Article
Cardiac & Cardiovascular Systems
Kyle L. Fulghum, Juliette B. Smith, Julia Chariker, Lauren F. Garrett, Kenneth R. Brittian, Pawel K. Lorkiewicz, Lindsey A. McNally, Shizuka Uchida, Steven P. Jones, Bradford G. Hill, Helen E. Collins
Summary: The goal of this study was to develop an atlas of the metabolic, transcriptional, and proteomic changes in the maternal heart during and after pregnancy. The results showed significant increases in heart size, cardiac hypertrophy, and myocyte cross-sectional area during pregnancy and post-birth, accompanied by changes in metabolites, gene expression, and protein levels. These findings provide important insights into the coordinated molecular changes that occur in the maternal heart during and after pregnancy.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biology
Karthickeyan Chella Krishnan, Elie-Julien El Hachem, Mark Keller, Sanjeet G. Patel, Luke Carroll, Alexis Diaz Vegas, Isabela Gerdes Gyuricza, Christine Light, Yang Cao, Calvin Pan, Karolina Elzbieta Kaczor-Urbanowicz, Varun Shravah, Diana Anum, Matteo Pellegrini, Chi Fung Lee, Marcus M. Seldin, Nadia A. Rosenthal, Gary A. Churchill, Alan Attie, Benjamin Parker, David E. James, Aldons J. Lusis
Summary: Mitochondrial variations can affect tissue-specific mitochondrial functions and contribute to heart hypertrophy. Common genetic variations in mitochondrial proteins were found to regulate cardiac functions in inbred mouse strains.
Article
Developmental Biology
Pavel Tsaytler, Jinhua Liu, Gaby Blaess, Dennis Schifferl, Jesse. Veenvliet, Lars Wittler, Bernd Timmermann, Bernhard G. Herrmann, Frederic Koch
Summary: Cardiac lineage specification in the mouse is controlled by TGFO and WNT signaling. BMP is crucial for heart induction and Bmp4 plays a vital role in cardiac mesoderm formation. Bmp4 activates Wnt3, upregulates Nodal, and works with pSmad1/5, Tcf3, and pSmad2/3 to activate mesoderm enhancers and Eomes. The cooperation between Eomes and T form a positive feedback loop and regulate early mesoderm genes, establishing the cardiac mesoderm lineage.
Article
Medicine, Legal
Yu Kakimoto, Atsushi Ueda, Masatoshi Ito, Masayuki Tanaka, Tomoko Kubota, Shotaro Isozaki, Motoki Osawa
Summary: Proteomic analysis can differentiate between acquired cardiac hypertrophy and compensated cardiac hypertrophy, which is important for the postmortem diagnosis of sudden cardiac death in middle-aged and older individuals.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Monica Cattaneo, Antonio P. Beltrami, Anita C. Thomas, Gaia Spinetti, Valeria Vincenza Alvino, Elisa Avolio, Claudia Veneziano, Irene Giulia Rolle, Sandro Sponga, Elena Sangalli, Anna Maciag, Fabrizio Dal Piaz, Carmine Vecchione, Aishah Alenezi, Stephen Paisey, Annibale A. Puca, Paolo Madeddu
Summary: The longevity-associated variant of the BPIFB4 gene, known as LAV-BPIFB4, can improve heart function and perfusion in older people, and prevent the decline of heart performance. Gene therapy with LAV-BPIFB4 can reverse the age-related decline in cardiac function, improve microvasculature density and pericyte coverage.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biology
Markus Johansson, Benjamin Ulfenborg, Christian X. Andersson, Sepideh Heydarkhan-Hagvall, Anders Jeppsson, Peter Sartipy, Jane Synnergren
Summary: This article presents a study on a human-induced pluripotent stem cell-based in vitro model of cardiac hypertrophy. The results demonstrate that the model displays a hypertrophic response at both the transcriptomic and secreted-proteomic levels, and provide insights into potential early biomarkers of cardiac hypertrophy.
Review
Cardiac & Cardiovascular Systems
Daliang Yan, Lu Hua
Summary: Studies have shown that the nucleolus plays an emerging role in stress response and the progression of cardiac diseases. Nucleolar stress can both facilitate the survival and repair of cardiomyocytes and contribute to the deterioration of cardiac diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medical Laboratory Technology
Ping Pang, Wei Si, Han Wu, Chunlei Wang, Kuiwu Liu, Yingqiong Jia, Zhengwei Zhang, Feng Zhang, Xue Kong, Yang Yang, Weitao Jiang, Jinglun Song, Linghua Zeng, Yuting Xiong, Jie Lian, Ning Wang, Yu Bian, Baofeng Yang
Summary: This study aimed to evaluate the effects and potential mechanisms of circHelz in cardiac fibrosis. The results showed that knockdown of circHelz alleviated cardiac fibrosis and myocardial fibroblast activation, while overexpression of circHelz exacerbated cell proliferation and differentiation. Mechanistically, circHelz was found to be upregulated by NFATc2 and bind to YAP to promote cell proliferation and growth. Silencing YAP1 reversed the detrimental effects caused by circHelz. Therefore, circHelz may be a novel target for the prevention and treatment of cardiovascular disease.
TRANSLATIONAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Yuichi J. Shimada, Yoshihiko Raita, Lusha W. Liang, Mathew S. Maurer, Kohei Hasegawa, Michael A. Fifer, Muredach P. Reilly
Summary: This study identified plasma protein biomarkers of HCM and revealed upregulated molecular pathways, such as the Ras-MAPK and TGF-beta pathways, in HCM patients. This investigation represents the largest-scale proteomics profiling in HCM, highlighting both novel and known pathways differentially regulated in the disease.
CIRCULATION-HEART FAILURE
(2021)
Article
Oncology
Xuelong Wang, Huiping Guo, Feifei Yu, Hui Zhang, Ying Peng, Chenghui Wang, Gang Wei, Jizhou Yan
Summary: The study observed cellular remodeling and chromatin remodeling in zebrafish hearts after resection of the ventricular apex, leading to myocardial recovery and tissue regeneration. The interaction of Krt5 with cytoskeleton and BMP4 plays a crucial role in angiogenesis and muscle regeneration.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Yan Chen, Junteng Zhou, Zisong Wei, Yue Cheng, Geer Tian, Yue Quan, Qihang Kong, Wenchao Wu, Xiaojing Liu
Summary: Cardiac hypertrophy initially serves as an adaptive response to physiological and pathological stimuli. However, sustained hypertrophy leads to pathological cardiac hypertrophy, cardiac fibrosis, and ultimately heart failure. Recent studies have highlighted the importance of circRNA and its regulation of mRNA in the posttranscriptional regulation of cardiac hypertrophy. This study identifies differentially expressed circRNAs and explores their coexpression with mRNAs and miRNAs, providing potential targets for the treatment of pathological cardiac hypertrophy and fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Hua-fei Deng, Jiang Zou, Nian Wang, Heng Ma, Li-li Zhu, Ke Liu, Mei-dong Liu, Kang-Kai Wang, Xian-zhong Xiao
Summary: This study demonstrates that nicorandil can alleviate myocardial remodeling post-MI by promoting autophagy and regulating the TGF-beta/Smad signaling pathway through up-regulating nucleolin expression.
CELLULAR SIGNALLING
(2022)
Article
Biochemistry & Molecular Biology
Xin-Liang Zhu, Huan Du, Lei-Lei Wang, Er-Ling Hu, Ning Li, Hai-Xia Lu, Guo-Qiang Chen, Xiao-Yun Lu
Summary: In this study, the researchers used a quantitative proteomics approach to analyze the changes in protein expression in neural cells after treatment with 3-hydroxybutyrate (3OHB). They identified a key epigenetic marker called histone lysine 27 trimethylation and found that 3OHB affects the involvement of bivalent transcription factors and neuronal development processes. Transcriptomic profiling revealed that 3OHB impairs the fate decision process of neural precursor cells by repressing differentiation and promoting proliferation. This study provides insights into the mechanisms underlying the neuroprotective effects of 3OHB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Alba Alvarez-Franco, Raquel Rouco, Rafael J. Ramirez, Guadalupe Guerrero-Serna, Maria Tiana, Sara Cogliati, Kuljeet Kaur, Mohammed Saeed, Ricardo Magni, Jose Antonio Enriquez, Fatima Sanchez-Cabo, Jose Jalife, Miguel Manzanares
Summary: Transcriptomic and proteomic analysis of AF progression in a large animal model shows significant changes occurring at early stages, including previously undescribed increase in mitochondria, changes to the chromatin of atrial CMs, and genes related to neural function and cell proliferation.
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, Research & Experimental
R. A. Di Mattia, L. A. Diaz-Zegarra, P. G. Blanco, C. A. Valverde, L. A. Gonano, C. Jaquenod De Giusti, E. L. Portiansky, M. G. Vila-Petroff, E. A. Aiello, A. Orlowski
Summary: There are two alkalinizing mechanisms in cardiac myocytes to maintain intracellular pH: sodium/bicarbonate cotransporter (NBCn1 and NBCe1) and sodium/proton exchanger (NHE1). Dysfunction of these transporters has been linked to cardiovascular diseases. This study aimed to investigate the role of NBCe1 downregulation in cardiac hypertrophy. The researchers used AAV9-shNBCe1 to specifically reduce NBCe1 expression in rat hearts, leading to hypertrophy, altered electrical features, and compensatory upregulation of NBCn1 and NHE1.
