Article
Biochemistry & Molecular Biology
Paola Matarrese, Sonia Maccari, Barbara Ascione, Rosa Vona, Vanessa Vezzi, Tonino Stati, Maria Cristina Gro, Giuseppe Marano, Caterina Ambrosio, Paola Molinari
Summary: This study found that beta-AR stimulation affects the proliferative activity of B16F10 cells by regulating cAMP levels. Additionally, alpha 2-AR agonists can inhibit cell proliferation, which is disrupted by the inhibitory effect of beta-AR agonists on alpha 2-AR. These findings suggest that the crosstalk between beta-AR and alpha 2-AR signaling pathways plays an important role in regulating melanoma proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Qing Gao, Yingying Zhang, Xiaoying Wang, Rui Wang, Limei Zhang
Summary: The mechanism of pain symptoms in Parkinson's disease is unclear, and this study aims to investigate the effect of NE on the activation of brain cells and regulate the nociception threshold in a PD animal model. It was found that changes in NE content can affect the activation of glial cells and participate in the regulation of nociception in PD rats. Both adrenergic a2 receptor agonist and central presynaptic membrane a2 receptor blocker can improve hyperalgesia.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Jin-Sook Kwon, Eric W. Barr, J. Kurt Chuprun, Walter J. Koch
Summary: Stimulation of alpha- or beta-adrenergic receptors in mice led to changes in the content of circulating blood EVs, with differential expression patterns of miRs. Pathway analysis revealed common and distinct pathways affected by PE and ISO treatment, indicating regulation of specific pathways by alpha- or beta-AR agonists. This study suggests that chronic sympathetic nervous system activation in heart failure may alter the content of EVs secreted from the heart and other organs, potentially impacting pathological remodeling.
Review
Substance Abuse
Paul Vanderkam, Marcello Solinas, Isabelle Ingrand, Nicolas Doux, Soghra Ebrahimighavam, Nematollah Jaafari, Claire Lafay-Chebassier
Summary: The study found that alpha-2 agonists significantly increased smoking cessation rates, while beta-blockers had no significant effect on smoking cessation. Additionally, alpha-1 antagonists were effective in reducing alcohol consumption but did not impact abstinence or heavy drinking days.
Article
Cell Biology
Lina Renkhold, Rike Kollmann, Leonie Inderwiedenstrasse, Marie-Cecile Kienitz
Summary: In this study, the contribution of specific phosphorylation sites in the alpha 1B-adrenergic receptor (alpha 1B-AR) to receptor desensitization and effector modulation by PKC and GRK2 was investigated. The results revealed that deletion of these phosphorylation sites abolished the contribution of PKC alpha to desensitization and specifically modulated the time course of mutant receptor activity by PKC beta. These findings are important for understanding the mechanisms of receptor regulation.
CELLULAR SIGNALLING
(2022)
Article
Pharmacology & Pharmacy
Wahiba Sifeddine, Saadia Ba-M'hamed, Marc Landry, Mohamed Bennis
Summary: This study investigated the effects of atomoxetine on ADHD-like symptoms and pain hypersensitivity. The results showed that chronic administration of atomoxetine significantly alleviated ADHD symptoms and attenuated pain responses, likely mediated by alpha- and beta-adrenergic and D2/D3 dopaminergic receptors. These findings suggest potential new indications for atomoxetine.
PHARMACOLOGICAL REPORTS
(2023)
Review
Dermatology
Nwanneka Okwundu, Abigail Cline, Steven R. Feldman
Summary: Topical oxymetazoline and brimonidine have been found to be effective in treating persistent facial erythema associated with rosacea, with mild and localized adverse effects. Further long-term research is necessary to understand their long-term effects.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Review
Psychiatry
Thatiane De Oliveira Sergio, Raizel M. Frasier, Frederic W. Hopf
Summary: Alcohol Use Disorder (AUD) is a prevalent mental disorder that costs around $250 billion/year in the US alone and causes significant medical and social harms. The number of deaths related to problem drinking is also rising dramatically. Compulsive alcohol drinking, which persists despite negative consequences, is a major obstacle to treatment. With the increasing number of people suffering from AUD, understanding the neurobiology behind compulsive alcohol drives and developing new pharmacological therapies is crucial.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Robert S. Jones
Summary: The review introduces the potential of Imidazoline derivatives in medicine, especially in the field of dentistry, and proposes a conceptual model for pulpal management using ImDs solutions, which have shown to be effective and biocompatible.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Xue-Ping Zhong, Wen-Fang Xia
Summary: Recent studies have shown that the sympathetic nervous system can regulate bone metabolism by activating beta-adrenergic receptors on osteoblasts and osteoclasts. It is important to investigate whether beta-blockers have a beneficial effect on bone metabolism in the treatment of cardiovascular diseases, in order to expand their clinical application. This article reviews the effects of beta-blockers on bone metabolism and the progress of clinical research in this area.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Endocrinology & Metabolism
Jiju Wang, Yunhui Tang, Songcun Wang, Liyuan Cui, Dajin Li, Meirong Du
Summary: This study found that excess norepinephrine inhibits endometrial decidualization by upregulating the alpha 1b-adrenergic receptor, affecting embryo and fetal development in a normal pregnancy model. The findings suggest a potential mechanism through which stress-related norepinephrine exposure could impact female reproductive health.
JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Peyton B. Sandroni, Kelsey H. Fisher-Wellman, Brian C. Jensen
Summary: This article reviews recent studies demonstrating the differential regulation of cardiac contractility by alpha 1- and beta-ARs in cardiomyocytes, with evidence suggesting that alpha 1-ARs may mitigate the deleterious effects of chronic beta-AR activation.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Santosh Alluri, Seth M. Eisenberg, Laurel A. Grisanti, Miles Tanner, Nora D. Volkow, Sung Won Kim, Kun-Eek Kil
Summary: Alpha 2C-ARs, one of the subtypes of adrenergic receptors in the brain, play important roles in emotion and memory, and are implicated in various neuropsychiatric disorders. A new PET radiotracer, [11C]ORM-13070, shows promise in imaging alpha 2C-ARs in the brain. In this study, highly potent C-11 labeled benzo-1,4-dioxane derivatives were prepared and compared with [11C]ORM-13070 to improve specific binding signal in vivo rodent brain PET imaging.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Barbara Jana, Jaroslaw Calka
Summary: The study aimed to investigate the role of alpha 1A-, alpha 1B-, and alpha 1D-adrenergic receptors in noradrenaline-induced contractility of inflammatory-changed porcine uterus. The results showed that activation of alpha 1A- and alpha 1D-adrenergic receptors promotes the contractile amplitude and frequency in the inflamed pig uterus, suggesting the potential for pharmacological modulation of these receptors to enhance uterine contraction.
Article
Oncology
Narges Gholizadeh, Amir-Hossein Mohebbi, Iraj Mirzaii-Dizgah, Nafiseh Sheykhbahaei
Summary: The study found significantly higher levels of alpha 1 adrenergic receptors in the saliva of OSCC patients compared to healthy controls, with no significant difference in serum levels between the two groups, suggesting potential over-expression of these receptors in OSCC cells. Further research and histological analysis are needed to confirm this finding.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Jagdeep S. S. Singh, Ify R. Mordi, Keeran Vickneson, Amir Fathi, Peter T. Donnan, Mohapradeep Mohan, Anna Maria J. Choy, Stephen Gandy, Jacob George, Faisel Khan, Ewan R. Pearson, J. Graeme Houston, Allan D. Struthers, Chim C. Lang
Letter
Cardiac & Cardiovascular Systems
Jacob George, Muhammad Hussain, Peter T. Donnan, Chim C. Lang, Faisel Khan
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Medicine, General & Internal
S. Holm Nielsen, A. Edsfeldt, C. Tengryd, H. Gustafsson, A. C. Shore, A. Natali, F. Khan, F. Genovese, E. Bengtsson, M. Karsdal, D. J. Leeming, J. Nilsson, I Goncalves
Summary: The study found that PRO-C6 can be localized in atherosclerotic plaques, and it is predictive of future cardiovascular events, cardiovascular death, and all-cause mortality.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Peripheral Vascular Disease
Nicholas Andrew Bradley, Campbell Roxburgh, Faisel Khan, Graeme Guthrie
Summary: Postimplantation syndrome (PIS) following endovascular aortic aneurysm repair (EVAR) is a poorly understood phenomenon with an incidence ranging from 17.4%-39.0%. Elevated IL-6 levels are commonly seen in PIS patients. Patients who receive polyester grafts rather than expanded-polytetrafluoroethylene (ePTFE) grafts have a higher incidence of PIS, with a lower rate of type 2 endoleaks. Early major adverse cardiovascular events (MACE) are higher in PIS patients, but long-term MACE outcomes are not yet reported.
VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Kunihiko Aizawa, Francesco Casanova, Phillip E. Gates, David M. Mawson, Kim M. Gooding, W. David Strain, Gerd Ostling, Jan Nilsson, Faisel Khan, Helen M. Colhoun, Carlo Palombo, Kim H. Parker, Angela C. Shore, Alun D. Hughes
Summary: Parameters derived from reservoir-excess pressure analysis can be used to assess cardiovascular disease risk in type 2 diabetes patients, indicating the potential prognostic value of these parameters in various populations.
Article
Biochemistry & Molecular Biology
Naveed Akbar, Calum Forteath, Muhammad S. Hussain, Kathleen Reyskens, Jill J. F. Belch, Chim C. Lang, Ify Mordi, U. Bhalraam, J. Simon C. Arthur, Faisel Khan
Summary: In this study, it was found that mitogen and stress kinase 1/2 (MSK1/2) play a significant role in the development of endothelial dysfunction in myocardial infarction patients and mouse models. Genetic deficiency of MSK1/2 increased plasma levels of pro-inflammatory cytokines and promoted endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Simone Leonetti, Domenico Trico, Lorenzo Nesti, Simona Baldi, Michaela Kozakova, Isabel Goncalves, Jan Nilsson, Angela Shore, Faisel Khan, Andrea Natali
Summary: In this study, CD40R was found to be one of the biomarkers most closely related to the extension of atherosclerosis. CD40R was the strongest predictor of carotid atherosclerosis burden in a high cardiovascular risk cohort.
