Article
Cardiac & Cardiovascular Systems
Yun Gi Kim, Kyung-Do Han, Jong-Il Choi, Yun Young Choi, Ha Young Choi, Ki Yung Boo, Do Young Kim, Kwang-No Lee, Jaemin Shim, Jin-Seok Kim, Yong Gyu Park, Young-Hoon Kim
Summary: The study found that obesity, male sex, heavy alcohol consumption, smoking, hypertension, diabetes, and chronic kidney disease were associated with an increased risk of new-onset atrial fibrillation, and these risk factors were consistently related to the risk of new-onset atrial fibrillation in various age groups. Therefore, controlling these non-genetic risk factors may be relevant for both young and old individuals.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Obstetrics & Gynecology
Nahid Punjani, Pietro Bortoletto, Phillip A. Romanski, James Kashanian, Steven Spandorfer
Summary: This study aimed to investigate the impact of advancing paternal age on fresh embryo transfer cycle outcomes. The study found that increasing paternal age did not show any statistically significant differences in implantation, clinical intrauterine pregnancy, pregnancy loss, or live birth.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Pediatrics
Ine Vervoort, Chantal Delger, Adelheid Soubry
Summary: Mental or neuropsychiatric disorders are prevalent globally and have a significant impact on individuals' quality of life, highlighting the need for improved mental health care. The potential impact of advanced paternal age on the development of certain mental disorders suggests the importance of considering multiple factors to establish a more comprehensive model. By gaining better knowledge of various risk factors and their roles in the development of mental disorders, optimization of mental health care and management can be achieved.
PEDIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Lingling Mai, Hitoshi Inada, Ryuichi Kimura, Kouta Kanno, Takeru Matsuda, Ryosuke O. Tachibana, Valter Tucci, Fumiyasu Komaki, Noboru Hiroi, Noriko Osumi
Summary: Paternal age has a significant effect on vocal development in offspring, with advanced paternal age leading to a reduction in the number and duration of syllables, changes in syllable composition, and potentially affecting body weight development. Offspring born to young fathers exhibit more consistent vocal characteristics and a rich repertoire, while those born to aged fathers show more diverse vocal patterns and limited repertoire.
Article
Pediatrics
Martin Johansson, Ylva Fredriksson Kaul, Cecilia Montgomery, Eva Larsson, Lena Hellstrom-Westas, Olga Kochukhova
Summary: This study investigated the relationship between visual perception and social functioning in preterm children. The findings showed that preterm children had difficulties in perceiving static shapes and biological motion, but not in emotion perception. In extremely preterm children, poorer shape perception and lower scores on emotion perception were associated with more social problems and lower visual acuity. Shape perception explained more variance in social functioning than emotion perception.
Article
Cell Biology
Andreas Prell, Mustafa Orkun Sen, Ramya Potabattula, Laura Bernhardt, Marcus Dittrich, Thomas Hahn, Martin Schorsch, Federica Zacchini, Grazyna Ewa Ptak, Heiner Niemann, Thomas Haaf
Summary: A growing number of sperm methylome analyses have identified genomic loci that are susceptible to paternal age effects in a variety of mammalian species. However, there is little overlap between different data sets. In this study, we compared methylation patterns of orthologous regulatory regions in human, bovine, and mouse sperm samples and found that the identified age-related differentially methylated regions (ageDMRs) were all species-specific. Most ageDMRs were in genomic regions with medium methylation levels and large methylation variation. Our results suggest that sperm ageDMRs may be part of an epigenetic mechanism for lineage-specific environmental adaptations.
Article
Obstetrics & Gynecology
Kate F. Walker, Jim G. Thornton
Summary: For women of advanced maternal age, induction of labour at 39 weeks does not appear to increase the risk of emergency caesarean section or have any short-term adverse effects on mother or baby. However, there is a lack of studies on the long-term effects of induction in this group. It seems reasonable to offer this option where resources are available to safely provide it.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Cell Biology
Yangyang Sun, Xu Li, Wei Jiang, Yuanming Fan, Qiong Ouyang, Wei Shao, Raphael N. Alolga, Yuqiu Ge, Gaoxiang Ma
Summary: The study suggests that advanced paternal age may be an independent protective factor against various cancers in offspring, and it is positively associated with cancer incidence of the female genitalia, respiratory and intrathoracic organs, and lungs.
