Article
Cardiac & Cardiovascular Systems
Mo Zhang, Xiaolu Sun, Guixin Wu, Dong Wang, Limei Wang, Channa Zhang, Yubao Zou, Jizheng Wang, Lei Song
Summary: This study analyzed the role of cis-compound variants in a Chinese hypertrophic cardiomyopathy (HC) pedigree. The findings suggest that the cis-compound variants of Met822Thr and Arg1420Trp in the MYH7 gene are causal but relatively benign, variants associated with familial HC. Different types of compound variants might need to be analyzed for a genotype-phenotype study.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Food Science & Technology
Maria Lopez-Pedrouso, Jose M. Lorenzo, Leticia Perez-Ciria, Guillermo Ripoll, Maria Angeles Latorre, Daniel Franco
Summary: This study analyzed the protein differences between dry cured ham from immunecastrated pigs and entire females, as well as between immunecastrated pigs and surgically castrated males. The results showed differential abundance of proteins in the samples, with an increase of structural proteins in females and higher abundance of trypsinogen and proteosome subunit C9-like protein in immunocastrated males. MYH4 and ACT were found to be potential biomarkers in both immunecastrated males and females.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Anatomy & Morphology
Kathryn M. van Boom, Johan P. Schoeman, Johan C. A. Steyl, Tertius A. Kohn
Summary: This study analyzed muscle samples from 35 adult dogs and found differences in muscle composition and metabolism among different breeds, which may explain their susceptibility to diseases. The dog muscles displayed high oxidative capacity but had different metabolic flux through high energy phosphate and glycolytic pathways compared to humans. These differences may be attributed to genetics, function, or lifestyle. This study provides an important foundation for understanding disease susceptibility.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Geriatrics & Gerontology
David Martin, Kevin Nay, Francois Robin, Amelie Rebillard, Luz Orfila, Brice Martin, Patricia Leroyer, Pascal Guggenbuhl, Suzanne Dufresne, Philippe Noirez, Martine Ropert, Olivier Loreal, Frederic Derbre
Summary: This study investigates the impact of iron excess on skeletal muscle structure and metabolic adaptations. The results suggest that skeletal muscle can protect itself from the deleterious effects of iron overload under pathophysiological conditions.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Anthropology
Andrea B. Taylor, Megan A. Holmes
Summary: The study found that gorillas have a higher proportion of slow, fatigue-resistant fiber types in their chewing muscle tissue, which may be related to their more frequent feeding behavior. This discovery provides a clue to the relationship between behavioral flexibility and muscle fiber phenotype.
JOURNAL OF HUMAN EVOLUTION
(2021)
Article
Physiology
Caiyun Zeng, Hao Shi, Laila T. Kirkpatrick, Aymeric Ricome, Sungkwon Park, Jason M. Scheffler, Kevin M. Hannon, Alan L. Grant, David E. Gerrard
Summary: Postnatal muscle growth is influenced by the transition from slow to fast fiber types, and disruption of this transition compromises muscle growth in mice. Expression of Myh4 gene and corresponding fiber type IIB may be necessary for fiber maintenance, transition, and hypertrophy. Moreover, promoting oxidative metabolism partially compensates for the loss of fast-twitch fibers in mice lacking a functional Myh4 gene.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Anatomy & Morphology
Anton Ronnblom, Lars-Eric Thornell, Farhan Shah, Krister Tano, Per Stal
Summary: The function of the middle ear muscles in hearing and protection is still unclear. This study analyzed the morphology, fiber composition, and metabolic properties of these muscles, and found that they have a high proportion of fast contracting myosin fibers and unique muscle characteristics. The middle ear muscles differ from other muscles in terms of fiber size, capillarization, oxidative activity, and nerve density.
