Article
Nutrition & Dietetics
Maria Helde Frankling, Caritha Klasson, Linda Bjoerkhem-Bergman
Summary: The purpose of this study was to explore the levels of 25-hydroxyvitamin D (25-OHD) in patients with palliative cancer care. The results showed that supplementation with vitamin D led to a significant increase in 25-OHD levels, regardless of season, age, tumor type, or colectomy.
Article
Nutrition & Dietetics
Etienne Cavalier, Callum G. Fraser, Harjit P. Bhattoa, Annemieke C. Heijboer, Konstantinos Makris, Candice Z. Ulmer, Hubert W. Vesper, Samuel Vasikaran, Pierre Lukas, Pierre Delanaye, Anna Carobene
Summary: The study evaluated the biological variation of 25(OH)D to set analytical performance specifications for measurement uncertainty. The findings showed that participants were not in a steady state, so APS based on measurement uncertainty appear to be more appropriate.
Article
Microbiology
Muneeb Ahmad Malik, Yasmeena Jan, Lamya Ahmed Al-Keridis, Afrozul Haq, Javed Ahmad, Mohd Adnan, Nawaf Alshammari, Syed Amir Ashraf, Bibhu Prasad Panda
Summary: This study found that UV irradiated mushrooms could effectively improve serum markers of vitamin D-deficient rats, improve bone condition, and regulate the expression of vitamin D-related genes. Mushrooms could potentially be an important food source for supplementing vitamin D.
Article
Biochemistry & Molecular Biology
Kazuki Maekawa, Michiyasu Ishizawa, Takashi Ikawa, Hironao Sajiki, Taro Matsumoto, Hiroaki Tokiwa, Makoto Makishima, Sachiko Yamada
Summary: The active form of vitamin D-3, 1,25-dihydroxyvitamin D-3, regulates calcium homeostasis through activation of the vitamin D receptor (VDR). Vitamin D derivatives with large adamantane (AD) rings at certain positions of the side chain were synthesized to study their VDR agonist and/or antagonist properties. Novel vitamin D derivatives with an alkyl group substituted at position 25 showed selective VDR activity and enhanced osteoblast differentiation compared to the original derivative, ADTK1. These modified derivatives have the potential for targeted therapy with increased stability and tissue selectivity.
Review
Nutrition & Dietetics
Luis Castano, Leire Madariaga, Gema Grau, Alejandro Garcia-Castano
Summary: Vitamin D is crucial for bone mineralization in children and deficiency is common. Certain medical conditions and genetic alterations can increase the risk of vitamin D deficiency rickets. Measurement of calcifediol levels is used to assess the status of the vitamin D endocrine system. Clinical trials have demonstrated the benefits of ensuring normal 25(OH)D levels and calcium intake in preventing or treating nutritional rickets in children.
Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songul Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study investigated the association between BPA, 25(OH)D, and 1,25(OH)(2)D levels in cord blood of newborn babies. The study found that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but BPA levels were not correlated with vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Fatma Pinar Tabanli, Siddika Songuel Yalcin, Sedef Ramoglu, Sadiman Kiykac Altinbas, Anil Yirun, Aylin Balci Ozyurt, Funda Gucel, Pinar Erkekoglu, Kadriye Yurdakok
Summary: This study aimed to investigate the association between bisphenol A (BPA), 25-hydroxy vitamin D [25(OH)D], and 1 alpha,25 dihydroxy vitamin D [1,25( OH)(2)D] levels in cord blood of newborn babies. The results showed that both BPA exposure and insufficient vitamin D transfer via cord blood are common in newborns, but there is no correlation between BPA levels and vitamin D levels in cord blood.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Nutrition & Dietetics
Manuel Rupprecht, Stefan Wagenpfeil, Jakob Schoepe, Reinhold Vieth, Thomas Vogt, Joerg Reichrath
Summary: A meta-analysis was conducted to investigate the impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in healthy adults in Europe. The findings suggest that vitamin D supplementation can significantly increase serum 25(OH)D levels, with the effect influenced by dosage and baseline serum levels.
Article
Multidisciplinary Sciences
Mehmet Emin Arayici, Sila Ovgu Korkut-Uysal, Asim Leblebici, Zeynep Akcali, Deniz Tuna Edizer, Seher Kabul, Dilek Cimrin, Ender Berat Ellidokuz
Summary: The aim of this study was to evaluate the change in 25-hydroxyvitamin D (25(OH)D) levels before and during the COVID-19 pandemic. The study found that restrictions, partial or complete closures, and curfews can significantly affect individuals' 25(OH)D levels during the COVID-19 outbreak. There is a need for multicenter studies with larger populations covering different regions to strengthen and support the results.
