Article
Neurosciences
Joseph C. Watso, Mu Huang, Gilbert Moralez, Matthew N. Cramer, Joseph M. Hendrix, Frank A. Cimino, Luke N. Belval, Carmen Hinojosa-Laborde, Craig G. Crandall
Summary: The study found that low dose ketamine administration can reduce pain perception and some cardiovascular responses, but does not affect muscle sympathetic nerve activity burst frequency. This suggests that low dose ketamine is effective in pain management.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cardiac & Cardiovascular Systems
Jeremy A. Bigalke, John J. Durocher, Ian M. Greenlund, Manda Keller-Ross, Jason R. Carter
Summary: Chronic anxiety is prevalent and associated with an increased risk of cardiovascular disease. This study reveals an independent relationship between trait anxiety, resting blood pressure, and muscle sympathetic nerve activity (MSNA) in healthy adults without cardiometabolic disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Massimo Nardone, Carlin Katerberg, Anthony V. Incognito, Andr E. L. Teixeira, Lauro C. Vianna, Philip J. Millar
Summary: The signal-averaged sympathetic transduction of blood pressure is inversely related to resting muscle sympathetic nerve activity burst frequency in healthy cohorts. The methodological limitations in the analysis of MSNA transduction at different levels of absolute blood pressure are still unclear. Further research is needed to understand the timing relationship between MSNA bursts and blood pressure fluctuations.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Luke. S. Dunaway, Marie Billaud, Edgar Macal, Miranda. E. Good, Christopher. B. Medina, Ulrike Lorenz, Kodi Ravichandran, Michael Koval, Brant. E. Isakson
Summary: This study suggests that Panx1 in smooth muscle cells plays a role in regulating sympathetic nerve constriction and blood pressure. The findings also demonstrate the feasibility of using Panx1-mouse models to test potential drugs for hypertension.
Article
Peripheral Vascular Disease
Seth W. Holwerda, Megan E. Gangwish, Rachel E. Luehrs, Virginia R. Nuckols, John P. Thyfault, John M. Miles, Gary L. Pierce
Summary: This study aimed to investigate the relationship between abdominal obesity and sympathetic nerve activity and blood pressure. The results showed that the transduction of sympathetic nerve activity to blood pressure was augmented in individuals with abdominal obesity and positively correlated with higher resting blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Physiology
Massimo Nardone, Carlin Katerberg, Andre L. Teixeira, Jordan B. Lee, Julian C. Bommarito, Philip J. Millar
Summary: The sympathetic transduction of blood pressure is negatively correlated with resting muscle sympathetic nerve activity. The acute effects of increasing sympathetic nerve activity on blood pressure are still unclear. This study used lower body negative pressure to increase sympathetic nerve activity and found that it did not alter the traditional measures of sympathetic transduction of blood pressure. Further research is needed to determine the factors that affect the firing of sympathetic nerve activity in relation to blood pressure oscillations.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Physiology
Andre L. Teixeira, Jordan B. B. Lee, Massimo Nardone, Jamie F. F. Burr, Philip J. J. Millar
Summary: The sympathetic nervous system plays a crucial role in cardiovascular regulation, particularly in response to acute stress. The relationship between renal and leg vasoconstriction at rest or during sympathetic stressors is not yet known. This study aimed to investigate the relationships between muscle sympathetic nerve activity (MSNA), leg vascular conductance (LVC), and renal vascular conductance (RVC) in young healthy adults, both at rest and during laboratory-based stressors. The findings revealed differential control of regional sympathetic vasoconstriction at rest and during stress in young healthy humans.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lu Qin, Jian Cui, Jianhua Li
Summary: This review discusses the impact of sympathetic nerve activity on blood pressure in patients with peripheral artery disease and the related neural mechanisms, and proposes intervention strategies to improve the deleterious effects of exercise-induced blood pressure changes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew W. D'Souza, Sarah L. Hissen, Kazumasa Manabe, Ryosuke Takeda, Takuro Washio, Geoff B. Coombs, Belinda Sanchez, Qi Fu, J. Kevin Shoemaker
Summary: Sympathetic vascular transduction is attenuated in older adults compared to young adults, and there is an inverse relationship between the central and peripheral arcs of the baroreflex. Age and sex have independent and interactive effects on sympathetic vascular transduction and sympathetic neurohemodynamic balance in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Review
Physiology
Michael M. Tymko, Lindsey F. Berthelsen, Rachel J. Skow, Andrew R. Steele, Graham M. Fraser, Craig D. Steinback
Summary: This review discusses the relationship between sympathetic nerve activity and the vasculature, examining both static and dynamic methods of measuring sympathetic transduction. Although each method has its limitations, they all hold significant implications for cardiovascular diseases.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Katarina Babarikova, Pavel Svitok, Libor Kopkan, Michal Zeman, Lubos Molcan
Summary: This study analyzed the impact of cross-fostering on cardiovascular parameters in hypertensive TGR and normotensive HanSD offspring, and found that cross-fostering can reduce sympathovagal balance in hypertensive TGR offspring and transiently decrease plasma Ang II levels and MR expression.
