Article
Multidisciplinary Sciences
Lauren F. Sestito, Kim H. T. To, Matthew T. Cribb, Paul A. Archer, Susan N. Thomas, J. Brandon Dixon
Summary: Formulating S-(-)-Bay K8644 (BayK) within lymph-draining nanoparticles (NPs) can improve lymphatic vessel function and reduce side effects. In a mouse model of lymphedema, treatment with BayK formulated in lymph-draining NPs improves pumping pressure and tissue remodeling associated with the pathology.
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Engineering, Environmental
Aliya Tiemuer, Hui Yu, Chao Zhao, Wanlu Sun, Yuanyuan Zhang, Yiming Jiang, Yueqing Gu, Yi Liu
Summary: Gas therapy, particularly utilizing NO gas transmitter, has shown promise for effective cancer treatment. This study focused on addressing the drawbacks of current NO prodrugs, developing NIR light-triggered NO-releasing donors with superb spatiotemporal controllability for efficient NO delivery and real-time drug monitoring. The use of frequency upconversion luminescence (FUCL) readout for imaging provides high sensitivity and resolution, making it a potential breakthrough in deep-seated tumor therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Biomedical
Panpan Xiao, Mengke Liang, Shuo Yang, Ying Sun, Jia Li, Zhewei Gu, Ling'e Zhang, Quli Fan, Xiqun Jiang, Wei Wu
Summary: The integration of near-infrared fluorescence (NIRF) and photoacoustic (PA) imaging techniques can complement each other and provide more useful medical information. Ratiometric imaging activated by disease-associated biomarkers can further enhance imaging specificity. However, there have been very few studies to date that have employed NIRF/PA dual-modal ratiometric imaging to improve the accuracy and specificity of disease diagnosis.
Article
Nanoscience & Nanotechnology
Zuoyue Liu, Yuta Okada, Yuma Ichinose, Daisuke Saitoh, Naoya Ieda, Seiji Yamasaki, Kunihiko Nishino, Hidehiko Nakagawa, Mamoru Fujitsuka, Yasuko Osakada
Summary: The development of efficient antibacterial agents is crucial for public health. In this study, we investigated the bactericidal effect of simultaneous heat and nitric oxide (NO) generated by near-infrared (NIR) light using vanadyl naphthalocyanine-doped polymer dots (P-dots). P-dots co-doped with vanadyl naphthalocyanine and N-nitroso compounds released NO and generated heat upon NIR light irradiation, resulting in enhanced antibacterial activity against Staphylococcus epidermidis and Pseudomonas aeruginosa.
ACS APPLIED NANO MATERIALS
(2023)
Article
Hematology
Drishya Iyer, Diandra M. Mastrogiacomo, Kunyu Li, Richa Banerjee, Ying Yang, Joshua P. Scallan
Summary: The study demonstrates a novel, NO-independent role for eNOS in regulating lymphatic valve specification and proposes a mechanism by which eNOS directly binds beta-catenin to regulate its nuclear translocation and thereby transcriptional activity.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Flavia Neto de Jesus, Pierre-Yves von der Weid
Summary: In a mouse model of arthritis overexpressing TNF-alpha, the contractile activity of popliteal lymphatic vessels was altered, which may be related to the response of eNOS and iNOS.
Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Takuro Miyazaki, Akira Miyazaki
Summary: Under hypercholesterolemic conditions, lymphatic functions may be limited and contribute to atherosclerosis, but the causal relationship between hypercholesterolemia and lymphatic defects remains unclear.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Satomi Kagota, Kana Morikawa, Hirotake Ishida, Junko Chimoto, Kana Maruyama-Fumoto, Shizuo Yamada, Kazumasa Shinozuka
Summary: The study found that the direct vasodilatory effects of certain benzodiazepines and non-BDZ sedative-hypnotics can cause vasorelaxation to varying extents, potentially contributing to their adverse effects, and may partly explain the decreased blood pressure observed in individuals taking these medications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Surgery
Xiaojin Wang, Yi Hu, Xiangwen Wu, Mingzhu Liang, Zhenhua Hu, Xiangfeng Gan, Dan Li, Qingdong Cao, Hong Shan
Summary: This study demonstrates the feasibility of thoracic esophageal cancer regional lymph node mapping using ICG/NIRF imaging, showing different preferred lymph node drainage stations in various anatomical locations of the thoracic esophagus.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Biochemistry & Molecular Biology
Lenka Tomasova, Marian Grman, Anton Misak, Lucia Kurakova, Elena Ondriasova, Karol Ondrias
Summary: This study investigates the effects of H2S, GSNO, and SSNO-mix on arterial pulse waveform and hemodynamic parameters, proposing patterns of their actions. The findings suggest that H2S transiently influences all 35 hemodynamic parameters and has different effects compared to GSNO. SSNO-mix has a minor effect on blood pressure, indicating a decrease in hemodynamic effect of NO.
Article
Chemistry, Physical
Maurice Vennewald, Andree Iemhoff, Daniel Ditz, Regina Palkovits
Summary: This article investigates the catalytic properties of carbonaceous materials in the direct decomposition of nitrogen oxides. Contrary to previous findings, it is shown that graphitic carbon nitride does not act as a catalyst but instead reacts stoichiometrically with NO to produce isocyanic acid at temperatures above 450 degrees C.
