Article
Multidisciplinary Sciences
Lili Guo, Yinling Li, Shuang Wen, Wen Jun Liu, Lei Yang, Yu Wan, Jia Xin Liu, We e Zhao, Shu-Wei Li
Summary: Shikonin has protective effects on endothelial cells by resisting ER stress, inhibiting inflammation and apoptosis, and regulating JAK2/STAT3 pathways to inhibit stress. It also promotes the expression of VEGF proteins in vascular endothelial cells, accelerating wound healing.
Article
Biochemistry & Molecular Biology
Gokul Sudhakaran, Abhirami Chandran, A. R. Sreekutty, S. Madesh, Raman Pachaiappan, Bader O. Almutairi, Selvaraj Arokiyaraj, Zulhisyam Abdul Kari, Guillermo Tellez-Isaias, Ajay Guru, Jesu Arockiaraj
Summary: Diabetes Mellitus is a metabolic disease that causes microvascular complications, including Diabetic retinopathy (DR), which is a leading cause of blindness worldwide. Current medications for DR have drawbacks, and there is a need for alternative medications. Interventional approaches targeting vascular endothelial growth factor (VEGF) are being investigated for treating DR. This study explored the effects of the flavonoid naringenin (NG) from citrus fruits on inhibiting early DR in zebrafish. The results showed that NG reduced oxidative stress and cellular damage in zebrafish larvae exposed to high glucose, and it also inhibited macular degeneration and normalized VEGF overexpression in adult zebrafish. The intervention of NG shows promise in ophthalmic research for treating DR.
Article
Cell Biology
Priyanka Banerjee, Subhashree Kumaravel, Sukanya Roy, Niyanshi Gaddam, Johnny Odeh, Kayla J. Bayless, Shannon Glaser, Sanjukta Chakraborty
Summary: Conjugated bile acids (BA) are elevated in liver pathologies and metastatic lymph nodes. This study investigates the effects of BAs on lymphangiogenesis. The results indicate that BAs promote lymphatic network expansion and enhance LEC invasion, migration, and tube formation through ROS-mediated activation of p90RSK and upregulation of VEGFR3. Furthermore, BAs induce YAP expression, a regulator of lymphangiogenesis. Overall, this study establishes a novel mechanism by which BAs promote lymphangiogenesis.
Article
Multidisciplinary Sciences
Na Li, Xi-Liang Guo, Min Xu, Ji-Lin Chen, Yu-Fei Wang, Yu-Gao Xiao, An-Shun Gao, Lan-Chun Zhang, Xue-Zheng Liu, Ting-Hua Wang
Summary: This study investigated the effect of scutellarin (SCU) in diabetic retinopathy (DR) and explored the associated molecular network mechanism. An animal model of DR was established in diabetic rats, and cell pyroptosis was detected. Through bioinformatics and network pharmacology, the hub gene involving in pyroptosis in DR was screened and validated. SCU effectively protected against cell pyroptosis in DR, and the underlying mechanism involved the inhibition of specific genes.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Yingkai Li, Songyuan He, Cong Wang, Wen Jian, Xueqian Shen, Yuchen Shi, Jinghua Liu
Summary: Vascular calcification is common in clinical practice and is associated with adverse events. Oxidative stress plays a role in the formation of vascular calcification. Fibroblast growth factor 21 (FGF21) has been shown to inhibit vascular calcification by restoring the level of antioxidant SOD and reducing oxidative stress. This study provides further evidence for FGF21 as a potential drug for cardiovascular protection.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Evan Paul Tracy, William Hughes, Jason E. Beare, Gabrielle Rowe, Andreas Beyer, Amanda Jo LeBlanc
Summary: The vasculature responds to tissue respiratory needs by modulating luminal diameter, but age-related reduction in blood flow contributes to and exacerbates pathological processes. Current research focuses on mechanisms behind aging-mediated vascular dysfunction and therapeutic strategies to restore youthful vascular responsiveness, aiming at symptom management, tissue damage reversal, and prevention of aging-induced vascular damage and dysfunction. Antioxidative therapeutic strategies are being developed to restore mitochondrial redox homeostasis and subsequently vascular function.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
Article
Urology & Nephrology
Kristen L. Nowak, Heather Farmer-Bailey, Wei Wang, Zhiying You, Cortney Steele, Melissa A. Cadnapaphornchai, Jelena Klawitter, Nayana Patel, Diana George, Anna Jovanovich, Danielle E. Soranno, Berenice Gitomer, Michel Chonchol
Summary: The study showed that curcumin supplementation did not improve vascular function or slow kidney growth in children/young adults with ADPKD.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hiva Sharebiani, Shayan Keramat, Abdolali Chavoshan, Bahar Fazeli, Agata Stanek
Summary: Obesity is a global trend with a fast-growing incidence rate. The dysfunction of adipose tissue caused by obesity is associated with oxidative stress. Oxidative stress and inflammation caused by obesity play a crucial role in the development of vascular diseases, specifically vascular aging. This study aims to review the impact of antioxidants on obesity-induced vascular aging resulting from oxidative stress.
Review
Biochemistry & Molecular Biology
Yukihito Higashi
Summary: Oxidative stress and chronic inflammation play a crucial role in the development of atherosclerosis, as vascular endothelial dysfunction leads to its progression and forms a vicious cycle with oxidative stress and inflammation.
Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Review
Biochemistry & Molecular Biology
Hollie Speer, Andrew J. McKune
Summary: Hypertension is a major risk factor for cardiovascular diseases, and studying the factors involved in its progression is crucial for healthy aging. Aging is associated with a loss of skeletal muscle quantity and quality, as well as an increase in Reactive Oxygen and Nitrogen Species, which may accelerate the aging process.
Article
Genetics & Heredity
Di Ye, Yongqi Feng, Heng Pan, Xiyi Lu, Zhen Wang, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wan
Summary: Previous studies have shown the importance of bone morphogenetic proteins (BMPs) in cardiovascular diseases. In this study, the role of Kielin/chordin-like protein (KCP) in cardiac aging was investigated. The results demonstrated that KCP knockout aggravated cardiac aging by increasing oxidative stress, inflammation, and cardiomyocyte apoptosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Multidisciplinary Sciences
Solmaz Dini, Mansoureh Zakeri, Shiva Ebrahimpour, Fariba Dehghanian, Abolghasem Esmaeili
Summary: The study demonstrates that QCSPION can regulate the expression of miR-29 family, leading to increased expression of glucose transporters and IGF-1, ultimately reducing diabetic complications.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Boying Zhao, Jiang Yu, Yuan Luo, Ming Xie, Can Qu, Qiong Shi, Xiaowen Wang, Xingji Zhao, Lingwen Kong, Yu Zhao, Yongzheng Guo
Summary: S100A9 plays a crucial role in the inflammatory response and contributes to aging-related pathologies and endothelial dysfunction. The deficiency of S100A9 alleviates vascular senescence, improves insulin resistance, reduces oxidative stress and inflammation in aged mice. The study suggests that targeting the S100A9/TLR4 signaling pathway may be a potential therapeutic strategy to prevent age-related cardiovascular diseases.
Article
Pharmacology & Pharmacy
Takashi Nose, Miwa Kondo, Masashi Shimizu, Hiroki Hamura, Yusuke Yamaguchi, Takako Sekine, Kouki Ishitani
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2016)