Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agronomy
Tingzhen Wang, Mingjia Liu, Yufeng Tian, Yingyan Han, Chaojie Liu, Jinghong Hao, Shuangxi Fan
Summary: This study investigates the important role of mitogen-activated protein kinase 6 (MAPK6) in high temperature bolting of lettuce. The researchers amplified the full-length coding sequence of the LsMAPK6 gene and analyzed its expression using real-time polymerase chain reaction. The results demonstrate that LsMAPK6 is mainly expressed in the stem, stem apex, and taproot, and its expression is significantly promoted by high temperatures.
Review
Gastroenterology & Hepatology
Benno Traub, Aileen Roth, Marko Kornmann, Uwe Knippschild, Joachim Bischof
Summary: Pancreatic cancer is a devastating disease with poor survival rates, prompting the need for new therapeutic approaches. Protein kinases play crucial roles in development and pathogenesis, making them potential targets for precision medicine in patients with deregulated kinase pathways.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mei-Lan Tsai, Ming-Kai Tsai, Yi-Giien Tsai, Yu-Chih Lin, Ya-Ling Hsu, Yi-Ting Chen, Yi-Ching Lin, Chih-Hsing Hung
Summary: This study investigated the effects of LTRAs on the expression of epithelium-derived cytokines in human airway epithelial cells and explored the underlying intracellular processes, including epigenetic regulation. It was found that LTRAs might induce the production of IL-25, IL-33, and TSLP by activating the MAPK and NF-kappa B pathways and regulating histone H3 acetylation and H3K36 and H3K79 trimethylation, exacerbating inflammation and asthma symptoms. Therefore, LTRA monotherapy may not be an appropriate therapeutic option for asthma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Xi Zhu, Ning Zhang, Xue Liu, Shigui Li, Jiangwei Yang, Xusheng Hong, Fangfang Wang, Huaijun Si
Summary: The study demonstrates that overexpression of StMAPK11 can promote potato growth, physiological activities, and photosynthesis under drought conditions, indicating its crucial role in enhancing potato drought resistance. The up-regulation of StMAPK11 intensifies drought resistance by elevating antioxidant activities and photosynthesis, providing new insights into its function in drought response.
PLANT CELL REPORTS
(2021)
Article
Microbiology
Wuyun Lv, Yu Xiao, Zhe Xu, Hong Jiang, Qi Tong, Zhengyi Wang
Summary: The role of paxillin in signal pathways in phytopathogenic fungi is not well understood. This study reveals that MoPax1 activates MAP kinase signaling pathways and autophagy through its interaction with MoMka1, and plays an important role in appressorium-mediated plant infection by the rice blast fungus.
Article
Food Science & Technology
Jeong-Won Kim, Jin-Hwa Kim, Chang-Yeop Kim, Ji-Soo Jeong, Je-Oh Lim, Jong-Choon Kim, Je-Won Ko, Tae-Won Kim
Summary: In this study, the protective effects of DADS against 1,3-DCP-induced hepatotoxicity and oxidative damage were investigated. The results showed that DADS treatment inhibited the increase in serum aminotransferase levels and reduced histopathological alterations in the liver induced by 1,3-DCP. Additionally, DADS treatment reduced 1,3-DCP-induced apoptotic changes in the liver and inhibited phosphorylation of MAPKs. These protective effects may be related to the inhibition of CYP2E1 expression, enhancement of antioxidant enzyme activity, and reduction of apoptotic activity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chaojun Kong, Longfei Jia, Jianping Jia
Summary: This study demonstrated that gamma-mangostin can attenuate oxidative stress and inflammation caused by Aβ42 oligomers, while protecting neurons from toxic medium-induced injury, suggesting its potential protective effect in Alzheimer's disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Feng-Yen Lin, Kuo-Feng Huang, Jui-Chieh Chen, Meng-Fu Lai, Kuo-Hsing Ma, Chun-Chang Yeh
Summary: Although PRF treatment is considered a safe alternative in refractory pain conditions, unexpected damage to normal nerves remains a possible complication. PRF stimulation may induce nerve inflammation, leading to inflammatory pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Irina A. Khvorova, Olga Nadei, Natalia Agalakova
Summary: The study found high expression of ERK1/2 and JNK in river lamprey erythrocytes and liver tissues, with only trace amounts of p38. ERK1/2 and JNK were identified as both cytosolic and membrane enzymes, while p38 was mainly cytosolic. During pre-spawning starvation, the total cellular amounts of ERK1/2 and phospho-ERK1/2 remained relatively stable.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Cell Biology
Hyang Lim, Do Kyung Kim, Tae-Hyeon Kim, Kyeong-Rok Kang, Jeong-Yeon Seo, Seung Sik Cho, Younghee Yun, Ye-yong Choi, Jungtae Leem, Hyoun-Woo Kim, Geon-Ung Jo, Chan-Jin Oh, Deuk-Sil Oh, Hong-Sung Chun, Jae-Sung Kim
Summary: Acteoside, a natural compound, shows promising potential as an anticatabolic agent by suppressing the expression of cartilage-degrading enzymes and inflammatory mediators to counteract the degeneration of articular cartilage in osteoarthritis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Jin Hee Kim, In Gyoung Ju, Namkwon Kim, Eugene Huh, So-Ri Son, Joon Pyo Hong, Yujin Choi, Dae Sik Jang, Myung Sook Oh
Summary: This study aimed to investigate the anti-neuroinflammatory effects of yomogin, isolated from Artemisia iwayomogi. The results showed that yomogin suppressed neuroinflammatory factors and regulated the MAPK pathway, suggesting its potential as a therapeutic candidate for inflammation-mediated neurological diseases.
Article
Respiratory System
Yanyu Li, Guomei Su, Yu Zhong, Zhilin Xiong, Tong Huang, Jingyun Quan, Jiewen Huang, Xiaoxia Wen, Chaole Luo, Weilin Zheng, Jinfeng Chen, Junfen Cheng, Weimin Yao, Tianwen Lai
Summary: The study found that HB-EGF-induced IL-8 promotes proliferation and migration of lung fibroblasts, with the effects attenuated after neutralizing IL-8, suggesting that HB-EGF may be involved in the pathology of airway fibrosis by inducing the release of IL-8 from airway epithelium.
BMC PULMONARY MEDICINE
(2021)
Article
Emergency Medicine
Chao Liu, Zhao-Rui Sun, Meng-Meng Wang, Zhi-Zhou Yang, Wei Zhang, Yi Ren, Xiao-Qin Han, Rui Liu, Quan Li, Shi-Nan Nie
Summary: This study found that arctigenin has a protective effect on PQ-induced lung injury by attenuating cell apoptosis and suppressing ROS/p38 MAPK signaling. Arctigenin may be considered as a potential candidate drug for PQ-induced ALI.
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)