Article
Immunology
Tor Kristian Andersen, Johanna Bodin, Fredrik Oftung, Bjarne Bogen, Siri Mjaaland, Gunnveig Grodeland
Summary: The 2009 swine flu pandemic exposed the limitations of egg-based vaccines in terms of global supply, prompting the urgent need for efficient new vaccine platforms; DNA vaccines have since been developed as a temperature stable, cost-effective option for pandemic responses, capable of inducing rapid protective immune responses without the need for adjuvants.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Richard Hodson
Summary: Researchers provide clear guidelines on what countries should do to prevent another disease outbreak with pandemic potential.
Review
Biochemistry & Molecular Biology
Walter N. Harrington, Christina M. Kackos, Richard J. Webby
Summary: The long history of preparing for and fighting influenza pandemics can inform the response to novel coronaviruses like SARS-Cov-2. Global influenza surveillance networks and detailed risk assessment tools have proven successful in containing outbreaks, such as the H7N9 influenza in 2013, and could serve as models for managing coronaviruses with pandemic potential. Containment efforts must continually adapt and incorporate new research and information gathered from global crises.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jeremy C. Jones, Hui-Ling Yen, Peter Adams, Kimberly Armstrong, Elena A. Govorkova
Summary: Effective antivirals play a crucial role in the early phase of an influenza pandemic, before vaccines are available. Currently, two classes of antiviral drugs are approved for influenza treatment, but resistance has been observed. Therefore, it is important to develop novel antiviral options that target both the virus and the host. This review explores the drawbacks of current antivirals and ongoing research on new agents or combination therapies to address these limitations.
ANTIVIRAL RESEARCH
(2023)
Review
Immunology
Steven Rockman, Beverly Taylor, John W. McCauley, Ian G. Barr, Ray Longstaff, Ranbir Bahra
Summary: The COVID-19 pandemic has led to rapid investigation and deployment of vaccine platforms never used before. Both new and existing vaccine platforms are likely to play a crucial role in combating future pandemics, especially influenza. The field of influenza vaccine manufacturing has a long history of successes and advancements in the past decade.
Article
Immunology
Norman W. W. Baylor, Jesse L. L. Goodman
Summary: The response to SARS-CoV-2 demonstrated the potential of vaccine research and development, but there is still room for improvement in combating pandemics. This review focuses on enhancing research and evaluation processes and emphasizes the importance of moving vaccine development and evaluation to the pre-pandemic period.
Article
Immunology
Perrine Marcenac, Margaret McCarron, William Davis, Ledor S. Igboh, Joshua A. Mott, Kathryn E. Lafond, Weigong Zhou, Marjorie Sorrells, Myrna D. Charles, Philip Gould, Carmen Sofia Arriola, Vic Veguilla, Erica Guthrie, Vivien G. Dugan, Rebecca Kondor, Eric Gogstad, Timothy M. Uyeki, Sonja J. Olsen, Gideon O. Emukule, Siddhartha Saha, Carolyn Greene, Joseph S. Bresee, John Barnes, David E. Wentworth, Alicia M. Fry, Daniel B. Jernigan, Eduardo Azziz-Baumgartner
Summary: Countries utilized existing surveillance systems and resources to track, study, and respond to SARS-CoV-2 infections during the COVID-19 pandemic, highlighting the importance of incorporating COVID-19 surveillance into global respiratory virus monitoring.
EMERGING INFECTIOUS DISEASES
(2022)
Review
Immunology
Celine H. Lemoine, Reviany V. Nidom, Roland Ventura, Setyarina Indrasari, Irine Normalina, Kuncoro Puguh Santoso, Francis Derouet, Christophe Barnier-Quer, Gerrit Borchard, Nicolas Collin, Chairul A. Nidom
Summary: Adequate global vaccine coverage is crucial during an influenza pandemic to mitigate morbidity, mortality, and economic impact. Adjuvant technologies can help increase vaccine doses, extend protection, and potentially enable single-dose vaccination. International cooperation is necessary to meet global vaccine demand.
Review
Virology
Hai Xu, Shanyuan Zhu, Roshini Govinden, Hafizah Y. Chenia
Summary: "Progress in research on avian influenza vaccines" reviews the recent progress and delivery systems of avian influenza vaccines. It provides ideas for the design and development of new vaccines in the avian influenza research community.
Article
Immunology
Kelly A. S. da Costa, Joanne Marie M. Del Rosario, Matteo Ferrari, Sneha Vishwanath, Benedikt Asbach, Rebecca Kinsley, Ralf Wagner, Jonathan L. Heeney, George W. Carnell, Nigel J. Temperton
Summary: By using NA pseudoviruses and developing the pELLA assay, we successfully measured neuraminidase inhibition levels in different influenza sera and found that pELLA is more sensitive than the commercially available NA-Fluor(TM). These studies may lead to the design of more potent, longer-lasting, and broader protective vaccines that can be used in a pre-pandemic approach in combination with HA vaccines.