Article
Nutrition & Dietetics
Massimo Nardone, Anthony Incognito, Andre L. Teixeira, Joseph A. Cacoilo, Lauro C. Vianna, Philip J. Millar
Summary: The study evaluated the impact of resting muscle sympathetic nerve activity (MSNA) burst size and firing pattern on time-to-peak sympathetic transduction in young healthy men and women. Results showed larger MSNA burst areas led to faster peak responses, independent of the pattern of sympathetic firing.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Sport Sciences
Megan M. Wenner, Jody L. Greaney, Evan L. Matthews, Shane Mcginty, Jasdeep Kaur, Wanpen Vongpatanasin, Paul J. Fadel
Summary: Postmenopausal women display exaggerated blood pressure and muscle sympathetic nerve activity responses during exercise compared to young women. Estradiol administration attenuates these responses.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Cardiac & Cardiovascular Systems
Benjamin E. Young, Jody L. Greaney, David M. Keller, Paul J. Fadel
Summary: Microneurographic recordings have significantly advanced our understanding of central sympathetic outflow in human health and disease, highlighting the importance of studying vascular and/or blood pressure responses for sympathetic transduction. Different paradigms, such as stress-induced and resting sympathetic transduction, have been used to study sympathetic transduction, emphasizing the need to interpret findings from investigations using different techniques as distinct processes.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physiology
Alicia Duval, Will Huckins, Danielle E. Berbrier, Charlotte W. Usselman
Summary: Polycystic ovary syndrome (PCOS) is a complex disorder associated with reproductive abnormalities, cardiometabolic disturbances, and an increased risk of cardiovascular disease. Research has shown that females with PCOS have elevated muscle sympathetic nerve activity (MSNA) at rest. Both lean and obese females with PCOS exhibit heightened MSNA, but there is evidence suggesting that androgens may have a stronger association with elevated MSNA in lean individuals with PCOS. Understanding the mechanisms behind elevated MSNA in PCOS is important as it may contribute to the development of cardiovascular diseases and provide a potential therapeutic target for mitigating cardiovascular risk.
EXPERIMENTAL PHYSIOLOGY
(2023)
Editorial Material
Physiology
Willis K. Samson, Jason R. Carter, Gina L. C. Yosten
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Stacie L. Daugherty, Jason R. Carter, Ghada Bourjeily
JOURNAL OF WOMENS HEALTH
(2020)
Article
Physiology
M. L. Keller-Ross, H. A. Cunningham, J. R. Carter
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Endocrinology & Metabolism
Jeremy A. Bigalke, Ian M. Greenlund, Jason R. Carter
BIOLOGY OF SEX DIFFERENCES
(2020)
Article
Cardiac & Cardiovascular Systems
Seth W. Holwerda, Jason R. Carter, Huan Yang, Jing Wang, Gary L. Pierce, Paul J. Fadel
Summary: The study examined methods for quantifying spontaneous MSNA baroreflex sensitivity using linear regression slopes, finding that a correlation coefficient above -0.70 can significantly improve consistency, longer recording durations and a 3mmHg diastolic blood pressure bin size are beneficial for analysis improvement.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ian M. Greenlund, Hannah A. Cunningham, Anne L. Tikkanen, Jeremy A. Bigalke, Carl A. Smoot, John J. Durocher, Jason R. Carter
Summary: Evening binge alcohol consumption disrupts sleep quality and morning-after autonomic function, leading to increased cardiovascular risk.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Physiology
Ian M. Greenlund, Carl A. Smoot, Jason R. Carter
Summary: The study found that men showed significantly greater blood pressure response following spontaneous K-complexes during sleep compared to women, indicating further differences in cardiovascular health between men and women.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Merry L. Lindsey, Zamaneh Kassiri, Kara Hansell Keehan, Keith R. Brunt, Jason R. Carter, Jonathan A. Kirk, Petra Kleinbongard, Amanda J. LeBlanc, Crystal M. Ripplinger
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Editorial Material
Clinical Neurology
Jason R. Carter, Babak Mokhlesi, Robert J. Thomas
Article
Clinical Neurology
Ian M. Greenlund, Jeremy A. Bigalke, Anne L. Tikkanen, John J. Durocher, Carl A. Smoot, Jason R. Carter
Summary: The study found that evening binge alcohol consumption can reduce cardiac vagal tone and baroreflex sensitivity in different sleep stages.
Article
Clinical Neurology
Neha A. John-Henderson, Benjamin Oosterhoff, Karalee M. Kothe, Taylor D. Kampf, Brad Hall, Lester R. Johnson, Mary Ellen LaFromboise, Melveena Malatare, Emily M. Salois, Alexandra K. Adams, Jason R. Carter
Summary: Study conducted among Blackfeet adults living on the Blackfeet reservation in Montana revealed that daily self-reported loneliness was associated with poorer sleep quality, including longer wake after sleep onset and lower sleep efficiency. Findings suggest that loneliness may be a contributing factor to poor sleep in American Indian communities.
Article
Clinical Neurology
Jeremy A. Bigalke, Ian M. Greenlund, Jennifer R. Nicevski, Jason R. Carter
Summary: This study aimed to test the hypothesis that blue light blocking glasses improve subjective sleep quality in healthy adults. The results showed that while the glasses reduced subjective sleep onset and awakenings, they did not significantly improve objective measures of sleep time or quality.
Article
Psychology, Multidisciplinary
Neha A. John-Henderson, Benjamin Oosterhoff, Taylor D. Kampf, Brad Hall, Lester R. Johnson, Mary Ellen Laframboise, Melveena Malatare, Emily Salois, Jason R. Carter, Alexandra K. Adams
Summary: This study found that the frequency of thought about historical loss is associated with increased subclinical risk for cardiovascular disease in the Blackfeet community.
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Article
Clinical Neurology
Jason R. Carter, Brett M. Gervais, Janelle L. Adomeit, Ian M. Greenlund
Letter
Physiology
Gabrielle E. W. Giersch, Nisha Charkoudian
JOURNAL OF APPLIED PHYSIOLOGY
(2020)