Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Chao Ye, Fen Zheng, Nan Wu, Guo-qing Zhu, Xiu-zhen Li
Summary: Vascular remodeling plays a crucial role in the development of various vascular diseases and is closely associated with the release of extracellular vesicles (EVs). EVs impact vascular remodeling by affecting oxidative stress, inflammation, calcification, and lipid plaque formation. Therefore, EVs have the potential to be used as biomarkers for diagnosis and prognosis, as well as therapeutic targets for vascular remodeling and cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Franziska Pankratz, Aziza Maksudova, Roman Goesele, Lena Meier, Kora Proelss, Katia Marenne, Ann-Kathrin Thut, Gerhard Sengle, Annkatrin Correns, Jeanina Begelspacher, Deniz Alkis, Patrick M. Siegel, Christian Smolka, Sebastian Grundmann, Martin Moser, Qian Zhou, Jennifer S. Esser
Summary: This study aims to investigate the role of BMP endothelial cell precursor-derived regulator (BMPER) in neointima formation. The expression of BMPER increased after vessel injury, but decreased in the tunica media. Silencing of BMPER enhanced the proliferation and migration capacity of vSMCs, while recombinant BMPER protein had the opposite effect. Mechanistically, BMPER modulated IGF signaling through binding to IGFBP4. Additionally, perivascular application of recombinant BMPER protein prevented neointima formation in mice after carotid ligation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zeyu Cai, Ze Gong, Zhiqing Li, Li Li, Wei Kong
Summary: The article summarizes the dynamic changes of ECM during hypertension and after treatment, as well as the unclear mechanism by which ECM remodeling initiates the development of hypertension. Further research on matridomic and degradomic approaches is needed for a more comprehensive understanding of ECM remodeling in hypertension.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Health Care Sciences & Services
Zhuangzhuang Jia, Shuai Wang, Haifeng Yan, Yawen Cao, Xuan Zhang, Lin Wang, Zeyu Zhang, Shanshan Lin, Xianliang Wang, Jingyuan Mao
Summary: Pulmonary vascular remodeling, involving changes in the intima, media and adventitia, is a critical structural alteration and pathological feature in pulmonary hypertension. It includes the proliferation and phenotypic transformation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs), as well as interactions with pulmonary artery fibroblasts (PAFs) and extracellular matrix (ECM). Inflammatory mechanisms, apoptosis, and other factors are influenced by different mechanisms that contribute to disease progression. This article reviews these pathological changes and discusses the underlying mechanisms in the remodeling process.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Engineering, Biomedical
Xuefeng Qiu, Benjamin Li-Ping Lee, Sze Yue Wong, Xili Ding, Kang Xu, Wen Zhao, Dong Wang, Ryan Sochol, Nianguo Dong, Song Li
Summary: Research found that fibrotic conduits as vascular grafts had low patency and many fibrotic cells in neointima. Decellularization and anti-thrombogenic coating of fibrotic conduits produced highly patent autografts, offering an effective approach for obtaining autografts for clinical therapy. Autografts recruited mostly anti-inflammatory macrophages for constructive remodeling, while allogenic DFCs had more T cells and pro inflammatory macrophages and lower patency.
Article
Engineering, Biomedical
Bingyang Lu, Xiao Han, Ansha Zhao, Dan Luo, Manfred F. Maitz, Haohao Wang, Ping Yang, Nan Huang
Summary: Coronary atherosclerosis lesions exhibit a low-pH chronic inflammatory response. A novel method using pH-responsive self-assembling films with hydrogen sulfide (H2S) releasing aspirin derivative ACS14 as drug has been developed to regulate drug release adjusted to the lesion's microenvironment, promoting self-healing capacity of blood vessels. Experimentation showed promising results for treating cardiovascular diseases.
BIOACTIVE MATERIALS
(2021)
Review
Cardiac & Cardiovascular Systems
Bryce R. Evans, Anais Yerly, Emiel P. C. van der Vorst, Iris Baumgartner, Sarah Maike Bernhard, Marc Schindewolf, Yvonne Doering
Summary: Atherosclerotic vascular disease is the most common cause of ischemia, myocardial infarction, and stroke. The structure and function of the arterial vessel wall, consisting of the adventitia, media, and intima, determine vascular function. Vascular smooth muscle cells and endothelial cells are key in shaping the vascular wall and maintaining proper function. Atherosclerosis, initiated by endothelial dysfunction, leads to pathological alterations known as vascular remodeling, ultimately causing insufficient vascular function and cardiovascular events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Stefano Masi, Samuele Ambrosini, Shafeeq A. Mohammed, Sebastiano Sciarretta, Thomas F. Luescher, Francesco Paneni, Sarah Costantino
Summary: The prevalence of obesity and cardiometabolic phenotypes is increasing globally, with epigenetic modifications emerging as a key regulator of gene transcription in vascular diseases. Deciphering the vascular epigenome is challenging but crucial for developing targeted therapies for obesity-related conditions.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Zakaria Mougin, Julia Huguet Herrero, Catherine Boileau, Carine Le Goff
Summary: Extracellular matrix (ECM) in the vascular wall is a dynamic structure composed of different molecules. Metalloproteases, including ADAMTS proteins, play a key role in maintaining ECM homeostasis. This review focuses on the potential role of ADAMTS proteins in the development of thoracic and abdominal aortic aneurysms, providing new insights on the involvement of the ADAMTS family in these pathologies.