Article
Biochemistry & Molecular Biology
Nino Rcheulishvili, Jiawei Mao, Dimitri Papukashvili, Cong Liu, Ziqian Wang, Jiao Zhao, Fengfei Xie, Xuehua Pan, Yang Ji, Yunjiao He, Peng George Wang
Summary: Despite advances in prevention, treatment, and immunization, the influenza virus remains a global threat due to its unpredictable pandemics and evolving nature. Seasonal vaccine mismatches decrease efficacy and increase outbreak risks. Development of a universal vaccine covering all influenza A and B strains would reduce the pervasiveness of the virus. This study designed a potentially universal multi-epitope vaccine based on conserved T cell and B cell epitopes, and demonstrated its immunogenicity and stability through immune simulation and molecular docking experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Infectious Diseases
Pui- Ho, Wei Liu, Tiger Zheng-Rong Li, Ta-Chien Chan, Chia-Chi Ku, Yu-Hui Lien, Yea-Huei Daphne Shen, Juine-Ruey Chen, Muh-Yong Yen, Yu-Kang Tu, Wan-Yu Lin, Richard Compans, Ping-Ing Lee, Chwan-Chuen King
Summary: This study evaluated the effectiveness of class suspension and mass vaccination among Taipei schoolchildren during the 2009 influenza pandemic. It also investigated the factors affecting antibody responses. The study found that schoolchildren who experienced class suspensions had a higher seroprevalence of H1N1pdm09 before vaccination compared to those who did not. Participating in after-school activities and having more than three hours of exercise per week were significantly correlated with H1N1pdm09 infection. Two doses of the vaccine showed better antibody persistence than one dose. Exercise and preexisting immunity were found to be associated with antibody waning/maintenance.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Virology
Joshua Yi Yeo, Samuel Ken-En Gan
Summary: The H5N8 avian influenza first emerged in South Korea in 2014 and quickly spread worldwide, resulting in the first human infection in Russia during the 2020-2021 outbreak. Despite being clinically asymptomatic and without human-to-human transmission, the World Health Organization emphasized the importance of continued risk assessment in order to prevent potential pandemics. Efforts to understand the mechanisms of species jumping and prevent disastrous outbreaks are becoming increasingly urgent as the virus has the potential to reassort and generate new strains.
Article
Multidisciplinary Sciences
Luis Penarrubia, Sonia N. Rao, Roberto Porco, Marta Varo, Patricia Munoz-Torrero, Fernando Ortiz-Martinez, Josep Pareja, Marta Lopez-Fontanals, Davide Manissero
Summary: Recent reports from the World Health Organization have drawn global attention to the threat of Influenza A pandemic, especially zoonotic strains. This study explores the potential use of the QIAstat-Dx Respiratory SARS-CoV-2 Panel in detecting and differentiating zoonotic Influenza A strains. Results show that the panel can detect and differentiate zoonotic strains from human seasonal strains, indicating its usefulness in diagnosing zoonotic Influenza A.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Fred Andayi, Gideon O. Emukule, Eric Osoro, Linus K. Ndegwa, Fredrick Otiato, Peter Muturi, Eduardo Azziz-Baumgartner, Rosalia Kalani, Edwina Anyango, Philip M. Muthoka, Malembe S. Ebama, Joseph Bresee, Sandra S. Chaves
Summary: Healthcare workers in Kenya have moderate knowledge of pandemic influenza and vaccination, which varies by profession and years of work experience. Continued in-service health education is needed to increase awareness and knowledge of pandemic influenza among healthcare workers and to improve acceptance of influenza vaccination during a pandemic.
