Review
Medicine, Research & Experimental
James May, Jane A. Mitchell, R. Gisli Jenkins
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with limited treatment options. This article proposes that vascular and endothelial cell abnormalities play a significant role in the pathobiology of IPF and calls for a comprehensive evaluation of these dysregulated pathways to find effective therapies and a cure for this devastating disease.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, General & Internal
Marissa Wisman, Mehmet Nizamoglu, Jacobien A. Noordhoek, Wim Timens, Janette K. Burgess, Irene H. Heijink
Summary: In idiopathic pulmonary fibrosis (IPF), disturbed crosstalk between alveolar progenitor cells and the stromal niche impairs regenerative capacity, potentially contributing to alveolar impairment. Organoid cultures from IPF lungs showed lower numbers and larger size compared to non-IPF lungs, indicating impaired crosstalk between supportive cells and epithelial cells. These findings suggest that disturbed interactions within the stromal micro-environment lead to abnormal alveolar repair and fibrosis in IPF.
FRONTIERS IN MEDICINE
(2023)
Review
Cell Biology
Shengnan Yang, Peipei Liu, Yale Jiang, Zai Wang, Huaping Dai, Chen Wang
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with unknown causes, and currently the only medications that can slow down the progression of the disease and improve survival rate are pirfenidone and nintedanib. The use of mesenchymal stem cells (MSCs) provides a new hope for treating interstitial lung disease, but optimal treatment protocols are still lacking.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Omer Faruk Hatipoglu, Eyyup Uctepe, Gabriel Opoku, Hidenori Wake, Kentaro Ikemura, Takashi Ohtsuki, Junko Inagaki, Mehmet Gunduz, Esra Gunduz, Shogo Watanabe, Takashi Nishinaka, Hideo Takahashi, Satoshi Hirohata
Summary: The study demonstrated that knocking down osteopontin (OPN) using small interfering RNA (siRNA) effectively reduced fibrotic areas in a mouse model of pulmonary fibrosis. OPN siRNA treatment also led to a decrease in inflammatory cell count in bronchoalveolar lavage fluid. Furthermore, both in vitro and in vivo experiments showed that OPN downregulation effectively reduced pulmonary fibrosis and epithelial-mesenchymal transition.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Sevindzh Kletukhina, Guzel Mutallapova, Angelina Titova, Marina Gomzikova
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive disease caused by the aberrant regeneration of pulmonary epithelium. Mesenchymal stem cells (MSCs) and extracellular vesicles (EVs) are promising therapies for pulmonary fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yi Han, Ling Ye, Fang Du, Maosong Ye, Chun Li, Xiaodan Zhu, Qin Wang, Hongni Jiang, Zilong Liu, Jiefei Ma, Jian Zhou, Chunxue Bai, Yuanlin Song, Jie Liu
Summary: Iron overload in the lungs of patients with idiopathic pulmonary fibrosis (IPF) has been found to increase the vulnerability of lung epithelial cells to iron-driven oxidant injury, triggering further autophagy during the process of epithelial-mesenchymal transition (EMT).
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Genetics & Heredity
Jiafeng Zheng, Hanquan Dong, Tongqiang Zhang, Jing Ning, Yongsheng Xu, Chunquan Cai
Summary: In idiopathic pulmonary fibrosis (IPF), epithelial-mesenchymal transition (EMT) and immunity play crucial roles, and IL1R2, S100A12, and CCL8 may serve as potential prognostic biomarkers for IPF. These genes are associated with immune cell infiltration.
FRONTIERS IN GENETICS
(2022)
Article
Critical Care Medicine
Yosafe Wakwaya, Deepa Ramdurai, Jeffrey J. Swigris
Summary: Chronic cough in patients with IPF may involve multiple mechanisms, including comorbid conditions and IPF itself. Diagnostic and management approaches need to be multi-faceted, but may lack robust data support.
Article
Medicine, Research & Experimental
Eirini Filidou, Leonidas Kandilogiannakis, Gesthimani Tarapatzi, Colin Su, Emilie Ng Foong Po, Vasilis Paspaliaris, George Kolios
Summary: The study evaluated the efficacy of CM-ADSCs on lung inflammation and fibrosis in a Bleomycin-induced pulmonary fibrosis model, demonstrating a significant reduction in both inflammation and fibrosis. The larger dose of 100 μg/kg CM-ADSCs was found to be the most efficient in reducing these effects.
