Article
Nutrition & Dietetics
Xiangyu Zheng, Zhuoxin Li, Jennifer Berg Sen, Luaye Samarah, Christina S. S. Deacon, Joseph Bernardo, Daniel R. R. Machin
Summary: The Western diet (WD) is linked to obesity and dysfunctional metabolism and arteries in humans. However, these effects are not consistently observed in genetically identical mice. Therefore, researchers studied the effects of WD on a genetically diverse strain of mice. Results showed that WD led to increased body weight and visceral adiposity, as well as lower metabolic function. Arterial dysfunction was also observed, indicating that this mouse model may provide insights into sex-related observations in humans consuming WD.
FRONTIERS IN NUTRITION
(2023)
Article
Peripheral Vascular Disease
Alexander C. Egbe, William R. Miranda, Carole A. Warnes, Crystal Bonnichsen, Juan Crestanello, Jason H. Anderson, Heidi M. Connolly
Summary: The study aimed to analyze procedural outcomes, hemodynamic improvement, regression of left ventricular mass hypertrophy, and cardiovascular events following repair of coarctation of aorta (COA). Results indicated that persistent hypertension post-repair was associated with suboptimal left ventricular mass index regression and cardiovascular events, suggesting that optimal blood pressure control with medical therapy may lead to improved outcomes.
Article
Peripheral Vascular Disease
Gilad Hamdani, Mark M. Mitsnefes, Joseph T. Flynn, Richard C. Becker, Stephen Daniels, Bonita E. Falkner, Michael Ferguson, Stephen R. Hooper, Coral D. Hanevold, Julie R. Ingelfinger, Marc Lande, Lisa J. Martin, Kevin E. Meyers, Bernard Rosner, Joshua Samuels, Elaine M. Urbina
Summary: Adult and pediatric standards differ in predicting LVH, with adult cut points being more sensitive. Pediatric standards are usually based on sex and height, while adult cut points are more effective.
Article
Physiology
Sho Okamura, Akinori Sairaku, Takehito Tokuyama, Yosaku Okubo, Yoshihiro Ikeuchi, Shunsuke Miyauchi, Yukihito Higashi, Yukiko Nakano
Summary: During the active standing test, changes in the Peripheral Arterial Tone (PAT) and low frequency to high frequency ratio (LF/HF) were observed, indicating that sympathetic nervous system activity and heart rate variability respond differently to orthostasis.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Mark M. Mitsnefes, Yunwen Xu, Derek K. Ng, Garick Hill, Thomas Kimball, Susan L. Furth, Bradley A. Warady
Summary: Diastolic dysfunction is an early cardiac abnormality in patients with chronic kidney disease, with E/e' ratio being a marker to assess it. Abnormal E/e' ratio is associated with younger age, lower glomerular filtration rate, lower hemoglobin, hypertension, left ventricular hypertrophy, and sustained hypertension. Ambulatory blood pressure may better identify chronic kidney disease in children at risk for subclinical cardiac dysfunction compared to casual blood pressure.
Article
Multidisciplinary Sciences
Rainer U. Pliquett, Ralf P. Brandes
Summary: In this study, the physiological mechanisms underlying the increase in blood pressure following partial kidney removal were investigated. The results showed that partial kidney removal was associated with reduced parasympathetic modulation of sinus node function, and the combination of taurine deficiency and high salt intake further led to arterial hypertension.
Article
Geriatrics & Gerontology
Avneet Oberoi, Caroline Giezenaar, Kylie Lange, Karen L. Jones, Michael Horowitz, Ian Chapman, Stijn Soenen
Summary: This study aimed to determine the effects of whey-protein, alone and mixed with other macronutrients, on blood pressure and heart rate in older men. The results showed that whey-protein drinks can significantly lower blood pressure and increase heart rate, and these effects are primarily dependent on the energy content rather than the macronutrient composition. These effects can persist for at least 3 hours after ingestion.
Review
Nutrition & Dietetics
Antonio Vacca, Luca Bulfone, Sebastiano Cicco, Gabriele Brosolo, Andrea Da Porto, Giorgio Soardo, Cristiana Catena, Leonardo A. A. Sechi
Summary: Alcoholic beverages are common in diets worldwide, and understanding their effects on human health is crucial. Studies have investigated the relationship between alcohol consumption and blood pressure, and have found that high doses of alcohol have a biphasic blood pressure response and sustained alcohol consumption can significantly increase the risk of hypertension. These effects on blood pressure may be mediated by multiple neurohormonal mechanisms.
Article
Peripheral Vascular Disease
Enrique Rodilla, Maria Dolores Lopez-Carmona, Xavi Cortes, Lidia Cobos-Palacios, Sergio Canales, Maria Carmen Saez, Samara Campos Escudero, Manuel Rubio-Rivas, Jesus Diez Manglano, Santiago J. Freire Castro, Nuria Vazquez Piqueras, Elisabeth Mateo Sanchis, Paula Maria Pesqueira Fontan, Jeffrey Oskar Magallanes Gamboa, Andres Gonzalez Garcia, Victor Madrid Romero, Lara Tamargo Chamorro, Julio Gonzalez Moraleja, Javier Villanueva Martinez, Amara Gonzalez Noya, Ana Suarez-Lombrana, Anyuli Gracia Gutierrez, Manuel Lorenzo Lopez Reboiro, Jose Manuel Ramos Rincon, Ricardo Gomez Huelgas
Summary: This study analyzed the association between arterial stiffness (AS) and all-cause mortality in COVID-19 patients, finding that AS and systolic blood pressure <120 mm Hg independently predicted in-hospital all-cause mortality after adjusting for other factors.