Article
Infectious Diseases
Helen E. Quinn, Heather F. Gidding, Helen S. Marshall, Robert Booy, Elizabeth J. Elliott, Peter Richmond, Nigel Crawford, Peter B. McIntyrean, Kristine K. Macartney, C. Blyth, P. Britton, J. Buttery, J. E. Clark, J. Connell, R. Dale, M. Deverell, S. Dougherty, C. Finucane, M. Gibson, M. Gold, C. Heath, L. Hickie, T. Hutchinson, C. Jones, J. Jones, J. Kent, H. Knight, A. Kynaston, D. Lee, G. Lewis, S. Low, N. Maclean, F. McDonald, N. McLaren, A. McMinn, J. McRae, J. Murphy, M. Nissen, C. Orr, K. Orr, N. Phillips, M. Pym, J. Quinn, L. Rhind, A. Roberts, C. Robins, L. Rost, J. Royle, T. Snelling, C. Talbott, S. Tan, L. Trinh, L. Vidler, M. Walker, R. West, C. Wharton, N. Wood, Y. Zurynski
JOURNAL OF INFECTION
(2019)
Article
Biotechnology & Applied Microbiology
Jane Tuckerman, Nigel W. Crawford, John Lynch, Helen S. Marshall
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2019)
Article
Medicine, General & Internal
Wendy V. Ingman, Bernadette Richards, Jacqueline M. Street, Drew Carter, Mary Rickard, Jennifer Stone, Pallave Dasari
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Health Care Sciences & Services
Jackie Street, Tania Stafinski, Edilene Lopes, Devidas Menon
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2020)
Article
Health Care Sciences & Services
Edilene Lopes, Jackie Street, Drew Carter, Tracy Merlin, Tania Stafinski
Article
Health Care Sciences & Services
Edilene Lopes, Jackie Street, Tania Stafinski, Tracy Merlin, Drew Carter
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2020)
Article
Health Care Sciences & Services
Hossein Haji Ali Afzali, Jackie Street, Tracy Merlin, Jonathan Karnon
Summary: Public involvement in health technology assessment (HTA) is increasingly recognized as important for ensuring legitimacy and fairness in public funding decisions. However, challenges remain in reorienting HTA to reflect public priorities. Australia has historically led in applying HTA to assess new health technologies, but current processes lack meaningful public inputs.
INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE
(2021)
Article
Health Care Sciences & Services
Jackie Street, Belinda Fabrianesi, Carolyn Adams, Felicity Flack, Merran Smith, Stacy M. Carter, Sean Lybrand, Anthony Brown, Serena Joyner, Judy Mullan, Luise Lago, Lucy Carolan, Katie Irvine, Coralie Wales, Annette J. Braunack-Mayer
Summary: Research indicates that Australian citizens are generally supportive of government sharing health data with private industry for research and development, provided that it serves public interest, is done responsibly, and within a secure data protection framework.
HEALTH EXPECTATIONS
(2021)
Article
Health Care Sciences & Services
Annette Braunack-Mayer, Belinda Fabrianesi, Jackie Street, Pauline O'Shaughnessy, Stacy M. Carter, Lina Engelen, Lucy Carolan, Rebecca Bosward, David Roder, Kylie Sproston
Summary: This nationally representative survey in Australia reveals uncertainty and caution among the public regarding sharing government health data with private companies. While slightly over half of the respondents support sharing health data, there is strong demand for strict conditions and opt-in consent for data sharing, along with concerns about the private sector's capability in managing government health data.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Patti Shih, Kathleen Prokopovich, Chris Degeling, Jacqueline Street, Stacy M. Carter
Summary: The Apple Watch ECG feature detects atrial fibrillation, but its direct-to-consumer marketing may lead to unnecessary medical tests and overuse.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Environmental Sciences
Jackie Street, Helen Barrie, Jaklin Eliott, Lucy Carolan, Fidelma McCorry, Andreas Cebulla, Lyn Phillipson, Kathleen Prokopovich, Scott Hanson-Easey, Teresa Burgess
Summary: There is a global need for solutions to support aging populations and reduce the burdens associated with it. Smart technologies implemented within homes and communities may be beneficial, but there has been little consultation with older Australians regarding their perceived benefits and potential social and ethical challenges. This study conducted five World Cafes to capture citizen knowledge about smart technologies, identifying themes of understanding, resistance, and acceptance, as well as ethical principles such as beneficence, privacy, and justice.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Health Care Sciences & Services
Kathleen Prokopovich, Lyn Phillipson, Leissa West (Pitts), Biljana Stanoevska, Jackie Street, Annette Braunack-Mayer
Summary: This study explores the engagement of a culturally and linguistically diverse community in school and human papillomavirus (HPV) vaccination. The World Cafe participatory research method was used to facilitate discussions with the community, revealing a positive attitude towards vaccines and a decision-making process based on trust relationships. The findings highlight the importance of existing trust relationships when tailoring vaccine communication to local communities.
HEALTH EXPECTATIONS
(2023)
Article
Economics
Tracy Merlin, Jackie Street, Drew Carter, Hossein Haji Ali Afzali
Summary: There is deep uncertainty about the clinical benefits and cost effectiveness of highly specialised technologies (HSTs). Standard health technology assessment processes have failed to address these uncertainties. A Living HTA framework is proposed to address these challenges by incorporating societal values, real-time data collection, and updating of reference models.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2023)
Review
Education & Educational Research
Annette J. Braunack-Mayer, Jackie M. Street, Rebecca Tooher, Xiaolin Feng, Katrine Scharling-Gamba
REVIEW OF EDUCATIONAL RESEARCH
(2020)
Article
Public, Environmental & Occupational Health
Lucy C. Farrell, Vivienne M. Moore, Megan J. Warin, Jackie M. Street
HEALTH PROMOTION JOURNAL OF AUSTRALIA
(2019)