Article
Nutrition & Dietetics
Hye Ran Shin, Hyeon Ju Park, Sun Yung Ly
Summary: Vitamin D deficiency is prevalent among young Korean women. This study aimed to determine the optimal vitamin D intake level for maintaining adequate serum 25-hydroxyvitamin D (25[OH]D) levels in young Korean women throughout different seasons. The study identified seasonal factors influencing 25(OH)D levels, calculated the necessary vitamin D intake for sufficient levels, and analyzed the relationship between 25(OH)D and intact parathyroid hormone (iPTH) levels. The results showed that 25(OH)D levels were higher in summertime compared to wintertime, and an increase in vitamin D intake led to a corresponding increase in 25(OH)D levels. The study suggests that increasing UV irradiation time in summertime and consuming vitamin D supplements and foods throughout the year is beneficial for maintaining sufficient levels of 25(OH)D in young Korean women.
Article
Medicine, General & Internal
Akira Horikawa, Yuji Kasukawa, Michio Hongo, Hiroyuki Kodama, Akihisa Sano, Naohisa Miyakoshi
Summary: This study aimed to compare the concentration of vitamin D among osteoporotic patients in two different regions in Japan. The results showed significant differences in vitamin D concentration between the two regions, with no clear relationship to sunlight exposure.
Article
Nutrition & Dietetics
Mehmet Emin Arayici, Yasemin Basbinar, Hulya Ellidokuz
Summary: This study used a meta-meta-analysis method to examine the effects of Vitamin D intake and serum 25-hydroxyvitamin-D levels on cancer incidence and mortality. The findings showed that higher Vitamin D intake and serum levels were associated with lower cancer risk and mortality. However, careful evaluation according to cancer types is important and recommended.
Article
Nutrition & Dietetics
Agnieszka Radom, Andrzej Wedrychowicz, Stanislaw Pieczarkowski, Szymon Skoczen, Przemyslaw Tomasik
Summary: Maintaining optimal vitamin D levels after breast cancer treatment is important for reducing recurrence risk and extending survival time. A study in Polish women after mastectomy found that vitamin D deficiency was more common in this group compared to the general population, highlighting the importance of vitamin D supplementation and monitoring. By providing recommendations and increasing awareness about vitamin D supplementation, there was a significant increase in the number of patients who started supplementing and the average dose of supplements.
Review
Nursing
Qiong Wang, Qinlai Ying, Wen Zhu, Junguo Chen
Summary: The study found that children with asthma had significantly lower levels of 25-OHD compared to those without asthma, and asthma patients who received vitamin D supplementation had a significantly lower recurrence rate. Thus, vitamin D may have potential roles in the prevention and treatment of asthma in children.
JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES
(2022)
Article
Multidisciplinary Sciences
Nguyen N. Nguyen, Muppala N. P. Raju, Briget da Graca, Dapeng Wang, Nada A. Mohamed, Manohar B. Mutnal, Arundhati Rao, Monica Bennett, Matthew Gokingco, Huy Pham, Amin A. Mohammad
Summary: There is an inverse relationship between vitamin D levels and hospital LOS for COVID-19 patients. Vitamin D status is a predictor for severity of outcomes. LC-MS/MS results are useful for assessing the odds of mortality and the need for ventilation during hospitalization.
Article
Radiology, Nuclear Medicine & Medical Imaging
Stijn E. Verleden, Arno Vanstapel, Joseph Jacob, Tinne Goos, Jeroen Hendriks, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Laurens De Sadeleer, Robin Vos, Johanna M. Kwakkel-van Erp, Arne P. Neyrinck, Geert M. Verleden, Matthieu N. Boone, Wim Janssens, Els Wauters, Birgit Weynand, Danny D. Jonigk, Johny Verschakelen, Wim A. Wuyts
Summary: This study determined the correlation between radiologic findings and histopathologic results in CT-defined interstitial lung abnormalities (ILAs) in human lung explants.
