Review
Immunology
Miranda D. Chavez, Hubert M. Tse
Summary: Mitochondrial dysfunction and oxidative stress are associated with T cell-mediated autoimmune diseases, and targeting metabolic pathways can inhibit autoreactive T cell activation. Increasing the requirements of Tregs for ROS and oxidative phosphorylation can promote self-tolerance and inhibit the activity of autoreactive T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Nan-Nan Liang, Ying Zhao, Yue-Yue Guo, Zhi-Hui Zhang, Lan Gao, De-Xin Yu, De-Xiang Xu, Shen Xu
Summary: This study found that mitochondria-derived reactive oxygen species (ROS) contribute to renal cell ferroptosis during lipopolysaccharide (LPS)-induced acute kidney injury (AKI). Inhibition of ferroptosis and scavenging of mitochondrial ROS with specific inhibitors, ferrostatin-1 and MitoQ, respectively, attenuated renal lipid peroxidation, ferroptosis-characteristic mitochondrial damage, and renal cell death. These findings suggest that mitochondria-targeted antioxidants may be potential therapeutic agents for sepsis-induced AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander S. Milliken, Sergiy M. Nadtochiy, Paul S. Brookes
Summary: The study found that succinate dynamics and mitochondrial ROS generation are key determinants of PT pore opening and IR injury outcomes in cardiac ischemia-reperfusion injury. Inhibiting MCT1 may exacerbate succinate accumulation-induced ROS generation and worsen IR injury.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
James H. Schofield, Zachary T. Schafer
Summary: The relationship between mitophagy and ROS production is complex and not fully understood. This review discusses mtROS generation and their detrimental effects on cellular viability, along with the cellular defense mechanisms against oxidative stress. Furthermore, the prominent mechanisms governing mitophagy induction that bear on oxidative stress are explored.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cardiac & Cardiovascular Systems
Sara Ranjbarvaziri, Kristina B. Kooiker, Mathew Ellenberger, Giovanni Fajardo, Mingming Zhao, Alison Schroer Vander Roest, Rahel A. Woldeyes, Tiffany T. Koyano, Robyn Fong, Ning Ma, Lei Tian, Gavin M. Traber, Frandics Chan, John Perrino, Sushma Reddy, Wah Chiu, Joseph C. Wu, Joseph Y. Woo, Kathleen M. Ruppel, James A. Spudich, Michael P. Snyder, Kevin Contrepois, Daniel Bernstein
Summary: The study found that metabolic signaling disruption and mitochondrial dysfunction are common pathogenic mechanisms in patients with HCM, highlighting potential new drug targets for mitigating the disease by improving metabolic function and reducing mitochondrial injury.
Article
Biochemistry & Molecular Biology
Senzhen Wang, Xiaojuan Xu, Delu Che, Ronghui Fan, Mengke Gao, Yue Cao, Chaochao Ge, Yongli Feng, Jinghua Li, Songqiang Xie, Chaojie Wang, Fujun Dai, Lei Gao, Yuxia Wang
Summary: The study confirmed that mitochondria are the main source of ROS induced by 6c, leading to mitochondrial dysfunction and lysosomal destabilization. Moreover, ROS regulated the expression of 6c-mediated proteins, promoted the formation of autophagosomes, and caused DNA damage, ultimately resulting in cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Sergejs Zavadskis, Adelheid Weidinger, Dominik Hanetseder, Asmita Banerjee, Cornelia Schneider, Susanne Wolbank, Darja Marolt Presen, Andrey Kozlov
Summary: The study found that the inhibitor DPI has different effects on ROS metabolism and mitochondrial function in various types of cells, such as stem cells and differentiated cells, depending on the cell's energy metabolism. Undifferentiated cells may be a better target for DPI compared to differentiated parenchymal cells.
Article
Biochemistry & Molecular Biology
Andrew P. Bischer, Timothy M. Baran, Andrew P. Wojtovich
Summary: Environmental surveillance-mediated behavior in Caenorhabditis elegans integrates multiple cues and is coordinated by neurons through signaling cascades. Despite lacking eyes, C. elegans is able to perceive and react to the color blue. This study explains this color perception by showing that internally-generated reactive oxygen species (ROS), in response to light, add to exogenous sources of ROS. Multiple sub-threshold sources of ROS are integrated to coordinate behavioral responses with internal cues. Blue light affects C. elegans behavior through ROS generation by endogenous flavins, mediated by the neuronal gustatory photoreceptor like protein, LITE-1. Overall, this study demonstrates that ROS and LITE-1 play central roles in C. elegans foraging behavior through integration of multiple inputs, including light.
