Article
Physiology
Daniela Ostrowski, Cheryl M. Heesch, David D. Kline, Eileen M. Hasser
Summary: Exposure to acute intermittent hypoxia induces prolonged increases in phrenic and sympathetic nerve activity, and enhanced respiratory and sympathetic responses to hypoxia.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher D. Czaplicki, Nan Zhang, M. Grace Knuttinen, Sailendra G. Naidu, Indravadan J. Patel, J. Scott Kriegshauser
Summary: This article describes the use of ultrasound-guided phrenic nerve block (PNB) before lung nodule biopsy, demonstrating its safety and effectiveness in improving biopsy outcomes.
ACADEMIC RADIOLOGY
(2022)
Article
Neurosciences
Ana Luiza C. Sayegh, Jui-Lin Fan, Lauro C. Vianna, Mathew Dawes, Julian F. R. Paton, James P. Fisher
Summary: This study compared the cardiorespiratory and sympathetic neurocirculatory responses to chemoreflex activation between healthy men and women. The results showed that young women displayed augmented sympathetic responses and attenuated respiratory responses during central chemoreflex activation.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Physiology
Mridula Pachen, Yonis Abukar, Julia Shanks, Nigel Lever, Rohit Ramchandra
Summary: The results of the experiment indicate that in an ovine model of heart failure, carotid body-mediated increases in coronary blood flow (CoBF) and vascular conductance (CVC) are more pronounced compared to control animals. This increase in CoBF is mediated by an increase in cardiac sympathetic nerve activity in the control group, but not in the heart failure group.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Christian A. Reynolds, Zeljka Minic
Summary: Chronic pain is linked to the development of cardiovascular disease through activation of the sympathetic nervous system. This review provides evidence for the direct relationship between sympathetic nervous system dysfunction and chronic pain. Maladaptive changes in the neural network regulating sympathetic nervous system and pain perception contribute to sympathetic overactivation and cardiovascular disease in chronic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Glen E. Foster, Brooke M. Shafer, Conan Shing
Summary: MSNA measurement is crucial for understanding sympathetic nerve activity in humans, and the process of identifying and quantifying sympathetic bursts is often laborious and variable across research labs. A newly developed open-source web application has shown good agreement with manual scoring methods for key MSNA metrics, providing an efficient and standardized approach for data analysis in research studies. This tool has the potential to improve reproducibility and streamline the analysis of MSNA in future studies.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Chemistry, Analytical
Yantao Xing, Yike Zhang, Zhijun Xiao, Chenxi Yang, Jiayi Li, Chang Cui, Jing Wang, Hongwu Chen, Jianqing Li, Chengyu Liu
Summary: This study proposed a method using TKE operator to preprocess SKNA signal, improved the detection accuracy for SKNA bursts with SKNAER feature, and showed significant differences in SNA evaluation compared to traditional methods.
Article
Cell Biology
Monika Jampolska, Kryspin Andrzejewski, Malgorzata Zaremba, Ilona Joniec-Maciejak, Katarzyna Kaczynska
Summary: In this study, the researchers investigated the hypoglossal and phrenic motoneuron dysfunction in a rat model induced by reserpine administration to understand the pathogenesis of respiratory disorders in Parkinson's disease. They found that the depletion of dopamine, noradrenaline, and serotonin in the brainstem may have an impact on pre-inspiratory activity of the hypoglossal motoneuron, potentially leading to obstructive sleep apnea in PD patients. The shortening of pre-inspiratory activity in the reserpine model suggests a problem in maintaining the correct diameter of upper airways during the preparation phase for inspiration. Therapies involving supplementation of amine depletion other than dopamine should be considered for PD patients.
Article
Physiology
Shizuka Ikegame, Misa Yoshimoto, Kenju Miki
Summary: This study investigated the functional relationships between central amygdala neuronal activity (CeANA) and sympathetic nerve activity (SNA) in freely moving rats. The results showed that CeANA was related to RSNA, LSNA and HR in a behavioral state-dependent and regionally different manner. This suggests that the amygdala may play a role in generating regional differences in sympathetic nerve activity.
