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Biochemistry & Molecular Biology
Jing Ren, Xiumei Feng, Yanan Guo, Dexiao Kong, Yongjing Wang, Juan Xiao, Wen Jiang, Xiaoli Feng, Xiaoli Liu, Ai Li, Congcong Sun, Mingming He, Bingen Li, Juandong Wang, Yang Jiang, Chengyun Zheng
Summary: The GSK-3 beta inhibitor, TWS119, enhances the cytotoxicity of NK cells against multiple myeloma cells by upregulating RAB27A expression and activating the beta-catenin/NF-kappa B pathway. In vivo experiments demonstrated that adoptive transfer of TWS119-treated NK-92 cells significantly reduces tumor volume and prolongs the survival time of myeloma-bearing mice.
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Medicine, Research & Experimental
Liping Cao, Zhenghong Li, Zhizhou Yang, Mengmeng Wang, Wei Zhang, Yi Ren, Liang Li, Junxian Hu, Zhaorui Sun, Shinan Nie
Summary: Ferulic acid showed significant protective effects in murine ALI and cellular ALI models, reducing inflammation and improving histopathological changes. FA exerts its effects by modulating the GSK-3 beta/NF-kappa B/CREB pathway to protect the liver.
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Genetics & Heredity
Huajie Mao, Ya Zhao, Li Lei, Yanxia Hu, Hangrui Zhu, Runzhi Wang, Dongsheng Ni, Jianing Liu, Lei Xu, Hua Xia, Zaikuan Zhang, Meng Ma, Zheng Pan, Qin Zhou, Yajun Xie
Summary: SELS is highly expressed in clear cell renal cell carcinoma (ccRCC) and associated with multiple pathological features. SELS overexpression promotes cell proliferation and inhibits apoptosis, while silence of SELS has the opposite effect. Mechanistically, SELS activates AKT/GSK3 beta/NF-kappa B signaling pathway to enhance cell proliferation and inhibit apoptosis, and stabilizes c-Myc by preventing ubiquitin-proteasome-mediated degradation. Furthermore, SELS inhibits ccRCC cell migration likely through repressing epithelial-mesenchymal transition (EMT).
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Biochemistry & Molecular Biology
Anil Kumar Rana, Rajneesh Kumar, Durgesh Nandan Shukla, Damanpreet Singh
Summary: This study investigates the efficacy of rutin and lithium co-treatment in improving post-stroke neurological outcomes in a transient global cerebral ischemia-reperfusion injury rat model. It is found that the co-administration of rutin and lithium improves overall survival, memory, and neurological score following cerebral ischemia-reperfusion, and has a neuroprotective potential through inhibiting oxidative stress and inflammatory response.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
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Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
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Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
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Cell Biology
Xuan Li, Wanlu Xie, Qiong Pan, Xiaoxun Zhang, Liangjun Zhang, Nan Zhao, Qiaoling Xie, Jingjing Ding, Jin Chai
Summary: This study found that both SEMA7A mutation and overexpression can activate the NF-κB p50/p65 pathway through integrin beta 1 and play a crucial role in inflammatory responses.
CELL COMMUNICATION AND SIGNALING
(2023)
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Agriculture, Multidisciplinary
Qi Zhang, Guowan Su, Qing Yang, Zhengpeng Wei, Jinmei Wang, Lin Zheng, Mouming Zhao
Summary: The study revealed that WCPFSRSF could ameliorate oxidative stress, promote the Nrf2-mediated defense system, and potentially reduce ROS generation by inhibiting NF kappa B. Additionally, WCPFSRSF showed potential as a radical scavenger and Nrf2 activator, with its antioxidant and anti-inflammatory effects possibly related to the presence of Cys and Trp. Furthermore, WCPFSRSF exhibited memory-improving effects in sleep-deprived mice, highlighting its potential as a candidate against neurotoxicity and memory deficits.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
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Environmental Sciences
Hao-Min Wu, Chen-Yu Chiang, Wen-Ying Chen, Chun-Jung Chen, Ching-Chi Tseng, Yu-Chi Chang, Wen-Min Cheng, Yu-Hsiang Kuan
Summary: Cyclizine exhibits sedation and treatment of nausea, vomiting, and motion sickness due to its antihistaminic and antimuscarinic effects. However, it has the potential for abuse due to its hallucinogenic and euphoric effects. Overdose and illegal abuse of Cyclizine can result in confusion, tremors, chest pain, ataxia, seizures, and even suicide.