JOURNAL OF ANATOMY
(2023)
Article
Pharmacology & Pharmacy
Hiroyasu Sakai, Yuta Suzuki, Yu Miyauchi, Fumiaki Sato, Yusuke Ando, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei, Tomoo Hosoe
Summary: Cancer patients often experience muscle atrophy, which is worsened by the decreased muscle regenerative capacity. Cisplatin, a cancer chemotherapeutic agent, has been found to cause muscle atrophy. This study explored the effects of cisplatin on the differentiation of myoblasts into myotubes. The results showed that cisplatin suppresses myogenesis and inhibits the expression of Sparcl1, which promotes C2C12 cell differentiation during myogenesis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Dominika Krakova, Andrew M. Holwerda, Milan W. Betz, Kaleen M. Lavin, Marcas M. Bamman, Luc J. C. van Loon, Lex B. Verdijk, Tim Snijders
Summary: This study investigated the relationship between fiber type grouping and muscle mass and physical function. The results showed that there was no association between fiber type grouping and lower body strength or muscle mass in healthy, older men. Additionally, 12 weeks of resistance training resulted in specific hypertrophy of type II muscle fibers but did not affect fiber type grouping.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Nutrition & Dietetics
Hye-Jin Lee, Hui-Ji Choi, Sang-Ah Lee, Dong Hyuk Baek, Jong Beom Heo, Gyu Yong Song, Wonhwa Lee
Summary: Rare ginsenosides, specifically protopanaxatriol-type, can improve skeletal muscle atrophy by promoting myoblast differentiation and repair, and reducing the expression of muscle atrophy-related molecules.
Article
Biology
Katharina Hennig, David Hardman, David M. B. Barata, Ines I. B. B. Martins, Miguel O. Bernabeu, Edgar R. Gomes, William Roman
Summary: In this study, a quantitative contractility assay based on optogenetics and particle image velocimetry was designed to induce fiber specification in vitro. Long-term intermittent light-stimulation patterns were applied to cultured myotubes, resulting in enhanced contractile functionality and advanced maturation. This strategy can be used to study fiber specification and refine muscle disease modelling.
LIFE SCIENCE ALLIANCE
(2023)
Article
Biochemistry & Molecular Biology
Bo Song, Yating Cheng, Md. Abul Kalam Azad, Sujuan Ding, Kang Yao, Xiangfeng Kong
Summary: This study investigated the molecular basis for differences in meat yield and quality between Duroc, Taoyuan black (TB), and Xiangcun black (XB) pigs. The results show that TB pigs have higher fat percentage, intramuscular fat content, and antioxidant capacity, but lower carcass weight, lean percentage, pH decline, and glycolytic potential compared to Duroc pigs. Moreover, TB pigs have lower expression of protein synthesis and lipolysis genes in their muscles. Targeted metabolome analysis revealed significant differences in 24 metabolites among the three pig breeds. Correlation analysis suggests that l-malic acid and β-alanine contents in muscles are closely related to meat quality. These findings suggest that the excellent meat quality of TB pigs is attributed to muscle metabolism and fiber characteristics, while lower protein synthesis and lipolysis contribute to less meat yield.
Review
Biochemistry & Molecular Biology
Gabryela Kuhnen, Tiago Guedes Russomanno, Marta Murgia, Nicolas J. Pillon, Martin Schoenfelder, Henning Wackerhage
Summary: Adult skeletal muscle fibres can be classified into different types based on the expression of specific genes. The proportions of these muscle fibre types can be altered through gene gain or loss-of-function. In particular, transcriptional regulators play a significant role in regulating the expression of muscle fibre-specific genes. After exercise, the expression of certain genes increases or decreases, suggesting their involvement in muscle fibre adaptation. DNA sequence variants of muscle fibre genes may contribute to the variation in muscle fibre type proportions in the human population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Anushree Bharadwaj, Jaydeep Sharma, Jagriti Singh, Mahima Kumari, Tanushri Dargar, Bhargab Kalita, Sam J. Mathew
Summary: Mutations in MYH3 gene cause congenital contracture syndromes, particularly recessive MYH3 mutations lead to spondylocarpotarsal synostosis (SCTS) characterized by vertebral fusions and scoliosis. Knockout of Myh3 in mice showed SCTS phenotypes along with reduced body weight, muscle weight, myofiber size, grip strength, changes in muscle fiber type, altered satellite cell numbers, and increased muscle fibrosis. Activation of YAP signaling pathway was identified as a key contributor to the musculoskeletal defects in Myh3 knockout mice, and inhibiting YAP signaling can rescue these defects.