EXPERIMENTAL PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Natasha G. Boyes, Darcy D. Marciniuk, Haissam Haddad, Corey R. Tomczak
Summary: Heart failure patients with reduced ejection fraction often experience exercise intolerance due to multi-organ dysfunction and abnormal autonomic nervous system regulation. Increased sympathetic activity, associated with elevated morbidity and mortality, is observed in these patients. Exercise training can help alleviate or reverse these counterproductive changes.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Neurosciences
Omar Ashraf, Trong Huynh, Benton S. Purnell, Madhuvika Murugan, Denise E. Fedele, Vineet Chitravanshi, Detlev Boison
Summary: SUDEP, a leading cause of death in patients with refractory epilepsy, is believed to be caused by centrally-mediated respiratory dysfunction. Research shows that seizures can trigger a surge in adenosine release, which suppresses breathing. Suppressing phrenic nerve activity may serve as a predictive biomarker for imminent SUDEP, allowing for timely intervention to potentially prevent SUDEP.
Article
Engineering, Biomedical
Yantao Xing, Yike Zhang, Chenxi Yang, Jianqing Li, Yuwen Li, Chang Cui, Jiayi Li, Hongyi Cheng, Yin Fang, Cheng Cai, Minglong Chen, Chengyu Liu
Summary: The proposed portable monitoring system based on skin sympathetic nerve activity (SKNA) allows simultaneous recording of SKNA and electrocardiogram (ECG). By modifying the analog front end (AFE) chip and using filtering and clipping techniques, the system achieves low noise levels and effectively rejects artifacts. Both laboratory and clinical experiments demonstrate the system's good performance and feasibility for autonomic nervous system assessment.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Neurosciences
Sunil Pradhan, Sucharita Anand
Summary: This study reports a new patient friendly technique for phrenic nerve conduction, using alternative sites of stimulation and recording. The results showed better consistency, morphology, higher amplitude, and lower amount of current strength compared to previous methods.
Article
Multidisciplinary Sciences
Yuecheng Yang, Yunkui Zhang, ShengLing Dai, Lu Wang, Jun Zhang
Summary: This observational study investigated the influence of surgical procedures on shoulder pain in patients undergoing hepatectomy. The study found that the incidence of shoulder pain was high 2 days after surgery and was associated with drainage volume. Different surgical sites were also identified as independent risk factors for shoulder pain.
SCIENTIFIC REPORTS
(2023)
Article
Physiology
Zhipeng Cai, Hongyi Cheng, Yantao Xing, Feifei Chen, Yike Zhang, Chang Cui
Summary: The proposed autonomic nervous activity analysis method based on VG and SKNA offers a new insight into ANS assessment in UST segments and ANS-Load quantification.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Milene R. Malheiros-Lima, Talita M. Silva, Ana C. Takakura, Thiago S. Moreira
Summary: The study found that blocking excitatory amino acids in the A5 region can reduce the increase in sympathetic and respiratory activities caused by selective stimulation of C1 neurons. This indicates that the C1-A5 pathway may be important for sympathetic-respiratory control.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Physiology
Luara A. Batista, Lais M. Cabral, Thiago S. Moreira, Ana C. Takakura
Summary: The study found that inhibition of anandamide hydrolysis does not reverse respiratory deficits in an animal model of Parkinson's disease, leading to increased variability in respiratory frequency and impaired response to hypercapnia.
