Cardiac-specific suppression of NF-κB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system

Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways

(2014) Karina Huynh et al.   PHARMACOLOGY & THERAPEUTICS

Cardiomyocyte-specific p65 NF-κB deletion protects the injured heart by preservation of calcium handling

(2013) Xiu Q. Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors

(2013) Qian Yong et al.   Cardiovascular Diabetology

Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Mediates Myocardial Ischemia/Reperfusion Injury Through Nuclear Factor-κB

(2013) Haiyun Ling et al.   CIRCULATION RESEARCH

Mechanisms of Altered Ca 2+ Handling in Heart Failure

(2013) Min Luo et al.   CIRCULATION RESEARCH

Multiple Antioxidants Improve Cardiac Complications and Inhibit Cardiac Cell Death in Streptozotocin-Induced Diabetic Rats

(2013) Santosh Kumar et al.   PLoS One

Cardiac-specific genetic inhibition of nuclear factor-κB prevents right ventricular hypertrophy induced by monocrotaline

(2012) Sandeep Kumar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor

(2012) Candice M. Thomas et al.   CLINICAL SCIENCE

Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress, Inflammation, and Fibrosis in Diabetic Cardiomyopathy

(2012) M. Rajesh et al.   DIABETES

Cardiomyocyte-specific I B kinase (IKK)/NF- B activation induces reversible inflammatory cardiomyopathy and heart failure

(2012) H. J. Maier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-κB activation in organs from STZ-treated rats

(2011) Marius Locke et al.   Applied Physiology Nutrition and Metabolism

Gain of function of cardiac ryanodine receptor in a rat model of type 1 diabetes

(2011) Chengju Tian et al.   CARDIOVASCULAR RESEARCH

Multiple Facets of NF-κB in the Heart

(2011) Joseph W. Gordon et al.   CIRCULATION RESEARCH

The effects of resveratrol on cyclooxygenase-1 and -2, nuclear factor kappa beta, matrix metalloproteinase-9, and sirtuin 1 mRNA expression in hearts of streptozotocin-induced diabetic rats

(2011) A.S. Yar et al.   GENETICS AND MOLECULAR RESEARCH

IκBβ Attenuates Angiotensin II–Induced Cardiovascular Inflammation and Fibrosis in Mice

(2011) Shanqin Xu et al.   HYPERTENSION

Contribution of a Nuclear Factor-κB Binding Site to Human Angiotensinogen Promoter Activity in Renal Proximal Tubular Cells

(2011) Omar W. Acres et al.   HYPERTENSION

Identification of a NF-κB cardioprotective gene program: NF-κB regulation of Hsp70.1 contributes to cardioprotection after permanent coronary occlusion

(2011) Michael E. Wilhide et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Potential Role of Nuclear FactorκB in Diabetic Cardiomyopathy

(2011) O. Lorenzo et al.   MEDIATORS OF INFLAMMATION

Tumor necrosis factor-α suppresses angiotensinogen expression through formation of a p50/p50 homodimer in human renal proximal tubular cells

(2010) Ryousuke Satou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Oxidative stress: a key contributor to diabetic cardiomyopathyThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Madhu Khullar et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

NEMO Nuances NF-κB

(2010) Andriy Nemchenko et al.   CIRCULATION RESEARCH

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Pleiotropic Effects of Inhibitors of the RAAS in the Diabetic Population: Above and Beyond Blood Pressure Lowering

(2010) Haisam Ismail et al.   Current Diabetes Reports

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy

(2010) Mohanraj Rajesh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dichotomous Actions of NF-κB Signaling Pathways in Heart

(2010) Rimpy Dhingra et al.   Journal of Cardiovascular Translational Research

Myocardial fibrosis and apoptosis, but not inflammation, are present in long-term experimental diabetes

(2009) S. Ares-Carrasco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NF-κB-induced oxidative stress contributes to mitochondrial and cardiac dysfunction in type II diabetes

(2009) Nithya Mariappan et al.   CARDIOVASCULAR RESEARCH

Antioxidant Amelioration of Dilated Cardiomyopathy Caused by Conditional Deletion of NEMO/IKKγ in Cardiomyocytes

(2009) P. Kratsios et al.   CIRCULATION RESEARCH

Gene Remodeling in Type 2 Diabetic Cardiomyopathy and Its Phenotypic Rescue with SERCA2a

(2009) Ioannis Karakikes et al.   PLoS One

Conditional increase in SERCA2a protein is able to reverse contractile dysfunction and abnormal calcium flux in established diabetic cardiomyopathy

(2008) Jorge Suarez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Intracellular Angiotensin II Production in Diabetic Rats Is Correlated With Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis

(2008) V. P. Singh et al.   DIABETES

Blockade of NF-κB Using IκBα Dominant-Negative Mice Ameliorates Cardiac Hypertrophy in Myotrophin-Overexpressed Transgenic Mice

(2008) David Young et al.   JOURNAL OF MOLECULAR BIOLOGY