Article
Geriatrics & Gerontology
Robert MacLachlan, Patrick Gavin Kehoe, J. Scott Miners
Summary: The activity of angiotensin-converting enzyme-1 (ACE-1) is induced in the early stages of Alzheimer's disease (AD), independently from the normal physiological changes in ACE-1 protein during aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Thomas L. Williams, Gregory Strachan, Robyn G. C. Macrae, Rhoda E. Kuc, Duuamene Nyimanu, Anna L. Paterson, Sanjay Sinha, Janet J. Maguire, Anthony P. Davenport
Summary: ACE2 is a membrane protein that regulates the cardiovascular system and acts as a receptor for human coronaviruses, including SARS-CoV-2. A newly discovered short ACE2 isoform, deltaACE2, may affect individual susceptibility to viral infection and likelihood of developing Long COVID. Research shows that deltaACE2 is more expressed in the lung and liver compared to full-length ACE2.
SCIENTIFIC REPORTS
(2021)
Article
Peripheral Vascular Disease
Brasilina Caroccia, Paul-Emmanuel Vanderriele, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Selene Prisco, Francesca Torresan, Oliver Domenig, Maurizio Iacobone, Marko Poglitsch, Gian Paolo Rossi
Summary: This study found that ACE-2 mRNA and Ang II were present in human adrenocortical tissues, but not Ang-(1-7) and Ang-(1-5). Ang-(1-7) and ACE-2 do not seem to play a significant role in regulating aldosterone and cortisol biosynthesis.
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, Research & Experimental
Mauro G. Silva, Gerardo R. Corradi, Juan Perez Duhalde, Myriam Nunez, Eliana M. Cela, Daniel H. Gonzales Maglio, Ana Brizzio, Martin R. Salazar, Walter G. Espeche, Mariela M. Gironacci
Summary: This study found that COVID-19 patients have higher levels of ACE2 expression and enzymatic activity in their blood compared to healthy individuals, while levels of AngII and Ang-(1-7) are lower. Even when excluding COVID-19 patients under RAS blockade treatment, ACE2 expression and enzymatic activity remain higher in COVID-19 patients, suggesting the involvement of RAS in COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Atila Duque Rossi, Joao Locke Ferreira de Araujo, Tailah Bernardo de Almeida, Marcelo Ribeiro-Alves, Camila de Almeida Velozo, Jessica Maciel de Almeida, Isabela de Carvalho Leitao, Samila Natiane Ferreira, Jessica da Silva Oliveira, Hugo Jose Alves, Helena Toledo Scheid, Debora Souza Faffe, Rafael Mello Galliez, Renata Eliane de Avila, Gustavo Gomes Resende, Mauro Martins Teixeira, Orlando da Costa Ferreira Junior, Terezinha Marta P. P. Castineiras, Renan Pedra Souza, Amilcar Tanuri, Renato Santana de Aguiar, Shana Priscila Coutinho Barroso, Cynthia Chester Cardoso
Summary: ACE2 and TMPRSS2 levels are positively correlated with age, which is strongly associated with respiratory distress. Increased ACE2 levels have a protective effect against this outcome, while the TMPRSS2/ACE2 ratio is associated with risk. In modeling COVID-19 severity, the TMPRSS2/ACE2 ratio outperforms ACE2.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Jing-Yuan Xu, Wei Chang, Qin Sun, Fei Peng, Yi Yang
Summary: The study found that plasma midkine levels were significantly elevated in sepsis patients and closely related to the ACE system. In a mouse model, increased midkine levels were associated with more severe lung injury. Regional interference of midkine expression in lung tissue was shown to alleviate acute lung injury.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biology
Hristo L. Svilenov, Florent Delhommel, Till Siebenmorgen, Florian Ruehrnoessl, Grzegorz M. Popowicz, Alwin Reiter, Michael Sattler, Carsten Brockmeyer, Johannes Buchner
Summary: The solution structure, stability, and dynamics of a broadly-acting antiviral ACE2-IgG-Fc fusion protein are determined. Small chemical compounds binding to ACE2 can be used to drastically increase the thermal stability of the ACE2 domain. Our findings reveal a general concept for stabilizing the labile receptor segments of therapeutic antiviral fusion proteins by chemical compounds.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anwarul Hasan, Bilal Ahamad Paray, Arif Hussain, Fikry Ali Qadir, Farnoosh Attar, Falah Mohammad Aziz, Majid Sharifi, Hossein Derakhshankhah, Behnam Rasti, Masoumeh Mehrabi, Koorosh Shahpasand, Ali Akbar Saboury, Mojtaba Falahati
Summary: This review discusses the interactions between the novel coronavirus SARS-CoV-2 and human cells, highlighting the role of important receptors like ACE-2 and furin in the virus invasion. It explores the potential inhibitory effects of compounds on the virus, as well as future prospects for drug development.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Pharmacology & Pharmacy
Steven D. Brooks, Rachel L. Smith, Aline S. Moreira, Hans C. Ackerman
Summary: Lisinopril increases ACE2 expression in tissues relevant to COVID-19, while adding losartan prevents the lisinopril-induced increase. A sex difference was observed with higher ACE2 levels in the kidneys of male mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carla S. S. Teixeira, Rita Biltes, Caterina Villa, Sergio F. Sousa, Joana Costa, Isabel M. P. L. V. O. Ferreira, Isabel Mafra
Summary: Edible insects are proposed as a sustainable protein source and alternative food. This study simulated the digestion of locust proteins and identified peptides that could selectively inhibit a specific enzyme, potentially providing bioactivity against cardiac and pulmonary fibrosis.
