Review
Sport Sciences
Raul Ricardo Festa, Matias Monsalves-alvarez, Jorge Cancino, Sebastian Jannas-Vela
Summary: Endurance training leads to adaptations that improve performance and health benefits. Monitoring oxygen uptake kinetics provides valuable information for prescribing aerobic exercise. In high-intensity aerobic exercise, short interval times may impact training outcomes. Research shows that at least 80% of the oxygen uptake amplitude is reached within 1 to 2 minutes after exercise begins. It is suggested that athletes engage in at least 1 minute of high-intensity interval training, while non-athletes should aim for 2 minutes.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Karin Vonbank, Daniel Haubenberger, Raphael Rosenhek, Matthias Schneider, Stefan Aschauer, Marco Idzko, Harald Gabriel
Summary: Endurance training significantly increased both peak oxygen uptake (peakVO(2)) and endurance capacity in patients with moderate-severe valvular heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Amane Hori, Ryuji Saito, Kenichi Suijo, Michael R. Kushnick, Daisuke Hasegawa, Koji Ishida, Norio Hotta
Summary: This study aimed to investigate whether blood flow restriction (BFR) during moderate-intensity aerobic training can accelerate the adaptation of the time constant (tau) of phase II oxygen uptake (<(V) over dot>O-2) kinetics in the moderate-intensity exercise domain. The results showed that tau significantly decreased in the BFR group at the mid-point of training, while the CON group showed a decrease at the end of training. The BFR group had significantly lower tau than the CON group at the mid-point, but there was no significant difference between the two groups at the end of training.
SCIENTIFIC REPORTS
(2022)
Article
Sport Sciences
Remzi Satiroglu, Sophie Lalande, Sungmo Hong, Mercedes J. Nagel, Edward F. Coyle
Summary: Training at near-maximal anaerobic power during cycling is effective in improving oxygen consumption, maximal anaerobic power, and total blood volume in young healthy individuals, indicating the potential for significant enhancements with minimal exercise time.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Medicine, General & Internal
Roberto Falz, Christian Bischoff, Rene Thieme, Uwe Tegtbur, Peter Hillemanns, Jens-Uwe Stolzenburg, Bahriye Aktas, Ulrich Bork, Juergen Weitz, Johannes Laessing, Christian Leps, Johannes Voss, Florian Lordick, Antina Schulze, Ines Gockel, Martin Busse
Summary: This randomized controlled trial examines the implementation and effects of home-based online training on cardiopulmonary variables and physical activity in post-surgical cancer patients. The study found that home-based online training can increase oxygen uptake and decrease myocardial workload among patients. This study is important for the implementation of widespread home-based training and online training in cancer care, as well as for studying long-term effects.
Article
Nutrition & Dietetics
Frederic N. Daussin, Francois Peronnet, Antoine Charton, Evelyne Lonsdorfer, Stephane Doutreleau, Bernard Geny, Ruddy Richard
Summary: The study found that water enriched with O-2 does not enhance cardiopulmonary response to exercise, improve exercise performance, or trigger oxidative stress at rest.
Article
Physiology
T. W. Jones, L. Eddens, J. Kupusarevic, D. C. M. Simoes, M. J. W. Furber, K. A. Van Someren, G. Howatson
Summary: This study investigates the effects of endurance stimuli intensity on the adaptation in strength and endurance following concurrent training, as well as the impact of training status on the acute molecular response to concurrent exercise. The results indicate that the intensity of endurance activity does not affect performance outcomes after concurrent training, and training status has no effect on the molecular responses assessed.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Sport Sciences
Rachel Tan, Matthew Black, Joseph Home, Jamie Blackwell, Ida Clark, Lee Wylie, Anni Vanhatalo, Andrew M. M. Jones
Summary: The purpose of this study was to investigate the effects of concurrent and independent administration of dietary nitrate and N-acetylcysteine on physiological responses during prolonged exercise and subsequent high-intensity exercise tolerance. The results showed that plasma levels of nitrate and nitrite were significantly increased in the group that ingested beetroot juice and N-acetylcysteine, and plasma cysteine levels were increased in the group that ingested N-acetylcysteine. Muscle excitability during prolonged cycling was better preserved in the group that ingested N-acetylcysteine compared to the other groups. However, there was no effect of supplementation on subsequent exercise tolerance.
