Review
Cell Biology
Qiang Zhao, Ping Song, Ming-Hui Zou
Summary: Pulmonary hypertension is a debilitating disease characterized by increased blood pressure in the pulmonary arteries. The role of AMPK in PH is controversial as both inhibition and activation of AMPK can potentially prevent the development of PH. Clinical studies suggest that metformin, an AMPK activator, is effective in treating early-stage PH and particularly beneficial for patients with PH associated with heart failure.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Rui Wang, Jinjin Pan, Jinzhen Han, Miaomiao Gong, Liang Liu, Yunlong Zhang, Ying Liu, Dingyou Wang, Qing Tang, Na Wu, Lin Wang, Jinsong Yan, Hua Li, Yuhui Yuan
Summary: This study demonstrates that melatonin can alleviate dasatinib-aggravated hypoxic pulmonary hypertension by inhibiting pulmonary vascular remodeling and protecting endothelial cells and inhibiting abnormal proliferation of smooth muscle cells.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Respiratory System
Yanxia Wang, Xiaoming Li, Wen Niu, Jian Chen, Bo Zhang, Xiumin Zhang, Yingmei Wang, Shaokang Dang, Zhichao Li
Summary: The study demonstrated that under hypoxia, alveolar epithelial cells (AECs) are involved in pulmonary vascular remodeling and constriction by secreting H2O2 into the pulmonary vascular microenvironment.
RESPIRATORY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Pengfei Liu, Aikai Zhang, Zheng Ding, Dongpu Dai, Boyan Li, Shao-Fei Liu, Jingjing Xu, Zhe Cheng, Song Zhao, Xiaoyan Zhao, Jianzeng Dong
Summary: This study reveals that m(6)A-modified GRAP mRNA is upregulated in PAH, while GRAP mRNA and protein are downregulated. Overexpression of GRAP alleviates the proliferative and invasive ability of PAH HPASMCs through inhibition of the Ras/ERK signaling pathway. Additionally, METTL14 and the m(6)A binding protein YTHDF2 are significantly increased in PAH.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Junting Zhang, Yiying Li, Jianchao Zhang, Lu Liu, Yuan Chen, Xusheng Yang, Xueyi Liao, Muhua He, Zihui Jia, Jun Fan, Jin-Song Bian, Xiaowei Nie
Summary: This study demonstrates that ADAR1 contributes to the development of PH through the m1A modification of circCDK17 and subsequent proliferation of PASMCs. The findings provide a novel therapeutic strategy for treating PH and identify circCDK17 as a potential new marker for the diagnosis of this disease.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Biochemistry & Molecular Biology
Jinjin Pan, Rui Wang, Yandong Pei, Dingyou Wang, Na Wu, Yuke Ji, Qing Tang, Liang Liu, Ke Cheng, Qiwang Liu, Jian Sun, Miaomiao Gong, Xu Zheng, Junxia Li, Changlin Zhang, Yuhui Yuan
Summary: This study aimed to investigate the effect and mechanism of sulforaphane (SFN) on hypoxic pulmonary hypertension (HPH). The results showed that SFN could inhibit the progression of HPH, reduce inflammation and oxidative stress, and promote apoptosis in pulmonary artery smooth muscle cells (PASMCs) under hypoxia conditions. SFN also prevented the apoptosis of pulmonary microvascular endothelial cells (ECs). These findings suggest that SFN has potential therapeutic effects on HPH by improving pulmonary vascular remodeling.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Health Care Sciences & Services
Zhuangzhuang Jia, Shuai Wang, Haifeng Yan, Yawen Cao, Xuan Zhang, Lin Wang, Zeyu Zhang, Shanshan Lin, Xianliang Wang, Jingyuan Mao
Summary: Pulmonary vascular remodeling, involving changes in the intima, media and adventitia, is a critical structural alteration and pathological feature in pulmonary hypertension. It includes the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs), as well as interactions with pulmonary artery fibroblasts (PAFs) and extracellular matrix (ECM). Inflammatory mechanisms, apoptosis, and other factors are influenced by different mechanisms that contribute to disease progression. This article reviews these pathological changes and discusses the underlying mechanisms in the remodeling process.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Physiology
Mayumi Nakahara, Homare Ito, John T. Skinner, Qing Lin, Rasa Tamosiuniene, Mark R. Nicolls, Achsah D. Keegan, Roger A. Johns, Kazuyo Yamaji-Kegan
Summary: IRS2 plays a crucial role in the pathology of pulmonary arterial hypertension by regulating macrophage activation and recruitment to limit vascular inflammation, remodeling, and right ventricular hypertrophy. Restoring the IRS2 pathway may be an effective therapeutic approach for the treatment of pulmonary hypertension and right heart failure.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Yun Liu, Xiaowei Nie, Jinquan Zhu, Tianyan Wang, Yanli Li, Qian Wang, Zengxian Sun
