Article
Fisheries
Sara Comesan, Cristina Velasco, Jose L. Soengas
Summary: Results from an in vitro study suggest that rainbow trout hypothalamus responds to changes in leucine levels in a similar way to in vivo observations, activating amino acid sensing systems and GCN2 kinase. However, the activation of mTOR signaling pathway by leucine observed in vivo appears to be indirect, potentially due to the lack of connections between hypothalamus and other brain areas or changes in hormone levels such as insulin.
Article
Endocrinology & Metabolism
Mauro Chivite, Rosa M. Ceinos, Jose M. Cerda-Reverter, Jose L. Soengas, Manuel Aldegunde, Marcos A. Lopez-Patino, Jesus M. Miguez
Summary: This study investigated changes in brain serotonin content, activity, and hypothalamic neuropeptide mRNA abundance during feeding time in rainbow trout, as well as the effects of fasting. The results showed that serotonin increased during feeding and remained elevated during the postprandial period. This increase was associated with higher levels of pomca1 mRNA, suggesting that serotonin may promote satiety by acting on neuropeptides. However, further research is needed to better understand the interaction between serotonin and brain centers involved in processing food-related signals.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Cristina Velasco, Marta Conde-Sieira, Sara Comesana, Mauro Chivite, Jesus M. Miguez, Jose L. Soengas
Summary: In this study using rainbow trout as a model, the G protein-coupled receptors GPR84 and GPR119 were investigated for their roles in food intake regulation. The treatment with agonists for these receptors induced an anorectic response in the fish, leading to changes in mRNA abundance of neuropeptides and related transcription factors. These changes were associated with phosphorylation status of FOXO1, AMPKa, and Akt, as well as signaling pathways related to PLC beta and IP3.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Behavioral Sciences
Mauro Chivite, Sara Comesana, Jessica Calo, Jose L. Soengas, Marta Conde-Sieira
Summary: This study demonstrated the presence of a rewarding response mediated by the endocannabinoid system (ECs) in rainbow trout fed a lipid-enriched diet. The agonists of ECs had a bimodal effect on feed intake, and the involvement of specific receptors of ECs in this response was assessed using receptor antagonists.
HORMONES AND BEHAVIOR
(2022)
Article
Fisheries
Jessica Calo, Marta Conde-Sieira, Sara Comesana, Jose L. Soengas, Ayelen M. Blanco
Summary: This study demonstrates the presence of a gut-brain axis in fish, as different types and lengths of fatty acids impact feed intake and appetite-regulatory centers in rainbow trout. The findings have important implications for aquaculture due to variations in fatty acid composition in aquafeeds.
Article
Neurosciences
Adrian Diaz-Rua, Mauro Chivite, Cristina Velasco, Sara Comesana, Jose L. Soengas, Marta Conde-Sieira
Summary: This study evaluated the main components of the cannabinoid system related to feeding conditions in fish. The results suggest a potential role of the endocannabinoid system in the regulation of food intake in fish, but further research is needed.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Adrian Diaz-Rua, Mauro Chivite, Sara Comesana, Cristina Velasco, Jose L. Soengas, Marta Conde-Sieira
Summary: The study found that low doses of endocannabinoids can stimulate appetite in rainbow trout, possibly through inhibiting gamma-aminobutyric acid neurotransmission and modulating neural plasticity in brain areas related to appetite control.
HORMONES AND BEHAVIOR
(2021)
Review
Endocrinology & Metabolism
Axelle Khouma, Moein Minbashi Moeini, Julie Plamondon, Denis Richard, Alexandre Caron, Natalie Jane Michael
Summary: Histamine, a neuromodulator in the brain, contributes to the regulation of various physiological processes, including energy balance, through histaminergic signaling in the hypothalamus. Two histamine receptors, H1R and H3R, play important roles in key hypothalamic nuclei involved in energy homeostasis. Activation of H1R suppresses food intake, while activation of H3R stimulates appetite. The central histaminergic system is implicated in weight gain induced by atypical antipsychotics and has potential as a therapeutic target for obesity treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Anna Aulinas, Maged Muhammed, Kendra R. Becker, Elisa Asanza, Kristine Hauser, Casey Stern, Julia Gydus, Tara Holmes, Helen Burton Murray, Lauren Breithaupt, Nadia Micali, Madhusmita Misra, Kamryn T. Eddy, Jennifer J. Thomas, Elizabeth A. Lawson
Summary: This study examined the response of anorexigenic oxytocin to food intake in adolescents and young adults with avoidant/restrictive food intake disorder (ARFID). It was found that individuals with ARFID had higher levels of oxytocin compared to healthy controls at all time points.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Allison W. Rautmann, Claire B. de la Serre
Summary: The gut microbiota plays a key role in modulating host physiology and behavior, particularly in relation to feeding behavior, energy balance, and obesity. Changes in microbiome composition due to diet can lead to weight gain, adiposity, and alterations in ingestive behavior. Research is focused on understanding the role of the microbiome in the development of obesity and using microbiome manipulation to reduce food intake and promote weight loss.
