Article
Food Science & Technology
Jihyun Won, Juhyung Kang, Keumhan Noh, Hee-Chul Chung, Wonku Kang
Summary: This study represents the first individual pharmacokinetics of Gly-Pro-Hyp, Pro-Hyp, and Gly-Pro in vivo. Gly-Pro-Hyp and Pro-Hyp showed a double-peak phenomenon after oral administration, while Gly-Pro had low levels in systemic circulation. Gly-Pro-Hyp tended to exhibit higher first-pass metabolism than Pro-Hyp.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Chemistry, Physical
Satish Kumar, Kshetrimayum Borish, Sanjit Dey, Jayashree Nagesh, Aloke Das
Summary: The folding motifs of Gly-Pro and Pro-Gly dipeptides were investigated and their structures were found to be dependent on the hydrogen bonding interactions. The structure of Gly-Pro peptide was consistent between gas phase and solution phase, while the Pro-Gly peptide had different structures in gas phase and solution phase. Solvent might play a crucial role in dictating the preferential stabilization of the C10 structure in the solution phase.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Paul J. Arcoria, Rachel Ware, Sunny Makwana, Diego Troya, Felicia A. Etzkorn
Summary: Fluoro- and chloro-alkene mimics of Gly-Pro and Pro-Pro can participate in n ->pi* donation to stabilize PPII conformations, but are poor n.p* acceptors. Proteo-alkene mimics lack significant n ->pi* interactions, leading to unstable PPII-like geometries.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Medicine, Research & Experimental
Chaoquan Lai, Rui Cao, Renda Li, Chunfeng He, Xiao Wang, Hui Shi, Chunrong Qu, Kun Qian, Shaoli Song, Wen-Hua Chen, Zhen Cheng
Summary: In this study, a novel FAP ligand (DOTA-GPFAPI-04) was designed and synthesized, which showed good FAP targeting ability for PET imaging of glioblastoma. Compared with the widely studied [Ga-68]Ga-FAPI-04, [Ga-68]Ga-DOTA-GPFAPI-04 exhibited higher tumor uptake values and longer retention time in the tumor.
MOLECULAR PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Hitoki Semizo, Ryusei Yabu, Haruka Kai, Yamato Ohgishi, Yasumitsu Matsuo
Summary: In recent years, there has been a demand for the use of biomaterials in electronic devices to enhance device biocompatibility. This study investigates the proton conductivity of Glycyl-L-proline (Gly-Pro) to understand the relationship between peptide hydration and proton conduction. The results suggest that proton conductivity in Gly-Pro is achieved through hydration. It is observed that proton conductivity in the hydrated Gly-Pro crystal is attributed to the breaking and rearrangement of hydrogen bonds along the c-axis between hydration shells formed by the amino acid and water molecules. Additionally, the steep increases in proton conductivity at hydration numbers n 0.15 and n 0.35 are found to result from the formation of a percolation network and faster rearrangement of hydrogen bonds within and between hydrated shells, respectively.
Article
Food Science & Technology
Qi Tian, Shi-Ming Li, Bo Li
Summary: This study identified eleven peptides in the absorbates of fish skin collagen hydrolysates, with OGSA showing the strongest inhibitory effect on platelet aggregation and thrombus formation. Molecular docking results suggested that OG-containing peptides may target the P2Y12 receptor. The abundant PG(OG) sequence in the collagen amino acid sequence of H. Molitrix indicates potential for developing the hydrolysates as dietary supplements for preventing cardiovascular diseases.
Article
Spectroscopy
Shuaibing Yu, Lei Gao, Rui Li, Chen Fu, Wei Meng, Lei Wang, Lianzhi Li
Summary: Mercury, a highly toxic environmental contaminant, can damage the human body with long-term accumulation. The newly synthesized D-P4 sensor exhibits excellent selectivity and sensitivity to Hg2+ for detection purposes.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Organic
Paul J. Arcoria, Felicia A. Etzkorn
Summary: We present the first experimental evidence that a fluoro-alkene amide isostere can participate in n ->pi* donation, thereby stabilizing the collagen triple helix. Substitution of the isomerizable 3 degrees Gly-Pro amide bond with a trans-locked fluoro-alkene improves the stability of the triple helix. The synthesized (Z)-fluoro-alkene isostere of Gly-trans-Pro shows a decreased thermostability compared to the control peptide, indicating a stabilizing n ->pi* electronic interaction.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Immunology
Na Liu, Michael Bauer, Adrian T. Press
Summary: The chemokine receptor CXCR2 and its ligands play a crucial role in the progression of liver inflammation and failure in sepsis. However, excessive receptor activation can lead to immune cell desensitization and further liver damage. Cell-type-specific CXCR2-directed therapeutics may offer a novel approach for sepsis treatment.