Review
Biochemistry & Molecular Biology
Gang Wang, Yulin Luo, Xiaojun Gao, Yu Liang, Feifei Yang, Jianbo Wu, Dan Fang, Mao Luo
Summary: Alterations in the vascular smooth muscle cells (VSMC) phenotype, regulated by microRNAs (miRNAs), play a critical role in cardiovascular diseases. Aberrant miRNA expression targets specific genes involved in VSMC phenotypic transformation, affecting atherosclerosis, hypertension, and coronary artery disease. This review highlights the progress in understanding miRNAs' mechanisms and functions in VSMC phenotypic regulation, with potential implications for clinical diagnosis, prognosis, and therapeutic targets.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell Biology
Michael R. Williamson, Cathleen Joy A. Fuertes, Andrew K. Dunn, Michael R. Drew, Theresa A. Jones
Summary: This study demonstrates that reactive astrocytes play a crucial role in vascular repair and remodeling after ischemic stroke in mice, by activating transcriptional programs related to vascular remodeling. Ablation of reactive astrocytes significantly impairs vascular and extracellular matrix remodeling, leading to prolonged blood flow deficits, exacerbated vascular permeability, ongoing cell death, and worsened motor recovery. These findings highlight the critical role of reactive astrocytes as cellular mediators of vascular remodeling during neural repair.
Review
Immunology
Mireia Medrano-Bosch, Blanca Simon-Codina, Wladimiro Jimenez, Elazer R. Edelman, Pedro Melgar-Lesmes
Summary: Monocytes are circulating leukocytes that interact with endothelial cells to regulate inflammation, angiogenesis, and tissue remodeling under physiological and pathophysiological conditions. They transdifferentiate into macrophages and release various substances that induce vascular and tissue remodeling or propagate inflammatory responses. The interactions between infiltrating monocytes and endothelial cells contribute to pathophysiological conditions such as cardiovascular and chronic liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaqian Huang, Zongmin Li, Lulu Zhang, Huan Tang, Heng Zhang, Chu Wang, Selena Ying Chen, Dingfang Bu, Zaifeng Zhang, Zhigang Zhu, Piaoliu Yuan, Kun Li, Xiaoqi Yu, Wei Kong, Chaoshu Tang, Youngeun Jung, Renan B. Ferreira, Kate S. Carroll, Junbao Du, Jing Yang, Hongfang Jin
Summary: Recent researches have found that sulfur dioxide(SO2) may mediate the transformation of hydrogen peroxide(H2O2) into peroxymonosulfite, leading to the sulfenylation of protein cysteine residues. This sulfenylation has a dynamic impact on vascular smooth muscle cells, particularly affecting the transcriptional modulator Smad3 and its function in vascular remodeling and hypertension.
Article
Pharmacology & Pharmacy
Jingsi Zhang, Yuanshu Hui, Fengyi Liu, Qian Yang, Yi Lu, Yeting Chang, Qinlong Liu, Yanchun Ding
Summary: This study found that neohesperidin, as an antioxidant, can effectively inhibit hypertension and vascular remodeling induced by angiotensin II. The results of this study are of great significance for addressing global health problems.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jaco Selle, Katrin Bohl, Katja Hoepker, Rebecca Wilke, Katharina Dinger, Philipp Kasper, Bastian Abend, Bernhard Schermer, Roman-Ulrich Mueller, Christine Kurschat, Kai-Dietrich Nuesken, Eva Nuesken, David Meyer, Soni Savai Pullamsetti, Bjoern Schumacher, Joerg Doetsch, Miguel A. Alejandre Alcazar
Summary: Chronic Kidney Disease (CKD) is strongly associated with age-related renal function decline, hypertension, and diabetes, which are consequences of obesity. The mechanisms determining susceptibility to CKD remain insufficiently understood. Perinatal metabolic disorders after intrauterine growth restriction or maternal obesity adversely affect kidney structure and function. Perinatal obesity causes premature aging-associated processes that determine the susceptibility for CKD early in life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Marija Gredic, Vinita Sharma, Stefan Hadzic, Cheng-Yu Wu, Oleg Pak, Baktybek Kojonazarov, Julia Duerr, Marcus A. A. Mall, Andreas Guenther, Ralph T. T. Schermuly, Friedrich Grimminger, Werner Seeger, Simone Kraut, Natascha Sommer, Norbert Weissmann
Summary: This study aimed to investigate the effect of iNOS gene deletion on elastase-induced emphysema in mice. The results showed that iNOS gene deletion did not produce significant therapeutic effects on elastase-induced lung emphysema and pulmonary hypertension. Therefore, this study suggests that iNOS expression in pulmonary vascular or stromal cells might play a critical role in lung regeneration in emphysema.
