Review
Immunology
Peter W. West, Silvia Bulfone-Paus
Summary: Mast cells exhibit heterogeneity in different tissues and their interactions with immune cells may be regulated by tissue-specific factors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Ruth A. Houseright, Veronika Miskolci, Oscar Mulvaney, Valeriu Bortnov, Deane F. Mosher, Julie Rindy, David A. Bennin, Anna Huttenlocher
Summary: MYDGF, induced by tissue damage, regulates neutrophil motility to damaged tissues through the HIF-1α pathway. Depletion of MYDGF impairs wound healing and inflammation resolution, while persistent neutrophil inflammation in MYDGF mutants is dependent on HIF-1α pathway.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Immunology
Juan Liu, Xiaomin Zhang, Yujie Cheng, Xuetao Cao
Summary: Dendritic cells play crucial roles in immune defense and tolerance, but dysregulation of their migration can lead to immune imbalance and diseases. Researchers are exploring new strategies targeting the migration of distinct dendritic cell subsets for the treatment of related diseases.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Shamila Vibhushan, Manuela Bratti, Juan Eduardo Montero-Hernandez, Alaa El Ghoneimi, Marc Benhamou, Nicolas Charles, Eric Daugas, Ulrich Blank
Summary: Chymase, an important protease found in mast cells, plays a key role in the development of kidney disease, contributing to the generation of angiotensin II, an important inflammatory mediator. While initially thought to contribute to pathogenesis, accumulating data suggest that chymase may also have beneficial effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Le He, Marie-Pierre Valignat, Lichen Zhang, Lena Gelard, Fanghui Zhang, Valentin Le Guen, Stephane Audebert, Luc Camoin, Even Fossum, Bjarne Bogen, Hui Wang, Sandrine Henri, Romain Roncagalli, Olivier Theodoly, Yinming Liang, Marie Malissen, Bernard Malissen
Summary: The study reveals that ARHGAP45 GAP plays a key role in the lifecycle of T and B cells, controlling cell deformability and motility which affect the entry of cells into lymph nodes and engraftment in the bone marrow.
Review
Engineering, Biomedical
Wenxuan Du, Praful Nair, Adrian Johnston, Pei-Hsun Wu, Denis Wirtz
Summary: Cell migration is a crucial process that regulates human organ development, disease progression and cancer metastasis. The migration of immune and tumor cells is closely associated with immune cell infiltration, immune escape, and tumor cell spread in cancer. Understanding the reciprocal regulation of immune and cancer cell migration mediated by soluble factors can provide valuable insights for the development of biomarkers and treatments for cancer.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Jufang Jia, Mengnan Zeng, Denghui Zhu, Xinmian Jiao, Beibei Zhang, Ruolan Yang, Weisheng Feng, Xiaoke Zheng
Summary: This study demonstrates for the first time that EB-A can ameliorate allergic asthma by inhibiting mast cell activation and dendritic cell maturation, and the molecular mechanism of EB-A's anti-asthmatic activity might be mediated by inhibiting PAR2 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jonathan Kuhn, Yiyan Lin, Peter N. Devreotes
Summary: Dictyostelium discoideum has been a valuable tool for dissecting eukaryotic cell biology due to its short growth cycle and genetic tractability. Recent advances in imaging, synthetic biology, and computational analysis allow researchers to tune the activity of individual molecules in living cells and measure the effects on cellular motility and signaling. This enables a better understanding and control of cell migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Narcy Arizmendi, Syed Benazir Alam, Khalid Azyat, Darren Makeiff, A. Dean Befus, Marianna Kulka
Summary: Sesquiterpenes are volatile compounds produced by plants, insects, and marine organisms, with diverse biological properties as potent inhibitors and modulators of inflammation. Their complex chemical structure and biosynthesis allow for a wide range of functional groups and substituents.
Review
Allergy
Martin Metz, Pavel Kolkhir, Sabine Altrichter, Frank Siebenhaar, Francesca Levi-Schaffer, Bradford A. Youngblood, Martin K. Church, Marcus Maurer
Summary: Chronic urticaria is a mast cell-dependent disease with limited therapeutic options. Current strategies focus on inhibiting IgE-mediated activation of mast cells and antagonizing the effects of released mediators. MC silencers have been developed as a new strategy to selectively block mast cell activation without causing immunosuppressive adverse effects.
