA compatibility in deceased donor kidney transplantation. A survey was conducted to investigate the practice patterns and perceptions regarding virtual crossmatch use in the US. The survey found that virtual crossmatch can reduce cold ischemia time, costs, and improve allocation efficiency. However, the preference for virtual crossmatch reduced as candidates' panel reactive antibodies increased.
Article
Computer Science, Interdisciplinary Applications
Scott A. Malec, Sanya B. Taneja, Steven M. Albert, C. Elizabeth Shaaban, Helmet T. Karim, Arthur S. Levine, Paul Munro, Tiffany J. Callahan, Richard D. Boyce
Summary: Traditional methods of identifying confounders rely on content-matter expertise and literature review, but these methods have limitations. To overcome these challenges, researchers propose a novel method based on knowledge graph, which combines computable literature-derived knowledge with biomedical ontologies for better causal feature selection. The application of this method identifies potential confounders and highlights the need for standardized databases of causal variables.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Article
Geriatrics & Gerontology
Hyejin Kim, Jennifer H. Lingler, Catherine M. Bender, Steven M. Albert, Susan M. Sereika
Summary: This study aimed to explore the differences in illness perceptions, focusing on perceived control and coherence, between patients with Type 2 diabetes (T2DM) and mild cognitive impairment (MCI). The results showed that MCI patients were more likely to perceive their condition as less controllable and understandable compared to T2DM patients. Therefore, healthcare professionals should consider patients' subjective perceptions of their conditions, especially in the context of disease characteristics, when discussing secondary prevention strategies for disease management.
INNOVATION IN AGING
(2023)
Book Review
Gerontology
Howard Degenholtz
JOURNAL OF AGING & SOCIAL POLICY
(2023)
Review
Respiratory System
Kristopher P. Clark, Howard B. Degenholtz, Kathleen O. Lindell, Daniel J. Kass
Summary: Supplemental oxygen use in interstitial lung diseases has limited evidence for its impact on clinical outcomes and should be considered in a patient-focused manner, considering cost and other barriers.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Computer Science, Information Systems
Richard D. Boyce, Olga Kravchenko, Subashan Perera, Jordan F. Karp, Sandra L. Kane-Gill, Charles F. Reynolds, Steven M. Albert, Steven M. Handler
Summary: This study aimed to develop and validate a model that predicts the risk of falls for nursing home residents using electronically available data from over 15,000 facilities in the United States. The model was built using a hybrid Classification and Regression Tree (CART)-logistic approach and tested with data from the Long-term Care Minimum Dataset (MDS) and drug data from skilled nursing facilities. The results showed that antidepressant medications have a significant protective association with fall risk in certain conditions. Compared to 22 other fall risk assessment tools, this novel hybrid CART-logit algorithm performed better for predicting falls within a 90-day window and utilizes easily obtainable features in nearly every facility in the United States.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2022)
Article
Gerontology
Steven M. Albert, Elizabeth M. Venditti, Robert M. Boudreau, Lori A. Kieffer, Judith R. Rager, Janice C. Zgibor, Joni Vander Bilt, Michelle E. Danielson, Lora E. Burke, Nancy W. Glynn, John M. Jakicic, Kenneth J. Smith, Linda N. Semler, Anne B. Newman
Summary: This study recruited 303 community-dwelling adults for a 32-session weight management intervention led by community health workers. The research found that promoting weight management in older adults can be an effective strategy for reducing the risk of disability.
Article
Gerontology
Eunhee Choi, Sung-Geun Kim, Laura B. Zahodne, Steven M. Albert
Summary: This study found that older workers with physically demanding jobs tend to have poorer cognitive function, with the perceived level of physical demands negatively linked with both memory and reasoning domains of cognition. Further longitudinal studies are needed to confirm this relationship.
AGEING INTERNATIONAL
(2022)