Article
Plant Sciences
Adeola Folasade Ehigie, Peng Wei, Taotao Wei, Xiyun Yan, Olufunso O. Olorunsogo, Fiyinfoluwa Demilade Ojeniyi, Leonard Ona Ehigie
Summary: The study aimed to investigate the mechanism of cell death in breast and lung cancer cell lines treated with fractions derived from bitter melon extract. The results showed that the fractions reduced mitochondrial membrane potential and intracellular ATP levels, while increasing reactive oxygen species levels. However, they did not activate caspase-3 or release cytochrome c in the cancer cells, suggesting a different mechanism of cell death induction.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kang Liu, Zheng Zhang, Rujia Liu, Jie P. Li, Dechen Jiang, Rongrong Pan
Summary: The study presents a new nanoelectrode-based pipette architecture for the in-depth study of single cells. The architecture allows the isolation and monitoring of a small region of mitochondrial membranes in a living cell using click chemistry. The study also provides direct evidence for the noninvolvement of glutathione peroxidase 4 in mitochondria during RSL3-induced reactive oxygen species (ROS) generation at the single-mitochondrion level.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Kim T. Hellgren, Hajani Premanandhan, Callum J. Quinn, Andrew W. Trafford, Gina L. J. Galli
Summary: The study found that male offspring from hypoxic pregnancies had mitochondria with increased H2O2 production and lower respiratory capacity, while females had higher respiratory capacity and lower H2O2 production. These results suggest that early exposure to hypoxia has long-term, sex-dependent effects on cardiac metabolic function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hiromu Ito, Hiromi Kurokawa, Hirofumi Matsui
Summary: Mitochondria, essential organelles for energy production in eukaryotes, generate reactive oxygen species during the process which play pivotal roles in cell signaling and iron homeostasis regulation. The regulation of iron transportation, involving proteins like HCP1, DMT1, and mitoferrin, is increasingly understood in relation to mitochondrial reactive oxygen species and diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Priyanka Karekar, Haley N. Jensen, Kathryn L. G. Russart, Devasena Ponnalagu, Sarah Seeley, Shridhar Sanghvi, Sakima A. Smith, Leah M. Pyter, Harpreet Singh, Shubha Gururaja Rao
Summary: The study suggests that tumor induction may cause cardiac dysfunction even before treatment or onset of cachexia. By investigating the Hippo-Yorkie pathway, it is found that Yki overexpression compromises cardiac function, which can be rescued with antioxidant treatment.
Article
Biochemistry & Molecular Biology
Andrey Y. Vinokurov, Olga A. Stelmashuk, Polina A. Ukolova, Evgeny A. Zherebtsov, Andrey Y. Abramov
Summary: The brain produces various reactive oxygen species at different rates in different brain regions, with the brain stem and cerebellum being more sensitive to oxidative stress. Mitochondrial ROS has minor implications to total ROS production, and levels of lipid peroxidation and GSH vary across brain regions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Molly Monsour, Jonah Gordon, Gavin Lockard, Adam Alayli, Cesar V. Borlongan
Summary: Despite a good understanding of the pathophysiology of cell death after ischemic injury, there are few established treatments for stroke. Mitochondrial dysfunction plays a key role in secondary cell death, and recent advancements in stem cell therapies suggest that restoring mitochondrial integrity may be beneficial. This review discusses the role of mitochondria in the anti-oxidative effects of stem cell therapies for stroke.
