Article
Agriculture, Dairy & Animal Science
L. K. Fehlberg, A. R. Guadagnin, B. L. Thomas, M. Ballou, J. J. Loor, Y. Sugimoto, I. Shinzato, F. C. Cardoso
Summary: This experiment aimed to investigate the effects of feeding rumen-protected lysine (RPL) on the immunometabolic status and liver composition in dairy cows. The results showed that cows consuming RPL exhibited improvements in liver composition, liver function, and immune status.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Orthopedics
B. D. Furman, J. H. Zeitlin, M. W. Buchanan, J. L. Huebner, V. B. Kraus, J. S. Yi, S. B. Adams, S. A. Olson
Summary: Research on human and mouse synovial fluid following articular fracture revealed that specific immune cell subsets, such as CD3+ T cells in humans and CD19+ B cells and CD3+ T cells in mice, were prominent. The study also detected other adaptive immune cells like macrophages, NK cells, dendritic cells, and monocytes. Macrophage and T cell findings were supported by immunohistochemistry on mouse synovial tissue.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Immunology
Alexis M. Crockett, Hania Kebir, Nail Benallegue, Philippa Adelman, Raquel E. Gur, Kathleen Sullivan, Stewart A. Anderson, Jorge I. Alvarez
Summary: Research shows that T cell counts in 22qDS patients are deficient in infancy, but can be normalized by adulthood. Additionally, the 22q11.2 deletion does not affect T cell differentiation or activity.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Physiology
Nikolaus Huber, Sebastian Vetter, Gabrielle Stalder, Hanno Gerritsmann, Sylvain Giroud
Summary: During hibernation, neutrophils show significant changes in oxidative burst capacity, with a marked increase during arousals and a decrease during torpor. This dynamic may be temperature-compensated, as indicated by the different responses at varying body temperatures. These findings could have clinical implications for therapeutic hypothermia and reperfusion injury.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guozhi Bi, Min Su, Nan Li, Yu Liang, Song Dang, Jiachao Xu, Meijuan Hu, Jizong Wang, Minxia Zou, Yanan Deng, Qiyu Li, Shijia Huang, Jiejie Li, Jijie Chai, Kangmin He, Yu-hang Chen, Jian-Min Zhou
Summary: The study showed that the activated ZAR1 protein can form pentameric complexes in the plasma membrane, exhibiting ion channel activity dependent on the conserved acidic residue Glu11. Pre-assembled ZAR1 resistosome readily incorporated into planar lipid-bilayers and displayed calcium-permeable cation-selective channel activity. Activation of ZAR1 in the plant cell resulted in Glu11-dependent Ca2+ influx, perturbation of subcellular structures, production of reactive oxygen species, and cell death.
Article
Environmental Sciences
Anja Bunge, Vincent Lugert, Melissa McClure, Ulrike Kammann, Reinhold Hanel, Joern P. Scharsack
Summary: Microplastic fibers are common contaminants in aquatic environments and are often found in the digestive tract of fish. However, a study found that the ingestion of polyester fibers does not affect the growth and immune parameters of sticklebacks, even at high concentrations. Furthermore, the study suggests that virgin microplastic fibers do not have different effects on fish compared to fibers from natural sources.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Anesthesiology
Tian-Zhi Guo, Xiaoyou Shi, Wenwu Li, Tzuping Wei, Wade S. Kingery, J. David Clark
Summary: DMF effectively reduces nociceptive sensitization, oxidative stress markers, activation of innate immune mediators, lymph node hypertrophy, and IgM accumulation in fractured limbs in a mouse model of CRPS. The Nrf2 transcription factor is not required for the effects of DMF, suggesting potential therapeutic benefits for conditions involving oxidative stress and immune system activation.
ANESTHESIA AND ANALGESIA
(2021)
Review
Plant Sciences
Maud Bernoux, Holger Zetzsche, Johannes Stuttmann
Summary: Plants can detect microbial molecules through surface receptors and intracellular receptors, and the different immune pathways are interconnected and require mutual enhancement for optimal immune responses.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Environmental Sciences
Doyel Roy, Sinchan Adhikari, Ayan Adhikari, Supriya Ghosh, Ikbal Azahar, Debapriya Basuli, Zahed Hossain
Summary: The toxicity of CuO bulk particles was higher than CuO nanoparticles, mainly due to higher Cu ions dissolution.