Editorial Material
Cardiac & Cardiovascular Systems
Tomohiro Yokota, Yibin Wang
CARDIOVASCULAR RESEARCH
(2021)
Article
Medicine, Research & Experimental
Bradley J. Baranowski, Matti D. Allen, Jennifer N. K. Nyarko, R. Scott Rector, Jaume Padilla, Darrell D. Mousseau, Christoph D. Rau, Yibin Wang, M. Harold Laughlin, Craig A. Emter, Rebecca E. K. MacPherson, T. Dylan Olver
Summary: Patients with heart failure often have comorbidities like obesity and insulin resistance, and a study using a swine model showed that both cerebrovascular and neuronal pathologies may contribute to dementia symptoms in the setting of cardiometabolic HF.
Editorial Material
Cardiac & Cardiovascular Systems
Chen Gao, Yibin Wang
CIRCULATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Kevin Van Bortle, David P. Marciano, Qing Liu, Tristan Chou, Andrew M. Lipchik, Sanjay Gollapudi, Benjamin S. Geller, Emma Monte, Rohinton T. Kamakaka, Michael P. Snyder
Summary: This study reveals that loss of subunit POLR3G in RNA polymerase III (Pol III) leads to a restricted repertoire of transcribed genes, particularly affecting the transcription of snaR-A, a noncoding RNA associated with cancer proliferation and metastasis. The findings suggest that Pol III identity plays an important role in transcriptional regulation. Upregulation of POLR3G, driven by MYC, is associated with unfavorable survival outcomes in certain cancers.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Matthew A. Fischer, Aman Mahajan, Maximilian Cabaj, Todd H. Kimball, Marco Morselli, Elizabeth Soehalim, Douglas J. Chapski, Dennis Montoya, Colin P. Farrell, Jennifer Scovotti, Claudia T. Bueno, Naomi A. Mimila, Richard J. Shemin, David Elashoff, Matteo Pellegrini, Emma Monte, Thomas M. Vondriska
Summary: This study identified DNA methylation biomarkers that can predict the future occurrence of POAF associated with cardiac surgery. The research demonstrates the use of precision medicine to develop models combining epigenomic and clinical data to predict disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Yifan F. Wang, Yibin Wang
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Isaac Perea-Gil, Timon Seeger, Arne A. N. Bruyneel, Vittavat Termglinchan, Emma Monte, Esther W. Lim, Nirmal Vadgama, Takaaki Furihata, Alexandra A. Gavidia, Jennifer Arthur Ataam, Nike Bharucha, Noel Martinez-Amador, Mohamed Ameen, Pooja Nair, Ricardo Serrano, Balpreet Kaur, Dries A. M. Feyen, Sebastian Diecke, Michael P. Snyder, Christian M. Metallo, Mark Mercola, Ioannis Karakikes
Summary: This study established a phenotypic screening platform using DCM iPSC-CMs for therapeutic target discovery. It found that a combination of SMKIs ameliorated contractile and metabolic dysfunction in DCM iPSC-CMs through the ATF4-dependent serine biosynthesis pathway. These findings suggest that modulation of serine biosynthesis signaling may represent a novel genotype-agnostic therapeutic strategy for genetic DCM.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Chen Gao, Jianli Gong, Nancy Cao, Yibin Wang, Susan F. Steinberg
Summary: Protein kinase C-alpha (PKCa) is a signaling molecule that plays a major role in various cellular processes. A previously unannotated PKCa variant, PKCa-novel exon (PKCa-NE), was identified through RNA-seq-based transcriptome analysis in mouse and human cardiac tissue. PKCa-NE has distinct biochemical properties and plays a unique role in regulating protein synthesis in cardiomyocytes.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jia-yu Yu, Nancy Cao, Christoph D. Rau, Ro-Po Lee, Jieping Yang, Rachel J. Roth Flach, Lauren Petersen, Cansheng Zhu, Yea-Lyn Pak, Russell A. Miller, Yunxia Liu, Yibin Wang, Zhaoping Li, Haipeng Sun, Chen Gao
Summary: Parallel to changes in fatty acid and glucose metabolism, defects in branched-chain amino acid (BCAA) catabolism have been recognized as a metabolic hallmark and potential therapeutic target for heart failure. This study developed two mouse models to investigate the impact of BCAA catabolic defects in cardiomyocytes. The results showed that inactivation of the BCKDHA gene in cardiomyocytes led to loss of cardiac function and pathological changes, while inactivation of the BCKDK gene did not impact cardiac function. These findings establish the cell-autonomous role of BCAA catabolism in cardiac physiology and provide valuable models for studying BCAA-targeted therapy for heart failure.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Chemistry, Multidisciplinary