Article
Respiratory System
Katharina Schaefer, Khodr Tello, Oleg Pak, Manuel Richter, Mareike Gierhardt, Grazyna Kwapiszewska, Christine Veith, Ludger Fink, Henning Gall, Matthias Hecker, Baktybek Kojonazarov, Simone Kraut, Kevin Lo, Jochen Wilhelm, Friedrich Grimminger, Werner Seeger, Ralph T. Schermuly, Hossein A. Ghofrani, Daniel Zahner, Rudiger Gerstberger, Norbert Weissmann, Akylbek Sydykov, Natascha Sommer
Summary: BDNF levels are decreased in patients with pulmonary hypertension and negatively correlated with right ventricular dilatation. However, decreased BDNF levels do not worsen RV dilatation in animal models.
Article
Urology & Nephrology
Esther N. M. de Rooij, Johan W. de Fijter, Saskia Le Cessie, Ewout J. Hoorn, Kitty J. Jager, Nicholas C. Chesnaye, Marie Evans, Karin Windahl, Fergus J. Caskey, Claudia Torino, Maciej Szymczak, Christiane Drechsler, Christoph Wanner, Friedo W. Dekker, Ellen K. Hoogeveen
Summary: This study found a U-shaped relationship between serum potassium and the risk of death or initiation of kidney replacement therapy in patients with stage 4-5 chronic kidney disease, with the lowest risk observed at a potassium level of approximately 4.9 mmol/L.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Critical Care Medicine
Cheng-Yu Wu, Anis Cilic, Oleg Pak, Ruth Charlotte Dartsch, Jochen Wilhelm, Magdalena Wujak, Kevin Lo, Monika Brosien, Ruoyu Zhang, Ibrahim Alkoudmani, Biruta Witte, Frauke Pedersen, Henrik Watz, Robert Voswinckel, Andreas G. Unther, Hossein A. Ghofrani, Ralf P. Brandes, Ralph T. Schermuly, Friedrich Grimminger, Werner Seeger, Natascha Sommer, Norbert Weissmann, Stefan Hadzic
Summary: CEACAM6 gene expression determines the susceptibility of some smokers to nitrosative/oxidative stress, thereby promoting the development and progression of COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Oncology
Xiang Zheng, Poonam Sarode, Andreas Weigert, Kati Turkowski, Prakash Chelladurai, Stefan Guenther, Carsten Kuenne, Hauke Winter, Albrecht Stenzinger, Simone Reu, Friedrich Grimminger, Thorsten Stiewe, Werner Seeger, Soni Savai Pullamsetti, Rajkumar Savai
Summary: Tumor-associated macrophages (TAMs), including antitumor M1-like TAMs and protumor M2-like TAMs, play diverse roles in lung cancer development. It has been found that the spatial proximity of HDAC2-overexpressing M2-like TAMs to tumor cells is significantly correlated with poor overall survival of lung cancer patients. Suppression of HDAC2 in TAMs alters macrophage phenotype, migration, and signaling pathways related to interleukins, chemokines, cytokines, and T-cell activation.
Article
Cardiac & Cardiovascular Systems
Sreenath Reddy Nayakanti, Aleksandra Friedrich, Poonam Sarode, Leili Jafari, Giovanni Maroli, Mario Boehm, Alice Bourgeois, Yann Grobs, Fatemeh Khassafi, Carsten Kuenne, Stefan Guenther, Swati Dabral, Jochen Wilhelm, Astrid Weiss, Astrid Wietelmann, Baktybek Kojonazarov, Wiebke Janssen, Mario Looso, Frances de Man, Steeve Provencher, Khodr Tello, Werner Seeger, Sebastien Bonnet, Rajkumar Savai, Ralph T. Schermuly, Soni Savai Pullamsetti
Summary: The ability of the right ventricle to adapt to an increased pressure afterload determines survival in patients with pulmonary arterial hypertension. The Wnt signaling pathway plays an important role in the development of the right ventricle and may also be implicated in adult cardiac remodeling.