Article
Orthopedics
Ying Li, Jiao Song, Yangyang Jiang, Xue Yang, Li Cao, Chun Xiao, Suli Li, Birong Dong, Xiaoli Huang
Summary: The ACE2/Ang-(1-7) axis plays a protective role in skeletal muscle function and administering exogenous Ang-(1-7) can delay age-related decline in skeletal muscle function. Aged mice showed reduced skeletal muscle function and Ang-(1-7) expression levels compared to younger mice. ACE2KO mice had significantly lower skeletal muscle function and MEF2A protein expression than age-matched wild-type mice. After one month of Ang-(1-7) treatment, skeletal muscle function in aged ACE2KO mice improved, with similar MEF2A protein expression to the untreated group. Ang-(1-7) was shown to promote Glut4 expression in C2C12 cells.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Fan Deng, Liang-Qing Zhang, Han Wu, Yu Chen, Wen-Qian Yu, Rong-Hui Han, Yuan Han, Xiao-Qi Zhang, Qi-Shun Sun, Ze-Bin Lin, Yu Wang, Yong-Pan Liu, Jing-Yi Chen, Ke-Xuan Liu, Jing-Juan Hu
Summary: This study found that propionate alleviates myocardial ischemia/reperfusion (I/R) injury aggravated by Ang II through the CAV-1/ACE2 axis dependent on GPR41. Propionate inhibits the elevation of Ang II levels, thereby reducing myocardial injury. This research provides a new direction for using diet to regulate intestinal flora for the treatment of myocardial I/R injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Critical Care Medicine
Genevieve L. Y. Rocheleau, Terry Lee, Yassene Mohammed, David Goodlett, Kevin Burns, Matthew P. Cheng, Karen Tran, David Sweet, John Marshall, Arthur S. Slutsky, Srinivas Murthy, Joel Singer, David M. Patrick, Bin Du, Zhiyong Peng, Todd C. Lee, John H. Boyd, Keith R. Walley, Francois Lamontagne, Robert Fowler, Brent W. Winston, Greg Haljan, Donald C. Vinh, Alison McGeer, David Maslove, Santiago Perez Patrigeon, Puneet Mann, Kathryn Donohoe, Geraldine Hernandez, James A. Russell
Summary: This study examined the effects of angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme (ACE) inhibitors in hospitalized COVID-19 patients, focusing on gender differences. The results showed that ARBs were associated with reduced use of ventilation and vasopressors in male patients, but not in female patients. Additionally, sex-based differences in the renin-angiotensin system (RAS) components may contribute to variations in outcomes and responses to ARBs in COVID-19.
CRITICAL CARE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jakub Jankowski, Hye Kyung Lee, Julia Wilflingseder, Lothar Hennighausen
Summary: This study reports on the genetic programs activated in kidney cells in response to interferons during COVID-19, and the inhibitory effect of a Janus kinase inhibitor. The findings help identify kidney-specific interferon responses.