Article
Food Science & Technology
Chao Ji, Yihan He, Yuanying Xing, Wei Liu, Yuxin Xie, Haoran Ba, Min Yang, Xiahong He, Wenjie Zheng, Xiaonan Lu
Summary: A PCR-based lateral flow immunoassay (LFIA) was developed to quickly identify rainbow trout ingredient in foods. The assay combines PCR amplification of rainbow trout DNA with the detection of labeled amplicon using LFIA, which allows color signals to be observed by the naked eye within 5 minutes. The reliability of the assay was confirmed by quantitative real-time PCR (qPCR) and showed high specificity and sensitivity in detecting rainbow trout DNA even at a low concentration of 0.1 ng/μL. This PCR-LFIA method offers a simpler and faster alternative to conventional qPCR for the authentication of rainbow trout ingredient in foods.
Article
Nutrition & Dietetics
Isabel van Ackern, Angela Kuhla, Bjoern Kuhla
Summary: The endocannabinoid system is crucial in regulating food intake, with pharmacological activation increasing intake in energy-deficient stages, particularly in intermittent feeders. Injection of 2-AG and AEA can boost food intake in the short term, with varying responses to food deprivation, 2-AG showing higher sensitivity than AEA.
Review
Nutrition & Dietetics
Daniela G. Costa, Claudia Almeida, Claudia Cavadas, Sara Carmo-Silva
Summary: This review provides an overview of physiological mechanisms involved in satiety and methodologies to assess food intake and satiety. It focuses on the differences between satiety and satiation, how the central nervous system regulates food intake and satiety, the impact of different macronutrients on satiety, and how the manipulation of food composition can influence overall satiety. Bringing together this knowledge on satiety mechanisms is useful for understanding and controlling obesity and other eating disorders.
Article
Food Science & Technology
Salud Maria Serrano Heredia, Javier Sanchez-Martin, Veronica Romero Gil, Francisco Noe Arroyo-Lopez, Antonio Benitez-Cabello, Elena Carrasco Jimenez, Antonio Valero Diaz
Summary: This study aimed to evaluate the hygienic-sanitary status of fresh-farmed rainbow trout fillets produced in a local fish farm in Andalusia, Spain. The results showed potential transmission of microbial contamination and suggested the implementation of control measures in fish farm facilities to extend the shelf-life of farmed fishery products.
Article
Multidisciplinary Sciences
Aude Kleiber, Jean-Michel Le-Calvez, Thierry Kerneis, Axel Batard, Lionel Goardon, Laurent Labbe, Valentin Brunet, Vitor Hugo Bessa Ferreira, Vanessa Guesdon, Ludovic Calandreau, Violaine Colson
Summary: Occupational enrichment shows promise for improving the welfare of farmed fish. This study tested different feeding predictability conditions for rainbow trout and found that using time and bubbles as feeding predictors can enhance their welfare. However, using only time as a predictor may have negative effects on fish welfare.
SCIENTIFIC REPORTS
(2022)
Review
Biology
Ayelen Melisa Blanco, Jessica Calo, Jose Luis Soengas
Summary: The gut and brain communicate and influence each other through the gut-brain axis, regulating food intake and physiological processes. Studies on this axis in non-mammalian vertebrates are limited, and gaps in knowledge need to be filled to better understand its function and significance.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Neurosciences
Adrian Diaz-Rua, Mauro Chivite, Cristina Velasco, Sara Comesana, Jose L. Soengas, Marta Conde-Sieira
Summary: This study evaluated the main components of the cannabinoid system related to feeding conditions in fish. The results suggest a potential role of the endocannabinoid system in the regulation of food intake in fish, but further research is needed.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Nuria Saiz, Lisbeth Herrera-Castillo, Esther Isorna, Maria Jesus Delgado, Marta Conde-Sieira, Jose Luis Soengas, Nuria de Pedro
Summary: This study demonstrates, for the first time in fish, the effects of REV-ERB alpha activation via SR9009, promoting a negative energy balance by reducing energetic inputs and regulating lipid and glucose metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Adrian Diaz-Rua, Mauro Chivite, Sara Comesana, Marta Conde-Sieira, Jose L. Soengas
Summary: We investigated the role of the opioid system in the regulation of food intake in rainbow trout. Our results suggest that the opioid system is not critical for the homeostatic regulation of food intake, but it may play a role in the hedonic regulation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Plant Sciences
Antia Verde, Jesus M. Miguez, Mercedes Gallardo
Summary: The role of melatonin during the growth and ripening of apple fruit was studied using local varieties. It was found that melatonin stimulates fruit ripening through the induction of ethylene synthesis, and melatonin treatments before ripening improve the final fruit quality.
