Editorial Material
Biology
Zhe Yang, Tongtong Wang, Yuki Oka
Summary: The passage indicates that two neural circuits control the release of vasopressin in response to eating and drinking, even before there are any detectable changes in blood water levels.
Article
Biology
Angela Kim, Joseph C. Madara, Chen Wu, Mark L. Andermann, Bradford B. Lowell
Summary: This study reveals a division of labor in the neural circuits that regulate vasopressin neurons, with two distinct sets of neurons dedicated to relaying anticipatory information about water or food intake. These findings provide insight into the maintenance of healthy water levels in the body and the neural mechanisms underlying anticipatory forms of regulation.
Article
Pharmacology & Pharmacy
Hamid Reza Moheimani, Taghi Amiriani, Ali Mohammad Alizadeh, Yahya Jand, Delaram Shakiba, Parham Sayyah Ensan, Fatemeh Jafarzadeh, Maryam Rajaei, Ayesheh Enayati, Mona Pourabouk, Shahriar Aliazadeh, Amir Hoshang Pourkhani, Zohreh Mazaheri, Mohammad Ali Zeyghami, Ahmadreza Dehpour, Vahid Khori
Summary: The study found that ischemic preconditioning can reduce myocardial infarct size, apoptotic indices, arrhythmia, and incidence of ventricular fibrillation in cirrhotic cardiomyopathy rats. Metformin and Cyclosporin-A can exert cardioprotective effects by balancing pAMPK and apoptosis in mitochondria.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Zihang Yuan, Jie Wang, Haoran Zhang, Yingying Miao, Qianhui Tang, Ziqiao Yuan, Cheng Nong, Zhicheng Duan, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu
Summary: In this study, researchers investigated the effects of triptolide (TP), a compound found in Tripterygium wilfordii Hook.f, on cholestasis-induced liver injury. They found that TP reduced liver enzyme levels and necrosis in a mouse model of common bile duct ligation (BDL) cholestasis. TP also inhibited cholangiocyte proliferation and alleviated BDL-induced hepatic fibrosis and inflammation by reducing the expression of RelB.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Trinh Van Le, Hong-Thuy Phan-Thi, My-Xuan Huynh-Thi, Thanh Minh Dang, Ai Xuan Le Holterman, Gabriele Grassi, Thao-Uyen Nguyen-Luu, Nhung Hai Truong
Summary: Chloroquine (CQ) treatment has been shown to prevent hepatic stellate cell (HSC) activation and autophagy, leading to a reduction in liver fibrogenesis. In both in vitro and in vivo experiments, CQ inhibited HSC activation, improved liver function, and reduced liver injury.
Article
Biochemistry & Molecular Biology
Armagan Begum Ozel, Ozlem Tugce Cilingir-Kaya, Goksel Sener, Dilek Ozbeyli, Ali Sen, Ozlem Sacan, Refiye Yanardag, Aysen Yarat
Summary: Bitter melon, chard, and parsley extracts have been found to have neuroprotective effects against oxidative damage in the brain of rats with BDL-induced biliary cirrhosis. These plant extracts possess antioxidant properties and can be used as alternative treatments for brain damage caused by cirrhosis. Their safety and effectiveness make them potential neuroprotective agents in the treatment of liver cirrhosis-induced brain damage.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Behavioral Sciences
Sepideh Ganjalikhan-Hakemi, Majid Asadi-Shekaari, Fahimeh Pourjafari, Gholamreza Asadikaram, Masoumeh Nozari
Summary: This study investigated the effects of oral administration of agmatine on motor and cognitive deficits induced by bile duct ligation in an animal model of hepatic encephalopathy. The results showed that agmatine effectively reduced liver damage, balance deficits, and neuronal damage caused by the encephalopathy.
