Article
Respiratory System
Florian Guisier, Gaetan Deslee, Philippe Birembaut, Bruno Escarguel, Francoise Chapel, Suzanna Bota, Josette Metayer, Samy Lachkar, Frederique Capron, Jean Paul Homasson, Marc Taulelle, Marie Quintana, Christophe Raspaud, Daniel Messelet, Jonathan Benzaquen, Paul Hofman, Jamal Baddredine, Christophe Paris, Valerie Cales, Philippe Laurent, Jean-Michel Vignaud, Olivier Menard, Marie-Christine Copin, Philippe Ramon, Brigitte Bouchindhomme, Jean-Yves Tavernier, Isabelle Quintin, Jean-Jacques Quiot, Francoise Galateau-Salle, Gerard Zalcman, Nicolas Piton, Luc Thiberville
Summary: Patients with moderate dysplasia are at a very high risk of developing lung cancer within 5 years, and quitting smoking significantly reduces this risk. Identifying dysplasia using initial bronchoscopy may be useful for risk stratification strategies in lung cancer screening programs.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Endocrinology & Metabolism
Khalid Mohamed Ali, Samantha A. A. Wolfe, Nimesh V. V. Nagururu, Stefanie Seo, Sung-Min Han, Yoseph Kim, Eugene Oh, Dong-Yun Kim, Bo Ning, Seung Yup Lee, Richard Jaepyeong Cha, Ralph P. P. Tufano, Jonathon O. O. Russell
Summary: Parathyroid glands can be compromised during thyroid surgery, and identifying their presence traditionally relies on the surgeon's experience and tissue biopsy. Near infrared autofluorescence technology, demonstrated by the hANDY-I prototype, offers a real-time, non-invasive way to identify the parathyroid glands. Initial results showed a 95% accuracy in identifying parathyroid glands in 71 out of 75 cases tested. Further testing with a larger sample size is necessary to study the impact on hypoparathyroidism and hypocalcemia levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Abhinav Agrawal, Elliot Ho, Udit Chaddha, Baris Demirkol, Sivasubramanium Bhavani, Kyle Hogarth, Septimiu Murgu
Summary: This study reviewed consecutive cases in which robotic bronchoscopy (RB) was used for diagnosing lung lesions at the University of Chicago Medical Center from June 15, 2018, to December 15, 2019. The overall diagnostic accuracy was 77%, with radial endobronchial ultrasound (r-EBUS) views playing a significant role. Rating: 8/10.
ANNALS OF THORACIC SURGERY
(2023)
Review
Medicine, General & Internal
Radu Serban Matache, Camelia Stanciu-Gavan, Daniel Pantile, Adrian Mihail Iordache, Andreea Octavia Bejganeanu, Crenguta Sorina Serboiu, Alexandra Floriana Nemes
Summary: The review article presents the clinical and paraclinical characteristics of endobronchial squamous cell carcinoma and discusses reliable technologies for early detection, opening new avenues for research and practice in lung parenchymal preservation surgery.