JOURNAL OF SPORTS SCIENCES
(2022)
Article
Physiology
Christopher B. Cooper, Alan Garfinkel
Summary: The kinetic response of oxygen uptake to transitions of exercise intensity is an important parameter of aerobic function. A novel geometric method is developed to determine the time constant of oxygen uptake using slopes and intercepts of a plot of cumulative oxygen uptake versus time, without requiring multiple repetitions of the exercise protocol.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Sport Sciences
Daiane Wommer, Tiago Turnes, KristopherMendes Souza, Luiz Guilherme Antonacci Guglielmo
Summary: The study found that work-matched interval training induced similar time near V. (O) 2max and associated physiological responses regardless of work rate manipulation.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2022)
Article
Physiology
Andrea Nicolo, Michele Girardi, Ilenia Bazzucchi, Massimo Sacchetti, Francesco Felici
Summary: Evidence suggests that respiratory frequency (fR) is sensitive to changes in exercise tolerance. This study compared arm+leg cycling (Arm+leg) and leg cycling (Leg) to further investigate this notion and found that Arm+leg had a greater exercise tolerance compared to Leg. Results also showed that minute ventilation, fR, and perceived exertion were sensitive indicators of exercise tolerance.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Sport Sciences
Samuel T. Tebeck, Jonathan D. Buckley, Jamie Stanley
Summary: This study evaluated the relationship between changes in training load, haematological responses, and endurance exercise performance during temperate and heat acclimation training. The results showed that the increase in chronic training load was associated with improvements in haemoglobin mass, plasma volume, and blood volume. Heat acclimation increased plasma volume and maintained haemoglobin mass without increasing training load. It is suggested that maintaining high chronic training load and haemoglobin mass could be beneficial for improving endurance exercise performance.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Halvard Grendstad, Jostein Hallen
Summary: This study aimed to investigate the effect of high-intensity training (HIT) on maximal oxygen uptake (VO2max) in youth athletes, compared to low-intensity strength and coordination training. The results showed that neither HIT nor low-intensity training had a significant effect on improving VO2max in youth athletes over an 8-week training period.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Physiology
Julie Chambault, Gregorine Grand, Bengt Kayser
Summary: The study showed that respiratory muscle endurance training has a greater effect on improving cycling performance in women compared to men, especially in hypoxic conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Alessio del Torto, Carlo Capelli, Roberto Peressutti, Adriana di Silvestre, Ugolino Livi, Chiara Nalli, Sandro Sponga, Gianpaolo Amici, Umberto Baccarani, Stefano Lazzer
Summary: Endurance training, especially single leg cycling, can significantly improve maximal oxygen consumption in heart, kidney, and liver transplant recipients by enhancing peripheral oxygen extraction and utilization. Single leg cycling training is as effective as double leg cycling training in improving cardiorespiratory fitness in these patients. Peripheral factors play a significant role in limiting maximal oxygen consumption in transplant recipients.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Malgorzata Borczyk, Marcin Piechota, Jan Rodriguez Parkitna, Michal Korostynski
Summary: This article discusses the variability of antidepressant effectiveness in treating major depressive disorder among patients, with genetic factors playing a significant role in individual responses. The integration of genomics and pharmacology can provide guidance for personalized treatment of depression.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Katarzyna Gaweda-Walerych, Emilia J. Sitek, Malgorzata Borczyk, Ewa Narozanska, Bogna Brockhuis, Michal Korostynski, Michal Schinwelski, Mariusz Sieminski, Jaroslaw Slawek, Cezary Zekanowski
Summary: Our study aimed to analyze the phenotypic-genetic correlations in a patient diagnosed with early onset corticobasal syndrome with progressive non-fluent aphasia (CBS-PNFA). Whole-exome sequencing identified rare single heterozygous variants in ATP7B, SORL1, SETX, and FOXP1 genes. Functional analysis revealed changes in splicing pattern and lower mRNA levels in the patient's fibroblasts, indicating loss-of-function as the underlying mechanism. The study also highlighted the association of CBS-PNFA phenotype with the ATP7B pathogenic variant p.H1069Q, previously linked to Wilson's disease and early onset Parkinson's disease. Furthermore, it expanded the clinical spectrum related to well-known disease genes and suggested the hypothesis of oligogenic inheritance. The study emphasized the possible relevance of the FOXP1 gene to adult-onset progressive apraxia of speech, which requires further investigation.
Article
Geriatrics & Gerontology
Marcin Grandys, Joanna Majerczak, Marzena Frolow, Krystyna Sztefko, Stefan Chlopicki, Jerzy A. Zoladz
Summary: This study aimed to evaluate the effects of age-dependent alterations in serum dihydrotestosterone and its circulating metabolite on endothelial function and arterial stiffness. The results showed that older men had significantly lower levels of dihydrotestosterone and higher values of cIMT, AI, crPWV, and SI, indicating impaired arterial wall characteristics and worsened endothelial function. The concentration of dihydrotestosterone was negatively correlated with arterial wall parameters, markers of inflammation, and positively correlated with markers of endothelial function.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Neurosciences
Jakub P. P. Fichna, Malgorzata Borczyk, Marcin Piechota, Michal Korostynski, Cezary Zekanowski, Piotr Janik
Summary: In this study, whole-genome sequencing was performed to identify rare variants associated with Tourette syndrome in families with affected members. Several genes involved in oxidoreductase activity in the brain and sensory processing of sound were identified. Enrichment analysis also revealed the involvement of cell-cell adhesion, synaptic transmission, and oxidative stress response in the pathology of Tourette syndrome.
