Article
Multidisciplinary Sciences
Anees Ur Rehman, Shahid Shah, Ghulam Abbas, Sabariah Noor Harun, Sadia Shakeel, Rabia Hussain, Mohamed Azmi Ahmad Hassali, Muhammad Fawad Rasool
Summary: This study aimed to investigate the impact of different factors on rapid deterioration of lung function in COPD patients, and found that smoking, disease severity, mMRC score, SGRQ-C score, 6MWT distance, exacerbation frequency, hospital admission days, Charlson comorbidity index, and emphysema were significant risk factors for FEV1 decline >= 60 ml in one year. Among these factors, a CCI score >= 3, abrupt decline in health status, exacerbation frequency >= 3, hospital admission days >= 8, and emphysema were reported as risk factors for rapid deterioration of lung function.
SCIENTIFIC REPORTS
(2021)
Article
Critical Care Medicine
Matthew Moll, Adel Boueiz, Auyon J. Ghosh, Aabida Saferali, Sool Lee, Zhonghui Xu, Jeong H. Yun, Brian D. Hobbs, Craig P. Hersh, Don D. Sin, Ruth Tal-Singer, Edwin K. Silverman, Michael H. Cho, Peter J. Castaldi
Summary: This study aims to evaluate the ability of peripheral blood biomarkers to assess chronic obstructive pulmonary disease (COPD) risk and progression. By developing a transcriptional risk score (TRS) and a polygenic risk score (PRS) model, it was found that TRS can improve the prediction of COPD and lung function decline.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mingzhi Ye, Qianhong Li, Ling Xiao, Zhongsheng Zheng
Summary: The study found that serum concentrations of magnesium and manganese were associated with lung function, FeNO, and questionnaire scores in ACO patients. A faster decline in lung function was observed in the low-FeNO group, while serum magnesium concentration may have a protective effect in ACO. This suggests that FeNO could be a biomarker for identifying individuals who may benefit from inhaled corticosteroid therapy in ACO patients.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Oncology
Celion Tang, Hitesh Mistry, Neil Bayman, Clara Chan, David Cobben, Corinne Faivre-Finn, Margaret Harris, Jason Kennedy, Laura Pemberton, Gareth Price, Hamid Sheikh, David Woolf, Joanna Coote, Ahmed Salem
Summary: The outcomes of NSCLC patients with COPD and ILD treated with curative-intent radiotherapy were retrospectively investigated. Poor overall survival was correlated with the presence of ILD, but not with decreased forced expiratory volume in 1-second. Increased breathlessness and oxygen requirements after radiotherapy were observed in severe/very severe COPD and ILD patients.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Yuan-Yang Cheng, Shih-Yi Lin, Chiann-Yi Hsu, Pin-Kuei Fu
Summary: The effectiveness of respiratory muscle training for COPD patients with mild cognitive impairment remains uncertain. This study found that an eight-week training program significantly improved lung function, cognitive function, and quality of life for patients, but there was no significant difference between the full training and single training groups.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Plant Sciences
Vahideh Ghorani, Mohammad Reza Khazdair, Majid Mirsadraee, Omid Rajabi, Mohammad Hossein Boskabady
Summary: The study suggests that Zataria multiflora may have therapeutic effects on chronic obstructive pulmonary disease (COPD) patients by reducing inflammatory cytokines, improving pulmonary function test values, and alleviating respiratory symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Koichi Nishimura, Masaaki Kusunose, Mio Mori, Ayumi Shibayama, Kazuhito Nakayasu
Summary: The hypothesis that health status is the highest ranking concept in COPD patients was tested in a real clinical setting, and approximately 85% of cases supported this hypothesis.