Article
Endocrinology & Metabolism
Caro Minschart, Nele Myngheer, Toon Maes, Christophe De Block, Inge Van Pottelbergh, Pascale Abrams, Wouter Vinck, Liesbeth Leuridan, Sabien Driessens, Chantal Mathieu, Jaak Billen, Christophe Matthys, Annouschka Laenen, Annick Bogaerts, Katrien Benhalima
Summary: This study aimed to identify risk factors for early postpartum weight retention (PPWR) and glucose intolerance (GI) in women with gestational diabetes (GDM). The results showed that excessive gestational weight gain, lack of breastfeeding, higher dietary fat intake, insulin use during pregnancy, multiparity, lower prepregnancy body mass index (BMI), and lower education degree were independent predictors for early PPWR. Women with high PPWR had a more impaired postpartum metabolic profile, breastfed less often, had higher rates of depression and anxiety, and lower quality of life. Additionally, 28% of participants had GI, with women with high PPWR being more likely to have GI. Only 12.9% of women with high PPWR perceived themselves at high risk for diabetes but were more willing to change their lifestyle.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Juan P. Frias, Srikanth Deenadayalan, Lars Erichsen, Filip K. Knop, Ildiko Lingvay, Stanislava Macura, Chantal Mathieu, Sue Pedersen, Melanie Davies
Summary: This study assessed the efficacy and safety of co-administered semaglutide with cagrilintide in participants with type 2 diabetes. The results showed that the combination treatment resulted in clinically relevant improvements in glycemic control and weight loss compared to cagrilintide alone, and it was well tolerated.
Article
Medicine, General & Internal
Chantal Mathieu, Bjorg Asbjornsdottir, Harpreet S. Bajaj, Wendy Lane, Ana Laura S. A. Matos, Sreenivasa Murthy, Karolina Stachlewska, Julio Rosenstock
Summary: The ONWARDS 4 trial aimed to compare the efficacy and safety of once-weekly insulin icodec with once-daily insulin glargine U100 in individuals with long-standing type 2 diabetes. The results showed that icodec demonstrated similar improvements in glycaemic control compared to glargine U100, with fewer basal insulin injections and no increase in hypoglycaemic rates. The trial had limitations including its relatively short duration and open-label design.
Article
Respiratory System
Kenneth Verstraete, Iwein Gyselinck, Helene Huts, Nilakash Das, Marko Topalovic, Maarten De Vos, Wim Janssens
Summary: This study developed machine learning models to estimate and predict individual treatment effects of interventions in patients with chronic obstructive pulmonary disease (COPD). The results showed that poor lung function and blood eosinophils were the strongest predictors of individual treatment effects. The findings suggest that machine learning models can be used to guide personalized treatment decisions in COPD.
Article
Medicine, General & Internal
Tomi Suomi, Inna Starskaia, Ubaid Ullah Kalim, Omid Rasool, Maria K. Jaakkola, Toni Gronroos, Tommi Valikangas, Caroline Brorsson, Gianluca Mazzoni, Sylvaine Bruggraber, Lut Overbergh, David Dunger, Mark Peakman, Piotr Chmura, Seren Brunak, Anke M. Schulte, Chantal Mathieu, Mikael Knip, Riitta Lahesmaa, Laura L. Elo
Summary: This study aimed to identify transcriptional changes associated with disease progression in patients with recent-onset type 1 diabetes. They found that genes and pathways related to innate immunity were downregulated during the first year after diagnosis. Associations between gene expression changes and ZnT8A autoantibody positivity were also observed. Additionally, changes in the expression of 16 genes were found to predict the decline in C-peptide at 24 months, and increased B cell levels and decreased neutrophil levels were associated with rapid progression, consistent with previous reports.
Article
Cell Biology
Samal Bissenova, Darcy Ellis, Aisha Callebaut, Guy Eelen, Rita Derua, Mijke Buitinga, Chantal Mathieu, Conny Gysemans, Lut Overbergh
Summary: This study investigated the proteomic characteristics of neutrophil extracellular traps (NETs) in patients with type 1 diabetes (T1D). The results showed that the NETome of T1D patients was enriched in metabolic proteins compared to healthy controls. Furthermore, the NETome of T1D patients was distinct from that of healthy controls, but there were no apparent alterations in bio-energetic profile or dysregulated NETosis. This may reflect an adaptation mechanism employed by activated T1D neutrophils to avoid impaired glycolysis and excessive or suboptimal NETosis.
