4.4 Article

The single-shot GnRH immunocontraceptive vaccine (GonaCon™) in white-tailed deer:: Comparison of several GnRH preparations

期刊

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 60, 期 3, 页码 214-223

出版社

WILEY
DOI: 10.1111/j.1600-0897.2008.00616.x

关键词

contraception; gonadotropin-releasing hormone; infertility; Odocoileus virginianus; overabundance; wildlife

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Problem An effective, single-injection, multi-year, GnRH contraceptive agent is needed to control reproduction in overabundant white-tailed deer populations. Method of study Two GnRH conjugates, GonaCon (TM) (GnRH-KLH) and GonaCon-B (TM) (GnRH-blue protein), were prepared in emulsion form as one-injection and two-injection immunocontraceptive vaccine formulations. In addition, the GnRH-KLH protein conjugate was lyophilized and suspended in AdjuVac (TM) adjuvant to produce a fifth vaccine formulation. Each formulation was administered to a group of five captive adult female white-tailed deer. Reproductive performance of treated female deer was monitored for 5 years to determine the comparative efficacy of the various treatments. Results The longevity of the contraceptive response (2-5 years) was strongly influenced by the design of the conjugate antigen, the adjuvant used, and the delivery form of the vaccine. Conclusion One-injection and two-injection formulations of GonaCon (TM) and GonaCon-B (TM) produced multi-year contraception in adult female white-tailed deer. GonaCon-B (TM) provided a longer lasting contraceptive effect.

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