Review
Cell Biology
Anna Waskiel-Burnat, Marta Osinska, Anna Salinska, Leszek Blicharz, Mohamad Goldust, Malgorzata Olszewska, Lidia Rudnicka
Summary: Alopecia areata is characterized by dysregulation of various systemic cytokines including Th1, Th2, and Th17. The severity and duration of the disease are positively correlated with elevated levels of certain cytokines, while others may serve as potential predictors of therapeutic efficacy.
Article
Immunology
Na Yu, Yiming Weng, Wei Liu, Lixia Chen, Furhan Iqbal, Zhe Yin, Yinyan He, Yanqiu Wang
Summary: The study demonstrates that Toll-like receptor (TLRs) agonists enhance CCL2 production, affecting cytokine secretion by immune cells and potentially promoting Th1/Th2 immune bias.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Ling -Yu Chang, Jing Shan, Xin-Xin Hou, Da-Jin Li, Xiao-Qiu Wang
Summary: Endometriosis is a chronic disorder associated with infertility and pelvic pain, commonly believed to be estrogen-dependent. Recent studies have shown a correlation between immune system disorders and endometriosis, particularly involving the dysregulation of T helper cells leading to a shift towards Th2 immune response. This review aims to explore the mechanisms behind the development of endometriosis, including cytokines, chemokines, signal pathways, transcription factors, and other factors associated with Th1/Th2 immune response, as well as discussing current treatment approaches and potential therapeutic targets.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Summary: Technology and evolving regulatory framework have led to changes in medical terminology, particularly in describing the relationships between gamete and embryo donors and recipients. The use of social media and DNA testing has made it necessary to move away from terms like "known" and "anonymous" and adopt more accurate terms like "directed" and "nonidentified".
FERTILITY AND STERILITY
(2022)
Article
Cell Biology
Naomi M. Fettig, Hannah G. Robinson, Jessica R. Allanach, Katherine M. Davis, Rachel L. Simister, Elsie J. Wang, Andrew J. Sharon, Jiayu Ye, Sarah J. Popple, Jung Hee Seo, Deanna L. Gibson, Sean A. Crowe, Marc S. Horwitz, Lisa C. Osborne
Summary: The study found that different sources of dietary fiber have different effects on the immune system. Guar gum can delay the progression of disease and neuroinflammation in a mouse model of multiple sclerosis. These effects are not related to fiber-induced changes in short-chain fatty acid levels or regulatory CD4(+) T cells, but are associated with reduced activation, proliferation, Th1 differentiation, and altered migratory potential of CD4(+) T cells.
Article
Biochemistry & Molecular Biology
Liping Qin, Yu Song, Fan Zhang, Ru Wang, Li Zhou, Shiqi Jin, Chaojia Chen, Chunyang Li, Molin Wang, Baichun Jiang, Gongping Sun, Chunhong Ma, Yaoqin Gong, Peishan Li
Summary: CUL4B plays a critical role in Th cell differentiation through regulating histone modifications.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Oncology
Maria Cristina Puzzolo, Ilaria Del Giudice, Nadia Peragine, Paola Mariglia, Maria Stefania De Propris, Luca Vincenzo Cappelli, Livio Trentin, Gianluigi Reda, Antonio Cuneo, Stefano Molica, Alfonso Piciocchi, Valentina Arena, Francesca Romana Mauro, Anna Guarini, Robin Foa
Summary: Research suggests that ibrutinib treatment can reverse T-cell polarization in chronic lymphocytic leukemia (CLL), decreasing Th2 cells and increasing Th1 cells, with a gradual reduction in the Th2/Th1 ratio after treatment initiation. Furthermore, patients with a Th2/Th1 ratio below 0.088 at M8 are more likely to achieve complete remission (CR).
FRONTIERS IN ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jasmine Grewal, Anne Marie Valente, Alexander C. Egbe, Fred M. Wu, Eric V. Krieger, Virginia P. Sybert, Iris M. van Hagen, Luc M. Beauchesne, Fred H. Rodriguez, Craig S. Broberg, Anitha John, Elisa A. Bradley, Jolien W. Roos-Hesselink
Summary: This study provides insights into pregnancy outcomes in women with Turner syndrome. Pregnancy in women with TS without structural heart disease does not increase the risk of cardiovascular outcomes. For women with TS with structural heart disease, pregnancy may not be as prohibitive as previously thought, but ongoing evaluation is necessary.