Article
Biology
Samal Bissenova, Mijke Buitinga, Markus Boesch, Hannelie Korf, Kristina Casteels, An Teunkens, Chantal Mathieu, Conny Gysemans
Summary: Neutrophils, an overlooked innate immune cell type, may play a crucial role in autoimmune diseases like type 1 diabetes. However, studying neutrophil function has been challenging due to disease heterogeneity and a lack of standardized methods. In this study, live-cell imaging was used to analyze neutrophil function and showed that neutrophils behave similarly in type 1 diabetes patients as healthy individuals. This suggests that neutrophils might contribute to autoimmune diseases through a mechanism called NET formation.
Article
Medicine, General & Internal
David Russell-Jones, Tetsuya Babazono, Roman Cailleteau, Susanne Engberg, Concetta Irace, Maiken Ina Siegismund Kjaersgaard, Chantal Mathieu, Julio Rosenstock, Vincent Woo, David C. Klonoff
Summary: This study compared the efficacy and safety of once-weekly subcutaneous insulin icodec and once-daily insulin degludec in adults with type 1 diabetes. The results showed that icodec was non-inferior to degludec in reducing HbA(1c), but had a higher rate of clinically significant or severe hypoglycaemia.
Article
Respiratory System
Vincent Geudens, Jan Van Slambrouck, Gitte Aerts, Lynn Willems, Tinne Goos, Janne Kaes, Andrea Zajacova, Iwein Gyselinck, Celine Aelbrecht, Astrid Vermaut, Hanne Beeckmans, Marie Vermant, Charlotte De Fays, Annelore Sacreas, Lucia Aversa, Michaela Orlitova, Arno Vanstapel, Ivan Josipovic, Matthieu N. Boone, John E. McDonough, Birgit Weynand, Charles Pilette, Wim Janssens, Lieven Dupont, Wim A. Wuyts, Geert M. Verleden, Dirk E. van Raemdonck, Robin Vos, Ghislaine Gayan-Ramirez, Laurens J. Ceulemans, Bart M. Vanaudenaerde
Summary: This study assessed disease progression in COVID-19 patients using in vivo CT and ex vivo microCT, and described the changes in lung volume and density as well as airway morphology. Results showed that COVID-19 lung volumes decreased and densities increased over time, mainly in the lower lobes. Ex vivo microCT revealed a 60% reduction in lung volume compared to controls, and increased visibility of airways in COVID-19 lungs, possibly due to fibrosis and increased airway diameter. Small-partition microCT further showed deformations in airway morphology and heterogeneous fibrotic organization in severely affected regions, which was confirmed by histology.
JOURNAL OF THORACIC DISEASE
(2023)
Meeting Abstract
Critical Care Medicine
M. Topalovic, P. Desbordes, J. Maes, F. de Jong, K. Sylvester, C. Vogelmeier, A. Dinh-Xuan, J. Mortensen, W. Janssens
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Meeting Abstract
Endocrinology & Metabolism
M. Visser, A. Van Muylder, S. Charleer, J. Isitt, S. Roze, C. De Block, T. Maes, G. Vanhaverbeke, F. Nobels, B. Keymeulen, C. Mathieu, J. Luyten, P. Gillard, N. Verhaeghe
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Meeting Abstract
Endocrinology & Metabolism
H. Bajaj, B. Asbjornsdottir, L. L. Lehrskov, C. Mathieu, A. Philis-Tsimikas, N. Wang, T. Battelino
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Ylke Bruggeman, Pieter-Jan Martens, Gabriele Sassi, Marijke Viaene, Clive H. Wasserfall, Chantal Mathieu, Conny Gysemans
Summary: This study investigates the dynamics and phenotypes of immune cells infiltrating the pancreas and their changes in peripheral blood during the development of type 1 diabetes (T1D) in non-obese diabetic (NOD) mice. The early stages of T1D are characterized by an influx of dendritic cells and neutrophils in the pancreas. CD4+ and CD8+ T cells migrate from the pancreatic draining lymph nodes to the pancreas, coinciding with increased beta cell autoimmunity and insulitis severity. These findings provide important insights into the disease process and may contribute to the development of new therapies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
S. Pazmino, E. Al-Ozairi, A. Al Attar, J. Al Kandari, P. Alm-Eda-Valdes, N. Antonio-Villa, C. Delfin, R. Faradji, J. Rosen, J. Soderberg, T. Sparso, N. Steenackers, C. Mathieu, B. Van der Schueren, C. Le Roux