Article
Biochemistry & Molecular Biology
Nichola Eliza Davies Calvani, Carolina De Marco Verissimo, Heather Louise Jewhurst, Krystyna Cwiklinski, Andrew Flaus, John Pius Dalton
Summary: This study demonstrates the presence of two different SOD enzymes in the parasite Fasciola hepatica, which are expressed at different stages and play distinct roles in counteracting reactive oxygen species. The enzymes protect the parasite from oxidative damage caused by the host's immune response, promoting the survival of the parasite.
Article
Agriculture, Dairy & Animal Science
F. R. Dinardo, A. Maggiolino, T. Martinello, G. M. Liuzzi, G. Elia, N. Zizzo, T. Latronico, F. Mastrangelo, G. E. Dahl, P. De Palo
Summary: This study aimed to investigate the effects of oral nucleotide administration on various aspects including oxidative stress biomarkers, immune responses, gut morphology, serum biochemical parameters, and growth performance in newborn calves. The results demonstrated that oral nucleotide administration can improve calves' weight, daily gain, nutrient utilization efficiency, antioxidant enzyme activity, antioxidant capacity, and the ability to counter reactive oxygen and nitrogen species-mediated damage in peripheral blood mononuclear cells.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Fisheries
Truong Quynh Nhu, Bui Thi Bich Hang, Do Thi Thanh Huong, Marie-Louise Scippo, Nguyen Thanh Phuong, Joelle Quetin-Leclercq, Patrick Kestemont
Summary: This study evaluates the immune-modulatory effects of guava extract fractions CC and EA on striped catfish. The results indicate that CC fraction can enhance the TLRs-MyD88-NF-κB signaling pathway, regulating immune, inflammatory, and apoptotic pathways.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Plant Sciences
Mohammad Faizan, Ahmad Faraz, Anayat Rasool Mir, Shamsul Hayat
Summary: Nanotechnology, specifically the use of zinc oxide nanoparticles (ZnO-NPs), has shown promising results in reducing cadmium (Cd) toxicity in tomato plants by enhancing growth, photosynthesis, antioxidant system, and protein content. The upregulation of antioxidative enzymes by ZnO-NPs helps protect plants from oxidative stress induced by Cd, ultimately leading to improved plant growth and physiological parameters. This study suggests that ZnO-NPs can be a beneficial tool in mitigating heavy metal toxicity in plants.
JOURNAL OF PLANT GROWTH REGULATION
(2021)
Article
Agriculture, Dairy & Animal Science
S. E. Sivinski, K. E. Meier, L. K. Mamedova, B. A. Saylor, J. E. Shaffer, A. Sauls-Hiesterman, I. Yoon, B. J. Bradford
Summary: This study evaluated the effects of a dietary Saccharomyces cerevisiae fermentation product on oxidative status, inflammation, and immune responses in dairy cattle during the transition period. The results showed that the product did not significantly affect oxidative, inflammatory, or immune parameters in the cows.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Han Li, Yifeng Zhang, Rong Li, Yan Wu, Dingran Zhang, Hongrun Xu, Yangdong Zhang, Zhili Qi
Summary: This study found that climatic conditions under different temperature-humidity index levels may induce varying degrees of oxidative stress, inflammation response, and stress hormone imbalances in lactating dairy cows.
Article
Critical Care Medicine
Grace E. Martin, Brent Xia, Young Kim, Mark D. Johnson, Rosalie Veile, Lou Ann Friend, Amy T. Makley, Charles C. Caldwell, Michael D. Goodman
Review
Pharmacology & Pharmacy
Katrin Anne Becker, Joachim Riethmueller, Aaron P. Seitz, Aaron Gardner, Ryan Boudreau, Markus Kamler, Burkhard Kleuser, Edward Schuchman, Charles C. Caldwell, Michael J. Edwards, Heike Grassme, Malcolm Brodlie, Erich Gulbins
ADVANCED DRUG DELIVERY REVIEWS
(2018)
Article
Biochemistry & Molecular Biology
Simone Keitsch, Joachim Riethmueller, Matthias Soddemann, Carotin Sehl, Barbara Wilker, Michael J. Edwards, Charles C. Caldwell, Martin Fraunholz, Erich Gulbins, Katrin Anne Becker
BIOLOGICAL CHEMISTRY
(2018)
Article
Critical Care Medicine
Xingjiang Mu, Xiaohong Wang, Wei Huang, Rui-Tao Wang, Kobina Essandoh, Yutian Li, Amanda M. Pugh, Jiangtong Peng, Shan Deng, Yigang Wang, Charles C. Caldwell, Tianqing Peng, Kai-Jiang Yu, Guo-Chang Fan
Review
Critical Care Medicine
Vanessa Nomellini, Lewis J. Kaplan, Carrie A. Sims, Charles C. Caldwell
Article
Critical Care Medicine
Young Kim, William A. Abplanalp, Andrew D. Jung, Rebecca M. Schuster, Alex B. Lentsch, Erich Gulbins, Charles C. Caldwell, Timothy A. Pritts
Article
Critical Care Medicine
Brent T. Xia, Nadine Beckmann, Leah K. Winer, Young Kim, Holly S. Goetzman, Rosalie E. Veile, Erich Gulbins, Michael D. Goodman, Vanessa Nomellini, Charles C. Caldwell
Article
Surgery
Young Kim, Brent T. Xia, Andrew D. Jung, Alex L. Chang, William A. Abplanalp, Charles C. Caldwell, Michael D. Goodman, Timothy A. Pritts
Article
Biochemistry & Molecular Biology
Anne Gulbins, Fabian Schumacher, Katrin Anne Becker, Barbara Wilker, Matthias Soddemann, Francesco Boldrin, Christian P. Mueller, Michael J. Edwards, Michael Goodman, Charles C. Caldwell, Burkhard Kleuser, Johannes Kornhuber, Ildiko Szabo, Erich Gulbins
MOLECULAR PSYCHIATRY
(2018)
Article
Multidisciplinary Sciences
Nadine Beckmann, Amanda M. Pugh, Charles C. Caldwell
Article
Orthopedics
Michael D. Liette, Peter A. Crisologo, Suhail Masadeh, Sung H. Yang, Christian B. Bergmann, Charles C. Caldwell, Jordan A. Henning
Summary: This study aimed to prospectively enroll patients with lower extremity infections in the emergency department, stratify their risk using the WIfI classification system, and record their outcomes. The results showed that the WIfI classification system was effective in predicting patient outcomes during hospitalization and one-year follow-up. The study also found significant differences in healing rates, surgical dehiscence, and one-year mortality with increasing WIfI stage. Therefore, the early application of the WIfI classification system can help assess risk, guide early intervention, and improve outcomes in severe multimorbid patients.
JOURNAL OF FOOT & ANKLE SURGERY
(2023)
Article
Surgery
M. Baimas-George, L. Cetrulo, A. Kao, K. R. Kasten
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Bobby L. Johnson, Emily F. Midura, Priya S. Prakash, Teresa C. Rice, Natalia Kunz, Kathrin Kalies, Charles C. Caldwell
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2017)
Article
Microbiology
Heike Grassme, Brian Henry, Regan Ziobro, Katrin Anne Becker, Joachim Riethmueller, Aaron Gardner, Aaron P. Seitz, Joerg Steinmann, Stephan Lang, Christopher Ward, Edward H. Schuchman, Charles C. Caldwell, Markus Kamler, Michael J. Edwards, Malcolm Brodlie, Erich Gulbins
CELL HOST & MICROBE
(2017)
Article
Immunology
Katrin Anne Becker, Bjoern Fahsel, Hannes Kemper, Joelina Mayeres, Cao Li, Barbara Wilker, Simone Keitsch, Matthias Soddemann, Carolin Sehl, Marcus Kohnen, Michael J. Edwards, Heike Grassme, Charles C. Caldwell, Aaron Seitz, Martin Fraunholz, Erich Gulbins
INFECTION AND IMMUNITY
(2018)