Article
Multidisciplinary Sciences
Chuanyan Wu, Yan Borne, Rui Gao, Maykel Lopez Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Juergen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickael Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali, Olle Melander, Marju Orho-Melander, Jan Nilsson, Hans-Ulrich Haering, Erik Renstrom, Claes B. Wollheim, Gunnar Engstrom, Jianping Weng, Ewan R. Pearson, Paul W. Franks, Morris F. White, Kevin L. Duffin, Allan Arthur Vaag, Markku Laakso, Norbert Stefan, Leif Groop, Yang De Marinis
Summary: The study shows that elevated plasma follistatin levels are associated with an increased risk of T2D and adipose tissue insulin resistance, suggesting a potential role of follistatin in the development of T2D and related metabolic disorders.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Abdulmalik Zuhair Arab, Aldo Alberto Conti, Fleur Davey, Faisel Khan, Alexander Mario Baldacchino
Summary: This study investigated the association between polysedative use and cardiovascular pathologies in drug deaths. Findings showed that the presence of opioids, benzodiazepines, and alcohol in the blood of the deceased could predict the severity of cardiovascular disease. These results may inform national clinical guidelines to monitor individuals who abuse opioids for cardiovascular disease risk factors and provide timely interventions to reduce mortality in the population.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Annelie Shami, Andreas Edsfeldt, Eva Bengtsson, Jan Nilsson, Angela C. Shore, Andrea Natali, Faisel Khan, Esther Lutgens, Isabel Goncalves
Summary: This study found that elevated plasma levels of sCD40 and sCD40L are associated with cardiovascular disease, with sCD40 levels correlating with the severity of carotid atherosclerosis and predicting future cardiovascular events, while intra-plaque levels are associated with a vulnerable plaque phenotype.
Article
Peripheral Vascular Disease
Kunihiko Aizawa, Alun D. Hughes, Francesco Casanova, Phillip E. Gates, David M. Mawson, Kim M. Gooding, Mark Gilchrist, Isabel Goncalves, Jan Nilsson, Faisel Khan, Helen M. Colhoun, Carlo Palombo, Kim H. Parker, Angela C. Shore
Summary: This study demonstrates that baseline reservoir pressure integral is associated with the decline in renal function in older adults, independently of conventional cardiovascular risk factors. This suggests that reservoir pressure integral may play a role in the functional decline of the kidneys.
Review
Medicine, General & Internal
Caitlin Sara MacLeod, Andrew Radley, David Strachan, Faisel Khan, John Nagy, Stuart Suttie
Summary: This study aims to evaluate the outcomes of arterial ligation alone compared with arterial reconstruction for the infected arterial pseudoaneurysm secondary to groin injecting drug use. The methods will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. The primary outcome is major lower limb amputation, and the secondary outcomes include reintervention rate, rebleeding rate, development of chronic limb-threatening ischaemia, 30-day mortality, and claudication.
Article
Pharmacology & Pharmacy
Andreas Edsfeldt, Isabel Goncalves, Isa Vigren, Anja Jovanovic, Gunnar Engstrom, Angela C. Shore, Andrea Natali, Faisel Khan, Jan Nilsson
Summary: This study found that sIL-6R is a poor marker of cardiovascular disease risk and associated vascular changes. However, the observation that sIL-6R reflects plaque inflammation highlights the complexity of the role of IL-6 in CVD.
VASCULAR PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Zhen Hui Peh, Adel Dihoum, Dana Hutton, J. Simon C. Arthur, Graham Rena, Faisel Khan, Chim C. C. Lang, Ify R. Mordi
Summary: HFpEF is a type of heart failure that accounts for around half of all cases and may become the dominant type in the future. Compared to heart failure with reduced ejection fraction, there are limited evidence-based treatment strategies available for HFpEF. Inflammation is believed to play a key role in the pathophysiology of HFpEF and could be a potential therapeutic target.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell Biology
Faisel Khan, Isabel Goncalves, Angela C. Shore, Andrea Natali, Carlo Palombo, Helen M. Colhoun, Gerd Ostling, Francesco Casanova, Cecilia Kennbaeck, Kunihiko Aizawa, Margaretha Persson, Kim M. Gooding, David Strain, Helen Looker, Fiona Dove, Jill Belch, Silvia Pinnola, Elena Venturi, Michaela Kozakova, Jan Nilsson
Summary: This study used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with changes in carotid disease severity in high-risk subjects. The results show that changes primarily occur in fibrotic plaques and are associated with increased levels of platelet-derived growth factor (PDGF).
CELL REPORTS MEDICINE
(2022)