Article
Neurosciences
Shoou-Jeng Yeh, Chi-Wen Lung, Yih-Kuen Jan, Ben-Yi Liau
Summary: Diabetes is a chronic disease that causes damage to various organs in the body. This study proposes a new method to detect autonomic neuropathy in diabetes patients by analyzing the changes in blood pressure and heart rate. The results show that this method can differentiate between different types of diabetes and uncover hidden changes in blood pressure control.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Domenico Di Raimondo, Gaia Musiari, Alessandra Casuccio, Daniela Colomba, Giuliana Rizzo, Edoardo Pirera, Antonio Pinto, Antonino Tuttolomondo
Summary: Several studies indicate that the degree of nocturnal blood pressure reduction is related to organ damage and prognosis in hypertensive patients, with extreme dippers potentially having the lowest 24-hour pressure load and less cardiac remodeling.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Otorhinolaryngology
Fuat Bulut, Erdem Soztutar
Summary: The study compared autonomic reflexes caused by inferior turbinate outfracture and bipolar cauterization for inferior turbinate reduction surgery, finding that bipolar cauterization did not cause significant changes in heart rate and blood pressure, while inferior turbinate outfracture procedure led to significant increases in heart rate and blood pressure.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Henner Hanssen
Summary: This editorial discusses a systematic review of international guidelines on the non-pharmacological factors for hypertension management.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Urology & Nephrology
Christian Ott, Roland E. Schmieder
Summary: In the past 4 years, guidelines for the management of arterial hypertension have been published with mostly concordant recommendations but some discordant opinions. Accurate blood pressure measurement is crucial for diagnosis, and out-of-office measurements are also important. Simplified antihypertensive drug treatment and personalized goals are emphasized. Renal denervation is supported for uncontrolled and treatment-resistant hypertension.
KIDNEY INTERNATIONAL
(2022)
Article
Psychology, Biological
Mark R. Scudder, J. Richard Jennings, Caitlin M. DuPont, Kimberly G. Lockwood, Shrenik H. Gadagkar, Belen Best, Swetha P. Jasti, Peter J. Gianaros
Summary: Impedance cardiography is an inexpensive and reliable method for measuring pulse wave velocity, showing high test-retest reliability and associations with cardiovascular disease risk factors.
Article
Cardiac & Cardiovascular Systems
Rebecca H. Ritchie, E. Dale Abel
CIRCULATION RESEARCH
(2020)
Article
Endocrinology & Metabolism
Adam R. Wende, John C. Schell, Chae-Myeong Ha, Mark E. Pepin, Oleh Khalimonchuk, Hansjoerg Schwertz, Renata O. Pereira, Manoja K. Brahma, Joseph Tuinei, Ariel Contreras-Ferrat, Li Wang, Chase A. Andrizzi, Curtis D. Olsen, Wayne E. Bradley, Louis J. Dell'Italia, Wolfgang H. Dillmann, Sheldon E. Litwin, E. Dale Abel
Article
Cardiac & Cardiovascular Systems
Jessica M. Ponce, Grace Coen, Kathryn M. Spitler, Nikola Dragisic, Ines Martins, Antentor Hinton, Margaret Mungai, Satya Murthy Tadinada, Hao Zhang, Gavin Y. Oudit, Long-Sheng Song, Na Li, Peter Sicinski, Stefan Strack, E. Dale Abel, Colleen Mitchell, Duane D. Hall, Chad E. Grueter
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Biochemistry & Molecular Biology
Boer Li, Wen-Chih Lee, Chao Song, Ling Ye, E. Dale Abel, Fanxin Long
Article
Biology
Caroline Contat, Pierre-Benoit Ancey, Nadine Zangger, Silvia Sabatino, Justine Pascual, Stephane Escrig, Louise Jensen, Christine Goepfert, Bernard Lanz, Mario Lepore, Rolf Gruetter, Anouk Rossier, Sabina Berezowska, Christina Neppl, Inti Zlobec, Stephanie Clerc-Rosset, Graham William Knott, Jeffrey C. Rathmell, E. Dale Abel, Anders Meibom, Etienne Meylan
Article
Cardiac & Cardiovascular Systems
Manoja K. Brahma, Chae-Myeong Ha, Mark E. Pepin, Sobuj Mia, Zhihuan Sun, John C. Chatham, Kirk M. Habegger, Evan Dale Abel, Andrew J. Paterson, Martin E. Young, Adam R. Wende
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Editorial Material
Medicine, Research & Experimental
E. Dale Abel
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Maoxue Tang, Sarah H. Park, Sabrina Petri, Hang Yu, Carlos B. Rueda, E. Dale Abel, Carla Y. Kim, Elizabeth M. C. Hillman, Fanghua Li, Yeojin Lee, Lei Ding, Smitha Jagadish, Wayne N. Frankel, Darryl C. De Vivo, Umrao R. Monani
Summary: Glut1 plays a crucial role in brain angiogenesis through its cell-autonomous function in brain microvascular endothelial cells. Depletion of Glut1 leads to neuroinflammation, reduced BDNF levels, and disease manifestation, with the most severe effects observed when Glut1 scarcity is induced during neonatal brain angiogenesis. Targeting brain endothelial cells during early development is essential for maintaining proper brain angiogenesis and preventing neuroinflammation in Glut1 deficiency syndrome.