Article
Multidisciplinary Sciences
Allen C. T. Teng, Tetsuaki Miyake, Shunichi Yokoe, Liyong Zhang, Luis Mario Rezende, Parveen Sharma, David H. MacLennan, Peter P. Liu, Anthony O. Gramolini
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Multidisciplinary Sciences
Parveen Sharma, Cynthia Abbasi, Savo Lazic, Allen C. T. Teng, Dingyan Wang, Nicole Dubois, Vladimir Ignatchenko, Victoria Wong, Jun Liu, Toshiyuki Araki, Malte Tiburcy, Cameron Ackerley, Wolfram H. Zimmermann, Robert Hamilton, Yu Sun, Peter P. Liu, Gordon Keller, Igor Stagljar, Ian C. Scott, Thomas Kislinger, Anthony O. Gramolini
NATURE COMMUNICATIONS
(2015)
Article
Multidisciplinary Sciences
Uros Kuzmanov, Hongbo Guo, Diana Buchsbaum, Jake Cosme, Cynthia Abbasi, Ruth Isserlin, Parveen Sharma, Anthony O. Gramolini, Andrew Emili
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Toxicology
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams, Steven D. Webb
TOXICOLOGY RESEARCH
(2016)
Article
Dermatology
Sarah A. Smith, Helen E. Colley, Parveen Sharma, Klaudia M. Slowik, Rowena Sison-Young, Andrew Sneddon, Steven D. Webb, Craig Murdoch
EXPERIMENTAL DERMATOLOGY
(2018)
Review
Toxicology
Jonathan A. Kyffin, Parveen Sharma, Joseph Leedale, Helen E. Colley, Craig Murdoch, Pratibha Mistry, Steven D. Webb
TOXICOLOGY IN VITRO
(2018)
Article
Toxicology
Jonathan A. Kyffin, Parveen Sharma, Joseph Leedale, Helen E. Colley, Craig Murdoch, Amy L. Harding, Pratibha Mistry, Steven D. Webb
TOXICOLOGY IN VITRO
(2019)
Article
Medicine, Research & Experimental
Lauren Tomlinson, Zhen Qi Lu, Robert A. Bentley, Helen E. Colley, Craig Murdoch, Steven D. Webb, Michael J. Cross, Ian M. Copple, Parveen Sharma
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Multidisciplinary Sciences
Shin-Haw Lee, Sina Hadipour-Lakmehsari, Harsha R. Murthy, Natalie Gibb, Tetsuaki Miyake, Allen C. T. Teng, Jake Cosme, Jessica C. Yu, Mark Moon, SangHyun Lim, Victoria Wong, Peter Liu, Filio Billia, Rodrigo Fernandez-Gonzalez, Igor Stagljar, Parveen Sharma, Thomas Kislinger, Ian C. Scott, Anthony O. Gramolini
NATURE COMMUNICATIONS
(2020)
Article
Biology
Joseph A. Leedale, Jonathan A. Kyffin, Amy L. Harding, Helen E. Colley, Craig Murdoch, Parveen Sharma, Dominic P. Williams, Steven D. Webb, Rachel N. Bearon
Article
Engineering, Biomedical
Uros Kuzmanov, Erika Yan Wang, Rachel Vanderlaan, Da Hye Kim, Shin-Haw Lee, Sina Hadipour-Lakmehsari, Hongbo Guo, Yimu Zhao, Meghan McFadden, Parveen Sharma, Filio Billia, Milica Radisic, Anthony Gramolini, Andrew Emili
NATURE BIOMEDICAL ENGINEERING
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Robert Bentley, Sunil Jit R. J. Logantha, Parveen Sharma, Richard R. Rainbow, Gregory Y. H. Lip
CARDIOVASCULAR RESEARCH
(2021)
Article
Multidisciplinary Sciences
Shin-Haw Lee, Sina Hadipour-Lakmehsari, Da Hye Kim, Michelle Di Paola, Uros Kuzmanov, Saumya Shah, Joseph Jong-Hwan Lee, Thomas Kislinger, Parveen Sharma, Gavin Y. Oudit, Anthony O. Gramolini
Article
Pharmacology & Pharmacy
Peter Kilfoil, Shuyun Lily Feng, Asser Bassyouni, Tiffany Lee, Derek Leishman, Dingzhou Li, David J. MacEwan, Parveen Sharma, Eric D. Watt, Stephen Jenkinson
Summary: This study examined the ability of hIPSC-CM model to predict clinically observed effects of various compounds on electrocardiogram endpoints. Measurements were taken acutely and chronically to capture responses from compounds with slow onset kinetics. The study showed high predictivity in defining TdP risk and correlation between QRS prolongation risk and an increase in action potential rise-time.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Joseph Leedale, Kieran J. Sharkey, Helen E. Colley, Aine M. Norton, David Peeney, Chantelle L. Mason, Jean G. Sathish, Craig Murdoch, Parveen Sharma, Steven D. Webb