Article
Astronomy & Astrophysics
M. Cruces, D. J. Champion, D. Li, M. Kramer, W. W. Zhu, P. Wang, A. D. Cameron, Y. T. Chen, G. Hobbs, P. C. C. Freire, E. Graikou, M. Krco, Z. J. Liu, C. C. Miao, J. Niu, Z. C. Pan, L. Qian, M. Y. Xue, X. Y. Xie, S. P. You, X. H. Yu, M. Yuan, Y. L. Yue, Y. Zhu
Summary: We report the follow-up of 10 pulsars discovered by FAST during its commissioning, showing interesting features like a young, energetic pulsar and a wide WD binary system. Discrepancies were found between estimations based on different electron density models.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Biotechnology & Applied Microbiology
Xuehao Cui, Xunda Ji, Yan Shao, Peiquan Zhao, Xiaorong Li
Summary: This retrospective study aimed to evaluate the application value of Optos 200Tx scanning laser ophthalmoscope (Optomap 200Tx) in the long-term follow-up of retinoblastoma (RB) patients. The results showed that Optomap 200Tx reduces the number of eye examinations under general anesthesia, increases the time between examinations, and allows for early treatment of recurrent tumors and seeding. This improves outcomes and protects children from the adverse effects of anesthesia.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Joshua J. Yim, Stefan Harmsen, Krzysztof Flisikowski, Tatiana Flisikowska, Hong Namkoong, Megan Garland, Nynke S. van den Berg, Jose G. Vilches-Moure, Angelika Schnieke, Dieter Saur, Sarah Glasl, Dimitris Gorpas, Aida Habtezion, Vasilis Ntziachristos, Christopher H. Contag, Sanjiv S. Gambhir, Matthew Bogyo, Stephan Rogalla
Summary: Fluorescently labeled probes show great potential for clinical application in highlighting gastrointestinal lesions, providing fluorescence-guided surveillance and enhancing histopathological analysis by highlighting areas of dysplasia as small as 400 microns, even in tissues with severe inflammation and ulceration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Letter
Pediatrics
Manoj Madhusudan, Tejaswi Chandra, Srikanta Jingade
Summary: We reported a case of Bronchial Dieulafoy disease in an 11-year-old girl, who presented with an endobronchial lesion. Embolization was performed for the underlying bronchial vascular malformation, and the patient remained asymptomatic. Follow-up showed near-total resolution of the endobronchial lesion.
PEDIATRIC PULMONOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ilkay Evren, Ahmad M. Najim, Jos B. Poell, Elisabeth R. Brouns, Leon J. Wils, Laura A. N. Peferoen, Ruud H. Brakenhoff, Elisabeth Bloemena, Erik H. van Der Meij, Jan G. A. M. de Visscher
Summary: This study evaluated whether regular follow-up of oral leukoplakia resulted in early detection of malignant transformation. The results showed that patients followed up by their dentist had smaller leukoplakia size, more hyperkeratosis, and less moderate/severe dysplasia. Malignant transformation occurred most frequently in patients followed up at the hospital, least frequently in patients followed up by their dentist, and intermediate in patients lost to follow-up. Regular follow-up allowed for early detection of malignant transformation, and follow-up by the dentist was found to be feasible.
Article
Medicine, General & Internal
Juliane Buettner, Anne-Marie Glimm, Georgios Kokolakis, Magdalena Erdmann-Keding, Gerd-Ruediger Burmester, Paula Hoff, Jens Klotsche, Sarah Ohrndorf
Summary: This study aims to follow-up patients with confirmed and suspected PsA, focusing on patients with a change from suspected to confirmed PsA by using fluorescence optical imaging (FOI) in comparison with musculoskeletal ultrasound (MSUS).
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Panagiotis Salvanos, Helgi D. Bjornsson, Valeria Vitelli, Ragnheiour Bragadottir, Morten C. Moe, Tor P. Utheim
Summary: This study aimed to analyze the changes in fundus autofluorescence (AF) in patients with retinal reattachment following scleral buckling surgery. The results showed that fundus AF plays an important role in evaluating postoperative conditions.
JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Mathematical & Computational Biology
Ewa Strzalkowska-Kominiak, Juan Romo
Summary: Functional data analysis is important in medical research due to patient follow-up over time. This study introduces an estimator for mean function using partly observed data, which is model-free and fully nonparametric. Extensive simulation shows the method outperforms existing approaches, and is applied to real data on lung growth in girls in the US.
STATISTICS IN MEDICINE
(2021)
Review
Rheumatology
Hsiu Yen Tung, James Galloway, Faith Matcham, Matthew Hotopf, Sam Norton
Summary: This scoping review focused on research in musculoskeletal disorders with high frequency follow-up of symptoms. The majority of studies examined short-term effects of symptoms on each other, but there is a lack of research on the long-term effects of symptom variability. Further research in this area is needed to help clinicians prioritize symptoms in patient care.