Article
Multidisciplinary Sciences
Patrick Sharman, Andrew J. Young, Alastair J. Wilson
Summary: The study found significant effects of maternal and paternal age on the speed of thoroughbred racehorses' offspring, with maternal effects being more negative. These results could help optimize breeding decisions and contribute to the evidence that both maternal and paternal age affect offspring traits.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Multidisciplinary Sciences
Patrick Sharman, Andrew J. Young, Alastair J. Wilson
Summary: This study aimed to investigate the effects of parental age on offspring speed in thoroughbred racehorses. The results showed significant effects of both maternal and paternal age on offspring speed, indicating that both parents' ages play a role in determining the speed of their offspring. While maternal age effects were stronger, the existence and magnitude of paternal effects are particularly noteworthy considering the lack of paternal involvement in parental care in thoroughbred sires.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Psychiatry
Tsung Yu, Kun-Chia Chang, Pao-Lin Kuo
Summary: This study examined the association between parental diagnosis of psychiatric disorders and the risk of autism spectrum disorders (ASD). The study found that children with a family history of psychiatric disorders were more likely to develop ASD, and maternal diagnosis of psychiatric disorders had a greater influence on ASD risk.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Alexandra Ramirez-Celis, Martin Becker, Miriam Nuno, Joseph Schauer, Nima Aghaeepour, Judy Van de Water
Summary: The study aimed to identify specific maternal autoantibody patterns against ASD-associated proteins, finding unique patterns associated with ASD and potential biomarkers for up to 18% of cases.
MOLECULAR PSYCHIATRY
(2021)
Article
Developmental Biology
Oana Kubinyecz, Fatima Santos, Deborah Drage, Wolf Reik, Melanie A. Eckersley-Maslin
Summary: The study reveals the importance of Dppa2/4 proteins in early mouse embryonic development, especially the impact of maternal Dppa2/4 on offspring survival.
Article
Behavioral Sciences
Misha K. Rowell, Tasmin L. Rymer
Summary: Problem solving ability is influenced by factors such as physiology, personality, and cognition. Age and experience play a role in problem solving, with individuals who have more experience solving tasks more quickly. Inexperienced older individuals tend to interact more with problems compared to inexperienced younger individuals. Previous solving experience is important for short-term success, while age, in the absence of experience, may lead to increased exploration of novel problems. Manipulating objects generally may also contribute to problem-solving success, offering advantages in changing resources and habitats.
Article
Plant Sciences
Ze Wang, Min Chen, Huan Yang, Zhengdao Hu, Youfeng Yu, Hao Xu, Shunping Yan, Keke Yi, Jing Li
Summary: Haploid production by outcrossing with inducers is a key technology in breeding. Manipulating centromere-specific histone H3 (CENH3/CENPA) has led to the development of a promising haploid inducer. Temperature can improve pollen vigor and haploid induction efficiency, enabling the efficient induction of maternal and paternal haploids.
Article
Psychology, Clinical
Mark Weiser, Or Frenkel, Daphna Fenchel, Dorit Tzur, Sven Sandin, Magdalena Janecka, Linda Levi, Michael Davidson, Lucian Laor, Eyal Fruchter, Abraham Reichenberg
Summary: Despite the differentiation of different psychiatric disorders by ICD and DSM, these disorders often share symptoms, risk factors, and treatments. This population-based study found shared etiologies among most psychiatric disorders and low IQ.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Behrang Mahjani, Christina Gustavsson Mahjani, Abraham Reichenberg, Sven Sandin, Christina M. Hultman, Joseph D. Buxbaum, Dorothy E. Grice
Summary: This study evaluated the psychometric properties of the Swedish translation of the Obsessive-Compulsive Inventory-Revised (OCI-R) and explored the frequency, severity, and symptom dimensions of OCD comorbid with other psychiatric disorders. The results showed that the Swedish translation of OCI-R had good internal consistency and clear agreement with the six-factor model. Females had significantly higher total scores on the OCI-R compared to males. The most common psychiatric comorbidities with OCD were anxiety disorders and major depression.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Letter
Genetics & Heredity
S. Sethuram, T. Levy, J. Foss-Feig, D. Halpern, S. Sandin, P. M. Siper, H. Walker, J. D. Buxbaum, R. Rapaport, A. Kolevzon
Summary: This study assessed the feasibility, safety, and efficacy of recombinant human growth hormone (rhGH) treatment in children with Phelan-McDermid syndrome (PMS). The results showed that rhGH treatment increased IGF-1 levels and improved social withdrawal, hyperactivity, and sensory symptoms in the children. However, caution should be exercised in interpreting the results due to the small sample size and lack of a placebo control.