Review
Cell Biology
Meng Feng, Shuping Zhou, Yong Yu, Qinghong Su, Xiaofan Li, Wei Lin
Summary: Dendritic cells (DCs) are a class of antigen-presenting cells with crucial roles in immune activation and tolerance. Understanding the migration mechanisms and regulatory factors of different DC subgroups provides new insights for disease treatment, such as infection, tumors, and vaccine preparation. Various factors, including chemokines, membrane molecules, and microenvironments, influence DC migration and immunological functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Allergy
Tahereh Derakhshan, Joshua A. Boyce, Daniel F. Dwyer
Summary: This article provides an overview of the differentiation and characteristics of mast cell (MC) progenitors, as well as the heterogeneity of MCs in health and disease. Single-cell profiling technologies offer a powerful approach to decipher complex cellular functions and interactions, and to identify candidate factors for targeted therapies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Daniel Schindler, Ted Moldenhawer, Maike Stange, Valentino Lepro, Carsten Beta, Matthias Holschneider, Wilhelm Huisinga
Summary: The article introduces a method based on curve flow for extracting cell morphology features from microscopy image sequences, and provides an open-source software package called AmoePy for analyzing amoeboid cell motility. This method allows for the automated extraction of properties of cell shape changes, including expansion area and growth time.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Immunology
Ahsen Ustaoglu, Fatema Arif Daudali, Manfredi D'afflitto, Stephen Murtough, Chung Lee, Estefania Moreno, Diana C. Blaydon, David P. Kelsell, Daniel Sifrim, Philip Woodland, Madusha Peiris
Summary: This study identified increased expression of nerve growth factor (NGF) and decreased abundance of dendritic cells in the mucosa of GERD patients, which may be related to neuronal sprouting and immune responses in GERD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Carolina M. Polonio, Patrick da Silva, Fabiele B. Russo, Brendo R. N. Hyppolito, Nagela G. Zanluqui, Cecilia Benazzato, Patricia C. B. Beltrao-Braga, Sandra M. Muxel, Jean Pierre S. Peron
Summary: Viral infections, particularly Zika virus, have a significant impact on public health, causing severe fetal neuropathogenesis and microcephaly. MiRNAs play a role in infected neuronal precursor cells and directly contribute to the pathogenesis of fetal microcephaly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Melina Messing, Sia Cecilia Jan-Abu, Kelly McNagny
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Sandro Mascena Gomes-Filho, Edmilson Ozorio dos Santos, Ester Riserio Matos Bertoldi, Luiza Coimbra Scalabrini, Vitor Heidrich, Bianca Dazzani, Elena Levantini, Eduardo Moraes Reis, Daniela Sanchez Basseres
Article
Biochemistry & Molecular Biology
Felipe Silva Rodrigues, Vanessa Silva Miranda, Tatiana Correa Carneiro-Lobo, Luiza Coimbra Scalabrini, Bjorn Kruspig, Elena Levantini, Daniel J. Murphy, Daniela Sanchez Basseres
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Hematology
Sridevi Surapally, Daniel G. Tenen, John A. Pulikkan
Summary: This review focuses on the key role of CBF beta-SMMHC in AML and recent advances in therapeutic strategies targeting CBF beta-SMMHC in inv(16) AML.
Article
Hematology
Bon Q. Trinh, Simone Ummarino, Yanzhou Zhang, Alexander K. Ebralidze, Mahmoud A. Bassal, Tuan M. Nguyen, Gerwin Heller, Rory Coffey, Danielle E. Tenen, Emiel van der Kouwe, Emiliano Fabiani, Carmelo Gurnari, Chan-Shuo Wu, Vladimir Espinosa Angarica, Henry Yang, Sisi Chen, Hong Zhang, Abby R. Thurm, Francisco Marchi, Elena Levantini, Philipp B. Staber, Pu Zhang, Maria Teresa Voso, Pier Paolo Pandolfi, Susumu S. Kobayashi, Li Chai, Annalisa Di Ruscio, Daniel G. Tenen
Summary: This study identifies a myeloid-specific lncRNA, LOUP, as a transcriptional inducer of PU.1 through recruiting RUNX1, forming an active chromatin loop. In AML, the oncogenic fusion protein RUNX1-ETO limits chromatin accessibility at the LOUP locus, leading to suppression of LOUP and PU.1 expression.