Article
Nutrition & Dietetics
Hyo Geun Choi, Juyong Chung, Dae Myoung Yoo, Chang Ho Lee, So Young Kim
Summary: This study found that adults with Meniere's disease are at a higher risk of osteoporosis, and adults with osteoporosis are also at a higher risk of Meniere's disease.
Article
Obstetrics & Gynecology
M. C. Rulanda, O. Mogensen, P. T. Jensen, D. G. Hansen, C. Wu, M. M. Jeppesen
Summary: This study compares the effects of patient initiated follow up (PIFU) versus hospital based follow up (HBFU) on fear of cancer recurrence (FCR), quality of life (QoL), and healthcare use after 34 months of follow up. The results indicate that patient initiated follow up is a valid alternative to hospital based follow up for low-intermediate risk endometrial carcinoma patients.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Oncology
Iris van 't Erve, Jamie E. Medina, Alessandro Leal, Eniko Papp, Jillian Phallen, Vilmos Adleff, Elaine Jiayuee Chiao, Adith S. Arun, Karen Bolhuis, John K. Simmons, Aanavi Karandikar, Kenneth C. Valkenburg, Mark Sausen, Samuel Angiuoli, Robert B. Scharpf, Cornelis J. A. Punt, Gerrit A. Meijer, Victor E. Velculescu, Remond J. A. Fijneman
Summary: The study demonstrates that accurate monitoring of treatment response using ctDNA can be achieved in a tumor tissue-independent manner by combining cfDNA and patient-matched WBC genomic DNA analysis. This approach prevents false-positives caused by germline or hematopoietic variants and provides more predictive information on overall survival compared to standard radiological evaluation. Additionally, ctDNA analysis reveals potential therapy resistance mutations in a significant portion of patients.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Sanne ten Hoorn, Linda Mol, Dirkje W. Sommeijer, Lisanne Nijman, Tom van den Bosch, Tim R. de Back, Bauke Ylstra, Erik van Dijk, Carel J. M. van Noesel, Roy J. Reinten, Iris D. Nagtegaal, Miriam Koopman, Cornelis J. A. Punt, Louis Vermeulen
Summary: We evaluated the potential efficacy of adding anti-EGFR therapy to anti-VEGF therapy in a subgroup of patients with metastatic colorectal cancer. The retrospective study (CAIRO2 trial, n = 736) showed no benefit of anti-EGFR addition within the subgroup, but an overall survival increase of 6.5 months compared to the original trial.
CLINICAL COLORECTAL CANCER
(2023)
Article
Pathology
Astrid Kramer, Ed Schuuring, Daan C. L. Vessies, Paul van der Leest, Maartje J. Geerlings, Pim Rozendal, Mirthe Lanfermeijer, Theodora C. Linders, Leon C. van Kempen, Remond J. A. Fijneman, Marjolijn J. L. Ligtenberg, Gerrit A. Meijer, Daan van den Broek, Valesca P. Retel, Veerle M. H. Coup
Summary: This study developed a micro-costing framework for consistent cost calculation of ctDNA testing. The framework takes into account the complete diagnostic workflow of ctDNA testing, including costs for personnel, materials, equipment, overhead, and failures. Evaluations and case studies were performed, showing a wide range of costs per sample and the sensitivity to platform, setting, and testing volume. An open access tool is provided for laboratory-specific calculations and exploring the total costs and impact of alternative prices or assumptions.
