Review
Gastroenterology & Hepatology
Stephen J. Keely, Andreacarola Urso, Alexandr Ilyaskin, Christoph Korbmacher, Nigel W. Bunnett, Daniel P. Poole, Simona E. Carbone
Summary: Bile acids play important regulatory roles in intestinal motility and electrolyte transport. Advances in studying their receptors, transporters, and ion channels have provided new insights into the molecular mechanisms involved in these processes. Recognizing bile acids and their modulated ion channels as potential targets could lead to new approaches for treating gastrointestinal disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zhuo-Er Qiu, Jian-Bang Xu, Lei Chen, Ze-Xin Huang, Tian-Lun Lei, Zi-Yang Huang, Xiao-Chun Hou, Hai-Long Yang, Qin-Hua Lin, Yun-Xin Zhu, Lei Zhao, Wen-Liang Zhou, Yi-Lin Zhang
Summary: Allicin induces Cl- and fluid secretion across airway epithelium via activation of CFTR, which might provide therapeutic strategies for the treatment of chronic pulmonary diseases associated with ASL dehydration.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Ilaria Lenci, Martina Milana, Alessandro Signorello, Giuseppe Grassi, Leonardo Baiocchi
Summary: The biliary tract is no longer considered as a passive system. Recent research has demonstrated the important role of biliary epithelia in bile formation. Bile acids, the most abundant organic molecules in bile, were initially seen as natural detergents but are now recognized as important signaling molecules. This review focuses on the effects of different bile acids on the biliary epithelia, particularly secondary bile acids derived from bacterial manipulation. Understanding the interaction between bile acids and cholangiocytes may contribute to better treatments for cholestatic diseases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Respiratory System
Janne Goossens, Anne-Charlotte Jonckheere, Sven F. Seys, Ellen Dilissen, Tatjana Decaesteker, Camille Goossens, Koen Peers, Vincent Vanbelle, Jeroen Stappers, Sven Aertgeerts, Barbara De Wilde, Jasmine Leus, Sophie Verelst, Marc Raes, Lieven Dupont, Dominique M. Bullens
Summary: The study investigated the effects of intense exercise and air pollution exposure on the airway barrier and exercise-induced bronchoconstriction (EIB) in adolescent elite athletes. Results showed that athletes had increased markers of air pollution exposure, epithelial damage, and airway inflammation compared with controls. The incidence of EIB in athletes was also linked to prior exposure to PM10 and PM2.5.
Review
Gastroenterology & Hepatology
James Lorenzen Boyer, Carol Jean Soroka
Summary: Bile formation is a crucial physiological process for the survival of vertebrates, with its mechanisms gradually understood after World War II. From classic physiologic studies in animal models and humans to research in isolated cells and membrane vesicles, the identification of specific transport systems has been key to understanding this secretion. Progress in this field was reviewed in 2013, and this update provides further insights into advancements made since then.
JOURNAL OF HEPATOLOGY
(2021)
Article
Cell Biology
Xiaojiao Zheng, Tianlu Chen, Runqiu Jiang, Aihua Zhao, Qing Wu, Junliang Kuang, Dongnan Sun, Zhenxing Ren, Mengci Li, Mingliang Zhao, Shouli Wang, Yuqian Bao, Huating Li, Cheng Hu, Bing Dong, Defa Li, Jiayu Wu, Jialin Xia, Xuemei Wang, Ke Lan, Cynthia Rajani, Guoxiang Xie, Aiping Lu, Weiping Jia, Changtao Jiang, Wei Jia
Summary: This study reveals that high levels of hyocholic acid (HCA) in pigs contribute to their resistance against type 2 diabetes, as depletion of bile acids (BA) in pigs leads to reduced glucagon-like peptide-1 (GLP-1) secretion and increased blood glucose levels. HCA administration in diabetic mouse models effectively improves GLP-1 secretion and glucose homeostasis by activating TGR5 and inhibiting FXR in enteroendocrine cells, a mechanism not seen in other BA species. Clinical findings also show a correlation between lower levels of HCA species and diabetes, indicating its importance in glycemic control.