Article
Fisheries
Ana Basto, Luisa M. P. Valente, Jose L. Soengas, Marta Conde-Sieira
Summary: Understanding the regulation of food intake in fish is crucial for formulating aquafeeds. This study evaluated the short- and mid-term response of European sea bass fed diets with partial and total fishmeal replacement by defatted Tenebrio molitor larvae meal (dTM). The results showed that dTM replacement did not affect food intake regulation in sea bass, but may lead to long-term changes in intermediary metabolism.
Article
Fisheries
Sara Comesana, Mauro Chivite, Ayelen M. Blanco, Maria Alborja-Valado, Jessica Calo, Marta Conde-Sieira, Jose L. Soengas
Summary: This study clarifies the importance of mTOR in the central orexigenic effect of valine in fish. The activation of mTOR is associated with increased feed intake levels, but the precise mechanisms are still unclear.
AQUACULTURE NUTRITION
(2022)
Article
Fisheries
Jessica Calo, Marta Conde-Sieira, Sara Comesana, Jose L. Soengas, Ayelen M. Blanco
Summary: This study demonstrates the presence of a gut-brain axis in fish, as different types and lengths of fatty acids impact feed intake and appetite-regulatory centers in rainbow trout. The findings have important implications for aquaculture due to variations in fatty acid composition in aquafeeds.
Article
Behavioral Sciences
Mauro Chivite, Sara Comesana, Jessica Calo, Jose L. Soengas, Marta Conde-Sieira
Summary: This study demonstrated the presence of a rewarding response mediated by the endocannabinoid system (ECs) in rainbow trout fed a lipid-enriched diet. The agonists of ECs had a bimodal effect on feed intake, and the involvement of specific receptors of ECs in this response was assessed using receptor antagonists.
HORMONES AND BEHAVIOR
(2022)
Article
Fisheries
Jessica Calo, Jose L. Soengas, Jose J. Pastor, Ayelen M. Blanco, Sofia Morais
Summary: This study aimed to investigate the amino acid sensing capacity and hormone production in the gastrointestinal tract (GIT) of rainbow trout in response to proline, fishmeal amino acids, and fishmeal aqueous extract. The results showed that the presence of proline in the GIT led to changes in amino acid sensing systems and hormone production, especially in the proximal regions, accompanied by anorectic response in the hypothalamus. Both the fishmeal aqueous extract and the fishmeal amino acids induced anorectic responses in the hypothalamus, accompanied by increased production of anorectic hormones in the intestine.
Article
Fisheries
F. Lai, S. Comesana, A. S. Gomes, D. Flatejord, I. Tolas, M. Espe, C. De Santis, M. B. Hartviksen, T. Verri, J. L. Soengas, I. Ronnestad
Summary: This study found that high leucine diets reduce feed intake, growth, and hepatosomatic index in Atlantic salmon. It was also found that high leucine diets activate amino acid sensing mechanisms in the brain, which further affects the expression of genes related to appetite control.
Article
Biochemistry & Molecular Biology
Jessica Calo, Sara Comesana, Angel L. Alonso-Gomez, Jose L. Soengas, Ayelen M. Blanco
Summary: This study provides the first evidence of fatty acid sensing mechanisms in the gastrointestinal tract (GIT) of fish and identifies differences in these mechanisms between rainbow trout and mammals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nuria Saiz, Cristina Velasco, Nuria de Pedro, Jose Luis Soengas, Esther Isorna
Summary: This study aimed to investigate the potential role of insulin as an intake signal mediating liver entrainment in fish. The experiments showed that the presence of insulin directly increased the abundance of per1a and per2 transcripts in the fish liver. It was found that the involvement of the PI3K/AKT pathway is crucial for insulin-mediated liver entrainment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alejandra Godino-Gimeno, Per-Ove Thornqvist, Mauro Chivite, Jesus M. Miguez, Svante Winberg, Jose Miguel Cerda-Reverter
Summary: In the past decade, the zebrafish has become an important model organism for studying behavior, neurological disorders, and metabolic diseases. This study used the zebrafish model to investigate how obesity induced by overfeeding affects emotional and cognitive processes. The results showed that obesity impaired short-term memory in zebrafish, but had no effect on anxiety-like behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Ana Basto, Luisa M. P. Valente, Vera Sousa, Marta Conde-Sieira, Jose L. Soengas
Summary: This study evaluated the impact of partial and total fishmeal replacement by insect meal on intermediary metabolism of European sea bass. The results showed that the selected insect meal can replace 50% of fishmeal without adversely affecting liver health or intermediary metabolism. However, total fishmeal replacement may compromise fish health in the long-term.
JOURNAL OF ANIMAL SCIENCE
(2023)