Article
Cardiac & Cardiovascular Systems
Kate L. Weeks, Yow Keat Tham, Suzan G. Yildiz, Yonali Alexander, Daniel G. Donner, Helen Kiriazis, Claudia A. Harmawan, Amy Hsu, Bianca C. Bernardo, Aya Matsumoto, Ronald A. DePinho, E. Dale Abel, Elizabeth A. Woodcock, Julie R. McMullen
Summary: This study found that the transcription factor FoxO1 is a critical mediator of exercise-induced cardiac hypertrophy, which has important implications when considering FoxO1 as a target for treating the diseased heart. Given that exercise-induced hypertrophy is protective, this finding is significant in the context of treating heart disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Oncology
Pierre-Benoit Ancey, Caroline Contat, Gael Boivin, Silvia Sabatino, Justine Pascual, Nadine Zangger, Jean Yannis Perentes, Solange Peters, E. Dale Abel, David G. Kirsch, Jeffrey C. Rathmell, Marie-Catherine Vozenin, Etienne Meylan
Summary: The study highlights the importance of GLUT1 in tumor-associated neutrophils (TAN) within lung tumors, with increased glucose uptake mediated by GLUT1 impacting tumor growth and radiotherapy resistance. Targeting metabolic vulnerabilities to support anti-tumor neutrophils may be a promising strategy for cancer treatment.
Review
Endocrinology & Metabolism
E. Dale Abel
Summary: Insulin receptors play a critical role in regulating cardiac growth, survival, substrate uptake, and mitochondrial metabolism. Altered insulin signaling in the heart can contribute to ventricular remodeling and heart failure progression. Understanding the role of insulin signaling in cardiac physiology and pathology may have therapeutic implications for conditions like obesity and diabetes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Satya Murthy Tadinada, Eric T. Weatherford, Greg Collins, Gourav Bhardwaj, Jesse Cochran, William Kutschke, Kathy Zimmerman, Alyssa Bosko, Brian T. O'Neill, Robert M. Weiss, E. Dale Abel
Summary: The study found that despite inducing cardiac hypertrophy and increasing cardiac fatty acid metabolism, long-term fat feeding in mice may not be enough to activate pathological hypertrophic mechanisms that impair cardiac function or induce cardiac fibrosis. Additionally, unknown factors may contribute to the cardiac abnormalities reported by many research groups.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jinxi Wang, Grace Ciampa, Dong Zheng, Qian Shi, Biyi Chen, E. Dale Abel, Tianqing Peng, Duane D. Hall, Long-Sheng Song
Summary: Calpain proteolysis, particularly by the isoforms CAPN1 and CAPN2, contributes to heart failure pathogenesis through cleavage of JP2. While both isoforms are induced by pressure overload stress, CAPN1 shows higher calcium sensitivity and cleavage efficacy compared to CAPN2, suggesting potential targeted therapy for heart failure by specific inhibition of CAPN1.
BIOCHEMICAL JOURNAL
(2021)
Article
Cell Biology
Jacob Lam, Prasanna Katti, Michelle Biete, Margaret Mungai, Salma AshShareef, Kit Neikirk, Edgar Garza Lopez, Zer Vue, Trace A. Christensen, Heather K. Beasley, Taylor A. Rodman, Sandra A. Murray, Jeffrey L. Salisbury, Brian Glancy, Jianqiang Shao, Renata O. Pereira, E. Dale Abel, Antentor Hinton
Summary: Transmission electron microscopy (TEM) provides high-resolution details of subcellular components within cells and tissues; Mitochondria and endoplasmic reticulum (ER) are of particular interest to researchers of metabolic disorders; Using open source software ImageJ allows accurate assessment of the morphology of these important subcellular structures.
Article
Biochemistry & Molecular Biology
Shawna L. L. McMillin, Parker L. L. Evans, William M. M. Taylor, Luke A. A. Weyrauch, Tyler J. J. Sermersheim, Steven S. S. Welc, Monique R. R. Heitmeier, Richard C. C. Hresko, Paul W. W. Hruz, Francoise Koumanov, Geoffrey D. D. Holman, E. Dale Abel, Carol A. A. Witczak
Summary: The study found that GLUT1 does not mediate basal muscle glucose uptake and suggests the existence of a novel glucose transport mechanism for overload-stimulated glucose uptake.