Article
Gastroenterology & Hepatology
Heidi L. Doden, Patricia G. Wolf, H. Rex Gaskins, Karthik Anantharaman, Joao M. P. Alves, Jason M. Ridlon
Summary: Intestinal microbiota can convert the orientation of bile acids, altering their water solubility and toxicity, while relevant genes have been identified and shown potential importance.
Article
Respiratory System
Elizabeth J. Becker, Alen Faiz, Maarten van den Berge, Wim Timens, Pieter S. Hiemstra, Kristopher Clark, Gang Liu, Xiaohui Xiao, Yuriy O. Alekseyev, George O'Connor, Stephen Lam, Avrum Spira, Marc E. Lenburg, Katrina Steiling
Summary: The study identified and replicated an airway gene expression signature associated with the rate of FEV1 decline in individuals with COPD. Genes that are elevated in individuals with a more rapid FEV1 decline are significantly enriched among the genes altered by modulation of XBP1 and are related to mucin production. These findings suggest that molecular processes related to the rate of FEV1 decline can be detected in the airway epithelium, potentially serving as an early indicator of rapid FEV1 decline in both smokers with and without COPD.
Article
Engineering, Environmental
Lan Yang, Yao Chen, Honglei Ji, Xi Zhang, Yan Zhou, Jianhui Li, Yan Wang, Zhenzhen Xie, Wei Yuan, Hong Liang, Maohua Miao
Summary: This study found associations between a mixture of per- and poly-fluoroalkyl substances (PFAS) and bile acid (BA) profiles in pregnant women, with certain BAs increased and specific BA ratios decreased. These findings provide insights into the potential biological pathways underlying the metabolic effects of PFAS exposure.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Shiqi Zhong, Raphael Chevre, David Castano Mayan, Maria Corliano, Blake J. Cochran, Kai Ping Sem, Theo H. van Dijk, Jianhe Peng, Liang Juin Tan, Siddesh V. Hartimath, Boominathan Ramasamy, Peter Cheng, Albert K. Groen, Folkert Kuipers, Julian L. Goggi, Chester Drum, Rob M. van Dam, Ru San Tan, Kerry-Anne Rye, Michael R. Hayden, Ching-Yu Cheng, Shaji Chacko, Jason Flannick, Xueling Sim, Hong Chang Tan, Roshni R. Singaraja
Summary: Reduced CYP8B1 activity is associated with increased insulin sensitivity in humans, possibly due to increased skeletal muscle insulin sensitivity caused by increased circulating CDCA.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Critical Care Medicine
Ryan C. Murphy, Ying Lai, Matthew Liu, Taha Al-Shaikhly, Matthew C. Altman, William A. Altemeier, Charles W. Frevert, Jason S. Debley, Adrian M. Piliponsky, Steven F. Ziegler, Sina A. Gharib, Teal S. Hallstrand
Summary: This study identified differentially expressed genes associated with exercise-induced bronchoconstriction in individuals with asthma using RNA-sequencing analysis. Experiments suggested that the interactions between airway epithelial cells, mast cells, and eosinophils are closely associated with indirect airway hyperresponsiveness and play a critical role in modulating airway inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemical Research Methods
Qiaoli Sun, Yingjue Tang, Liang Dai, Zhipeng Tang, Wenjun Zhou, Tao Wu, Guang Ji
Summary: This study investigated the levels of bile acid metabolites in patients with ulcerative colitis (UC) and the effects of mesalazine therapy. Compared to healthy controls, UC patients had lower levels of serum secondary bile acids (SBAs), which increased after mesalazine treatment. Specific bile acid biomarkers were identified for the diagnosis of UC and mesalazine responsiveness. The study suggests that measuring these biomarkers can be a useful approach for predicting the response to mesalazine therapy in UC patients.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Toxicology
Jingxuan Wang, Wouter Bakker, Weijia Zheng, Laura de Haan, Ivonne M. C. M. Rietjens, Hans Bouwmeester
Summary: This study found that deoxynivalenol (DON) inhibits the reabsorption of bile acids in the intestines by reducing the expression of bile acid transporters. This has an impact on the metabolism of bile acids in the intestines. The results of this study provide new insights into the hazards of DON exposure.
