Article
Biochemical Research Methods
Kristina Lietz, Babak Saremi, Lena Wiese
Summary: This study developed a web application that simplifies the analysis of microarray data and allows for the comparison of results from different technologies and organisms. The application provides a convenient and customizable analysis process and allows users to gain further insights from existing study data.
BMC BIOINFORMATICS
(2023)
Article
Virology
Serdal Arslan, Mehmet Bakir, Burcu Bayyurt, Eylem Aydemir, Kenan Kinaci, Aynur Engin
Summary: This study investigated the lncRNA gene expression profiles in CCHF using microarray for the first time. Several lncRNAs were found to be significantly regulated in both case and fatal case groups. These lncRNAs could be considered as important therapeutic targets for further studies on CCHF.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Pharmacology & Pharmacy
Sarayut Radapong, Kelvin Chan, Satyajit D. Sarker, Kenneth J. Ritchie
Summary: Oxyresveratrol (OXY) alters key gene expression and biological pathways in MCF-7 breast cancer cells, inducing apoptosis and inhibiting cell cycle control. These changes were validated through quantitative PCR analysis and protein assays.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Delphine Boche, Marcia N. Gordon
Summary: The review explores the diversity of microglial phenotypes in healthy brains, aging, and Alzheimer's disease, identifies knowledge gaps, and suggests areas for further research. Comparisons between human samples and mouse models are made to understand the molecular complexity of microglial response repertoire, which could lead to new therapeutic avenues for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Psychiatry
Zhijun Li, Xinwei Li, Mengdi Jin, Yang Liu, Yang He, Ningning Jia, Xingyao Cui, Yane Liu, Guoyan Hu, Qiong Yu
Summary: This study identified 15 key genes potentially associated with schizophrenia through analyzing multiple gene expression datasets using various bioinformatics algorithms. The study also found correlations between the expression of these hub genes and immune infiltrating cells. Furthermore, a risk prediction model based on these genes and immune cells achieved high accuracy in early diagnosis of schizophrenia.
PSYCHIATRY RESEARCH
(2022)
Article
Chemistry, Medicinal
Md Toufiqur Rahman, Ann M. Decker, Lucas Laudermilk, Rangan Maitra, Weiya Ma, Sami Ben Hamida, Emmanuel Darcq, Brigitte L. Kieffer, Chunyang Jin
Summary: This study identified a series of novel GPR88 agonists, with one showing high potency and suitability for studying the function of GPR88 in the brain.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Genetics & Heredity
Aleksandra Dunislawska, Maria Siwek, Katarzyna Stadnicka, Marek Bednarczyk
Summary: The study compared the transcriptomic and epigenetic profiles of gonadal PGCs from White Leghorn and Green-legged Partridgelike chickens at different developmental stages, revealing significant differences in gene expression levels and DNA methylation patterns, suggesting faster embryonic development in Green-legged Partridgelike chickens compared to White Leghorn chickens.
Article
Biology
Raissa Coelho Andrade, Mariana Boroni, Marion Kielmanowicz Amazonas, Fernando Regla Vargas
Summary: This study conducted a meta-analysis of gene expression signature of primary osteosarcoma and proposed potential small molecules to reverse this signature. Through further verification, a final gene expression signature of 266 genes was obtained, providing potential new therapeutic genetic targets and drug options for osteosarcoma.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Yunqi Li, Francois Lefebvre, Edith Nakku-Joloba, Allan Ronald, Glenda Gray, Guy de Bruyn, James Kiarie, Connie Celum, Mark J. Cameron, Jairam R. Lingappa, Romel D. Mackelprang
Summary: In individuals exposed to HIV-1, higher expression of PTPRC (CD45 antigen) and interferon-response pathways may indicate an increased risk of acquiring HIV-1.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemical Research Methods
Ludwig Geistlinger, Gergely Csaba, Mara Santarelli, Marcel Ramos, Lucas Schiffer, Nitesh Turaga, Charity Law, Sean Davis, Vincent Carey, Martin Morgan, Ralf Zimmer, Levi Waldron
Summary: Researchers developed a framework for assessing enrichment methods based on defined criteria, evaluated 10 major enrichment methods using a curated compendium of expression datasets, and provided practical recommendations for efficient interpretation of results when applying these methods.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Clinical Neurology
Leila Asad Samani, Kamran Ghaedi, Ahmad Majd, Maryam Peymani, Masoud Etemadifar
Summary: This study aimed to assess the overlap of PD patients' transcriptomes in the substantia nigra (SN) with peripheral blood mononuclear cells (PBMCs) to discover potential biomarkers for diagnosis. Through the analysis of gene expression differences and validation using RT-qPCR, HSPA1A/B, DGKH, and NOTCH2 were identified as potential biomarkers for PD diagnosis.
NEUROLOGICAL SCIENCES
(2023)
Review
Computer Science, Artificial Intelligence
Mahnaz Vahmiyan, Mohammadtaghi Kheirabadi, Ebrahim Akbari
Summary: Feature selection is crucial in medicine and genetics research, especially in high-dimensional data. This paper provides a systematic survey of studies on FS techniques in microarrays, with results highlighting the importance of classification and the wide application of evolutionary methods in FS.
NEURAL COMPUTING & APPLICATIONS
(2022)
Article
Pharmacology & Pharmacy
Albert Martinez-Pinteno, Patricia Gasso, Llucia Prohens, Alex G. Segura, Mara Parellada, Jeronimo Saiz-Ruiz, Manuel J. Cuesta, Miguel Bernardo, Amalia Lafuente, Sergi Mas, Natalia Rodriguez
Summary: This study identified EP300 as a key gene involved in the metabolic abnormalities induced by antipsychotic drugs. Modulating EP300 levels may be beneficial in mitigating treatment side effects. However, further research is needed to determine the exact role of this gene in the mechanism of action of medications.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shun Ying Quah, Charng Choon Wong, Hui Chyn Wong, Kok Lian Ho, Nizar Abdul Manan, Pran Kishore Deb, Sreenivasa Rao Sagineedu, Johnson Stanslas
Summary: The study revealed that acquired chemoresistance to SRJ09 and SRJ23 in colon and prostate cancer cells may be attributed to alterations in the expression of genes related to the PI3K and autophagy pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Rassanee Bissanum, Sitthichok Chaichulee, Rawikant Kamolphiwong, Raphatphorn Navakanitworakul, Kanyanatt Kanokwiroon
Summary: TNBC lacks well-defined molecular targets and is highly heterogeneous, making treatment challenging. This study attempted to define gene signatures for each TNBC subtype and develop a classification method using machine learning. SVM algorithm achieved the highest accuracy in classifying TNBC into four subtypes, but some samples could not be classified.
JOURNAL OF PERSONALIZED MEDICINE
(2021)