Shu-yuan Sheng, Jia-min Li, Xin-yang Hu, Yibin Wang
Summary: Heart disease is a global health threat, and the key cellular process associated with cardiomyopathy is cardiomyocyte death. Regulating molecular pathways, including apoptosis, necroptosis, ferroptosis, autophagy, and pyroptosis, play important roles in the pathogenesis of various cardiomyopathies. Therefore, it is urgent to uncover the molecular and cellular mechanisms for regulated cell death in order to better understand and treat cardiomyopathies.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cell Biology
Nicholas W. S. Chew, Cheng Han Ng, Darren Jun Hao Tan, Gwyneth Kong, Chaoxing Lin, Yip Han Chin, Wen Hui Lim, Daniel Q. Huang, Jingxuan Quek, Clarissa Elysia Fu, Jieling Xiao, Nicholas Syn, Roger Foo, Chin Meng Khoo, Jiong-Wei Wang, Georgios K. Dimitriadis, Dan Yock Young, Mohammad Shadab Siddiqui, Carolyn S. P. Lam, Yibin Wang, Gemma A. Figtree, Mark Y. Chan, David E. Cummings, Mazen Noureddin, Vincent Wai-Sun Wong, Ronald Ching Wan Ma, Christos S. Mantzoros, Arun Sanyal, Mark Dhinesh Muthiah
Summary: Global estimates from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 reveal increasing prevalence rates for metabolic diseases, particularly in high socio-demographic index countries. While mortality rates have decreased for some metabolic diseases, such as hyperlipidemia, hypertension, and non-alcoholic fatty liver disease, rates remain unchanged for type 2 diabetes mel-litus and obesity. The highest mortality rates are observed in the World Health Organization Eastern Mediterranean region and low to low-middle socio-demographic index countries.
Article
Cardiac & Cardiovascular Systems
Gwyneth Kong, Audrey Zhang, Bryan Chong, Jieyu Lim, Shankar Kannan, Yip Han Chin, Cheng Han Ng, Chaoxing Lin, Chin Meng Khoo, Mark Muthiah, Mayank Dalakoti, William Kristanto, Yibin Wang, William Kong, Kian Keong Poh, Ping Chai, Roger Foo, Mark Yan-Yee Chan, Poay-Huan Loh, Nicholas W. S. Chew
Summary: This study examines the combined effects of obesity and malnutrition on patients with acute myocardial infarction (AMI). The study found that malnourished AMI patients have a more unfavorable prognosis compared to nourished patients, especially in those with severe malnutrition regardless of obesity status. However, long-term survival is the most favorable among nourished obese patients.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Adam D. Langenbacher, Fei Lu, Lauren Crisman, Zi Yi Stephanie Huang, Douglas J. Chapski, Thomas M. Vondriska, Yibin Wang, Chen Gao, Jau-Nian Chen
Summary: In this study, the importance of Rtf1 in neonatal and adult cardiomyocytes was investigated through knockdown and knockout approaches. The results showed that loss of Rtf1 activity disrupted cell morphology, sarcomeres, cell-cell junctions, and led to fibrosis and systolic dysfunction. Moreover, Rtf1 knockout hearts exhibited structural and gene expression defects resembling dilated cardiomyopathy, indicating that Rtf1 is continuously required for the expression of the cardiac gene program.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Multidisciplinary Sciences
John W. Hickey, Winston R. R. Becker, Stephanie A. A. Nevins, Aaron Horning, Almudena Espin Perez, Chenchen Zhu, Bokai Zhu, Bei Wei, Roxanne Chiu, Derek C. C. Chen, Daniel L. L. Cotter, Edward D. D. Esplin, Annika K. K. Weimer, Chiara Caraccio, Vishal Venkataraaman, Christian M. M. Schurch, Sarah Black, Maria Brbic, Kaidi Cao, Shuxiao Chen, Weiruo Zhang, Emma Monte, Nancy R. R. Zhang, Zongming Ma, Jure Leskovec, Zhengyan Zhang, Shin Lin, Teri Longacre, Sylvia K. K. Plevritis, Yiing Lin, Garry P. P. Nolan, William J. J. Greenleaf, Michael Snyder
Summary: The intestine is a complex organ with various functions including digestion, immune surveillance, and maintaining symbiotic relationships with microbiota. It has differences in structure and function along its over nine-meter length. Through multiplexed imaging and single-cell assays, this study reveals substantial differences in cell compositions across different regions of the intestine, highlighting distinct immunological niches. The findings also suggest a regulatory differentiation cascade and associate specific cell types with intestinal disease heritability. This research provides an important reference map for understanding human biology and disease.
Editorial Material
Cardiac & Cardiovascular Systems
Chen Gao, Yibin Wang
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)