Article
Oncology
Q. Liu, W. Yin, J. J. Meijsen, A. Reichenberg, J. R. Gadin, A. J. Schork, H-O Adami, A. Kolevzon, S. Sandin, F. Fang
Summary: Individuals with autism spectrum disorders (ASDs) have a slightly increased overall risk of cancer, particularly in narrowly defined autistic disorder, ASD with comorbid birth defects, and ASD with both birth defects and intellectual disability (ID).
ANNALS OF ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Martina Persson, Abraham Reichenberg, Mikael Andersson Franko, Sven Sandin
Summary: This study suggests that maternal type 1 diabetes (T1D) may increase the risk of autism spectrum disorder (ASD) in offspring. It is found that this risk may be mediated by pre-term birth, which affects about one-third of pregnancies with T1D. Additionally, maternal levels of glycated haemoglobin (HbA1c) do not impact the risk of ASD beyond the T1D diagnosis itself.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Weiyao Yin, Martina Persson, Sven Sandin
Summary: This study examined the risk of type 1 diabetes mellitus (T1DM) in the offspring of parents with a psychiatric history at the birth of the child. The findings suggested a higher risk of T1DM in children of mothers with psychiatric disorders at delivery, but not in children of fathers with psychiatric disorders or those diagnosed after delivery. The association disappeared after adjusting for T1DM in parents, but remained significant in female offspring. Maternal eating disorder and obsessive-compulsive disorder were independently associated with offspring T1DM.
DIABETES & METABOLISM
(2023)
Article
Oncology
Theodore M. Brasky, Erinn M. Hade, David E. Cohn, Alison M. Newton, Stacey Petruzella, Kelli O'Connell, Kimberly A. Bertrand, Linda S. Cook, Immaculata De Vivo, Mengmeng Du, Jo L. Freudenheim, Christine M. Friedenreich, Marc T. Goodman, Jessica Gorzelitz, Torukiri I. Ibiebele, Vittorio Krogh, Linda M. Liao, Loren Lipworth, Lingeng Lu, Susan McCann, Tracy A. O'Mara, Julie R. Palmer, Jeanette Ponte, Anna Prizment, Harvey Risch, Sven Sandin, Leo J. Schouten, Veronica Wendy Setiawan, Xiao-ou Shu, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Nicolas Wentzensen, Lynne R. Wilkens, Alicja Wolk, Herbert Yu, Marian L. Neuhouser
Summary: This study analyzed data from 12 prospective cohort studies and found that higher dietary intake of long-chain omega-3 polyunsaturated fatty acids (LCn3PUFA) may increase the risk of endometrial cancer, especially among specific subgroups characterized by body weight and tumor pathology.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Psychiatry
Vahe Khachadourian, Arad Kodesh, Stephen Z. Levine, Emma Lin, Joseph D. Buxbaum, Veerle Bergink, Sven Sandin, Abraham Reichenberg, Magdalena Janecka
Summary: This study aimed to examine the associations between mental and somatic disorders before and during pregnancy. The results showed that comorbidity between mental and somatic disorders during pregnancy was two times higher than comorbidity between different somatic disorders. Mental disorders were positively associated with seven somatic disorder categories, including musculoskeletal and digestive system diseases. These findings highlight the importance of screening for mental disorders and potential comorbid conditions during pregnancy.