EMBO MOLECULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Mahdi Hesaraki, Ugur Bora, Sara Pahlavan, Najmeh Salehi, Seyed Ahmad Mousavi, Maryam Barekat, Seyed Javad Rasouli, Hossein Baharvand, Gunes Ozhan, Mehdi Totonchi
Summary: A novel genetic variant in the MYH7 gene may be responsible for the incidence of left ventricular non-compaction cardiomyopathy (LVNC) by causing defects in actin-myosin binding. Mouse and zebrafish models showed impaired cardiovascular development when this variant was present.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Allergy
A. Panariti, C. J. Baglole, V. Sanchez, D. H. Eidelman, S. Hussain, R. Olivenstein, J. G. Martin, Q. Hamid
CLINICAL AND EXPERIMENTAL ALLERGY
(2018)
Article
Allergy
Roma Sehmi, Hui Fang Lim, Manali Mukherjee, Chynna Huang, Katherine Radford, Paul Newbold, Louis-Philippe Boulet, Delbert Dorscheid, James G. Martin, Parameswaran Nair
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Oleg S. Matusovsky, Linda Kachmar, Gijs Ijpma, Alice Panariti, Andrea Benedetti, James G. Martin, Anne-Marie Lauzon
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Tomohiro Ichikawa, Alice Panariti, Severine Audusseau, Andrea Karen Mogas, Ronald Olivenstein, Jamila Chakir, Michel Laviolette, Zoulfia Allakhverdi, Saba Al Heialy, James G. Martin, Qutayba Hamid
RESPIRATORY MEDICINE
(2019)
Article
Physiology
Toby McGovern, Soroor Farahnak, Michael Chen, Kjell Larsson, James G. Martin, Mikael Adner
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Immunology
Soroor Farahnak, Leora Simon, Toby K. McGovern, Michael Chen, Niusha Khazaei, James G. Martin
JOURNAL OF IMMUNOLOGY
(2019)
Editorial Material
Allergy
I Ojanguren, S. Chaboillez, Y. Cloutier, A. Panariti, T. K. McGovern, J. G. Martin, C. Lemiere
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2019)
Article
Allergy
Benoit Allard, Alice Panariti, Erwan Pernet, Jeffrey Downey, Satoshi Ano, Marieme Dembele, Emily Nakada, Utako Fujii, Toby K. McGovern, William S. Powell, Maziar Divangahi, James G. Martin
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Letter
Allergy
Manali Mukherjee, Melanie Kjarsgaard, Katherine Radford, Chynna Huang, Richard Leigh, Delbert R. Dorscheid, Catherine Lemiere, Louis-Philippe Boulet, Susan Waserman, James Martin, Parameswaran Nair
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2019)
Article
Physiology
Joyce Hojin Jang, Alice Panariti, Michael J. O'Sullivan, Melissa Pyrch, Chris Wong, Anne-Marie Lauzon, James G. Martin
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Respiratory System
Manali Mukherjee, David Felipe Forero, Stephanie Tran, Marie-Eve Boulay, Mylene Bertrand, Anurag Bhalla, Jayant Cherukat, Hajar Al-Hayyan, Anmar Ayoub, Spencer D. Revill, Tanvi Javkar, Katherine Radford, Melanie Kjarsgaard, Chynna Huang, Anna Dvorkin-Gheva, Kjetil Ask, Ronald Olivenstein, Nandini Dendukuri, Catherine Lemiere, Louis-Philippe Boulet, James G. Martin, Parameswaran Nair
EUROPEAN RESPIRATORY JOURNAL
(2020)
Article
Biochemistry & Molecular Biology
Toby McGovern, Satoshi Ano, Soroor Farahnak, Sarah McCuaig, James G. Martin
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Allergy
Benjamin M. Smith, Nan Zhao, Ronald Olivenstein, Catherine Lemiere, Qutayba Hamid, James G. Martin
Summary: Long-term FAO in moderate-to-severe asthma is characterized by neutrophilic sputum inflammation and airway remodelling, but FEV(1) decline is similar to those without FAO. Long-term incident FAO is preceded by higher exacerbation frequency, higher sputum eosinophil content, and significant FEV(1) decline.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Review
Veterinary Sciences
Laurent Couetil, Jacqueline M. Cardwell, Renaud Leguillette, Melissa Mazan, Eric Richard, Dorothee Bienzle, Michela Bullone, Vinzenz Gerber, Kathleen Ivester, Jean-Pierre Lavoie, James Martin, Gabriel Moran, Artur Niedzwiedz, Nicola Pusterla, Cyprianna Swiderski
FRONTIERS IN VETERINARY SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Rui Sun, Joyce H. Jang, Anne-Marie Lauzon, James G. Martin
Summary: The study discovered that increased ASM mass in asthmatic airways is mainly attributable to hyperplasia. CD4+ T cells infiltrate asthmatic airways and induce ASMC proliferation via contact-dependent mechanisms. The CXCL10/11-CXCR3 axis enhances the recruitment of CD4+ T cells to ASM in asthmatic airways, amplified by T cell-derived IFN-gamma.