Article
Pediatrics
Camilla Rigotti, Daniela Doni, Emanuela Zannin, Abedulrhman S. Abdelfattah, Maria Luisa Ventura
Summary: By evaluating the trajectory of left ventricular diastolic function through serial echocardiographic evaluations and its association with respiratory outcomes, we found that abnormalities in left ventricular diastolic function may contribute to the pathophysiology of bronchopulmonary dysplasia. Serial echocardiographic measurements could help identify infants at risk of worse respiratory outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Neurosciences
Arvind Sehgal, Marcel F. Nold, Calum T. Roberts, Samuel Menahem
Summary: This study investigated the impact of low-dose dexamethasone on cardiac indices in extremely preterm infants. The results showed that low-dose dexamethasone influenced cardiovascular parameters related to pulmonary circulation, such as ductal diameter and left pulmonary artery end-diastolic velocity. Left heart architecture and function were maintained, but there was a transient increase in blood pressure.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Pediatrics
Regan E. Giesinger, Amy H. Stanford, Brady Thomas, Steven H. Abman, Patrick J. McNamara
Summary: The effects of riociguat, an oral-soluble guanylate-cyclase stimulator, were studied in 10 infants with chronic pulmonary arterial hypertension. Improvement in respiratory status, right heart dilation, function, and chronic pulmonary arterial hypertension were observed. There were decreases in systolic, diastolic, and mean arterial pressures, without any critical hypotension or hypoxemia.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Marilena Savoia, Francesca Rech Morassutti, Luigi Castriotta, Daisy Pavoni, Peter M. Mourani, Paola Freschi, Luigi Cattarossi, Antonio Tonutti
Summary: This study evaluated the feasibility of using neonatologist-performed echocardiography for follow-up of preterm infants with moderate/severe bronchopulmonary dysplasia (BPD) and described the course of pulmonary hypertension (PH) in these infants. NPE follow-up was found to be safe for infants with BPD, aiding in early detection of mild PH.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pharmacology & Pharmacy
L. Mao, Y. Wu, X. Shu, S. Li, L. Huang
Summary: Echocardiographic parameters can be used to understand the degree of impaired cardiac function in preterm infants and for early detection of PH, which may reduce the mortality rate to a certain extent. The risk of BPD is significantly increased when TR velocity is higher than 1.45 m/s.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Pediatrics
Silvia Martini, Iuri Corsini, Luigi Corvaglia, Pradeep Suryawanshi, Belinda Chan, Yogen Singh
Summary: Despite recent improvements in neonatal care, moderate to severe bronchopulmonary dysplasia (BPD) is still associated with high mortality and increased risk of pulmonary hypertension (PH). Echocardiographic and lung ultrasound biomarkers can reflect the development and severity of BPD and PH. Early assessment may not accurately predict later BPD, while lung ultrasound at day 7 after birth can predict later BPD development. Routine surveillance and echocardiographic assessment for PH in at-risk preterm infants may provide useful information for management. More studies are needed to validate proposed parameters and timing of assessment for routine clinical practice.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Ann Hellstrom, Aldina Pivodic, Lotta Granse, Pia Lundgren, Ulrika Sjobom, Anders K. Nilsson, Helena Soderling, Anna-Lena Hard, Lois E. H. Smith, Chatarina Alice Lofqvist
Summary: This study found that higher mean daily serum levels of DHA during the first 28 postnatal days were associated with less severe ROP, even after adjustment for known risk factors, but only in infants with sufficiently high AA levels. Further research is needed to identify LC-PUFA supplementation strategies that may prevent ROP and other morbidities.
Article
Biochemistry & Molecular Biology
Quinn A. Bonafiglia, Yu-Qing Zhou, Guangpei Hou, Rhidita Saha, Ying-Han R. Hsu, Jonah Burke-Kleinman, Michelle P. Bendeck
Summary: Pulmonary hypertension is a disease characterized by elevated pulmonary arterial pressure, leading to right ventricular dysfunction and failure. This study shows that the DDR1 gene deletion results in abnormal muscularization of pulmonary arteries and impaired alveolar development, causing pulmonary hypertension and bronchopulmonary dysplasia.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Monalisa Patel, Japmeet Sandhu, Fu-Sheng Chou
Summary: This study examined the feasibility of predicting respiratory outcomes in extremely preterm infants of Asian descent using a machine learning approach. The results suggested an interrelationship among racial/ethnic groups for respiratory outcomes in this population.