JOURNAL OF MOLECULAR DIAGNOSTICS
(2023)
Review
Oncology
Jan M. Van Rees, Lissa Wullaert, Alexander A. J. Grueter, Yassmina Derraze, Pieter J. Tanis, Henk M. W. Verheul, John W. M. Martens, Saskia M. Wilting, Geraldine Vink, Jeroen L. A. Van Vugt, Nick Beije, Cornelis Verhoef
Summary: This systematic review and meta-analyses demonstrate a strong association between ctDNA and recurrent disease in non-metastatic rectal cancer. ctDNA analysis can stratify patients into high and low risk groups for recurrence, especially when detected after neoadjuvant treatment and surgery. Future research should focus on the feasibility of ctDNA-guided treatment and follow-up strategies in rectal cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Maarten te Groen, Lauranne A. A. P. Derikx, Lisa van Lierop, Bauke Ylstra, Frank Hoentjen, Iris D. Nagtegaal, Femke Simmer
Summary: The presence of previous colorectal neoplasia is the most significant indicator for the development of pouch neoplasia in inflammatory bowel disease. However, the underlying mechanism remains unknown. Our study found evidence of clonality between colorectal and pouch neoplasia in 30% of patients, suggesting that most pouch neoplasia develops independently from prior colorectal lesions.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Gregory J. Riely, Egbert F. Smit, Myung-Ju Ahn, Enriqueta Felip, Suresh S. Ramalingam, Anne Tsao, Melissa Johnson, Francesco Gelsomino, Raymond Esper, Ernest Nadal, Michael Offin, Mariano Provencio, Jeffrey Clarke, Maen Hussain, Gregory A. Otterson, Ibiayi Dagogo-Jack, Jonathan W. Goldman, Daniel Morgensztern, Ann Alcasid, Tiziana Usari, Paul Wissel, Keith Wilner, Nuzhat Pathan, Svitlana Tonkovyd, Bruce E. Johnson
Summary: The combination of encorafenib and binimetinib showed clinical efficacy and acceptable safety in patients with BRAF(V600E)-mutant metastatic NSCLC.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Anna Lena van Gulik, Ellen Sluydts, Liesbet Vervoort, Mark Kockx, Pim Kortman, Bauke Ylstra, Stephen P. Finn, Lukas Bubendorf, Idris Bahce, Daoud Sie, Teodora Radonic, Birgit Lissenberg-Witte, Erik Thunnissen
Summary: This study investigates the impact of cell size and ploidy on FISH results. The results show that in liver cell nuclei, the number of FISH signals increases with nuclear size and section thickness. In non-small cell lung cancer cases, tumor cells with higher ploidy levels and nuclear size have an increased chance of single signals. In addition, no rearrangements were found in lung cancer samples with borderline ALK FISH results, proving a false positive result.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Oncology
Elisabeth M. Jongbloed, Hedwig M. Blommestein, Hannah M. van Schoubroeck, John W. M. Martens, Saskia M. Wilting, Carin A. Uyl-de Groot, Agnes Jager
Summary: The addition of two years of abemaciclib treatment to high-risk ER+, HER2-early breast cancer patients has been approved by the FDA. Using detection of minimal residual disease (MRD) through patient-informed circulating tumor DNA assays, the addition of abemaciclib treatment shows cost-effectiveness for high-risk patients. However, adding abemaciclib to all high-risk patients is not cost-effective, while MRD-guided treatment is more cost-effective compared to standard treatment.