Article
Respiratory System
Donato Lacedonia, Giulia Scioscia, Piera Soccio, Massimo Conese, Lucia Catucci, Grazia P. Palladino, Filomena Simone, Carla M. I. Quarato, Sante Di Gioia, Roberto Rana, Francesco Sollitto, Maria P. Foschino-Barbaro
Summary: This study analyzed the expression of exosomal miRNAs in serum from IPF patients and found significant down-regulation of let-7d and unexpectedly, miR-16. A clustering of miR-16, miR-21, and miR-26a expression was also identified. These findings may help identify key players in the pathophysiology of IPF and potential targets for future medications.
BMC PULMONARY MEDICINE
(2021)
Article
Cell Biology
Ashesh Chakraborty, Michal Mastalerz, Meshal Ansari, Herbert B. Schiller, Claudia A. Staab-Weijnitz
Summary: This review investigates the alterations in airway epithelial cells in idiopathic pulmonary fibrosis (IPF) and highlights their significant role in disease development. The findings support further exploration of therapeutic strategies targeting these alterations, which represent important future research directions.
Review
Respiratory System
Julien Guiot, Monique Henket, Claire Remacle, Maureen Cambier, Ingrid Struman, Marie Winandy, Catherine Moermans, Edouard Louis, Michel Malaise, Clio Ribbens, Renaud Louis, Makon-Sebastien Njock
Summary: This study identified overlapping miRNAs in COVID-19 and IPF patients, which are associated with the progression of lung fibrosis. The study also reported elevated levels of pro-fibrotic miRNAs and imbalances in anti-fibrotic miRNAs in COVID-19 patients.
RESPIRATORY RESEARCH
(2023)
Article
Cell Biology
Mi Ho Jeong, Ha Ryong Kim, Yong Joo Park, Kyu Hyuck Chung, Hyung Sik Kim
Summary: This study reveals the impact of miRNAs from epithelium-derived EVs on lung fibrogenesis, specifically through the regulation of miR-451a in inducing EMT by targeting OSR1. The levels of miR-451a are found to be reduced in EVs from pulmonary fibrosis mice and lung tissues exposed to PHMG-p, leading to increased OSR1 expression. Transfected EVs with miR-451a show potential as a therapeutic target for maintaining pulmonary homeostasis disrupted by PHMG-p exposure.
CELL BIOLOGY AND TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xinxin Liang, Ziyan Yan, Ping Wang, Yuhao Liu, Xingkun Ao, Zheng Liu, Duo Wang, Xiaochang Liu, Maoxiang Zhu, Shanshan Gao, Dafei Xie, Pingkun Zhou, Yongqing Gu
Summary: The study investigated the regulatory role of miR-541-5p in radiation-induced EMT and RIPF repression by MZF1, suggesting that miR-541-5p suppressed EMT by targeting Slug and alleviated RIPF development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Rui Xia, Liqun Wang, Ting Zhou, Yiting Zeng, Xingjie Li, Shouxun Wu, Xiaoyi Huang, Yuhong Kang, Wenya Yin
Summary: This study evaluated the effect of pomegranate juice (POMJ) in ameliorating pulmonary fibrosis (PF) and explored the underlying mechanisms. It was found that POMJ improved lung injury by regulating the inflammatory response and the process of epithelial-mesenchymal transition (EMT), indicating its potential for treating pulmonary fibrosis.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Critical Care Medicine
Laurens J. De Sadeleer, Stijn E. Verleden, Jonas C. Schupp, John E. McDonough, Tinne Goos, Jonas Yserbyt, Elena Bargagli, Paola Rottoli, Naftali Kaminski, Antje Prasse, Wim A. Wuyts
Summary: Gene expression-based endotyping is feasible in IPF and can inform clinical evolution, opening up the possibility of personalized therapy.