Summary: This study demonstrated that NDUFA4L2 plays a critical role in the development of pulmonary arterial hypertension (PAH) by mediating ROS production and proliferation of pulmonary artery smooth muscle cells (PASMCs), suggesting NDUFA4L2 as a potential new therapeutic target for PAH. The findings also revealed the involvement of HIF-1 alpha and downstream signalling pathways like p38-5-LO in the mechanism of NDUFA4L2-induced PASMC proliferation in hypoxia. Elevated levels of 4-hydroxynonene (4-HNE) in both PAH patients and hypoxic PAH model rats were observed, indicating a potential role of oxidative stress in PAH pathogenesis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Nikolai V. Pakhomov, Daria S. Kostyunina, Guerrino Macori, Eugene Dillon, Tara Brady, Geetha Sundaramoorthy, Claire Connolly, Alfonso Blanco, Seamus Fanning, Lorraine Brennan, Paul McLoughlin, John A. Baugh
Summary: This study demonstrates for the first time that a high-soluble-fiber diet attenuates hypoxia-induced pulmonary vascular remodeling and the development of pulmonary hypertension in a mouse model of hypoxic pulmonary hypertension and highlights diet-derived metabolites that may have an immuno-modulatory role in the lung.
Article
Respiratory System
Meng He, Kelong Tao, Min Xiang, Jian Sun
Summary: Through bioinformatics analysis of HPH-related scRNA-seq and bulk RNA-seq data, Hpgd gene was identified as having important regulatory roles in the development of HPH. Experimental confirmation showed that downregulation of Hpgd promotes the occurrence and development of HPH. This study is of great significance for revealing the molecular mechanisms underlying HPH.
BMC PULMONARY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Benjamin Grimmer, Adrienn Krauszman, Xudong Hu, Golam Kabir, Kim A. Connelly, Mei Li, Jana Grune, Christian Madry, Brant E. Isakson, Wolfgang M. Kuebler
Summary: This study identifies Panx1 as a novel regulator of HPV, but its role is not necessarily linked to ATP release and downstream signaling via P2Y receptors or TRPV4 activation. Instead, Panx1 appears to modulate the Ca2+ response of PASMC to hypoxia. Furthermore, Panx1 does not affect the development of chronic hypoxic PH.
CARDIOVASCULAR RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Ling Chen, Liquan Ren, Hongping Song, Hui Ren, Rong Xu, Xuying Huang
Summary: The study investigated the protective effects of triflavones from Selaginella doederleini against pulmonary hypertension (PH) in a rat model. Triflavones effectively reduced mPAP and arterial thickness, reversed increased proliferation and inhibited apoptosis induced by chronic hypoxia, and exhibited inhibitory effects on vascular remodeling through the PI3K/Akt signaling pathway.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2021)
Article
Respiratory System
Xiaopei Cao, Xiaoyu Fang, Mingzhou Guo, Xiaochen Li, Yuanzhou He, Min Xie, Yongjian Xu, Xiansheng Liu
Summary: TRB3 is upregulated in hypoxic pulmonary artery smooth muscle cells and is influenced by endoplasmic reticulum stress. It plays a key role in the pathogenesis of hypoxia-induced pulmonary hypertension by modulating the ERK, JNK, and p38 MAPK pathways, indicating that TRB3 may be a promising target for the treatment of hypoxic pulmonary hypertension.
RESPIRATORY RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Wu Ye, Tingyu Tang, Zhijun Li, Xuefang Li, Qingdong Huang
Summary: Piperlongumine attenuates vascular remodeling in hypoxic pulmonary hypertension by regulating autophagy, showing promising therapeutic potential for this condition.
JOURNAL OF CARDIOLOGY
(2022)
Article
Critical Care Medicine
Roxana Wasnick, Martina Korfei, Katarzyna Piskulak, Ingrid Henneke, Jochen Wilhelm, Poornima Mahavadi, Ruth Charlotte Dartsch, Daniel von der Beck, Miriam Koch, Irina Shalashova, Astrid Weiss, Oleksiy Klymenko, Ingolf Askevold, Ludger Fink, Heiko Witt, Holger Hackstein, Elie El Agha, Saverio Bellusci, Walter Klepetko, Melanie Koenigshoff, Oliver Eickelberg, Ralph Theo Schermuly, Thomas Braun, Werner Seeger, Clemens Ruppert, Andreas Guenther
Summary: This study reveals that Notch signaling plays a crucial role in the proliferation and dedifferentiation of type II alveolar epithelial cells (AEC2s), as well as the development of lung fibrosis in idiopathic pulmonary fibrosis (IPF).