Article
Infectious Diseases
Sunita Mulpuru, Melissa K. Andrew, Lingyun Ye, Todd Hatchette, Jason LeBlanc, May El-Sherif, Donna MacKinnon-Cameron, Shawn D. Aaron, Gonzalo G. Alvarez, Alan J. Forster, Ardith Ambrose, Shelly A. McNeil
Summary: The study found that seasonal respiratory viral infections are associated with intensive care unit admission and mechanical ventilation requirement among hospitalized COPD patients, but not with mortality. Influenza and respiratory syncytial virus (RSV) are the main viruses associated with exacerbations in COPD patients. Therefore, viral testing at admission can be helpful in predicting prognosis, guiding clinical management, and implementing infection control practices for hospitalized COPD patients during winter seasons.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2022)
Article
Medicine, General & Internal
Christopher L. Mosher, Michael G. Nanna, Oliver K. Jawitz, Vignesh Raman, Norma E. Farrow, Samia Aleem, Richard Casaburi, Neil R. MacIntyre, Scott M. Palmer, Evan R. Myers
Summary: This economic evaluation study found that pulmonary rehabilitation after hospitalization for chronic obstructive pulmonary disease (COPD) can result in cost savings and improve quality of life. These findings emphasize the need to develop policies to increase access and adherence to pulmonary rehabilitation for patients with COPD.
Article
Respiratory System
Taehwa Kim, Sungchul Huh, Jae Heun Chung, Yun Seong Kim, Ra Yu Yun, Onyu Park, Seung Eun Lee
Summary: This study aimed to analyze the association between diaphragm function variables and forced expiratory volume in the first second (FEV1) among COPD patients, and to estimate the clinical significance of diaphragm function in the correlation between COPD severity and lung function. The results showed that the right diaphragmatic forced excursion had a significant correlation with FEV1, and the analysis based on the cut-off value of right diaphragmatic forced excursion demonstrated a significant difference between groups. The data suggest that diaphragmatic function should be taken into consideration when interpreting pulmonary function tests.
BMC PULMONARY MEDICINE
(2023)
Article
Clinical Neurology
Eunhye Bae, Nakwon Kwak, Sun Mi Choi, Jinwoo Lee, Young Sik Park, Chang-Hoon Lee, Sang-Min Lee, Chul-Gyu Yoo, Jaeyoung Cho
Summary: This study assessed mortality in patients with chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA), and overlap syndrome, and found that patients with overlap syndrome had increased mortality, although not higher than those with COPD alone. In predicting mortality, measurement of hypoxemic load was found to be more accurate than the apnea-hypopnea index.
Article
Engineering, Environmental
Kuo Lu, Keng Po Lai, Tobias Stoeger, Shuqin Ji, Ziyi Lin, Xiao Lin, Ting Fung Chan, James Kar-Hei Fang, Michael Lo, Liang Gao, Chen Qiu, Shanze Chen, Guobing Chen, Lei Li, Lingwei Wang
Summary: Research indicates that exposure to microplastics has detrimental effects on the respiratory system in both healthy and asthmatic mice, causing inflammation, increased mucus production, and immune response disruption. Molecular mechanisms suggest that microplastics may modulate cellular stress and programmed cell death.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Respiratory System
Antonino Di Stefano, Francesca Dossena, Isabella Gnemmi, Silvestro Ennio D'Anna, Paola Brun, Bruno Balbi, Alessio Piraino, Antonio Spanevello, Francesco Nucera, Vitina Carriero, Francesca Bertolini, Mauro Maniscalco, Ian M. Adcock, Gaetano Caramori, Fabio L. M. Ricciardolo
Summary: The study found that COPD patients with rapid functional decline exhibited reduced expression of secretory IgA and decreased plasma cell numbers in the bronchial lamina propria, suggesting an impaired humoral immune response in rapid decliners.
RESPIRATORY RESEARCH
(2022)
Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Article
Medicine, General & Internal
Kuang-Ming Liao, Chung-Feng Liu, Chia-Jung Chen, Yu-Ting Shen
Summary: The study constructed prediction models for acute respiratory failure, ventilator dependence, and mortality in COPD patients after hospitalization using machine learning algorithms. The best models were built by XGBoost, random forest, and LightGBM algorithms, showcasing excellent predictive quality.