Article
Critical Care Medicine
Regan E. Giesinger, Danielle R. Rios, Trassanee Chatmethakul, Adrianne R. Bischoff, Jeremy A. Sandgren, Alison Cunningham, Madeline Beauchene, Amy H. Stanford, Jonathan M. Klein, Patrick Ten Eyck, Patrick J. McNamara
Summary: This study evaluates the role of early hemodynamic screening in the risk of death or severe intraventricular hemorrhage in preterm infants. The findings show that screening significantly reduces the primary composite outcome of death or severe intraventricular hemorrhage, suggesting that early hemodynamic screening and tailored care may improve neonatal outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Shin Kato, Osuke Iwata, Hiroyuki Kato, Satoko Fukaya, Yukari Imai, Shinji Saitoh
Summary: This study reveals the involvement of furin in the alveolarization of immature lungs and its critical role in the pathogenesis of bronchopulmonary dysplasia (BPD). The findings highlight furin as a potential treatment target for ameliorating the impact of BPD.
Article
Pediatrics
Samir Gupta, Edmund Juszczak, Pollyanna Hardy, Nimish Subhedar, Jonathan Wyllie, Wilf Kelsall, Sunil Sinha, Sam Johnson, Tracy Roberts, Elisabeth Hutchison, Justine Pepperell, Louise Linsell, Jennifer L. Bell, Kayleigh Stanbury, Marketa Laube, Clare Edwards, David Field
Summary: The question of whether to treat patent ductus arteriosus (PDA) early or wait until symptoms appear is still a focus of neonatal medicine research. This study aims to investigate the effects of using ibuprofen to treat PDA in extremely preterm babies. Early targeted treatment of PDA may improve short and long-term health and economic outcomes.
Article
Pediatrics
Irina Branescu, Sandeep Shetty, Justin Richards, Simona Vladareanu, Anay Kulkarni
Summary: This study aimed to describe the clinical characteristics of pulmonary hypertension (PH) associated with moderate to severe bronchopulmonary dysplasia (MSBPD) in premature infants. The incidence of BPD-associated PH (BPD PH) was 12.6%, with 41% of infants having severe PH. The need for positive pressure respiratory support at 36 weeks post menstrual age (PMA) was independently associated with PH. Babies with MSBPD and PH had a higher mortality rate.
Article
Pediatrics
Yang Du, Lin Yuan, Jian-Guo Zhou, Xiang-Yuan Huang, Sam Bill Lin, Meng Yuan, Yue He, Wei-Ying Mao, Dan-Yang Ai, Chao Chen
Summary: Echocardiogram-assessed PH severity is significantly associated with mortality and readmission in very preterm infants with BPD, with moderate and severe PH linked to higher risk of mortality, and mild PH associated with increased likelihood of readmission. The accuracy of the PH severity model based on echocardiography in predicting mortality was demonstrated with an AUC of 0.79.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Pediatrics
Katharine Press Callahan, Matthew J. Kielt, Chris Feudtner, Darlene Barkman, Nicolas Bamat, Julie Fierro, Elizabeth Fiest, Sara B. DeMauro
Summary: A discrete choice experiment was conducted to assess the importance of potential future outcomes associated with bronchopulmonary dysplasia for parents of preterm infants. The results showed that parents ranked "Will my child be more vulnerable to other problems because of having lung disease?" as the most important outcome, with other respiratory health related outcomes also highly ranked. Outcomes related to child development and effects on the family were among the lowest ranked. However, there was a broad distribution of importance scores for many outcomes due to individual differences in parents' ratings.
JOURNAL OF PEDIATRICS
(2023)
Article
Acoustics
K. A. Kosiv, A. Moon-Grady, W. Hogan, R. Keller, R. Rapoport, E. Rogers, V. A. Feldstein, H. Lee, S. Peyvandi
Summary: Congenital diaphragmatic hernia (CDH) can lead to significant mass effect in the fetal thorax, affecting cerebral blood flow. Fetuses with left-sided CDH (L-CDH) were found to have lower middle cerebral artery (MCA) pulsatility index and the lower cardiac output was correlated with decreased cerebrovascular impedance.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Acoustics
W. J. Hogan, A. J. Moon-Grady, Y. Zhao, N. M. Cresalia, H. Nawaytou, E. Quezada, M. Brook, P. McQuillen, S. Peyvandi
Summary: This study used maternal hyperoxygenation (MH) to evaluate cerebrovascular reactivity in fetuses with specific congenital heart disease (CHD), finding that fetal response to high oxygen varied depending on the underlying CHD diagnosis, suggesting that cardiovascular physiology may influence the autoregulatory capacity of the fetal brain.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Letter
Acoustics
L. V. Ghimire, F. -S. Chou, A. J. Moon-Grady
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Letter
Acoustics
Christiana Tai, Tracy Conner, Shabnam Pevyandi, Anita J. Moon-Grady
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Shabnam Peyvandi, Duan Xu, Yan Wang, Whitnee Hogan, Anita Moon-Grady, A. James Barkovich, Orit Glenn, Patrick McQuillen, Jing Liu
Summary: The study found lower cerebral tissue oxygenation in fetuses with CHD as a result of impaired fetal oxygen delivery, with variability in response to maternal hyperoxia. Cardiovascular physiology is critical when designing neuroprotective clinical trials in fetuses with CHD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Rima Arnaout, Lara Curran, Yili Zhao, Jami C. Levine, Erin Chinn, Anita J. Moon-Grady
Summary: Deep learning and ensemble neural networks can accurately identify complex congenital heart disease in fetal ultrasound screening, improving sensitivity and specificity, potentially addressing the global diagnostic challenge of fetal CHD.