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Manuel J. Richter, Federico Fortuni, Fawaz Alenezi, Michele D'Alto, Roberto Badagliacca, Nathan W. Brunner, Arie P. van Dijk, Philipp Douschan, Henning Gall, Stefano Ghio, Francesco Lo Giudice, Ekkehard Grunig, Francois Haddad, Luke Howard, Sudarshan Rajagopal, Niels Stens, Davide Stolfo, Dick H. J. Thijssen, Carmine Dario Vizza, Roham T. Zamanian, Liang Zhong, Werner Seeger, Hossein A. Ghofrani, Khodr Tello
Summary: A meta-analysis of 35 studies found that right atrial (RA) imaging assessment is a relevant prognostic marker in patients with pulmonary hypertension (PH). RA area, RA indexed area, RA peak longitudinal strain, and RA total emptying fraction were significantly associated with combined end-points including death, clinical worsening, and/or lung transplantation. RA volume and volume index showed marginal significant associations.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
William G. Herrington, Natalie Staplin, Christoph Wanner, Jennifer B. Green, Sibylle J. Hauske, Jonathan R. Emberson, David Preiss, Parminder Judge, Kaitlin J. Mayne, Sarah Y. A. Ng, Emily Sammons, Doreen Zhu, Michael Hill, Will Stevens, Karl Wallendszus, Susanne Brenner, Alfred K. Cheung, Zhi-Hong Liu, Jing Li, Lai Seong Hooi, Wen Liu, Takashi Kadowaki, Masaomi Nangaku, Adeera Levin, David Cherney, Aldo P. Maggioni, Roberto Pontremoli, Rajat Deo, Shinya Goto, Xavier Rossello, Katherine R. Tuttle, Dominik Steubl, Michaela Petrini, Dan Massey, Jens Eilbracht, Martina Brueckmann, Martin J. Landray, Colin Baigent, Richard Haynes
Summary: Empagliflozin therapy reduces the risk of disease progression or cardiovascular death in patients with chronic kidney disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cell & Tissue Engineering
N. Walter, D. Szymski, S. M. Kurtz, D. W. Lowenberg, V. Alt, E. Lau, M. Rupp
Summary: This study investigated the incidence and mortality rates of proximal humerus fractures (PHFs) in the elderly population in the USA, as well as the factors influencing mortality rate. The results showed a decrease in incidence rate from 2009 to 2019, although not statistically significant. The one-year mortality rate was higher for nonoperative treatment compared to surgical treatment and shoulder arthroplasty. Significant mortality risk factors after operative treatment included age, sex, COPD, cerebrovascular disease, chronic kidney disease, concomitant fracture, congestive heart failure, and osteoporotic fracture.
BONE & JOINT RESEARCH
(2023)
Review
Cell Biology
Andreas Mamilos, Lina Winter, Volker H. Schmitt, Friedrich Barsch, David Grevenstein, Willi Wagner, Maximilian Babel, Karsten Keller, Christine Schmitt, Florian Guertler, Stephan Schreml, Tanja Niedermair, Markus Rupp, Volker Alt, Christoph Brochhausen
Summary: Macrophages have a significant impact on the biocompatibility and degradation of implanted biomaterials, making them important in biomaterial-based tissue engineering and regeneration. Understanding their functionality allows for guiding and modulating inflammation towards regeneration. This knowledge improves scaffold material biocompatibility, integration, maturation, preservation, and regeneration.
Article
Infectious Diseases
Markus Rupp, Nike Walter, Daniel Popp, Florian Hitzenbichler, Robert Heyd, Sebastian Geis, Melanie Kandulski, Sylvia Thurn, Thomas Betz, Christoph Brochhausen, Volker Alt
Summary: Fracture-related infection (FRI) is a major complication in orthopedic and trauma surgery. The implementation of a structured multidisciplinary treatment (MDT) approach with a weekly case discussion can improve clinical outcomes in FRI patients.
