Article
Neurosciences
Joseph C. Watso, Mu Huang, Gilbert Moralez, Matthew N. Cramer, Joseph M. Hendrix, Frank A. Cimino, Luke N. Belval, Carmen Hinojosa-Laborde, Craig G. Crandall
Summary: The study found that low dose ketamine administration can reduce pain perception and some cardiovascular responses, but does not affect muscle sympathetic nerve activity burst frequency. This suggests that low dose ketamine is effective in pain management.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Physiology
Ahmed A. Rahman, Vanesa Stojanovska, Paul Pilowsky, Kulmira Nurgali
Summary: Chronic oxaliplatin treatment leads to increased MAP, sSNA, and PNf, and decreased HR and PNamp. Acute oxaliplatin has no effects on these parameters. Platinum accumulation in the brain may be responsible for the altered cardiovascular and respiratory functions as well as reflexes induced by oxaliplatin.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jeremy A. Bigalke, John J. Durocher, Ian M. Greenlund, Manda Keller-Ross, Jason R. Carter
Summary: Chronic anxiety is prevalent and associated with an increased risk of cardiovascular disease. This study reveals an independent relationship between trait anxiety, resting blood pressure, and muscle sympathetic nerve activity (MSNA) in healthy adults without cardiometabolic disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Massimo Nardone, Carlin Katerberg, Anthony V. Incognito, Andr E. L. Teixeira, Lauro C. Vianna, Philip J. Millar
Summary: The signal-averaged sympathetic transduction of blood pressure is inversely related to resting muscle sympathetic nerve activity burst frequency in healthy cohorts. The methodological limitations in the analysis of MSNA transduction at different levels of absolute blood pressure are still unclear. Further research is needed to understand the timing relationship between MSNA bursts and blood pressure fluctuations.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Katarina Babarikova, Pavel Svitok, Libor Kopkan, Michal Zeman, Lubos Molcan
Summary: This study analyzed the impact of cross-fostering on cardiovascular parameters in hypertensive TGR and normotensive HanSD offspring, and found that cross-fostering can reduce sympathovagal balance in hypertensive TGR offspring and transiently decrease plasma Ang II levels and MR expression.
Article
Peripheral Vascular Disease
Seth W. Holwerda, Megan E. Gangwish, Rachel E. Luehrs, Virginia R. Nuckols, John P. Thyfault, John M. Miles, Gary L. Pierce
Summary: This study aimed to investigate the relationship between abdominal obesity and sympathetic nerve activity and blood pressure. The results showed that the transduction of sympathetic nerve activity to blood pressure was augmented in individuals with abdominal obesity and positively correlated with higher resting blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Physiology
Andre L. Teixeira, Jordan B. B. Lee, Massimo Nardone, Jamie F. F. Burr, Philip J. J. Millar
Summary: The sympathetic nervous system plays a crucial role in cardiovascular regulation, particularly in response to acute stress. The relationship between renal and leg vasoconstriction at rest or during sympathetic stressors is not yet known. This study aimed to investigate the relationships between muscle sympathetic nerve activity (MSNA), leg vascular conductance (LVC), and renal vascular conductance (RVC) in young healthy adults, both at rest and during laboratory-based stressors. The findings revealed differential control of regional sympathetic vasoconstriction at rest and during stress in young healthy humans.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Luke. S. Dunaway, Marie Billaud, Edgar Macal, Miranda. E. Good, Christopher. B. Medina, Ulrike Lorenz, Kodi Ravichandran, Michael Koval, Brant. E. Isakson
Summary: This study suggests that Panx1 in smooth muscle cells plays a role in regulating sympathetic nerve constriction and blood pressure. The findings also demonstrate the feasibility of using Panx1-mouse models to test potential drugs for hypertension.
Review
Biochemistry & Molecular Biology
Lu Qin, Jian Cui, Jianhua Li
Summary: This review discusses the impact of sympathetic nerve activity on blood pressure in patients with peripheral artery disease and the related neural mechanisms, and proposes intervention strategies to improve the deleterious effects of exercise-induced blood pressure changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Michael F. La Fountaine, Asante N. Hohn, Caroline L. Leahy, Anthony J. Testa, Joseph P. Weir
Summary: This study found that after 48 hours of concussion, patients had significantly lower Mayer wave activity compared to controls, which returned to normal levels by 1 week post-injury. Additionally, early after concussion, attenuated sympathetic vasomotor tone was present as the main manifestation of autonomic dysfunction.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Mazher Mohammed, Blessing Ogunlade, Mona Elgazzaz, Clara Berdasco, Navya Lakkappa, Ioana Ghita, Jessie J. Guidry, Srinivas Sriramula, Jiaxi Xu, Luke Restivo, Michelle A. Mendiola Pla, Dawn E. Bowles, Andreas M. Beyer, Xinping Yue, Eric Lazartigues, Catalin M. Filipeanu
Summary: This study aimed to identify E3 ubiquitin ligases associated with ACE2 ubiquitination in neurogenic hypertension and establish their clinical relevance. By combining bioinformatics and proteomics, the researchers were able to identify Nedd4-2 as the first E3 ubiquitin ligase involved in ACE2 ubiquitination in Ang-II-mediated hypertension. They also demonstrated the important role of ACE2 in GABAergic neurons in maintaining inhibitory tone and regulating pre-sympathetic activity. These findings provide a new understanding of the development of neurogenic hypertension and potential therapeutic strategies. Rating: 9/10.