BREAST CANCER-TARGETS AND THERAPY
(2023)
Article
Oncology
Koichi Goto, Yasushi Goto, Toshio Kubo, Kiichiro Ninomiya, Sang-We Kim, David Planchard, Myung-Ju Ahn, Egbert F. Smit, Adrianus Johannes de Langen, Maurice Perol, Elvire Pons-Tostivint, Silvia Novello, Hidetoshi Hayashi, Junichi Shimizu, Dong-Wan Kim, Chih-Hsi Kuo, James Chih-Hsin Yang, Kaline Pereira, Fu-Chih Cheng, Ayumi Taguchi, Yingkai Cheng, Wenqin Feng, Zenta Tsuchihashi, Pasi A. Janne
Summary: T-DXd demonstrates clinically meaningful responses in patients with previously treated HER2-positive non-small-cell lung cancer, with favorable safety at a dosage of 5.4 mg/kg.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Zofia Piotrowska, Daniel Shao-Weng Tan, Egbert F. Smit, Alexander I. Spira, Ross A. Soo, Danny Nguyen, Victor Ho-Fun Lee, James Chih-Hsin Yang, Vamsidhar Velcheti, John M. Wrangle, Mark A. Socinski, Marianna Koczywas, John E. Janik, Jeffrey Jones, Helena Alexandra Yu
Summary: This study demonstrates that Zipalertinib has encouraging antitumor activity in heavily pretreated patients with EGFR ex20ins-mutant NSCLC, with an acceptable safety profile and low frequency of high-grade diarrhea and rash.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Pathology
Tanya T. D. Soeratram, Hedde D. Biesma, Jacqueline M. P. Egthuijsen, Elma Meershoek-Klein Kranenbarg, Henk H. Hartgrink, Cornelis J. H. van de Velde, Aart Mookhoek, Erik van Dijk, Yongsoo Kim, Bauke Ylstra, Hanneke W. M. van Laarhoven, Nicole C. T. van Grieken
Summary: Tumor-infiltrating lymphocytes are important for the survival of gastric cancer patients, and T-cell densities in different regions of the tumor can serve as prognostic markers. CD8OIM and FOXP3TC are identified as key factors for survival, and the combination of their densities can stratify patients into distinct subgroups with different prognosis. These immune subgroups are independent predictors for cancer-specific survival in resectable gastric cancer.
Article
Oncology
Noortje Verschoor, Vanja de Weerd, Mai N. Van, Jaco Kraan, Marcel Smid, Joan B. Heijns, Jan C. Drooger, Johanna M. Zuetenhorst, Annemieke van der Padt-pruijsten, Agnes Jager, Stefan Sleijfer, John W. M. Martens, Saskia M. Wilting
Summary: This study demonstrates that mFAST-SeqS can serve as a strong prognostic marker for MBC patients. It is an affordable and easily implementable method for assessing ctDNA levels, offering an alternative tool for prognosis. The aneuploidy score obtained using mFAST-SeqS is significantly correlated with CTC count and is a significant prognostic marker for both PFS and OS in MBC patients.
Article
Multidisciplinary Sciences
Margaretha G. M. Roemer, Tim van de Brug, Erik Bosch, Daniella Berry, Nathalie Hijmering, Phylicia Stathi, Karin Weijers, Jeannette Doorduijn, Jacoline Bromberg, Mark van de Wiel, Bauke Ylstra, Daphne de Jong, Yongsoo Kim
Summary: In order to understand the clinical relevance of the tumor microenvironment (TME), it is important to study the interactions between malignant and non-malignant cells in clinical samples. Researchers have developed a computational framework to comprehensively analyze the spatial context of the TME, including close and long-distance interactions between different cell types. This framework was applied to imaging data from 88 primary central nervous system lymphomas, revealing significant prognostic subgroups mainly determined by the spatial context. The results highlight the importance of spatial context in predicting patient survival, particularly in relation to macrophage infiltration near specific cell types.
Article
Oncology
D. M. Mens, J. M. van Rees, S. M. Wilting, C. Verhoef
Summary: Chemoradiation therapy (CRT) is the standard of care for treating rectal cancer, but it can cause damage to the surrounding healthy tissue and not all patients benefit from it. This study aims to develop a diagnostic innovation using DNA methylation to predict the effectiveness of CRT for rectal cancer patients.
Article
Oncology
Noortje Verschoor, Marcel Smid, Agnes Jager, Stefan Sleijfer, Saskia M. Wilting, John W. M. Martens
Summary: In this study, the researchers investigated the characteristics and therapy resistance of HER2-positive breast cancer through integrating genomics and transcriptomics data. They found that the genomic profiles of primary and metastatic HER2-positive breast cancers were similar, and certain genomic features were predictive of progression-free survival on post-biopsy anti-HER2 treatment. Additionally, a HER2-driven expression profile grouped different types of HER2-positive tumors and indicated the possibility of transformation to ER independence. Integrated genomic and transcriptomic analyses may play a key role in establishing therapeutic options.
BREAST CANCER RESEARCH
(2023)