Article
Medicine, General & Internal
Fritz C. Roller, Armin Schuessler, Nils Kremer, Sebastian Harth, Steffen D. Kriechbaum, Christoph B. Wiedenroth, Stefan Guth, Andreas Breithecker, Manuel Richter, Khodr Tello, Werner Seeger, Eckhard Mayer, Gabriele A. Krombach
Summary: The aim of this study was to assess the RV and LV blood pool T1 and T2 values in CTEPH patients and their correlation to pulmonary hemodynamic. Results showed that compared to control subjects, CTEPH patients had significantly reduced RV T2 values, which increased significantly after balloon pulmonary angioplasty. RV T2 values were positively correlated with hemodynamic measures. Therefore, RV T2 mapping can be a novel non-invasive CMR imaging marker for assessing disease severity, prognosis, follow-up, and therapy monitoring in PH.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Baktybek Kojonazarov, Norbert Weissmann, Werner Seeger, Ralph Theo Schermuly
CARDIOLOGY JOURNAL
(2023)
Article
Immunology
Andres Alberro-Brage, Vitalii Kryvenko, Christina Malainou, Stefan Guenther, Rory E. Morty, Werner Seeger, Susanne Herold, Christos Samakovlis, Istvan Vadasz
Summary: Acute respiratory distress syndrome (ARDS) is a common complication of influenza virus (IV) infection, which leads to the accumulation and impairment of alveolar protein. It has been found that IV infection inhibits the clearance of alveolar protein, possibly through upregulation of a proteinase called MMP. In addition, inhibition of MMP proteinase may improve the clearance of alveolar protein and thus provide a potential therapeutic approach for ARDS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
N. Walter, D. Szymski, S. M. Kurtz, D. W. Lowenberg, V. Alt, E. C. Lau, M. Rupp
Summary: This study aimed to investigate the rates of mechanical complications, nonunion, and infection for different types of proximal femoral fractures in the elderly population in the USA, and to identify the factors that influence adverse outcomes. The study analyzed data from the Medicare Physician Service Records Database and found the complication rates and risk factors for distinct proximal femoral fractures.
Article
Orthopedics
Nike Walter, Dominik Szymski, Steve Kurtz, Volker Alt, David W. Lowenberg, Edmund Lau, Markus Rupp
Summary: Proximal femoral fractures are a serious complication for elderly patients, and risk factors such as age, gender, and chronic diseases are associated with increased mortality. Early assessment of individual risk factors plays a crucial role in reducing mortality rates among the elderly in the US.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2023)
Article
Orthopedics
Dominik Szymski, Nike Walter, Paula Krull, Oliver Melsheimer, Melanie Schindler, Alexander Grimberg, Volker Alt, Arnd Steinbrueck, Markus Rupp
Summary: This study aimed to compare mortality and revisions in THA for primary OA and FNF. The study found that mortality was significantly increased in FNF, as well as the proportion of septic and aseptic revisions. The main influencing factors for septic and aseptic failure were BMI and Elixhauser comorbidity score for septic failure, and BMI and fracture for aseptic failure.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2023)
Article
Orthopedics
Dominik Szymski, Nike Walter, Paula Krull, Oliver Melsheimer, Alexander Grimberg, Volker Alt, Arnd Steinbrueck, Markus Rupp
Summary: This study compared the occurrence of aseptic revisions and pulmonary embolism after cemented and uncemented hemiarthroplasty for the treatment of femoral neck fractures. The results showed a significantly increased rate of aseptic revisions and periprosthetic fractures with uncemented hemiarthroplasty within 5 years after implantation. Although patients with cemented hemiarthroplasty experienced a higher rate of pulmonary embolism during hospitalization, the difference was not statistically significant. Based on these findings, cemented hemiarthroplasty should be preferred in the treatment of femoral neck fractures.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2023)
Article
Orthopedics
Melanie Schindler, Susanne Baertl, Nike Walter, Siegmund Lang, Dominik Szymski, Volker Alt, Markus Rupp
Summary: A German center for trauma and orthopedic surgery conducted a study on the reasons for major ablative surgeries, as well as the mortality and quality of life after hip disarticulation and hemipelvectomy. The study found that the postoperative mortality rate was high and the quality of life of the affected patients was impaired. Especially, amputations performed due to infections had a high mortality rate within one month after surgery.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Letter
Urology & Nephrology
Hristos Karakizlis, Vipul Agarwal, Mostafa Aly, Kevin Strecker, Benjamin Csala, Isla Esso, Jiangping Chen, Christian Nahrgang, Martin Wolter, Heiko Slanina, Christian G. Schuettler, Soenke Jessen, Claudio Ronco, Werner Seeger, Rolf Weimer, Martina Sester, Horst-Walter Birk, Faeq Husain-Syed
JOURNAL OF NEPHROLOGY
(2023)