BRAIN AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Chang Ke, Jianlong Gao, Jiyuan Tu, Yan Wang, Yangxin Xiao, Yuan Wu, Yanju Liu, Zhongshi Zhou
Summary: This study aimed to investigate the protective effect of Ganfule capsule (GFL) on liver fibrosis and its possible mechanism. The cholestatic liver fibrosis model was prepared by bile duct ligation (BDL) in mice. The results showed that GFL could alleviate liver injury and fibrosis caused by BDL. Metabonomic analysis revealed metabolic disorder after surgery, which could be alleviated by GFL through regulation of glutamine metabolism and other pathways. GFL inhibited the activity of glutaminase 1 (GLS1) and the NF-kappa B pathway, leading to the alleviation of liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongquan Yu, Shuangshuang Xie, Kaiqi Wang, Fuzhi Zhang, Chao Jiang, Caixin Qiu, Jinxia Zhu, Wen Shen
Summary: This study demonstrates that ASL allows quantitative assessment of AKI induced by cholestatic cirrhosis in rats and serves as a noninvasive marker for the early and accurate diagnosis of AKI. The results show that RBF is closely correlated with HE score, HIF-1 alpha score, and PTC density, and can be used to distinguish AKI from non-AKI and mild from severe kidney injury in cirrhosis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Medicine, Research & Experimental
Zhi Ma, Xiaoyong Xue, Jinzhao Bai, Yajie Cai, Xuejing Jin, Kexin Jia, Mingning Ding, Xiangjun Lyu, Xiaojiaoyang Li
Summary: Si-Wu-Tang (SWT) has been found to improve liver fibrosis by modulating the immune microenvironment. It repairs the imbalanced immune microenvironment by regulating the biological functions of different immune cells, especially macrophages, neutrophils, and CD8+ T cells. SWT inhibits the release of profibrotic cytokines and promotes the apoptosis of activated hepatic stellate cells. This research provides insights into the mechanisms of SWT's hepatoprotective activities and offers a novel therapeutic strategy for liver fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Zhen-ning Lu, Wei-xiao Niu, Na Zhang, Mao-xu Ge, Yun-yang Bao, Yu Ren, Xiu-li Guo, Hong-wei He
Summary: This study found that pantoprazole (PPZ) could inhibit the expression of liver fibrosis-related genes, through affecting the expression and degradation of Yes-associated protein (YAP), thus preventing HSC activation and alleviating liver tissue pathological damage and fibrosis.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Danbi Jo, Hee Kyung Kim, Young-Kook Kim, Juhyun Song
Summary: Thyroid hormone plays an important role in liver metabolism, and its levels are disrupted in liver failure and hepatic encephalopathy. This study investigates the gene expression changes in the thyroid glands of a bile duct ligation mouse model and confirms the alteration in thyroid function-related genes. Increased levels of free T4 and TSH are also observed in the blood of the mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Vikram Nimbalkar, Neeraj Vyawahare
Summary: The study demonstrates that L-carnitine has a protective effect against liver fibrosis induced by bile duct ligation, reducing oxidative stress and inhibiting the release of cytokines. L-carnitine can normalize body and liver weight in rats, and decrease iNOS levels.
Article
Toxicology
Manar M. Esmail, Noha M. Saeed, Haidy E. Michel, Reem N. El-Naga
Summary: Niclosamide shows promising potential as an antifibrotic agent in CLF through inhibition of NOTCH and Wnt pathways, reducing liver enzymes levels, oxidative stress, inflammation, and fibrosis markers.