Article
Multidisciplinary Sciences
Maor Sauler, John E. McDonough, Taylor S. Adams, Neeharika Kothapalli, Thomas Barnthaler, Rhiannon B. Werder, Jonas C. Schupp, Jessica Nouws, Matthew J. Robertson, Cristian Coarfa, Tao Yang, Maurizio Chioccioli, Norihito Omote, Carlos Cosme, Sergio Poli, Ehab A. Ayaub, Sarah G. Chu, Klaus H. Jensen, Jose L. Gomez, Clemente J. Britto, Micha Sam B. Raredon, Laura E. Niklason, Andrew A. Wilson, Pascal N. Timshel, Naftali Kaminski, Ivan O. Rosas
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide, but our understanding of cell-specific mechanisms underlying COPD pathobiology remains incomplete. In this study, the authors used single-cell RNA sequencing to analyze human lung tissue and identified transcriptional changes in alveolar niche cells associated with the disease.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Avraham Unterman, Tomokazu S. Sumida, Nima Nouri, Xiting Yan, Amy Y. Zhao, Victor Gasque, Jonas C. Schupp, Hiromitsu Asashima, Yunqing Liu, Carlos Cosme, Wenxuan Deng, Ming Chen, Micha Sam Brickman Raredon, Kenneth B. Hoehn, Guilin Wang, Zuoheng Wang, Giuseppe DeIuliis, Neal G. Ravindra, Ningshan Li, Christopher Castaldi, Patrick Wong, John Fournier, Santos Bermejo, Lokesh Sharma, Arnau Casanovas-Massana, Chantal B. F. Vogels, Anne L. Wyllie, Nathan D. Grubaugh, Anthony Melillo, Hailong Meng, Yan Stein, Maksym Minasyan, Subhasis Mohanty, William E. Ruff, Inessa Cohen, Khadir Raddassi, Laura E. Niklason, Albert Ko, Ruth R. Montgomery, Shelli F. Farhadian, Akiko Iwasaki, Albert C. Shaw, David van Dijk, Hongyu Zhao, Steven H. Kleinstein, David A. Hafler, Naftali Kaminski, Charles S. Dela Cruz
Summary: Using multi-omics single-cell analysis, this study reveals the immune abnormalities associated with progressive COVID-19, including S100A(hi)/HLA-DRlo classical monocytes and activated LAG-3(hi) T cells. It also finds a correlation between T cell receptor repertoire and B cell somatic hypermutation frequency with disease progression.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Christopher J. Brereton, Liudi Yao, Elizabeth R. Davies, Yilu Zhou, Milica Vukmirovic, Joseph A. Bell, Siyuan Wang, Robert A. Ridley, Lareb S. N. Dean, Orestis G. Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M. Ewing, Aiman Alzetani, Benjamin G. Marshall, Sophie Fletcher, Philipp J. Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J. Schofield, Matthew Loxham, Donna E. Davies, Yihua Wang, Mark G. Jones
Summary: This study provides evidence that the activation of the hypoxia-inducible factor (HIF) pathway is a critical regulator of pathogenetic collagen structure-function in fibrosis. Oxidative stress can drive the activation of pseudohypoxic HIF pathway, which alters collagen nanostructure and increases tissue stiffness.
Article
Physiology
Dinesh Babu Uthaya Kumar, Efthymios Motakis, Marina Yurieva, Vivek Kohar, Jan Martinek, Te-Chia Wu, Johad Khoury, Jessica Grassmann, Mingyang Lu, Karolina Palucka, Naftali Kaminski, Jonathan L. Koff, Adam Williams
Summary: This study identified a novel epithelial cell type called aberrant basaloid cells in fibrotic lung tissue. The role of epithelial-mesenchymal transition (EMT) in the development of these cells was investigated, and it was found that EMT induction led to transcriptional changes and a partial EMT gene signature in the cells. The study highlights the importance of using physiologically relevant models, such as air-liquid interface (ALI) cultures, to study aberrant basaloid-like cells and EMT mechanisms.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Immunology
Tomokazu S. Sumida, Shai Dulberg, Jonas Schupp, Matthew Lincoln, Helen A. Stillwell, Pierre-Paul Axisa, Michela Comi, Avraham Unterman, Naftali Kaminski, Asaf Madi, Vijay K. Kuchroo, David A. Hafler
Summary: This study demonstrates the regulation of coinhibitory receptor expression on human T cells by type 1 interferon (IFN-I) and reveals the dynamic regulatory networks involved. The key transcription factor SP140 is highlighted as one of the regulators that differentiate LAG-3 and TIGIT expression. The study also shows that the in vitro IFN-I response closely mirrors T cell features in acute SARS-CoV-2 infection.
Article
Respiratory System
Ming Chen, Yiliang Zhang, Taylor Adams, Dingjue Ji, Wei Jiang, Louise Wain, Michael Cho, Naftali Kaminski, Hongyu Zhao
Summary: Our study identified new genes associated with IPF susceptibility through integrative analysis, expanding the understanding of the complex genetic architecture and disease mechanism of IPF.