CARDIOVASCULAR RESEARCH
(2023)
Article
Neurosciences
Lyndsey N. Matus, Olivia D. Flessland, Patrick J. Mueller
Summary: The RVLM may contribute to sex-based differences in CVD, with female rats showing greater sympathetic activity and lower resting blood pressure following activation. Sedentary conditions promote higher sympathetic output regardless of age and sex, while the interaction between female reproductive cycle and sedentary conditions plays a complex role in CVD incidences.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyue Wei, Ruijie Li, Xiangyu Li, Boyan Wang, Jianyang Huang, Hanyiqi Mu, Qinmu Zhang, Ziyuan Zhang, Yifei Ru, Xinxiang Wu, Yuan Qiu, Yanchen Ye, Yuanyuan Feng, Shiyu Wang, Hui Chen, Chenju Yi, Jiancheng Wang
Summary: Perimenopause is a natural transition to menopause that can cause hormone disturbances leading to mental disorders and neuroinflammation. This study aims to find effective treatments to prevent these neurological consequences.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zoe H. Adams, Hazel C. Blythe, Nisha Charkoudian, Timothy B. Curry, Michael J. Joyner, Adrian H. Kendrick, Angus K. Nightingale, Ana P. Abdala Sheikh, Emma C. Hart
Summary: Respiratory modulation of sympathetic nerve activity is reduced in postmenopausal females, which is associated with higher resting blood pressure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew W. D'Souza, Sarah L. Hissen, Kazumasa Manabe, Ryosuke Takeda, Takuro Washio, Geoff B. Coombs, Belinda Sanchez, Qi Fu, J. Kevin Shoemaker
Summary: Sympathetic vascular transduction is attenuated in older adults compared to young adults, and there is an inverse relationship between the central and peripheral arcs of the baroreflex. Age and sex have independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Nicholas A. Mischel, Madhan Subramanian, Maryetta D. Dombrowski, Ida J. Llewellyn-Smith, Patrick J. Mueller
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2015)
Letter
Pharmacology & Pharmacy
Nicholas Mischel, Christian Bjerre-Real, Jonathan Komisar, Brian Ginsberg, Steven T. Szabo, Xavier Preud'Homme
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Nicholas A. Mischel, Ida J. Llewellyn-Smith, Patrick J. Mueller
JOURNAL OF COMPARATIVE NEUROLOGY
(2014)
Letter
Behavioral Sciences
Gopalkumar Rakesh, Nicholas A. Mischel, Bruce Luber, Richard S. E. Keefe, Sara Emory, Sarah H. Lisanby, Steven T. Szabo
Editorial Material
Pharmacology & Pharmacy
Nicholas A. Mischel, Richard Balon
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2021)
Review
Psychiatry
Michael D. Kritzer, Nicholas A. Mischel, Jonathan R. Young, Christopher S. Lai, Prakash S. Masand, Steven T. Szabo, Sanjay J. Mathew
Summary: Ketamine has evolved from an anesthetic to a rapid treatment for mood disorders and suicidal ideation. Evidence supports its effectiveness in treating depression and suicidality, with potential benefits for anxiety and PTSD, but further research is needed. Intranasal esketamine has been FDA-approved for depression treatment, highlighting recent developments in the field.
ANNALS OF CLINICAL PSYCHIATRY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Soumya Kulkarni, Nicholas Mischel, Patrick Mueller
Article
Psychiatry
Nicholas A. Mischel, GenaLynne C. Mooneyham, Cecilia Lau, Heather Van Mater, Richard D. Weiner
Meeting Abstract
Neurosciences
Nicholas Mischel
NEUROPSYCHOPHARMACOLOGY
(2020)
Meeting Abstract
Neurosciences
Katherine Thomashow, Cynthia Arfken, Nicholas Mischel
NEUROPSYCHOPHARMACOLOGY
(2020)
Letter
Behavioral Sciences
Gopalkumar Rakesh, Nicholas A. Mischel, Grace Gunderson-Falcone, Amanda Anderson, Denna Copeland, Steven T. Szabo, Richard D. Weiner
Review
Psychiatry
Nicholas Mischel, Gopalkumar Rakesh, Sanjay Gupta, Andrew Muzyk, Prakash Masand
ANNALS OF CLINICAL PSYCHIATRY
(2020)
Meeting Abstract
Neurosciences
Jonathan Young, Michael Kritzer, Nicholas Mischel, Jeffrey Taekman, Richard Weiner
BIOLOGICAL PSYCHIATRY
(2020)
Review
Substance Abuse
Jonathan R. Young, Shayan A. Smani, Nicholas A. Mischel, Michael D. Kritzer, Lawrence G. Appelbaum, Ashwin A. Patkar
JOURNAL OF ADDICTIVE DISEASES
(2020)
Review
Pharmacology & Pharmacy
Nicholas A. Mischel, Michael D. Kritzer, Ashwin A. Patkar, Prakash S. Masand, Steven T. Szabo
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2019)