Article
Peripheral Vascular Disease
Ana R. Gaspar, Beatriz Andrade, Sara Mosca, Mariana Ferreira-Duarte, Ana Teixeira, Dina Cosme, Antonio Albino-Teixeira, Fernanda A. Ronchi, Ana P. Leite, Dulce E. Casarini, Jose C. Areias, Teresa Sousa, Alberto C. Afonso, Manuela Morato, Liane Correia-Costa
Summary: This study found that childhood obesity is associated with increased activities of angiotensin-converting enzymes (ACE) and ACE2. Overweight/obese children had significantly higher ACE and ACE2 activities compared to normal weight children. In girls, ACE and ACE2 activities were associated with increased night-time systolic and diastolic blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Chemistry, Analytical
Linjie Wang, Lejuan Wen, Shujun Zheng, Feifei Tao, Jie Chao, Fei Wang, Caolong Li
Summary: In this research, a ratiometric fluorescent sensor for quantitative analysis of domoic acid (DA) was designed by integrating NH2-MIL-101(Fe) with molecular imprinting. The sensor exhibited outstanding sensitivity, anti-interference ability, and selectivity. The limit of detection was 8.2 nM and successful spike and recovery experiments in real samples demonstrated its practical application promise.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Juan Yin, Jing Wang, Xinxin Zhang, Yan Liao, Wei Luo, Sha Wang, Jiawei Ding, Jie Huang, Mengling Chen, Wei Wang, Shencun Fang, Jie Chao
Summary: This study revealed a specific pattern of fibroblast proliferation and found that targeting anoikis resistance may inhibit the pathological process of pulmonary fibrosis. This provides a new approach for treating pulmonary fibrosis and offers new insights into the potential application of ZC3H4 in the development of novel therapeutic strategies for mitigating pulmonary fibrosis.
CELL AND BIOSCIENCE
(2022)
Article
Education & Educational Research
Shiyan Jiang, Yingxiao Qian, Hengtao Tang, Rabia Yalcinkaya, Carolyn P. Rose, Jie Chao, William Finzer
Summary: With the increasing prevalence of artificial intelligence (AI) technologies in our daily lives, there is a growing urgency for students to understand how these technologies work. This study examines high school students' patterns of iterative model development and themes of computational thinking processes in developing machine learning models from unstructured data.
EDUCATION AND INFORMATION TECHNOLOGIES
(2023)
Article
Chemistry, Physical
Lili Zhao, Chunni Jiang, Jie Chao, Zhuoan Cai, Yongtao Chen, Xiaomin Liang, Guifei Zhong, Bing Hu, Lei Miao, Wenbo Liao
Summary: Transition metal oxides are promising electrochromic and energy-saving materials, and the presence of hydroxides can further enhance their performance. In this study, NiO/Co(OH)2 heterogenous nanoflake arrays were successfully prepared, exhibiting improved performance and revealing the relationship between performance and structural parameters.
APPLIED SURFACE SCIENCE
(2023)
Article
Biophysics
Zaozao Chen, Jie Huang, Jing Zhang, Zikang Xu, Qiwei Li, Jun Ouyang, Yuchuan Yan, Shiqi Sun, Huan Ye, Fei Wang, Jianfeng Zhu, Zhangyan Wang, Jie Chao, Yuepu Pu, Zhongze Gu
Summary: Creating a biomimetic in vitro lung model is an important and challenging task for biomedical researchers. The existing cell culture models lack certain key physiological conditions, but this newly developed lung physiological system can simulate infection and inflammatory reactions and integrate multiple immune cells. Additionally, a microdroplet/aerosol transmission system has been designed and a deep-learning algorithm has been employed to study cell activation.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Zhimei He, Wenjie Xiang, Qin Fan, Lianhui Wang, Jie Chao
Summary: A rectangle DNA origami nanostructure with doxorubicin-derived prodrugs targeting a tumor cell-specific enzyme (NQO1) is created. By combining the high drug payload of DNA origami and NQO1-activated chemotherapy, this nanosystem exhibits therapeutic selectivity for NQO1-overexpressing MCF-7 cells compared to healthy L02 cells, presenting a promising approach for precision cancer therapy.
CHEMICAL COMMUNICATIONS
(2023)
Article
Materials Science, Characterization & Testing
Lijun Zhuo, Xin Yang, Jianguo Zhu, Zhen Huang, Jie Chao, Weihua Xie
Summary: This study focuses on estimating the size of a subsurface defect using step heating thermography. By inverting the temperature images, the information loss during the propagation of thermal waves is overcome. The feasibility of the proposed approach is assessed through numerical simulations and experiments.
NDT & E INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Bin Li, Wen Xi, Ying Bai, Xue Liu, Yuan Zhang, Lu Li, Liang Bian, Chenchen Liu, Ying Tang, Ling Shen, Li Yang, Xiaochun Gu, Jian Xie, Zhongqiu Zhou, Yu Wang, Xiaoyu Yu, Jianhong Wang, Jie Chao, Bing Han, Honghong Yao
Summary: This study reveals that circular RNA SCMH1 promotes vascular repair after ischemic stroke by mediating m6A methylation. It is found that SCMH1 interacts with FTO and regulates m6A modification to enhance vascular repair following ischemic stroke. This finding provides important insights into the mechanism of vascular repair.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Jing Wang, Xinxin Zhang, Min Long, Mengqin Yuan, Juan Yin, Wei Luo, Sha Wang, Yu Cai, Wei Jiang, Jie Chao
Summary: Pulmonary fibrosis is a progressive lung disease characterized by chronic inflammation and excessive ECM deposition. The protein changes in fibrotic ECM and their role in fibrosis progression are still unclear.