CATALYSIS SCIENCE & TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jianwen Song, Xiaoying Kang, Lu Wang, Dan Ding, Deling Kong, Wen Li, Ji Qi
Summary: Researchers have developed a polymer nanoplatform for thrombus imaging and treatment in the near-infrared-II region, offering a versatile approach for the diagnosis and treatment of life-threatening diseases caused by thrombotic disorders.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Iris M. Lu, Michael J. Weiler, Nathan D. Frank, John Jordi, J. Brandon Dixon
LYMPHATIC RESEARCH AND BIOLOGY
(2020)
Article
Orthopedics
Jill M. Binkley, Michael J. Weiler, Nathan Frank, Lauren Bober, J. Brandon Dixon, Paul W. Stratford
Article
Engineering, Biomedical
Tyler S. Nelson, Zhanna Nepiyushchikh, Joshua S. T. Hooks, Mohammad S. Razavi, Tristan Lewis, Cristina C. Clement, Merrilee Thoresen, Matthew T. Cribb, Mindy K. Ross, Rudolph L. Gleason, Laura Santambrogio, John F. Peroni, J. Brandon Dixon
NATURE BIOMEDICAL ENGINEERING
(2020)
Article
Multidisciplinary Sciences
Mohammad S. Razavi, Julie Leonard-Duke, Becky Hardie, J. Brandon Dixon, Rudolph L. Gleason
SCIENTIFIC REPORTS
(2020)
Article
Medicine, Research & Experimental
Xinguo Jiang, Wen Tian, Eric J. Granucci, Allen B. Tu, Dongeon Kim, Petra Dahms, Shravani Pasupneti, Gongyong Peng, Yesl Kim, Amber H. Lim, F. Hernan Espinoza, Matthew Cribb, J. Brandon Dixon, Stanley G. Rockson, Gregg L. Semenza, Mark R. Nicolls
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Mohammad S. Razavi, J. Brandon Dixon, Rudolph L. Gleason
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2020)
Article
Biochemistry & Molecular Biology
Matthew T. Cribb, Lauren F. Sestito, Stanley G. Rockson, Mark R. Nicolls, Susan N. Thomas, J. Brandon Dixon
Summary: The study suggests that the loss of lymphatic function during lymphedema may be driven by immune-mediated mechanisms, and simply ameliorating this loss is not enough to reverse swelling. Addressing both lymphatic vessel dysfunction and immune cell expansion within dLNs may be necessary to prevent or reverse lymphedema when partial lymphatic function is sustained.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mechanics
Ki Tae Wolf, J. Brandon Dixon, Alexander Alexeev
Summary: The study found that valves significantly improve pumping efficiency in biomimetic lymphatic systems, especially when pumping against adverse pressure gradients and at low vessel contraction wave speeds. However, the presence of valves also increases viscous resistance, requiring greater work. Optimal valve elasticity can maximize pumping flow rate.
JOURNAL OF FLUID MECHANICS
(2021)
Article
Engineering, Biomedical
Alexandra Atalis, J. Brandon Dixon, Krishnendu Roy
Summary: This study compared how different types of adjuvants and delivery methods influence chemotaxis of dendritic cells, providing insights for the rational design of vaccine formulations.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Physical
Martin Scales, Joel Anderson, Jeffrey A. Kornuta, Nathan Switzner, Ramon Gonzalez, Peter Veloo
Summary: Federal rule changes have made non-destructive testing techniques an attractive alternative for verifying steel pipeline properties. Incorporating chemical composition data has been found to enhance the accuracy of instrumented indentation testing (IIT).
Article
Hematology
Eleftheria Michalaki, Josephine M. Rudd, Lauren Liebman, Rahul Wadhwani, Levi B. Wood, Nick J. Willett, J. Brandon Dixon
Summary: This study aims to combine the benefits of stem cell therapy and VEGFC administration to restore lymphatic drainage and improve lymphedema. The engineered MSCs overexpressing VEGFC were shown to significantly increase lymphatic contraction frequency and reduce swelling in a mouse lymphedema model.
Article
Cardiac & Cardiovascular Systems
Yanina Kuzminich, J. Brandon Dixon
Summary: Verteporfin and modified PDT were used to injure lymphatics in the mouse tail, and the remodeling response of lymphatic tissue to injury, as well as potential therapeutic interventions to normalize lymphatic permeability or contractile function after injury, were evaluated.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Engineering, Mechanical
M. Scales, J. A. Kornuta, N. Switzner, P. Veloo
Summary: The existing ASTM standards for extracting mechanical properties from uniaxial tension test data lack automation, making them unsuitable for high-volume applications. This paper presents an algorithm developed by the Pacific Gas and Electric Company (PG&E) for automatically extracting mechanical properties, such as power-law hardening exponent and strength coefficient, from tensile data. The algorithm incorporates a novel approach to calculate power-law parameters for low carbon pipeline steels, accounting for their yielding and hardening behaviors. The algorithm is found to be more accurate than other approaches and demonstrates greater hardening in pipeline steels compared to previously published results.
EXPERIMENTAL TECHNIQUES
(2023)
Editorial Material
Hematology
Sanjukta Chakraborty, Brandon J. Dixon, Joseph M. Rutkowski, Jorge A. Castorena-Gonzalez, Jerome W. Breslin
Article
Multidisciplinary Sciences
Lauren F. Sestito, Kim H. T. To, Matthew T. Cribb, Paul A. Archer, Susan N. Thomas, J. Brandon Dixon
Summary: Formulating S-(-)-Bay K8644 (BayK) within lymph-draining nanoparticles (NPs) can improve lymphatic vessel function and reduce side effects. In a mouse model of lymphedema, treatment with BayK formulated in lymph-draining NPs improves pumping pressure and tissue remodeling associated with the pathology.