Article
Medicine, General & Internal
Julian N. Acosta, Cameron P. Both, Cyprien Rivier, Natalia Szejko, Audrey C. Leasure, Thomas M. Gill, Seyedmehdi Payabvash, Kevin N. Sheth, Guido J. Falcone
Summary: This study examines the association between the Life’s Simple 7 (LS7) score and brain health in individuals without stroke or dementia, finding that healthier LS7 profiles are associated with significant brain health benefits. It also explores the role of genomic information in recapitulating this association.
Article
Health Care Sciences & Services
John A. Dodson, Antoinette Schoenthaler, Greg Sweeney, Ana Fonceva, Alicia Pierre, Jonathan Whiteson, Barbara George, Kevin Marzo, Wendy Drewes, Elizabeth Rerisi, Reena Mathew, Haneen Aljayyousi, Sarwat Chaudhry, Alexandra M. Hajduk, Thomas M. Gill, Deborah Estrin, Lara Kovell, Lee A. Jennings, Samrachana Adhikari
Summary: The RESILIENT trial aims to evaluate the effectiveness of mHealth-CR in older adults with ischemic heart disease in a home setting, targeting functional mobility and other health outcomes. By analyzing engagement patterns, the trial will provide insights into sustained use of mHealth-CR and inform future precision medicine approaches in older adult populations.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Environmental Sciences
Honghyok Kim, Natalia Festa, Kate Burrows, Dae Cheol Kim, Thomas M. Gill, Michelle L. Bell
Summary: The study examines the association between residential exposure to petroleum production and refining and stroke prevalence in the southern United States. The findings suggest a significant relationship between residential exposure to petroleum pollutants and stroke, with the prevalence of stroke increasing with proximity to petroleum refineries. Socioeconomic factors were found to influence the increased prevalence of stroke due to petroleum production and refining.
ENVIRONMENTAL RESEARCH LETTERS
(2022)
Article
Immunology
Julie A. Womack, Terrence E. Murphy, Linda Leo-Summers, Jonathan Bates, Samah Jarad, Alexandria C. Smith, Thomas M. Gill, Evelyn Hsieh, Maria C. Rodriguez-Barradas, Phyllis C. Tien, Michael T. Yin, Cynthia A. Brandt, Amy C. Justice
Summary: This study examined the applicability of an algorithm for predicting falls in middle-aged veterans to older persons living with HIV (PWH) and found that model fit improved after adjusting for specific conditions of older PWH.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2022)
Article
Geriatrics & Gerontology
Lauren E. Ferrante, Terrence E. Murphy, Linda S. Leo-Summers, John R. O'Leary, Brent Vander Wyk, Margaret A. Pisani, Thomas M. Gill
Summary: A prediction model has been developed and validated to identify high-risk older adults who may experience persistent functional impairment in the year following an ICU hospitalization. This model, which includes factors such as age, pre-ICU disability, and comorbidities, can help healthcare providers target interventions and follow-up care for these individuals.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Brienne Miner, Margaret Doyle, Melissa Knauert, Henry Klar Yaggi, Katie L. Stone, Sonia Ancoli-Israel, Jane A. Cauley, Susan Redline, Terri Blackwell, Thomas M. Gill
Summary: ISSD, characterized by insomnia or poor sleep quality with short sleep duration, is common among older adults and is associated with various factors. Future research should focus on determining causal relationships and whether these factors are modifiable risk factors.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Natalia Festa, John Hsu, James K. K. Hammitt, Thomas M. M. Gill
Summary: Although environmental pollution and societal aging are concurrent public health challenges, the relationship between the two is rarely considered. The current approach to valuing public health benefits of environmental policy may not be suitable for aging populations. We describe the limitations of the age-invariant approach used by the US EPA for estimating public health benefits of environmental regulation. We offer an empirical framework that could address these limitations and improve the calibration of environmental regulatory analysis to the changing age distribution of the US population.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Clinical Neurology
Julian N. Acosta, Cameron P. Both, Zachariah S. Demarais, Carolyn J. Conlon, Audrey C. Leasure, Victor M. Torres-Lopez, Adam de Havenon, Nils H. Petersen, Thomas M. Gill, Lauren H. Sansing, Kevin N. Sheth, Guido J. Falcone
Summary: This study examines the relationship between genetic susceptibility to hypertension and blood pressure control in stroke survivors. The results show that stroke survivors with higher genetic susceptibility tend to have worse blood pressure control, with a higher prevalence of uncontrolled and resistant hypertension.
