Chronic rapamycin treatment causes diabetes in male mice

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

(2013) Dudley W. Lamming et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

Duration of Rapamycin Treatment Has Differential Effects on Metabolism in Mice

(2013) Yimin Fang et al.   Cell Metabolism

Diabetic myopathy: impact of diabetes mellitus on skeletal muscle progenitor cells

(2013) Donna M. D'Souza et al.   Frontiers in Physiology

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

Rapamycin Paradox Resolved

(2012) K. J. Hughes et al.   SCIENCE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Selective estrogen receptor modulation in pancreatic β-cells and the prevention of type 2 diabetes

(2012) Joseph P. Tiano et al.   Islets

Loss of Estrogen Receptor a Signaling Leads to Insulin Resistance and Obesity in Young and Adult Female Mice

(2012) Camila Manrique et al.   CardioRenal Medicine

Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors

(2011) M. R. Meyer et al.   Acta Physiologica

Rapamycin-Induced Hypophosphatemia and Insulin Resistance Are Associated With mTORC2 Activation and Klotho Expression

(2011) T. Tataranni et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

(2011) N Deblon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Estrogen modulates abdominal adiposity and protects female mice from obesity and impaired glucose tolerance

(2011) Renee E. Stubbins et al.   EUROPEAN JOURNAL OF NUTRITION

Update: Hypogonadotropic Hypogonadism in Type 2 Diabetes and Obesity

(2011) Paresh Dandona et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes

(2011) Joseph P. Tiano et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin induces glucose intolerance in mice by reducing islet mass, insulin content, and insulin sensitivity

(2011) Shi-Bing Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Estrogen receptor alpha gene polymorphisms are associated with type 2 diabetes and fasting glucose in male subjects

(2011) Reza Meshkani et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

Effect of combined hormonal and insulin therapy on the steroid hormone receptors and growth factors signalling in diabetic mice prostate

(2010) Wagner J. Fávaro et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Androgen Excess Produces Systemic Oxidative Stress and Predisposes to β-Cell Failure in Female Mice

(2010) Suhuan Liu et al.   PLoS One

Effects of testosterone on Type 2 diabetes and components of the metabolic syndrome

(2010) T. Hugh JONES   Journal of Diabetes

Long-term Administration of Rapamycin Reduces Adiposity, but Impairs Glucose Tolerance in High-Fat Diet-fed KK/HlJ Mice

(2009) Geng-Ruei Chang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Estrogens Protect against High-Fat Diet-Induced Insulin Resistance and Glucose Intolerance in Mice

(2009) Elodie Riant et al.   ENDOCRINOLOGY

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

(2009) C. Chen et al.   Science Signaling

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Pancreatic β-cell mass in European subjects with type 2 diabetes

(2008) J. Rahier et al.   DIABETES OBESITY & METABOLISM

Estradiol Attenuates Neuroprotective Benefits of Isoflurane Preconditioning in Ischemic Mouse Brain

(2008) Lan Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sirolimus Is Associated with New-Onset Diabetes in Kidney Transplant Recipients

(2008) O. Johnston et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY