Article
Behavioral Sciences
Kyle A. Sullivan, Corena V. Grant, Kelley R. Jordan, Selina S. Vickery, Leah M. Pyter
Summary: The study found that exercise helps faster recovery from paclitaxel-induced weight loss and deficits in melanocortin signaling, but did not alleviate fatigue or inflammation. Body mass recovery was associated with the wheel running-induced recovery of body composition and associated peripheral circulating hormones.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Akiko Nakamoto, Natsuko Ohashi, Lucia Sugawara, Katsutaro Morino, Shogo Ida, Rachel J. Perry, Ikki Sakuma, Tsuyoshi Yanagimachi, Yukihiro Fujita, Satoshi Ugi, Shinji Kume, Gerald I. Shulman, Hiroshi Maegawa
Summary: O-GlcNAcylation in adipose tissue plays a crucial role in healthy fat expansion and regulation of lipogenesis and fatty acid efflux, affecting body weight gain and obesity.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Medicine, Research & Experimental
Yan Gao, Zhaoyun Yang, Kang He, Zeyu Wang, Tingyu Zhang, Jiang Yi, Lijing Zhao
Summary: This study found that exercise has anti-inflammatory and antioxidant effects on pulmonary fibrosis induced by paraquat, reducing the infiltration of inflammatory cells and fibrotic lesions. Furthermore, exercise also increased the expression of antioxidative distress proteins, improved the degree of epithelial-mesenchymal transition in alveolar epithelial cells, and ultimately alleviated paraquat-induced pulmonary fibrosis.
Article
Biochemistry & Molecular Biology
Laura Niiranen, Ville Stenback, Mikko Tulppo, Karl-Heinz Herzig, Kari A. Makela
Summary: Exercise has been proven to improve cognitive function, and studies on both humans and animals have shown this. Laboratory mice are often used as a model to study the effects of exercise, and running wheels provide a voluntary and stress-free form of exercise for mice. This study aimed to analyze the relationship between the cognitive state of a mouse and its wheel-running behavior. The results showed that high-runner mice exhibited enhanced learning capabilities and ate more compared to the other groups. Interestingly, individual mice had different reactions when introduced to running wheels, suggesting the importance of considering individual differences in voluntary endurance exercise studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
J. Sanchez-Ventura, L. Gimenez-Llort, C. Penas, E. Udina
Summary: PNN is a promising candidate for harnessing neural plasticity, especially in rehabilitation. SCI reduces PNN density in the spinal cord, while activity-based therapies can reverse this decrease and improve functional recovery.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Phillipe Huber, Brandon J. J. Ausk, K. Lionel Tukei, Steven D. D. Bain, Ted S. S. Gross, Sundar Srinivasan
Summary: The study developed a convolutional neural network model to accurately assess the running frequency of aged mice. The model achieved a 94% accuracy rate. This research method provides a higher resolution of information for studying the physiological effects of voluntary wheel running activity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Neurosciences
Kyeong Jin Yoon, Suhong Park, Seung Hee Kwak, Hyo Youl Moon
Summary: Anxiety disorders are commonly diagnosed psychological conditions that are often treated with drugs, but these medications can have side effects. Exercise is an effective treatment for anxiety, and it has been found to release extracellular vesicles (EVs) that may help reduce anxiety. Research suggests that exercise-derived EVs may have anti-anxiety effects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam J. Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.
Article
Biology
Monica P. McNamara, Emily M. Venable, Marcell D. Cadney, Alberto A. Castro, Margaret P. Schmill, Lawrence Kazzazi, Rachel N. Carmody, Theodore Garland
Summary: In this study, the fecal microbial community composition and diversity were compared between a group of mice selectively bred for high wheel-running activity and a control group. The results showed that the high wheel-running mice had a higher relative abundance of the bacterial family Clostridiaceae, which differed from a previous study on rats. Additionally, the replicate lines within the high wheel-running and control groups had unique microbiomes, indicating potential random genetic drift and/or multiple adaptive responses to selection.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang
Summary: Increasing evidence suggests that the intrauterine environment affects fetal hypothalamic energy intake, and maternal inulin intervention can modify offspring lipid metabolism through gene methylation in the hypothalamus feeding circuit.
Article
Immunology
Kiersten S. Scott, Brandon Chelette, Chinenye Chidomere, A. Phillip West, Robert Dantzer
Summary: Cisplatin decreases energy-consuming activities but not energy-procuring activities unless they require a choice between options differing in their cost-benefit ratio. The physical dimension of fatigue is more likely to develop in cisplatin-treated individuals than the motivational dimension of fatigue.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Annika Reuser, Kristin Wenzel, Stephan B. Felix, Marcus Doerr, Martin Bahls, Stephanie Koenemann
Summary: This article introduces a method that combines radiotelemetry system and running wheels to determine spontaneous cage activity and voluntary exercise levels of individual animals in group-housed rodents. A software tool is developed for fast and reliable data analysis. This method can be used to study the benefits of physical activity and the impact of therapeutic interventions on animal behavior.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Mei Yu, Mengxian Ju, Penghua Fang, Zhenwen Zhang
Summary: Consumption of a high calorie diet with irregular eating and sedentary behavior habits is typical of the current suboptimal lifestyle, contributing to the development of metabolic diseases such as obesity and type 2 diabetes mellitus. The adipokines spexin and leptin play important roles in regulating adipogenesis and glucose metabolism. Their levels and interaction in patients with obesity and diabetes also affect the development of these diseases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Fangjun Yu, Zhigang Wang, Tianpeng Zhang, Xun Chen, Haiman Xu, Fei Wang, Lianxia Guo, Min Chen, Kaisheng Liu, Baojian Wu
Summary: The intestinal circadian clock functions as an accelerator in dietary fat absorption, protecting against obesity and related abnormalities induced by a high-fat diet. Targeting intestinal BMAL1 to regulate dietary fat absorption may be a promising approach for managing metabolic diseases caused by excess fat intake.
NATURE COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Annesofie Thorup Olesen, Lasse Alchow-Moller, Rune Duus Bendixen, Michael Kjaer, Rene Bruggebusch Svensson, Jesper Lovind Andersen, S. Peter Magnusson
Summary: The study showed that ten weeks of high intensity training could attenuate age-related loss of muscle mass and function, with greater effects observed in old mice in the HR group. The HR running increased fiber CSA and shifted fiber types in the older mice, suggesting its effectiveness in counteracting sarcopenia.
EXPERIMENTAL GERONTOLOGY
(2021)