TOXICOLOGY LETTERS
(2021)
Article
Gastroenterology & Hepatology
Jia-Yi Liu, Zhu-Yuan Ding, Zi-Yi Zhou, Sheng-Zhen Dai, Jie Zhang, Hao Li, Qiu Du, Ye-Yu Cai, Quan-Liang Shang, Yong-Heng Luo, En-Hua Xiao
Summary: Bile duct ligation in mice is a classical method for studying cholestatic fibrosis. This study aimed to evaluate the correlation between pathological changes and multiparameter MRI characteristics of liver fibrosis in a BDL mouse model. Results show that MRI parameters correlate with hepatic fibrosis rate and can be used for detecting cholestatic fibrosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Endocrinology & Metabolism
Kirthikaa Balapattabi, Joel T. Little, George E. Farmer, J. Thomas Cunningham
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Article
Physiology
Brent Shell, George E. Farmer, T. Prashant Nedungadi, Lei A. Wang, Alexandria B. Marciante, Brina Snyder, Rebecca L. Cunningham, J. Thomas Cunningham
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2019)
Article
Physiology
Alissa A. Frame, Casey Y. Carmichael, Jill T. Kuwabara, J. Thomas Cunningham, Richard D. Wainford
EXPERIMENTAL PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Kirthikaa Balapattabi, George E. Farmer, Blayne A. Knapp, Joel T. Little, Martha Bachelor, Joseph P. Yuan, J. Thomas Cunningham
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Article
Multidisciplinary Sciences
George E. Farmer, Anna Amune, Martha E. Bachelor, Phong Duong, Joseph P. Yuan, J. Thomas Cunningham
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Kirthikaa Balapattabi, Joel T. Little, Martha Bachelor, J. Thomas Cunningham
NEUROENDOCRINOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Alexandria B. Marciante, Lei A. Wang, Joel T. Little, J. Thomas Cunningham
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Peripheral Vascular Disease
Casey Y. Carmichael, Jill T. Kuwabara, Crissey L. Pascale, Jesse D. Moreira, Sarah E. Mahne, Daniel R. Kapusta, Douglas L. Rosene, Jonathan S. Williams, J. Thomas Cunningham, Richard D. Wainford
Article
Endocrinology & Metabolism
Kirthikaa Balapattabi, Joel T. Little, Martha E. Bachelor, Rebecca L. Cunningham, J. Thomas Cunningham
Summary: This study found that unlike male bile duct-ligated (BDL) rats, female and ovariectomized (OVX) BDL rats did not develop hyponatremia, supraoptic vasopressin (AVP) neuron activation, or increased copeptin secretion compared to female controls. Adrenal estradiol may have compensated for the lack of ovarian estrogens in OVX BDL rats.
NEUROENDOCRINOLOGY
(2021)
Article
Neurosciences
Alexandria B. Marciante, George E. Farmer, J. Thomas Cunningham
JOURNAL OF NEUROPHYSIOLOGY
(2020)
Review
Geriatrics & Gerontology
Dianna H. Nguyen, J. Thomas Cunningham, Nathalie Sumien
Summary: Vascular cognitive impairment (VCI) and vascular dementia (VaD) represent an intersection between cardiovascular disease and neurodegenerative disorders, with potential implications for novel therapeutic approaches. While some studies have identified causes of disease development, particularly in terms of sex differences, many aspects remain unclear and require further exploration.
Review
Endocrinology & Metabolism
Ato O. Aikins, Dianna H. Nguyen, Obed Paundralingga, George E. Farmer, Caroline Gusson Shimoura, Courtney Brock, J. Thomas Cunningham
Summary: AVP and OXY are released by magnocellular neurosecretory cells projecting to the posterior pituitary. While traditionally not believed to contribute to basal cardiovascular function, recent studies suggest potential re-evaluation as evidence indicates their role in cardiovascular pathophysiology.
Article
Physiology
George E. Farmer, Joel T. Little, Alexandria B. Marciante, J. Thomas Cunningham
Summary: The study reveals that CIH can impair GABA(A)-mediated inhibition in the MnPO through the activity of AT1a receptors, contributing to sustained hypertension.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Dianna H. Nguyen, Victor Duque, Nicole Phillips, Andre Souza Mecawi, J. Thomas Cunningham
Summary: This study used spatial transcriptomics to analyze sex differences in gene expression in the hypothalamus of rats. The results revealed differences in gene expression related to cell signaling and ribosomal pathways between males and females.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Neurosciences
Alexandria B. Marciante, Lei A. Wang, George E. Farmer, J. Thomas Cunningham