EUROPEAN PSYCHIATRY
(2023)
Article
Oncology
Hazel B. Nichols, Melissa G. House, Rina Yarosh, Sara Mitra, Mandy Goldberg, Kimberly A. Bertrand, A. Heather Eliassen, Graham G. Giles, Michael E. Jones, Roger L. Milne, Katie M. O'Brien, Julie R. Palmer, Sven Sandin, Walter C. Willett, Weiyao Yin, Dale P. Sandler, Anthony J. Swerdlow, Minouk J. Schoemaker
Summary: In this study, the data from 184,866 parous women were analyzed and it was found that preterm birth was not associated with breast cancer risk, while preeclampsia was inversely associated with breast cancer risk. However, among women with hypertensive conditions, preterm birth was positively associated with breast cancer risk. These results suggest that other conditions of pregnancy may influence the relationship between preterm birth and breast cancer.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Public, Environmental & Occupational Health
Summer Harvey, Nicolas Wentzensen, Kimberly Bertrand, Amanda Black, Louise A. Brinton, Chu Chen, Laura Costas, Luigino Dal Maso, Immaculata De Vivo, Mengmeng Du, Montserrat Garcia-Closas, Marc T. Goodman, Jessica Gorzelitz, Lisa Johnson, James Lacey, Linda Liao, Loren Lipworth, Jolanta Lissowska, Anthony B. Miller, Kelli O'Connell, Tracy A. O'Mara, Xiao Ou, Julie R. Palmer, Alpa Patel, Sonia Paytubi, Beatriz Pelegrina, Stacey Petruzella, Anna Prizment, Thomas Rohan, Sven Sandin, Veronica Wendy Setiawan, Rashmi Sinha, Britton Trabert, Penelope M. Webb, Lynne R. Wilkens, Wanghong Xu, Hannah P. Yang, Wei Zheng, Megan A. Clarke
Summary: This study evaluated the associations between obesity in young adulthood and adulthood with endometrial cancer risk. The results showed that obesity in both periods was positively associated with endometrial cancer risk, and weight gain was also positively associated with this risk while weight loss was inversely associated.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Behrang Mahjani, Lambertus Klei, Ariela S. Buxbaum Grice, Henrik Larsson, Christina M. Hultman, Sven Sandin, Bernie Devlin, Joseph D. Buxbaum, Dorothy E. Grice
Summary: This study found that both genetic and environmental factors contribute to the background risk of Tourette disorder and chronic motor or vocal tic disorders (CTD). The analysis of data from the Swedish Medical Birth Register showed that genetic maternal effect plays a role in the risk of CTD. The results estimated that 60.7% of CTD risk is due to direct genetic effect, 4.8% is due to genetic maternal effect, and 0.5% is due to environmental maternal effect.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Psychology, Clinical
Weiyao Yin, Mattias Norrback, Stephen Z. Levine, Natalia Rivera, Joseph D. Buxbaum, Hailin Zhu, Benjamin Yip, Abraham Reichenberg, Johan Askling, Sven Sandin
Summary: A study from Sweden found that maternal rheumatoid arthritis (RA) may increase the risk of offspring autism spectrum disorder (ASD), possibly through inflammation/autoimmunity. The study also found that maternal RA before delivery was associated with an increased risk of offspring ASD, while paternal RA, maternal sisters with RA, or RA diagnosed after delivery did not show a similar association. Additionally, maternal arthralgia, which has similar symptoms to RA but without inflammation/autoimmunity, was also associated with an increased risk of ASD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Vahe Khachadourian, Behrang Mahjani, Sven Sandin, Alexander Kolevzon, Joseph D. Buxbaum, Abraham Reichenberg, Magdalena Janecka
Summary: This study examines the frequency and distribution of comorbidities in individuals with ASD, and explores the potential link between pre- and postnatal exposures and distinct comorbidities. The findings show that the majority of individuals with ASD have at least one comorbidity, and preterm birth and hypoxia at birth are the most common perinatal exposures. These exposures are associated with several distinct comorbidities in both ASD cases and non-ASD siblings.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Obstetrics & Gynecology
Chen Liang, Hsin-Fang Chung, Annette J. Dobson, Janet E. Cade, Darren C. Greenwood, Kunihiko Hayashi, Rebecca Hardy, Diana Kuh, Yvonne T. van der Schouw, Sven Sandin, Elisabete Weiderpass, Gita D. Mishra
Summary: This study analyzed data from 9 observational studies and found that infertility, miscarriage, and stillbirth were associated with premature and early menopause, and the association differed between Asian and non-Asian women. Asian women had a higher risk of premature and early menopause compared to non-Asian women with the same reproductive history.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Weiyao Yin, Jonas F. Ludvigsson, Ulrika Aden, Kari Risnes, Martina Persson, Abraham Reichenberg, Michael E. Silverman, Eero Kajantie, Sven Sandin
Summary: This study investigated the association between psychiatric diagnoses in fathers, mothers, and both parents and gestational age. The results showed that both paternal and maternal psychiatric diagnoses were associated with earlier gestational age, and the risk increased when both parents were diagnosed. The risk also increased when fathers and mothers were diagnosed with different psychiatric disorders. These findings suggest that the presence of psychiatric diagnoses in parents impacts gestational age at birth.