Article
Respiratory System
Rene Cortese, Taylor S. Adams, Kylie H. Cataldo, Justin Hummel, Naftali Kaminski, Leila Kheirandish-Gozal, David Gozal
Summary: Obstructive sleep apnoea (OSA) is a prevalent disease that affects neurocognitive, behavioural, metabolic, and cardiovascular function. This study used single-cell transcriptomics analysis to show the impact of OSA on the composition of immune cells in peripheral blood mononuclear cells (PBMCs), and identified severity-dependent differences in cell lineages. A molecular signature consisting of 32 genes was also identified, which could accurately distinguish OSA patients from controls.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Kensuke Kataoka, Osamu Nishiyama, Takashi Ogura, Yoshihiro Mori, Ryo Kozu, Shinichi Arizono, Tohru Tsuda, Hiromi Tomioka, Keisuke Tomii, Koji Sakamoto, Hiroshi Ishimoto, Michiko Kagajo, Hiroyuki Ito, Kazuya Ichikado, Hajime Sasano, Seiichirou Eda, Machiko Arita, Yasuhiro Goto, Osamu Hataji, Satoshi Fuke, Ryota Shintani, Hirotsugu Hasegawa, Masahiko Ando, Tomoya Ogawa, Masashi Shiraishi, Fumiko Watanabe, Koichi Nishimura, Takuma Sasaki, Shinjiro Miyazaki, Hideo Saka, Yasuhiro Kondoh
Summary: This open-label randomized controlled trial investigated the effects of long-term pulmonary rehabilitation on exercise tolerance in patients with IPF. The results showed that pulmonary rehabilitation significantly improved endurance time, but did not have a significant effect on 6-minute walking distance.
Article
Medicine, Research & Experimental
Bianca M. . Vamesu, Teodora Nicola, Rui Li, Snehashis Hazra, Sadis Matalon, Naftali Kaminski, Namasivayam Ambalavanan, Jegen Kandasamy
Summary: Mitochondrial dysfunction at birth is associated with the development of bronchopulmonary dysplasia (BPD) in extremely low-birth weight (ELBW) infants. Nebulized thyroid hormone (TH) has shown potential to improve mitochondrial function and reduce pulmonary fibrosis in adult animals. This study investigated the effects of intranasal T3 on neonatal lung injury and mitochondrial dysfunction in newborn mice, as well as its impact on lung fibroblasts and mesenchymal stem cells from ELBW infants. The results demonstrated that inhaled T3 attenuated hyperoxia-induced lung injury and improved mitochondrial function in mice, suggesting that TH supplementation might be a valuable therapeutic strategy for BPD.
Article
Cell & Tissue Engineering
Katherine L. Leiby, Yifan Yuan, Ronald Ng, Micha Sam Brickman Raredon, Taylor S. Adams, Pavlina Baevova, Allison M. Greaney, Karen K. Hirschi, Stuart G. Campbell, Naftali Kaminski, Erica L. Herzog, Laura E. Niklason
Summary: By modulating the components of the alveolar epithelial cell niche, researchers have successfully guided the regeneration of functional alveolar cells, potentially expanding treatment options for patients with end-stage lung disease.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Critical Care Medicine
John C. Huston, Naftali Kaminski
Summary: With digital technology, medical education has transitioned from chalk talks to digital formats, and now artificial intelligence-generated art is being introduced as a powerful tool. This tool can improve medical education in narrative medicine and educational imagery.
Editorial Material
Critical Care Medicine
Jonas C. Schupp, Naftali Kaminski
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Letter
Critical Care Medicine
Jonas C. Schupp, Edward P. Manning, Maurizio Chioccioli, Jan C. Kamp, Leonard Christian, Changwan Ryu, Erica Herzog, Mark P. Kuehnel, Antje Prasse, Naftali Kaminski, Danny D. Jonigk, Robert J. Homer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Alison G. Lee, Jason Maley, Kathryn Hibbert, Kathleen M. Akgun, Katrina E. Hauschildt, Anica Law, Naftali Kaminski, Margaret Hayes, Yaron Gesthalter, Gabriel T. Bosslet, Lekshmi Santhosh, Alison Witkin, Kelsey Hills-Dunlap, Basak Coruh, Hayley B. Gershengorn, C. Corey Hardin
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)