Article
Acoustics
W. J. Hogan, R. Punn, P. Dean, J. Strainic, J. Rychik, R. Williams, A. J. Moon-Grady, N. H. Silverman
Summary: Pseudoaneurysm of the MAIVF is a rare condition that can occur in adults and children, with cases identified prenatally or postnatally, and varying degrees of clinical significance.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anjali Chelliah, Anita J. Moon-Grady, Shabnam Peyvandi, Joanne S. Chiu, James E. Bost, David Schidlow, Sheila J. Carroll, Brooke Davey, Allison Divanovic, Lisa Hornberger, Lisa W. Howley, Ann Kavanaugh-McHugh, John P. Kovalchin, Stephanie M. Levasseur, Christopher L. Lindblade, Shaine A. Morris, Deliwe Ngwezi, Jay D. Pruetz, Michael D. Puchalski, Jack Rychik, Cyrus Samai, Theresa A. Tacy, Wayne Tworetzky, Margaret M. Vernon, Jay Yeh, Mary T. Donofrio
Summary: Perinatal mortality in tetralogy of Fallot with absent pulmonary valve remains high, with an overall survival of 64% in fetuses with intention to treat. Right ventricular dysfunction independently predicts overall mortality, while left ventricular dysfunction independently predicts fetal mortality and may influence prenatal management and delivery planning. Medistinal shift may reflect secondary effects of airway obstruction and abnormal lung development, associated with increased mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Martina A. Steurer, Shabnam Peyvandi, John M. Costello, Anita J. Moon-Grady, Robert H. Habib, Kevin D. Hill, Marshall L. Jacobs, Laura L. Jelliffe-Pawlowski, Roberta L. Keller, Sara K. Pasquali, Vadiyala M. Reddy, Sarah Tabbutt, Satish Rajagopal
Summary: This study reveals that infants with fetal growth restrictions are at increased risk of mortality and morbidity after congenital heart disease surgery, with the strongest association found in early-term infants. Even slightly below average birth weight Z-scores are independent risk factors for poor surgical outcomes in infants.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Wadi Mawad, Lisa Hornberger, Bettina Cuneo, Marie-Josee Raboisson, Anita J. Moon-Grady, Jane Lougheed, Karim Diab, Julia Parkman, Earl Silverman, Edgar Jaeggi
Summary: This study reviewed the effects of transplacental fetal treatment on immune-mediated fetal heart disease. The results showed that starting dexamethasone and other treatments from the time of new diagnosis of immune-mediated heart disease can reduce the risk of perinatal mortality and postnatal cardiomyopathy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Laxmi Ghimire, Fu-Sheng Chou, Kavitha Pundi, Anita J. Moon-Grady
Summary: The actual timing of the Fontan operation can vary, but it does not adversely affect the in-hospital outcomes. Children under the age of 2 are less likely to have elective surgery, have a higher incidence of chromosomal anomalies and require repair of atrioventricular valves. Mortality is higher in patients with atrioventricular septal defect, who often require valve repair.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Edgar Jaeggi, Lisa Hornberger, Bettina Cuneo, Anita J. Moon-Grady, Marie-Josee Raboisson, Jane Lougheed, Karim Diab, Wadi Mawad, Earl Silverman
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Anita J. Moon-Grady, Hyejung Lee, Leo Lopez, Oluwatosin Fatusin, Lindsay R. Freud, Whitnee Hogan, Anita Krishnan, Carol Mcfarland, L. LuAnn Minich, Shaine A. Morris, Nelangi Pinto, Angela P. Presson, Theresa A. Tacy, Fetal Heart Society
Summary: This study evaluated the feasibility and variability of measurements in normal fetal echocardiograms, and provided suggestions for further research. The results showed considerable variability in measurements of fetal echocardiography in clinical practice, with good consistency for specific measurements but poor consistency between raters.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Vidhushei Yogeswaran, Christopher Anigwe, Ayesha Salahuddin, Anika Aggarwal, Anita Moon J. Grady, Ian S. Harris, Aarthi Sabanayagam, Peter C. Kouretas, Vaikom S. Mahadevan, Anushree Agarwal
Summary: This study examines the association between body mass index (BMI) and clinical characteristics and outcomes in adults with Fontan, finding that higher BMI is associated with poor hemodynamics and increased risk of heart failure hospitalization and thromboembolic complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Laxmi. Ghimire, Fu-Sheng Chou, Othman A. Aljohani, Anita J. Moon-Grady
AMERICAN JOURNAL OF CARDIOLOGY
(2023)