EXPERIMENTAL PHYSIOLOGY
(2022)
Review
Neurosciences
Yasmin C. Aquino, Lais M. Cabral, Nicole C. Miranda, Monique C. Naccarato, Barbara Falquetto, Thiago S. Moreira, Ana C. Takakura
Summary: Parkinson's disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons. It mainly affects individuals over the age of 60 and leads to both classic and nonclassical symptoms. Respiratory changes associated with PD are the main cause of mortality in patients. However, there is limited research and knowledge about these respiratory disorders, making treatment challenging.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Editorial Material
Physiology
Thiago S. Moreira, Ana C. Takakura, Eduardo Colombari
FRONTIERS IN PHYSIOLOGY
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Thiago S. Moreira, Yingtang Shi, Cleyton R. Sobrinho, Brenda M. Milla, Jaseph Sota-Perez, Daniel S. Stornetta, Ruth L. Stornetta, Ana C. Takakura, Daniel K. Mulkey, Douglas A. Bayliss
Item Withdrawal
Biochemistry & Molecular Biology
T. De Melo e Silva, C. B. Ferreira, P. E. Silva, F. C. Sousa, C. J. Czeisler, J. J. Otero, A. C. Takakura, T. S. Moreira
Meeting Abstract
Biochemistry & Molecular Biology
Lais Maria C. Cabral, Luiz M. Oliveira, Thiago dos Santos Moreira, Ana C. Takakura
Article
Neurosciences
Yingtang Shi, Cleyton R. Sobrinho, Jaseph Soto-Perez, Brenda M. Milla, Daniel S. Stornetta, Ruth L. Stornetta, Ana C. Takakura, Daniel K. Mulkey, Thiago S. Moreira, Douglas A. Bayliss
Summary: Research suggests that the role of 5-HT7 receptors in RTN neurons in response to CO2 stimulation is minimal, and these receptors are not essential for respiratory activity. 5-HT7 receptors are mainly expressed in a small subset of RTN neurons, and have no impact on CO2-stimulated breathing.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Medicine, General & Internal
Camilo Toledo, Esteban Diaz-Jara, Hugo S. Diaz, Karla G. Schwarz, Katherin Pereyra, Alexandra Las Heras, Angelica Rios-Gallardo, David C. Andrade, Thiago Moreira, Ana Takakura, Noah J. Marcus, Rodrigo Del Rio
Summary: This study found that RTN astrocytes play a pivotal role in the generation and maintenance of breathing disorders (BD) in chronic heart failure (CHF) patients through the mechanism of P2X7 receptor (P2X7r) signaling. The activity and ATP bioavailability of RTN astrocytes were reduced in CHF patients, and restoring normal astrocyte activity and ATP levels improved breathing regularity in CHF. Additionally, delivering human P2X7 receptor into astrocytes increased ATP bioavailability and abolished BD in CHF.
Article
Physiology
Camilo Toledo, David C. Andrade, Esteban Diaz-Jara, Domiziana Ortolani, Ignacio Bernal-Santander, Karla G. Schwarz, Fernando C. Ortiz, Noah J. Marcus, Luiz M. Oliveira, Ana C. Takakura, Thiago S. Moreira, Rodrigo Del Rio
Summary: Intermittent activation of RVLM-C1 neurons induces long-term autonomic and breathing dysfunction, suggesting that episodic stimulation of RVLM-C1 may serve as a pathological substrate for the development of cardiorespiratory disorders.
Article
Neurosciences
Nicole C. Miranda, Luiz M. Oliveira, Yasmin C. Aquino, Thiago S. Moreira, Ana C. Takakura
Summary: This study investigated the effects of degenerated Pedunculopontine Tegmental Nucleus (PPTg) neurons on respiratory activity in a Parkinson's disease (PD) model. The results showed that PPTg neurons in PD model were less activated by hypercapnia, suggesting the involvement of PPTg in the ventilatory response to high carbon dioxide.
Article
Biology
Caroline B. Ferreira, Talita M. Silva, Phelipe E. Silva, Claudio L. Castro, Catherine Czeisler, Jose J. Otero, Ana C. Takakura, Thiago S. Moreira
Summary: Mutations in the Phox2b gene, specifically the non-polyalanine repeat expansion mutations (NPARM) form, were found to affect respiratory control and the number of certain neurons. This study contributes to our understanding of the neuropathology of congenital central hypoventilation syndrome (CCHS) and provides new evidence for the mechanisms underlying NPARM CCHS.