JOURNAL OF INFLAMMATION-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Shuyu Liu, Shinsuke Mohri, Yuki Manabe, Akika Ejima, Kenji Sato, Tatsuya Sugawara
Summary: This study evaluated the photoprotective effects of Gly-Pro on photoaging and found that it effectively inhibited ROS generation and attenuated UVA-induced signaling pathway activation in normal human dermal fibroblasts. Compared to structurally similar dipeptides, Gly-Pro exhibited better anti-photoaging effects.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Biochemical Research Methods
Tomoko Hashimoto, Yuka Nakamura, Sachiro Kakinoki, Naoko Sano, Tsunenori Kameda, Yasushi Tamada, Tetsuji Yamaoka, Hiromichi Kurosu
Summary: This study proposes a simple method to immobilize the functional peptide of GRGDS on the surface of SF films using GAGAGS sequences. This method does not involve any chemical reaction, preserving the original properties of SF molecules. The density of GRGDS peptides on GAGAGS-bound SF films was found to be higher compared to non-GAGAGS-bound films. Furthermore, the amount of immobilized (GAGAGS)GRGDS peptide increased with the promotion of β-sheet crystallization in the SF film. Fibroblasts adhered to the SF film showed increased extensibility due to (GAGAGS)GRGDS immobilization, indicating effective cell adhesion activity of RGD.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Food Science & Technology
Zhao Deng, Huichao Yu, Zhipeng Yang, Lingling Hu, Qi Liu, Yanan Wang, Hong-Kui Wei, Jian Peng
Summary: The study showed that GPA peptide isolated from fish skin gelatin hydrolysate fraction 3 has a protective effect in alleviating the toxicity and oxidative stress induced by Deoxynivalenol (DON). Treatment with FGSHF3 and GPA significantly increased animal weight, inhibited organ enlargement, and reduced intestinal injury.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Engineering, Environmental
Sylvanus B. Ruvubu, Indrajit Roy
Summary: Malachite green was successfully adsorbed from aqueous solutions using magnetic chitosan nanoparticles coated with triglycine and 2-mercaptoethylamine hydrochloride. The adsorption process was optimized by considering factors such as pH, MG concentration, sorbent dosage, time, sonication or shaking, and temperature. The fabricated nanoadsorbents showed high MG removal efficiency under optimal conditions. This study provides insights into the potential application of magnetic chitosan nanoparticles for water purification.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Review
Medicine, General & Internal
Adriana Marques, Carla Torre, Rui Pinto, Bruno Sepodes, Joao Rocha
Summary: Sepsis is a life-threatening condition caused by a dysregulated host response to infection, affecting over 25 million people annually. Septic shock, a severe subset of sepsis, is characterized by persistent low blood pressure, with hospital mortality rates exceeding 40%. Despite advances in early sepsis mortality, long-term complications such as secondary infection remain a significant cause of death, and there are currently no sepsis-specific therapies. Immunostimulatory therapy, including cytokines, growth factors, immune checkpoint inhibitors, and cellular therapies, holds promise in addressing this unmet medical need.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Chemistry, Medicinal
Yishi Xie, Wenbin Kuang, Dawei Wang, Kai Yuan, Peng Yang
Summary: C-X-C motif chemokine receptor 2 (CXCR2) is a G protein-coupled receptor (GPCR) that is involved in various inflammatory diseases and cancers. It is closely associated with the migration of neutrophils and monocytes. Small-molecule CXCR2 antagonists have shown promising safety and therapeutic effects in clinical trials. CXCR2 could potentially serve as a biomarker and therapeutic target for diabetes, and CXCR2 antagonists may also have a role in attenuating lung injury in COVID-19.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Urszula Godlewska, Bernadetta Bilska, Aneta Zegar, Piotr Brzoza, Arkadiusz Borek, Krzysztof Murzyn, Oliwia Bochenska, Agnieszka Morytko, Patryk Kuleta, Andrzej Kozik, Elzbieta Pyza, Artur Osyczka, Brian A. Zabel, Joanna Cichy
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Kareem L. Graham, Bonnie J. Werner, Kimberly M. Moyer, Alycia K. Patton, Charles R. Krois, Hong Sik Yoo, Maria Tverskoy, Melissa LaJevic, Joseph L. Napoli, Raymond A. Sobel, Brian A. Zabel, Eugene C. Butcher
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Sung Kyun Lee, Geon Ho Bae, Ye Seon Kim, Hyung Sik Kim, Mingyu Lee, Jaewang Ghim, Brian A. Zabel, Sung Ho Ryu, Yoe-Sik Bae
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Russell K. Pachynski, Ping Wang, Nicole Salazar, Yayue Zheng, Leona Nease, Jesse Rosalez, Weng-In Leong, Gurpal Virdi, Keith Rennier, Woo Jae Shin, Viet Nguyen, Eugene C. Butcher, Brian A. Zabel
FRONTIERS IN IMMUNOLOGY
(2019)
Editorial Material
Immunology
Giovanni Bernardini, Brian A. Zabel
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Min Young Park, Hyung Sik Kim, Ha Young Lee, Brian A. Zabel, Yoe-Sik Bae
Article
Microbiology
Urszula Godlewska, Bernadetta Bilska, Pawel Majewski, Elzbieta Pyza, Brian A. Zabel, Joanna Cichy
FRONTIERS IN MICROBIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Piotr Brzoza, Urszula Godlewska, Arkadiusz Borek, Agnieszka Morytko, Aneta Zegar, Patrycja Kwiecinska, Brian A. Zabel, Artur Osyczka, Mateusz Kwitniewski, Joanna Cichy
Summary: This review focuses on exploring cysteine-based redox active antimicrobial proteins/peptides in the skin and intestine, discussing the causal links between different redox environments of these barrier tissues and the ability of AMPs to control cutaneous and intestinal microbes, and highlighting how bacteria can influence the bactericidal potential of redox-sensitive AMPs through intrinsic mechanisms.