Article
Medicine, General & Internal
Natalia Festa, Kaitlin F. Throgmorton, Nora Heaphy, Maureen Canavan, Thomas M. Gill
Summary: This study examined the preparedness of US nursing homes in coastal areas for hurricane-related inundation and found regional variations in emergency preparedness. Some areas showed deficiencies in emergency preparedness, while there were opportunities to reduce regional heterogeneity and improve nursing home preparedness.
Article
Medicine, General & Internal
Xingqi Cao, Zhenqing Yang, Xueqin Li, Chen Chen, Emiel O. Hoogendijk, Jingyun Zhang, Nengliang Aaron Yao, Lina Ma, Yawei Zhang, Yong Zhu, Xuehong Zhang, Yuxian Du, Xiaofeng Wang, Xifeng Wu, Thomas M. Gill, Zuyun Liu
Summary: Using two widely used frailty indicators, this study found that frailty, even in the very early stage, was positively associated with the incidence risk of cardiovascular disease and type 2 diabetes mellitus among long-term cancer survivors.
Article
Geriatrics & Gerontology
Thomas M. M. Gill, Ling Han, Terrence E. E. Murphy, Shelli L. L. Feder, Evelyne A. A. Gahbauer, Linda Leo-Summers, Robert D. D. Becher
Summary: Little is known about how distressing symptoms change among older persons after major surgery. This study found that the occurrence and number of distressing symptoms increased substantially after major surgery, especially in nonelective procedures. Men had a greater increase in symptoms compared to women. Reducing symptom burden can improve quality of life and functional outcomes after major surgery.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Geriatrics & Gerontology
Julie A. A. Womack, Terrence E. E. Murphy, Linda Leo-Summers, Jonathan Bates, Samah Jarad, Thomas M. M. Gill, Evelyn Hsieh, Maria C. C. Rodriguez-Barradas, Phyllis C. C. Tien, Michael T. T. Yin, Cynthia A. A. Brandt, Amy C. C. Justice
Summary: Among older individuals living with HIV, risk factors commonly associated with serious falls and fragility fractures in the general population also play a significant role.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Geriatrics & Gerontology
Emily J. Smail, Jordan M. Alpert, Mamoun T. Mardini, Christopher N. Kaufmann, Chen Bai, Thomas M. Gill, Roger B. Fillingim, Erta Cenko, Ruben Zapata, Yashaswi Karnati, Michael Marsiske, Sanjay Ranka, Todd M. Manini
Summary: This study introduces a Real-time Online Assessment and Mobility Monitor (ROAMM) smartwatch application that captures daily fluctuations in mobility in ecological settings. The usability and feasibility of ROAMM were assessed using a sample of 31 participants, showing high satisfaction and engagement. Some features of the smartwatch were correlated with traditional measurements, indicating its potential contribution to mobility measurement and risk factors for mobility decline.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Erwin Stolz, Hannes Mayerl, Graciela Muniz-Terrera, Thomas M. Gill
Summary: This study reveals that there is a terminal decline in physical function among older adults, which is comparable to the established terminal decline phenomenon in cognition and may be associated with impending death.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Daniela Renedo, Julian N. Acosta, Andrew B. Koo, Cyprien Rivier, Nanthiya Sujijantarat, Adam de Havenon, Richa Sharma, Thomas M. Gill, Kevin N. Sheth, Guido J. Falcone, Charles C. Matouk
Summary: This study aims to investigate the relationship between the hospital frailty risk score (HFRS) and the risk of stroke, as well as to determine whether there is a significant association between genetically determined frailty and stroke. The results showed that frailty status is positively associated with the risk of stroke, and genetically determined frailty is independently associated with the risk of stroke.