Article
Obstetrics & Gynecology
Ermanno Greco, Valeria Donno, Alessia Greco, Maria Giulia Minasi, Andrea Pristera, Giulia Pirastu, Maria Teresa Varricchio, Katarzyna Litwicka, Cristina Arrivi, Cecilia Mencacci, Pierfrancesco Greco
Summary: In addition to the number of available oocytes after warming, male BMI, semen characteristics, and blastocyst transfer are critical factors influencing the reproductive outcomes of egg donation programmes with imported vitrified oocytes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Immunology
Philipp Burt, Michael Peine, Caroline Peine, Zuzanna Borek, Sebastian Serve, Michael Flossdorf, Ahmed N. Hegazy, Thomas Hoefer, Max Loehning, Kevin Thurley
Summary: Selective differentiation of CD4+ T helper (Th) cells into specialized subsets is crucial for appropriate immune responses. While canonical Th-cell lineages are well understood, the transcriptional architecture of hybrid phenotypes remains unclear. This study explored the transcriptome of Th-cell differentiation, revealing an early bifurcation point in gene expression programs. Hybrid Th1/2 cells showed mixed effects from Th1 and Th2 cells for a minority of genes, while others followed a Th1 and Th2 cell-independent transcriptional program. These findings emphasize the importance of longitudinal data for characterizing cellular phenotypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Ekaterina Martynova, Albert Rizvanov, Richard A. Urbanowicz, Svetlana Khaiboullina
Summary: This review focuses on the mechanisms of inflammasome activation and their role in the development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines released from activated inflammasomes to the immune response is summarized, along with the discussion of the role of cytokines released from tissue cells in promoting lymphocyte differentiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Genetics & Heredity
Alexandra Peyser, Stephanie Brownridge, Mary Rausch, Nicole Noyes
Summary: Analyzing donor oocyte (DE) data over 6 years revealed that using freshly retrieved eggs (FRESH-EGG) was more effective than purchasing frozen eggs (FROZEN-EGG). Additionally, utilizing the combination of FRESH-EGG and FRESH-ET was superior to newer DE treatment combinations, whereas the use of PGT-A did not improve success rates.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Genetics & Heredity
Carolina Lumertz Martello, Marcos Iuri Roos Kulmann, Luiza Mezzomo Donatti, Adriana Bos-Mikich, Nilo Frantz
Summary: The study found that preimplantation genetic testing for aneuploidies (PGT-A) in fresh oocyte donation cycles did not show a significant improvement in clinical outcomes compared to cycles without PGT-A. Despite a slightly higher euploidy rate in the PGT-A group, there was no statistically significant difference in implantation rate between the two groups. Live birth rates also did not differ between the groups.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Rachele Di Donato, Raffaella Bonecchi, Francesca Albano
Summary: Chemokines have local functions in controlling leukocyte extravasation and also play additional roles in regulating hematopoiesis and leukocyte differentiation at a systemic level. Atypical chemokine receptors (ACKRs) are regulators of the chemokine system and have a selective role in neutrophil production and differentiation. This review provides an overview of the role of chemokines and chemokine receptors in neutrophil biology with a focus on the regulation exerted by ACKRs.
Article
Oncology
Hana Yamaguchi, Miki Hiroi, Kazumasa Mori, Ryosuke Ushio, Ari Matsumoto, Nobuharu Yamamoto, Jun Shimada, Yoshihiro Ohmori
Summary: This study investigated the gene expression kinetics of chemokines/cytokines during oral cancer development in a mouse model using the carcinogen 4NQO. The results showed that both Th1- and Treg-associated chemokines were simultaneously expressed in premalignant lesions, suggesting the initiation of anti-tumor immune responses and immunosuppression in the early stages of OLP development. This study highlights the role of chemokines and cytokines in immune cell recruitment and activation during oral cancer progression.
Article
Immunology
Viktor P. Chernyshov, Boris V. Dons'koi, Iryna O. Sudoma, Yana O. Goncharova
IMMUNOLOGY LETTERS
(2016)
Meeting Abstract
Immunology
Boris V. Dons'koi, Viktor P. Chernyshov
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Meeting Abstract
Immunology
Kseniia Khazhylenko, Tamara D. Zadorojna, Boris V. Dons'koi, Viktor P. Chernyshov
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Meeting Abstract
Immunology
Boris V. Dons'koi, Tatyana O. Popova, Viktor P. Chernyshov
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Meeting Abstract
Immunology
Boris V. Dons'koi, Viktor P. Chernyshov, Sergiy M. Baksheev, Olga G. Kotsuyba
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Meeting Abstract
Immunology
Viktor P. Chernyshov, Boris V. Dons'koi, Iryna O. Sudoma, Yana O. Goncharova
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Article
Immunology
Boris V. Dons'koi, Viktor P. Chernyshov, Vera Y. Sirenko, Galina V. Strelko, Dariia V. Osypchuk
Article
Immunology
Viktor P. Chernyshov, Boris V. Dons'koi, Iryna O. Sudoma, Yana O. Goncharov
IMMUNOLOGY LETTERS
(2014)
Meeting Abstract
Immunology
Viktor P. Chernyshov, Boris V. Dons'koi, Iryna O. Sudoma, Yana O. Goncharova
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2014)
Article
Biochemical Research Methods
Boris Dons'koi, Dariia Osypchuk, Viktor P. Chernyshov
JOURNAL OF IMMUNOLOGICAL METHODS
(2019)
Article
Immunology
Boris Dons'koi, Tetiana M. Tutchenko, Viktor P. Chernyshov, Katerina S. Stepaniuk
IMMUNOLOGY LETTERS
(2020)
Article
Obstetrics & Gynecology
Boris Dons'koi, Dariia Osypchuk, Viktor P. Chernyshov, Kseniia G. Khazhylenko
Summary: The diversity of peripheral blood natural killer (NK) cells is highly complex, with over a thousand phenotypes described across leukocyte lineages. This study found that high levels of NKp46(+)NK cells in women with a history of recurrent implantation failures were associated with poor prognostic for embryo implantation. Additionally, a low level of NKp46(neg)NK cells in women with RIF was found to be a negative prognostic factor for embryo implantation.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Immunology
Boris Dons'koi, Victor P. Chernyshov, Dariia Osypchuk, Irina Sudoma, Kseniia G. Khazhylenko, Galina Strelko, Wera J. Sirenko
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
(2020)
Article
Immunology
Viktor P. Chernyshov, Boris Dons'koi, Iryna O. Sudoma, Yana O. Goncharova
CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Integrative & Complementary Medicine
Boris V. Dons'koi, Viktor P. Chernyshov, Dariia V. Osypchuk, Sergiy M. Baksheev
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2016)