ENVIRONMENTAL TOXICOLOGY
(2023)
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Immunology
Linjie He, Yinan Pan, Jiapei Yu, Ben Wang, Gaole Dai, Xiaozhou Ying
Summary: This study found that DE could inhibit inflammatory responses mediated by IL-1 beta by reducing the secretion of inflammatory factors and preventing extracellular matrix collapse. Molecular docking analysis indicated strong binding affinity of DE with PI3K inhibitory targets. In an animal model of OA, DE treatment improved articular cartilage destruction and reduced serum inflammatory factors, suggesting potential for osteoarthritis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
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Biochemistry & Molecular Biology
Duo Wang, Zheng Liu, Ziyan Yan, Xinxin Liang, Xiaochang Liu, Yuhao Liu, Ping Wang, Chenjun Bai, Yongqing Gu, Ping-Kun Zhou
Summary: This study demonstrated the critical role of miR-155-5p in radiation-induced EMT and RIPF, with its regulation through the GSK-3 beta/NF-kappa B pathway. The downregulation of miR-155-5p induced EMT and contributed to RIPF formation, while ectopic expression of miR-155-5p alleviated RIPF in mice. These findings provide further insights into the regulation of RIPF and potential therapeutic targets.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
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Cell Biology
Yan-Lin Chen, De-Yi Yan, Chen-Yu Wu, Jiang-Wei Xuan, Chen-Qiang Jin, Xin-Li Hu, Guo-Dong Bao, Yu-Jie Bian, Zhi-Chao Hu, Zhong-Hai Shen, Wen-Fei Ni
Summary: OA is characterized by destruction of articular cartilage and inflammation plays a key role in its progression. Maslinic acid (MA) from olive fruit has been shown to have anti-inflammatory effects. In in vitro and in vivo experiments, MA was found to attenuate inflammatory mediators and inhibit the progression of OA disease.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
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Biochemistry & Molecular Biology
Qiaohong Xu, Fang Cui, Xiaodong Li, Nan Wang, Yingrui Gao, Shiping Yin, Fangdi Hu
Summary: Dangshen, a medicinal and edible plant, has been found to have protective effects on gastric mucosa. It can improve chronic non-atrophic gastritis by enhancing antioxidant capacity, suppressing inflammatory responses, and reducing cell apoptosis. This study reveals the potential value of Dangshen in the treatment of gastric diseases.
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Biochemistry & Molecular Biology
Lei Xu, Yangfan Ye, Zeqiang Tao, Tian Wang, Yutian Wei, Wanzhi Cai, Xin Wan, Pengzhan Zhao, Wei Gu, Bin Gu, Liuchao Zhang, Yufei Tian, Ning Liu, Yiming Tu, Jing Ji
Summary: This study elucidated the role of MLPH in GBM radiation resistance, showing that MLPH promotes radiotherapy resistance by regulating the NF-kappa B pathway. Additionally, O-GlcNAcylation of MLPH protects it from degradation and stabilizes its presence in cells. These findings provide insights into a potential mechanism of GBM radiation resistance and suggest a therapeutic strategy for GBM treatment.
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Dermatology
Mohammad Shahidi Dadras, Azadeh Rakhshan, Sahar Dadkhahfar, Tara Barat
Summary: The study compared IL-17 positive cell counts in LPP and DLE patients, finding significantly higher levels in both groups compared to controls, with LPP having higher IL-17 levels. Using immunohistochemistry to detect IL-17 positive cells can effectively distinguish between LPP and DLE.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)