COMMUNICATIONS BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Dan Zhu, Xiaojian Li, Yu Zhu, Qingyun Wei, Yang Hu, Shao Su, Jie Chao, Lianhui Wang, Lixing Weng
Summary: Monitoring and tracking multiple low-abundance messenger RNAs (mRNAs) simultaneously in situ at subcellular level is crucial for the diagnosis and pathologic analysis of cancer. This study presents polyA-mediated dual-color sticky flares for simultaneous imaging of two types of intracellular mRNA biomarkers. The sticky flares greatly improve the uniformity, detection sensitivity, and response kinetics compared to traditional nanoprobes, enabling enhanced efficiency in live-cell imaging of mRNAs. The proposed polyA-mediated dual-color sticky flares are a pivotal tool for multiple targets imaging in living cells with excellent cell entry efficiency and low cytotoxicity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Xin Hua, Xiao Feng, Geyu Liang, Jie Chao, Dayong Wang
Summary: The potential neurotoxicity of 6-PPDQ after long-term exposure and the underlying mechanism are unclear. In this study, abnormal locomotion behaviors and neurodegeneration of motor neurons were observed in nematodes exposed to 6-PPDQ. The activation of the DEG-3-mediated signaling cascade and the involvement of genes like jnk-1, dbl-1, daf-7, and glb-10 were also identified.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Education & Educational Research
Shiyan Jiang, Hengtao Tang, Cansu Tatar, Carolyn P. Rose, Jie Chao
Summary: Fostering AI literacy for high school students is critical in order for them to understand the workings of data-driven AI technologies and make informed decisions about automated predictions. This study examined the data modeling practices and processes of high school students who developed machine learning models for classifying ice cream store reviews. The findings highlight the need for accessible data modeling experiences and understanding the role and responsibility of data modelers in creating AI technologies.
LEARNING MEDIA AND TECHNOLOGY
(2023)
Article
Toxicology
Shaoqi Yang, Yuheng Sun, Min Long, Xinbei Zhou, Mengqin Yuan, Liliang Yang, Wei Luo, Yusi Cheng, Xinxin Zhang, Wei Jiang, Jie Chao
Summary: Chronic silica exposure can cause silicosis, a severe occupational lung disease with limited therapeutic options. This study used single-cell transcriptome sequencing and a mouse model to investigate the molecular mechanisms underlying epithelial mesenchymal transition (EMT) in silicosis. The researchers found that glycoprotein non-metastatic melanoma protein B (GPNMB) played a significant role in promoting EMT and persistent lung pathological changes in silicosis. GPNMB released extracellular vesicles that contributed to abnormal changes in the extracellular matrix and collagen structure. The findings suggest that GPNMB could be a potential target for preventing fibrosis in silicosis.
PARTICLE AND FIBRE TOXICOLOGY
(2023)
Review
Multidisciplinary Sciences
Xinxin Zhang, Xiaoni Shi, Feiyan Xie, Yaping Liu, Xinyan Wei, Yu Cai, Jie Chao
Summary: Lung fibroblasts are crucial in pulmonary interstitium and have diverse functions and characteristics in different lung conditions. In this review, we explore the heterogeneity of pulmonary fibroblasts during lung development, in healthy and pathological lungs. We also discuss their implications in fibrotic diseases, infectious diseases, and lung cancers, emphasizing the importance of comparative studies to understand their overlapping characteristics and signaling pathways.
Article
Chemistry, Multidisciplinary
Hongyu Wu, Chengwen Zhang, Fulin Zhu, Yu Zhu, Xinhui Lu, Ying Wan, Shao Su, Jie Chao, Lianhui Wang, Dan Zhu
Summary: Here, a poly-adenine (polyA)-mediated programmable FRET-nanoflare is presented for ratiometric intracellular ATP imaging with anti-interference capability. The programmable polyA attachment enhances the signal response for ATP, and the FRET-based nanoflare avoids false-positive signals due to probe degradation in complex environments, showing great potential for clinical diagnosis.
CHEMICAL COMMUNICATIONS
(2023)