Article
Cell Biology
Kerri Somebang, Joshua Rudolph, Isabella Imhof, Luyi Li, Erene C. Niemi, Judy Shigenaga, Huy Tran, T. Michael Gill, Iris Lo, Brian A. Zabel, Gabriela Schmajuk, Brian T. Wipke, Stefka Gyoneva, Luke Jandreski, Michael Craft, Gina Benedetto, Edward D. Plowey, Israel Charo, James Campbell, Chun Jimmie Ye, S. Scott Panter, Mary C. Nakamura, Walter Eckalbar, Christine L. Hsieh
Summary: In traumatic brain injury, various types of myeloid cells play different roles in either exacerbating damage or assisting in healing. Through single-cell RNA sequencing analysis, multiple subsets of microglia, monocyte/macrophage, and dendritic cells were identified in acute TBI and normal brains, providing new therapeutic targets for brain trauma treatment.
Article
Immunology
Hyung Sik Kim, Min Young Park, Nam Joo Yun, Hye Sun Go, Mi Young Kim, Je Kyung Seong, Minyoung Lee, Eun Seok Kang, Jaewang Ghim, Sung Ho Ryu, Brian A. Zabel, Ara Koh, Yoe-Sik Bae
Summary: Kim et al. found that deficiency of phospholipase D2 enhances thermogenic program and enhances mitochondrial quality in adipose tissues, leading to resistance to high fat diet-induced obesity and insulin resistance. Targeting PLD2 may offer potential therapeutics for obese and/or type 2 diabetic patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Microbiology
Aneta Zegar, Urszula Godlewska, Dorota Kozlowska-Chmielewska, Pawel Majewski, Brian A. Zabel, Joanna Cichy
Summary: Chemerin-derived peptide p4 can restrict the growth of methicillin-resistant Staphylococcus aureus (MRSA) and collaborates additively with LL-37 in inhibiting the growth of S. aureus, including MRSA. It has been shown to be effective in reducing MRSA burden in vivo and levels of skin-infiltrating leukocytes in S. aureus-infected AD-like skin.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Hematology
Geon Ho Bae, Ye Seon Kim, Ji Ye Park, Mingyu Lee, Sung Kyun Lee, Ji Cheol Kim, Jang Gyu Kim, Ye Ji Shin, Ho Lee, Soo-Youl Kim, Yong-Soo Bae, Brian A. Zabel, Hong Sook Kim, Yoe-Sik Bae
Summary: Lung-resident neutrophils (LNs) play essential roles in protecting the lungs against damage and inflammation, and they show distinct characteristics compared to bone marrow and blood neutrophils.
Review
Immunology
Ewa Oleszycka, Kamila Kwiecien, Patrycja Kwiecinska, Agnieszka Morytko, Natalia Pocalun, Michelle Camacho, Piotr Brzoza, Brian A. A. Zabel, Joanna Cichy
Summary: The skin, as the largest organ exposed to the environment, plays a critical role in integrating signals and defending against external threats. The interactions between the epidermis, immune system, and nervous system are now recognized for their importance in regulating and maintaining the skin barrier function in relation to skin pathophysiology. Dysregulation of these connections can lead to chronic inflammatory diseases and conditions associated with chronic pain or itch.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Krishna P. Kota, Natasza E. Ziolkowska, Jiayi Wei, Junzhong Peng, David Ordonez, Christy Raney, Jon Prigge, Jay W. Hooper, Mayanka Awasthi, Scott J. Goebel, Brian A. Zabel, Farooq Nasar, Seth Lederman, Sina Bavari
Summary: Antibody-based therapy is emerging as a critical approach to treat acute viral infections by offering rapid protection. This study developed and optimized high-content image (HCI)-based assays to screen for therapeutic antibodies against monkeypox virus (MPXV), and identified several potent anti-MPXV neutralizing antibodies.
ANTIVIRAL RESEARCH
(2023)
Review
Immunology
Nicole Salazar, Brian A. Zabel
FRONTIERS IN IMMUNOLOGY
(2019)