Article
Immunology
Kelly C. Higa, Andrew Goodspeed, James S. Chavez, Marco De Dominici, Etienne Danis, Vadym Zaberezhnyy, Jennifer L. Rabe, Daniel G. Tenen, Eric M. Pietras, James DeGregori
Summary: The study found that chronic exposure to interleukin-113 (IL-113) can induce Cebpa loss, leading to increased myeloid lineage output. In addition, overexpression of the CEBPA gene may reduce the fitness of acute myeloid leukemias, resulting in increased differentiation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biology
Giorgia Maroni, Mahmoud A. Bassal, Indira Krishnan, Chee Wai Fhu, Virginia Savova, Rapolas Zilionis, Valerie A. Maymi, Nicole Pandell, Eva Csizmadia, Junyan Zhang, Barbara Storti, Julio Castano, Riccardo Panella, Jia Li, Corinne E. Gustafson, Sam Fox, Rachel D. Levy, Claire Meyerovitz, Peter J. Tramontozzi, Kimberly Vermilya, Assunta De Rienzo, Stefania Crucitta, Daniela S. Basseres, Marla Weetall, Art Branstrom, Alessandra Giorgetti, Raffaele Ciampi, Marzia Del Re, Romano Danesi, Ranieri Bizzarri, Henry Yang, Olivier Kocher, Allon M. Klein, Robert S. Welner, Raphael Bueno, Maria Cristina Magli, John G. Clohessy, Azhar Ali, Daniel G. Tenen, Elena Levantini
Summary: A tumor-specific, mutant-KRAS-associated subpopulation was identified in human and murine lung cancer, offering promise for targeted therapy developments.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Arif A. Arif, Yu-Hsuan Huang, Spencer A. Freeman, Jawairia Atif, Pamela Dean, Jacqueline C. Y. Lai, Marie-Renee Blanchet, Kimberly C. Wiegand, Kelly M. McNagny, T. Michael Underhill, Michael R. Gold, Pauline Johnson, Calvin D. Roskelley
Summary: Inflammation-induced monocyte-derived macrophages (MoDM) and hepatocyte growth factor (HGF) have been found to increase the formation of early micrometastatic lesions in the lung, enhancing the survival rate of tumor cells.
MOLECULAR CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Kar-Tong Tan, Ling-Wen Ding, Chan-Shuo Wu, Daniel G. Tenen, Henry Yang
Summary: Studying RNA modifications in large clinical cohorts can provide insights into the relationship between the epitranscriptome and human diseases, with ModTect offering a way to identify known and unknown types of mRNA modifications. This tool can help discover associations between RNA modifications and clinical outcomes in patient cohorts.
Article
Oncology
Elena Levantini, Giorgia Maroni, Marzia Del Re, Daniel G. Tenen
Summary: EGFR plays an important role in maintaining epithelial tissues, but when its signaling is altered, it becomes a major regulator of epithelial transformation and is one of the most studied tyrosine kinase receptors involved in neoplasia worldwide. EGFR-targeted therapies have revolutionized cancer treatment, but the dream of turning solid tumors into chronic diseases remains unfulfilled.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemical Research Methods
Tiam Heydari, Matthew A. Langley, Cynthia W. Fisher, Daniel A. Aguilar-Hidalgo, Shreya Shukla, Ayako A. Yachie-Kinoshita, Michael Hughes, Kelly A. M. McNagny, Peter Zandstra
Summary: This article introduces IQCELL, a platform based on single-cell RNA sequencing data to infer, simulate, and study executable logical gene regulatory networks (GRNs). Using scRNA-seq datasets from mouse T-cell and red blood cell development, IQCELL can infer the majority of previously reported causal gene interactions and simulate the effects of known gene perturbations. It also provides a gene selection pipeline for identifying candidate genes without prior knowledge.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
William Yip, Xuan Li, Graeme J. Koelwyn, Stephen Milne, Fernando Sergio Leitao Filho, Chen Xi Yang, Ana I. Hernandez Cordero, Julia Yang, Cheng Wei Tony Yang, Tawimas Shaipanich, Stephan F. van Eeden, Janice M. Leung, Stephen Lam, Kelly M. McNagny, Don D. Sin
Summary: Changes in the microbiome following inhaled corticosteroid/long-acting beta 2-agonist combination therapy in COPD patients are related to alterations in the host transcriptome in the small airways. This may explain why some COPD patients treated with inhaled corticosteroids may be at an increased risk for airway infections.
Article
Cell Biology
Anthony Tam, Emmanuel Twumasi Osei, Chung Y. Cheung, Michael Hughes, Chen X. Yang, Kelly M. McNagny, Delbert R. Dorscheid, Gurpreet K. Singhera, Teal S. Hallstrand, Stephanie Warner, James C. Hogg, Tillie L. Hackett, Chinten J. Lim, Don D. Sin
Summary: This study found that the Hedgehog signaling pathway is involved in the process of airway remodeling in asthma, which is partially mediated via the PTCH1-SMO-GLI axis. This provides hope for finding new targets for treating airway tissue remodeling in patients with allergic airways disease.
Meeting Abstract
Immunology
Robert S. Welner, Deepak Bararia, Elena Levantini, Virginia Camacho, Sweta Patel, Victoria R. Matkins, Daniel G. Tenen
JOURNAL OF IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Tan-Min Chin, Gandhi T. K. Boopathy, Ellen P. S. Man, John G. Clohessy, Eva Csizmadia, Margaret P. Quinlan, Thomas Putti, Seow-Ching Wan, Chen Xie, Azhar Ali, Fhu Chee Wai, Yan Shan Ong, Boon-Cher Goh, Jeff Settleman, Wanjin Hong, Elena Levantini, Daniel G. Tenen