Review
Biochemistry & Molecular Biology
Nadia Lampiasi
Summary: Mast cells and macrophages are innate immune cells that play important roles in maintaining tissue homeostasis and responding to inflammatory conditions. Their crosstalk is essential for optimal coordination of their functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Kazuhide Takada, Vyacheslav G. Melnikov, Ryoki Kobayashi, Shihoko Komine-Aizawa, Noriko M. Tsuji, Satoshi Hayakawa
Summary: This review discusses the bidirectional communication between the female reproductive tract (FRT) and remote/versatile organs in the body. The framework of the FRT-organ axes, including various axes such as the vagina-gut axis and uterus-brain axis, is comprehensively discussed. Each axis is not only involved in gynecological diseases, but also diseases occurring outside the FRT. The investigation of the FRT-organ axes provides a multi-centric approach to understand the homeostatic mechanism of women's bodies and may lead to new therapeutic approaches for women's health.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Developmental Biology
Logan D. Stacey, Jonathan M. Gubbrud, Alek C. Keegan, Kelly R. Kleekamp, Meghan A. Kuntz, Matthew J. Osmanski, Joshua J. Schumacher, Jennifer A. A. Gubbels, Paul G. Egland
Summary: This study separated and analyzed the maternal and fetal portions of two different types of mammalian placentas using a culture-independent method to measure antibacterial activity. The results showed that both maternal and fetal portions of all placenta types tested exhibited antibacterial activity. Further investigations suggested that the factor responsible for this activity was activated upon release from a larger molecule. Identifying and understanding the activation mechanism of this factor will contribute to a better understanding of the innate immune function provided by the placenta.
Review
Genetics & Heredity
Cindrilla Chumduri, Margherita Y. Turco
Summary: The healthy functioning of the female reproductive tract relies on balanced hormonal regulation during different reproductive stages. The mucosal epithelial lining in various regions of the FRT enables selective transport of gametes and successful transfer of the zygote. Three-dimensional organoid systems from the FRT now offer valuable experimental models for studying normal physiology and disease.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Multidisciplinary Sciences
Jasmine C. Labuda, Oanh H. Pham, Claire E. Depew, Kevin D. Fong, Bokyung Lee, Jordan A. Rixon, Stephen J. McSorley
Summary: Barrier tissues can be protected from infections such as Chlamydia via circulating immune memory, even in the absence of tissue-resident immune cells. Blocking the rapid mobilization of circulating memory CD4 T cells to the female reproductive tract inhibits this protective response. This provides an unexpected opportunity for vaccine development against infections of the female reproductive tract.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Han Gu, Suya Zheng, Guangwei Han, Haotian Yang, Zhuofan Deng, Zehui Liu, Fang He
Summary: PRRSV manipulates MALT1 expression in a precise manner to counteract the antiviral effects of RNases and restore immune homeostasis.
Article
Biology
Sara Pagliarani, Chiara Palmieri, Michael McGowan, Frank Carrick, Jackson Boyd, Stephen D. Johnston, Dongbao Chen
Summary: The koala has recently been listed as an endangered species due to challenges associated with habitat fragmentation, climate change, and disease. This article presents the findings of two PhD theses, providing a detailed description of the female koala reproductive anatomy and histology. The research focuses on artificial insemination and the histopathological changes in the urogenital system caused by Chlamydia spp. infections.
Review
Microbiology
Bin Zhu, Zhi Tao, Laahirie Edupuganti, Myrna G. Serrano, Gregory A. Buck
Summary: The microbiome of the female reproductive tract has a unique biodiversity, with a homogeneous Lactobacillus-based microbiome associated with health and other taxa associated with dysbiosis and disease. Recent research efforts have focused on understanding how these microorganisms influence gynecologic and reproductive health.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2022)
Article
Biology
Yuan Su, Shilin Tian, Diyan Li, Wei Zhu, Tao Wang, Shailendra Kumar Mishra, Ranlei Wei, Zhongxian Xu, Mengnan He, Xiaoling Zhao, Huadong Yin, Xiaolan Fan, Bo Zeng, Mingyao Yang, Deying Yang, Qingyong Ni, Yan Li, Mingwang Zhang, Qing Zhu, Mingzhou Li
Summary: The microbiota in the reproductive tract of chickens plays a significant role in egg production, with microbial species related to immune function potentially enhancing egg production. Differences in reproductive tract microbiota were found to be more strongly associated with egg production than those in the digestive tract.
Article
Environmental Sciences
Peng-Wei Tseng, Hau-Wen Li, Chih Chen, Yung-Che Tseng, Ching-Fong Chang, Guan-Chung Wu
Summary: This study evaluated the transcript features of bacterial selection and maintenance during the development of the accessory nidamental gland (ANG) in bigfin reef squid using RNA-seq. The results showed that immune responses play an important role in the regulatory mechanisms of initial bacterial colonization and later bacterial pigmentation in the ANG of the squid.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Endocrinology & Metabolism
Analuce Canha-Gouveia, Inmaculada Perez-Prieto, Carmen Martinez Rodriguez, Teresa Escamez, Irene Leones-Banos, Eduardo Salas-Espejo, Maria Teresa Prieto-Sanchez, Maria Luisa Sanchez-Ferrer, Pilar Coy, Signe Altmae
Summary: The female reproductive tract harbours distinct microbial communities in the endometrium and the Fallopian tubes. These microbiome profiles are unique to each individual but also share some similarities. Understanding the composition of the upper reproductive tract microbiome is important for reproductive functions and infertility treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Haofei Song, Jima Quan, Chang Li, Wan Liang, Lan Zhang, Shuangshuang Wang, Hongyu Lu, Keli Yang, Danna Zhou, Peng Li, Yongxiang Tian
Summary: In this study, we found that overexpression of the SLAMF1 gene significantly inhibited PRRSV replication and reduced the levels of key signaling pathways and inflammatory factors. On the other hand, knockdown of the SLAMF1 gene enhanced PRRSV replication and the levels of key signaling pathways and inflammatory factors.
Review
Biochemistry & Molecular Biology
Emilio Frances-Herrero, Adolfo Rodriguez-Eguren, Maria Gomez-Alvarez, Lucia de Miguel-Gomez, Hortensia Ferrero, Irene Cervello
Summary: Bioengineering and reproductive medicine have progressed together, focusing on the development and clinical translation of technologies to support reproductive health, such as hydrogels. This literature review highlights the recent advances in using organ-specific ECM hydrogels in reproductive medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Veterinary Sciences
Lluis Ferre-Dolcet, Maria Montserrat Rivera del Alamo
Summary: The female reproductive tract undergoes structural changes during different reproductive stages, and the expression and location of aquaporins (AQPs) are regulated by ovarian steroid hormones. AQPs play important roles in water and solute transportation, follicular development, lubrication and preparation of the endometrium for embryo implantation and fetal development. In the placenta, AQPs ensure fluid support and fetal homeostasis during pregnancy.
VETERINARY SCIENCES
(2023)
Review
Microbiology
Xin-xin Chen, Songlin Qiao, Rui Li, Jing Wang, Xuewu Li, Gaiping Zhang
Summary: By studying how PRRSV evades host immune responses, we can understand that the virus establishes long-term infection through various complex mechanisms, which is a major obstacle in controlling PRRS disease. Understanding the exact mechanisms of PRRSV immune evasion will contribute to the development of novel antiviral strategies.
FRONTIERS IN MICROBIOLOGY
(2023)