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Marcin Grandys, Joanna Majerczak, Marzena Frolow, Stefan Chlopicki, Jerzy A. Zoladz
Summary: Professional athletes exposed to high training loads may experience overfatigue, overreaching and overtraining with detrimental effects on vascular health. This study found that female track and field athletes had impaired endothelial function and imbalances in hormone levels after intensive training. The study suggests that regular monitoring of endothelial status is important to minimize vascular health risks in athletes.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Nancy Alnassar, Malgorzata Borczyk, Georgia Tsagkogeorga, Michal Korostynski, Namshik Han, Dariusz C. Gorecki
Summary: Mutations in the DMD gene cause Duchenne muscular dystrophy (DMD), but recent research shows that reduced DMD expression is also associated with various malignancies. The downregulation of DMD in tumors is correlated with reduced patient survival and tumor stage. These findings challenge the current understanding of dystrophin expression and suggest a broader significance of the DMD gene beyond DMD.
Article
Plant Sciences
Hanna Fuchs, Arleta Malecka, Adrianna Budzinska, Wieslawa Jarmuszkiewicz, Liliana Ciszewska, Aleksandra M. Staszak, Joanna Kijowska-Oberc, Ewelina Ratajczak
Summary: We present a novel method to measure the oxygen consumption rate in isolated mitochondria of plant seeds. The optimized protocol allows for gradual decrease in respiratory function and provides information on the activity and condition of plant mitochondria.
Review
Cell Biology
Hanna Galganska, Wieslawa Jarmuszkiewicz, Lukasz Galganski
Summary: Inflammation becomes a threat when it exceeds the immune system's control, and it is a cause and/or symptom of many diseases. Advanced age and comorbidities lead to more severe cases of viral infections, such as COVID-19. Mitogen-activated protein kinases (MAPKs) play a crucial role in COVID-19, affecting the infection mechanisms, cytokine storm, disease pathogenesis, and post-COVID-19 complications. Carbon dioxide (CO2) regulates MAPKs and may have therapeutic benefits for COVID-19 and related comorbidities.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Nina Antos-Krzeminska, Anna Kicinska, Witold Nowak, Wieslawa Jarmuszkiewicz
Summary: This study provides functional evidence that the Acucp gene in the free-living protozoan amoeba, A. castellanii, encodes a mitochondrial protein with UCP-like activity and investigates its role during oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marcin Piechota, Dzesika Hoinkis, Michal Korostynski, Slawomir Golda, Joanna Pera, Tomasz Dziedzic
Summary: Gene expression profiling in blood cells stimulated with lipopolysaccharide may be useful for predicting post-stroke depressive symptoms in patients without a history of depression. A model containing 6 genes (PKM, PRRC2C, NUP188, CHMP3, H2AC8, NOP10) showed good discriminatory properties for identifying post-stroke depressive symptoms.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Adrianna Budzinska, Lukasz Galganski, Wieslawa Jarmuszkiewicz
Summary: Nitrogen-containing bisphosphonates (NBPs), commonly used in the treatment of bone disorders, have been found to cause endothelial dysfunction, oxidative stress, and mitochondrial impairment in cultured human endothelial cells. These drugs reduce cell viability, induce inflammation, and disrupt the cellular energy state and mitochondrial respiratory function.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Elzbieta Szczygiel-Pilut, Daniel Pilut, Michal Korostynski, Piotr Kopinski, Daniel P. Potaczek, Ewa Wypasek
Summary: This article describes a case of CCM in a Polish female with a single-nucleotide variant in the PDCD10 gene, which is the first genetically characterized case of FCCM in Poland.
Review
Biochemistry & Molecular Biology
Wieslawa Jarmuszkiewicz, Karolina Dominiak, Adrianna Budzinska, Krzysztof Wojcicki, Lukasz Galganski
Summary: Mitochondrial coenzyme Q (mtQ) is a redox active carrier involved in electron transfer and mitochondrial reactive oxygen species (mtROS) formation. The redox state of the mtQ pool reflects mitochondrial bioenergetic activity and oxidative stress. This study provides an overview of the factors affecting mtQ redox homeostasis and its relationship to mtROS production. The level of mtQ reduction may be a useful marker for assessing mtROS formation, which is influenced by the size of the mtQ pool and the activity of respiratory chain pathways.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Cell & Tissue Engineering
Jakub Chwastek, Marta Kedziora, Malgorzata Borczyk, Michal Korostynski, Katarzyna Starowicz
Summary: The development of in vitro models is crucial for experiments using human material and reducing the need for laboratory animals. This study differentiated neuroepithelial stem cells into peripheral-like neurons and confirmed their phenotype at the genetic and protein levels. Pro-inflammatory factors were used to stimulate human fibroblast-like synoviocytes and measure the expression of genes involved in the immune response. The stimulated synoviocytes were then combined with the peripheral-like neurons, resulting in increased cell activity.
INTERNATIONAL JOURNAL OF STEM CELLS
(2023)
Article
Oncology
Kinga Kwiecinska, Wojciech Strojny, Miroslaw Bik-Multanowski, Michal Korostynski, Marcin Piechota, Walentyna Balwierz, Szymon Skoczen
Summary: This study investigated the gene expression in children with high risk or relapsed ALL referred for HSCT. The results showed deep immunosuppression in these patients, which may enhance the probability of successful transplantation.