CIRCULATION RESEARCH
(2023)
Editorial Material
Respiratory System
Elena A. Goncharova, Tatiana V. Kudryashova, Soni Savai Pullamsetti
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Oncology
Veronika Lutz, Veronique M. Hellmund, Felix S. R. Picard, Hartmann Raifer, Teresa Ruckenbrod, Matthias Klein, Tobias Bopp, Rajkumar Savai, Peter Duewell, Corinna U. Keber, Andreas Weigert, Ho-Ryun Chung, Malte Buchholz, Andre Menke, Thomas M. Gress, Magdalena Huber, Christian Bauer
Summary: Signaling through IL18R induces exhaustion of CD8(+) T cells, characterized by expression of coinhibitory receptors and loss of effector function. This exhaustion is mediated by an NLRP3-expressing tumor microenvironment that releases IL18. These findings suggest that NLRP3-mediated IL18R signaling could be a potential target for immunotherapy in pancreatic carcinoma.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Athiththan Yogeswaran, Manuel J. Richter, Faeq Husain-Syed, Zvonimir Rako, Natascha Sommer, Friedrich Grimminger, Werner Seeger, Hossein Ardeschir Ghofrani, Henning Gall, Khodr Tello
Summary: In patients with idiopathic pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension, estimated plasma volume status is associated with central venous congestion and prognosis. Patients with high estimated plasma volume status and without edema have a poorer transplant-free survival rate, which may represent an under-recognized subgroup.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Baktybek Kojonazarov, Norbert Weissmann, Werner Seeger, Ralph Theo Schermuly
CARDIOLOGY JOURNAL
(2023)
Article
Medicine, General & Internal
Dirk Bandorski, Khodr Tello, Harun Erdal, Janine Sommerlad, Jochen Wilhelm, Istvan Vadasz, Matthias Hecker, Dieter Walmrath, Werner Seeger, Ekaterina Krauss, Stefan Kuhnert
Summary: This study evaluates the diagnostic value of gastric biomarkers, such as pepsin and bile acid, in detecting aspiration in the intensive care unit (ICU). The results indicate that measuring pepsin and bile acid does not reliably diagnose aspiration or significantly impact survival outcomes. Further validation studies are needed to assess the clinical usefulness and reliability of these biomarkers in diagnosing aspiration-related conditions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Dharmesh V. Hirani, Florian Thielen, Siavash Mansouri, Soula Danopoulos, Christina Vohlen, Pinar Haznedar-Karakaya, Jasmine Mohr, Rebecca Wilke, Jaco Selle, Thomas Grosch, Ivana Mizik, Margarete Odenthal, Cristina M. Alvira, Celien Kuiper-Makris, Gloria S. Pryhuber, Christian Pallasch, S. van Koningsbruggen-Rietschel, Denise Al-Alam, Werner Seeger, Rajkumar Savai, Joerg Doetsch, Miguel A. Alejandre Alcazar
Summary: Through experimental and clinical studies, it has been discovered that macrophage-derived CXCL10 plays a crucial role in the pathogenesis of BPD by causing macrophage chemotaxis through CXCR3, leading to lung fibrosis and alveolarization arrest. Targeting the CXCL10-CXCR3 axis could offer a new therapeutic approach for BPD.
INFLAMMATION AND REGENERATION
(2023)
Article
Respiratory System
Athiththan Yogeswaran, Zvonimir A. Rako, Selin Yildiz, Hossein Ardeschir Ghofrani, Werner Seeger, Bruno Brito da Rocha, Henning Gall, Nils C. Kremer, Philipp Douschan, Silvia Papa, Carmine Dario Vizza, Domenico Filomena, Ryan J. Tedford, Robert Naeije, Manuel J. Richter, Roberto Badagliacca, Khodr Tello
Summary: Our study demonstrates the usefulness of echocardiography-derived S'/RAAi for noninvasive assessment of RV diastolic function and prognosis in PH.
Article
Biophysics
Milad Eyvazi Hesar, Niloofar Sadat Seyedsadrkhani, Dibyendu Khan, Adib Naghashian, Mateusz Piekarski, Henning Gall, Ralph Schermuly, Hossein Ardeschir Ghofrani, Sven Ingebrandt
Summary: This research presents a wearable epidermal electronic system for continuous monitoring of a prognostic parameter for hypertension. The system is flexible, wireless, and smartphone-enabled, allowing real-time monitoring of electrocardiograms and seismocardiograms. The system shows promising performance in predicting hypertension.
BIOSENSORS & BIOELECTRONICS
(2023)