ARCHIVES OF TOXICOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jingwei Cai, Bipin Rimal, Changtao Jiang, John Y. L. Chiang, Andrew D. Patterson
Summary: The diversity, composition, and function of the bacterial community in the human gastrointestinal tract play a crucial role in host health. Bile acids, as potent metabolic and immune signaling molecules, have significant impacts on host metabolic and immunological functions. Manipulating the microbiota-bile acid-bile acid receptor axis has emerged as a novel therapeutic approach for human health.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Chemistry, Applied
Noora Makela, Natalia Rosa-Sibakov, Yu-Jie Wang, Outi Mattila, Emilia Nordlund, Tuula Sontag-Strohm
Summary: This study investigated the impact of 8-glucan on bile acid binding, showing that viscosity and 8-glucan concentration are key factors affecting bile acid mobility. The 8-glucan gel network can trap bile acids, while the hydrolysis of phytate can increase bile acid binding by improving 8-glucan extractability.
Letter
Respiratory System
Laura Gribaldo, Killian Hurley, Pieter Hiemstra, Catherine Greene
EUROPEAN RESPIRATORY JOURNAL
(2021)
Editorial Material
Biochemistry & Molecular Biology
Chiara De Santi, Catherine M. Greene
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Critical Care Medicine
Davies Adeloye, Omer Elneima, Luke Daines, Krisnah Poinasamy, Jennifer K. Quint, Samantha Walker, Chris E. Brightling, Salman Siddiqui, John R. Hurst, James D. Chalmers, Paul E. Pfeffer, Petr Novotny, Thomas M. Drake, Liam G. Heaney, Igor Rudan, Aziz Sheikh, Anthony De Soyza
Summary: An international consensus exercise was conducted to identify research priorities for understanding the long-term effects of acute COVID-19, focusing on individuals with pre-existing airways disease. High priority was given to investigations on prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge, as well as comparisons of prevalence and severity of post-COVID-19 symptoms between patients with and without pre-existing airways disease.
LANCET RESPIRATORY MEDICINE
(2021)
Editorial Material
Genetics & Heredity
Arlene M. A. Glasgow, Catherine M. Greene
Article
Public, Environmental & Occupational Health
Davies Adeloye, Dhiraj Agarwal, Peter J. Barnes, Marcel Bonay, Job F. van Boven, Jamie Bryant, Gaetano Caramori, David Dockrell, Anthony D'Urzo, Magnus Ekstrom, Gregory Erhabor, Cristobal Esteban, Catherine M. Greene, John Hurst, Sanjay Juvekar, Ee Ming Khoo, Fanny W. Ko, Brian Lipworth, Jose L. Lopez-Campos, Matthew Maddocks, David M. Mannino, Fernando J. Martinez, Miguel A. Martinez-Garcia, Renae J. McNamara, Marc Miravitlles, Hilary Pinnock, Alison Pooler, Jennifer K. Quint, Peter Schwarz, George M. Slavich, Peige Song, Andrew Tai, Henrik Watz, Jadwiga A. Wedzicha, Michelle C. Williams, Harry Campbell, Aziz Sheikh, Igor Rudan
Summary: The global prevalence of COPD has been increasing, emphasizing the need for defining research priorities in respiratory medicine. Through the CHNRI methodology, new effective strategies for smoking cessation and feasible pulmonary rehabilitation delivery were identified as key research priorities. Additional priorities include improved screening and accurate diagnosis methods for COPD in low-resource settings.
JOURNAL OF GLOBAL HEALTH
(2021)
Article
Genetics & Heredity
Paul J. McKiernan, Kevin P. Molloy, Arlene M. A. Glasgow, Noel G. McElvaney, Catherine M. Greene
Summary: The altered expression patterns of X-linked microRNAs in peripheral blood monocytes of cystic fibrosis patients may be correlated with exacerbation rate and lung function, particularly with miR-545-5p and miR-224-5p levels.
FRONTIERS IN GENETICS
(2021)
Review
Respiratory System
Arlene M. A. Glasgow, Catherine M. Greene
Summary: This review discusses how various host and microbial factors can contribute to airway epithelium dysfunction in the CF lung, focusing on mechanisms related to the mucociliary escalator and protease expression and function. It also explores how alterations in microRNA expression can impact the behavior of the airway epithelium.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria Abancens, Brian J. Harvey, Jean McBryan
Summary: Women have lower incidence and mortality rates for colorectal cancer compared to men. Estrogen may protect against colorectal cancer progression through GPER-mediated modulation of the Wnt/beta-catenin pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mari Ozaki, Arlene Glasgow, Irene K. Oglesby, Wan Lin Ng, Sile Kelly, Catherine M. Greene, Laura Durcan, Killian Hurley
Summary: Interstitial lung diseases (ILD) are heterogeneous progressive pulmonary disorders characterized by tissue remodeling and/or fibrotic scarring of the lung parenchyma. Men are more prone to idiopathic pulmonary fibrosis (IPF), while women are more affected by systemic or connective tissue diseases (CTD). The mechanisms underlying the sex differences in these diseases remain unclear, but environmental exposures, gene expression, and sex hormones may play a role. This article outlines the sex-related differences in incidence, progression, and mechanisms of ILD, and highlights the lack of consideration for gender differences in clinical models and underrepresentation of women in clinical trials.
Article
Biochemistry & Molecular Biology
Stephen G. J. Smith, Catherine M. Greene
Summary: This study investigates the expression of long non-coding RNAs (lncRNAs) in alpha-1 antitrypsin (AAT) deficiency and explores the effect of AAT augmentation therapy on the lncRNA expression profile in ZZ monocytes. Results show that AAT augmentation therapy alters the expression of numerous lncRNAs in ZZ monocytes, and many of these changes are consistent with the effects observed in ZZ monocytes treated ex vivo with AAT. These findings provide insights into the potential mechanisms underlying the diverse effects of AAT augmentation therapy.
Article
Biochemistry & Molecular Biology
Michio Yamashita, Junko Shibato, Randeep Rakwal, Naoko Nonaka, Takahiro Hirabayashi, Brian J. Harvey, Seiji Shioda, Fumiko Takenoya
Summary: Sweat plays a critical role in thermoregulation and skin health. Abnormalities in sweat secretion can lead to excessive sweating and anhidrosis. PACAP has been identified as a potential regulator of sweat secretion and translocation of AQP5 in sweat glands. Understanding the signaling mechanisms of PACAP can contribute to the development of new therapies for sweating disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Respiratory System
James D. Chalmers, Stuart Elborn, Catherine M. Greene
Summary: Bronchiectasis is a respiratory disease characterized by radiological abnormalities and a clinical syndrome of cough, sputum production, and recurrent respiratory infections. Inflammation, particularly neutrophilic inflammation, plays a central role in bronchiectasis pathophysiology. This article discusses the roles of infection, inflammation, and mucociliary clearance dysfunction in the development and progression of bronchiectasis. It also explores the concept of inflammatory endotypes and the potential of treating inflammation as a target. Current treatments for bronchiectasis focus on addressing underlying causes, improving mucociliary clearance, controlling infection, and managing complications. Additionally, the article discusses future therapies targeting host-mediated immune dysfunction.
EUROPEAN RESPIRATORY REVIEW
(2023)
Article
Biochemistry & Molecular Biology
Warren Thomas, Brian J. Harvey
Summary: The kidney is highly responsive to estrogen, and different estrogen receptors show sex-specific differences in expression along the nephron. The expression of these receptors also changes with the female estrous cycle. Estradiol can modify the salt and water conservation processes of the kidney through transporter regulation, supporting the fluid and electrolyte homeostasis changes required for mammalian reproduction.
Editorial Material
Genetics & Heredity
Catherine M. Greene
Meeting Abstract
Respiratory System
Irene Oglesby, Arlene Glasgow, Mari Ozaki, Catherine Greene, Killian Hurley
EUROPEAN RESPIRATORY JOURNAL
(2021)