Article
Cardiac & Cardiovascular Systems
Jeanne du Fay de Lavallaz, Alexandra Prepoudis, Maria Janina Wendebourg, Eva Kesenheimer, Diego Kyburz, Thomas Daikeler, Philip Haaf, Julia Wanschitz, Wolfgang N. Loescher, Bettina Schreiner, Mira Katan, Hans H. Jung, Britta Maurer, Angelika Hammerer-Lercher, Agnes Mayr, Danielle M. Gualandro, Annemarie Acket, Christian Puelacher, Jasper Boeddinghaus, Thomas Nestelberger, Pedro Lopez-Ayala, Noemi Glarner, Samyut Shrestha, Robert Manka, Joanna Gawinecka, Salvatore Piscuoglio, John Gallon, Sophia Wiedemann, Michael Sinnreich, Christian Mueller
Summary: This study aimed to confirm the cardiac specificity of cTnT in patients with various skeletal muscle disorders (SMDs). The results showed that elevations in cTnT concentrations in patients with active chronic SMDs are common and not attributable to cardiac disease, while this phenomenon was not observed for cTnI. The re-expression of cTnT in skeletal muscle may partially explain this.
Article
Biochemistry & Molecular Biology
Wujing Ren, Zujie Xu, Shou Pan, Yixuan Ma, Hangzhuo Li, Fangnan Wu, Wenyan Bo, Mengxin Cai, Zhenjun Tian
Summary: Skeletal muscle in patients with heart failure undergoes changes in structure, function, and metabolism. Oxidative stress and cell apoptosis play a role in the development of skeletal muscle atrophy induced by myocardial infarction (MI) and heart failure (HF). Aerobic exercise (AE) has been shown to prevent skeletal muscle atrophy after MI, but the underlying mechanism and molecular targets are not fully understood. This study investigated the effects of AE on skeletal muscle in a MI model using Fndc5-/- and Alcat1- /- mice. The results showed that AE partially reversed the decreased expression of Irisin and antioxidant capacity, increased ALCAT1 expression, protein degradation, and cell apoptosis induced by MI. Knockout of Fndc5 further aggravated the oxidative stress and cell apoptosis in skeletal muscle, while knockout of Alcat1 reduced them and strengthened the beneficial effects of AE. In vitro experiments on C2C12 cells confirmed that Irisin and AICAR intervention inhibited ALCAT1 expression, oxidative stress, and cell apoptosis. These findings suggest that AE can alleviate oxidative stress and apoptosis in skeletal muscle following MI, partly through up-regulating Irisin and inhibiting ALCAT1 expression.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biology
Sarai Sanchez-Duarte, Rocio Montoya-Perez, Sergio Marquez-Gamino, Karla S. Vera-Delgado, Cipriana Caudillo-Cisneros, Fernando Sotelo-Barroso, Luis A. Sanchez-Briones, Elizabeth Sanchez-Duarte
Summary: In response to diabetes mellitus, the skeletal muscle is affected negatively. Apocynin, a NADPH oxidase inhibitor, has shown antioxidant and anti-inflammatory potential and has been effective in treating various disorders, including diabetic complications. This study aimed to evaluate the effects and mechanisms of apocynin in slow- and fast-twitch muscles of diabetic rats. The results showed that apocynin reduced blood glucose levels, enhanced insulin tolerance, and prevented muscle contractile dysfunction in fast-twitch muscles. It also mitigated oxidative stress and regulated gene expression. Overall, apocynin exhibits myoprotective properties in diabetic animals, acting predominantly as an antioxidant in both types of muscles.
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Marty, Pierre-Yves Baudin, Ericky Caldas de Almeida Araujo, Yves Fromes, Karim Wahbi, Harmen Reyngoudt
Summary: This study used MR fingerprinting with water and fat separation to quantitatively evaluate skeletal muscle tissue alterations in patients with Becker muscular dystrophy. The results showed a significant increase in extracellular volume fraction (ECV) in the muscles of these patients, which was associated with fat fraction (FF) and water relaxation time quantification.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kirti Magudia, Christopher P. Bridge, Camden P. Bay, Subrina Farah, Ana Babic, Florian J. Fintelmann, Lauren K. Brais, Katherine P. Andriole, Brian M. Wolpin, Michael H. Rosenthal
Summary: This study aimed to determine whether body composition (BC) measurements obtained from routine CT scans using a fully automated deep learning algorithm could predict subsequent cardiovascular events independently from weight, BMI, and additional cardiovascular risk factors. The results showed that VFA derived from automated and normalized abdominal CT analysis predicts the occurrence of myocardial infarction (MI) or stroke in Black and White patients.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Junichi Matsumoto, Shingo Takada, Takaaki Furihata, Hideo Nambu, Naoya Kakutani, Satoshi Maekawa, Wataru Mizushima, Ippei Nakano, Arata Fukushima, Takashi Yokota, Shinya Tanaka, Haruka Handa, Hisataka Sabe, Shintaro Kinugawa
Summary: The study showed that treatment with rhBDNF improved exercise capacity in mice with heart failure through enhancing fatty acid oxidation via the activation of the AMPK alpha-PGC1 alpha axis in skeletal muscle. This suggests that BDNF may be a potential therapeutic option to improve exercise capacity in heart failure.
CIRCULATION-HEART FAILURE
(2021)
Article
Cell Biology
Prashant J. Ruchaya, Fiona C. C. Lewis-McDougall, Nitiphat Sornkarn, Sachin Amin, Benjamin Grimsdell, Abeer Shaalan, Guilia Gritti, Kyi Thar Soe, James E. E. Clark, Georgina M. M. Ellison-Hughes
Summary: Skeletal muscle-derived interstitial cells have significant regenerative potential and can attenuate cardiac remodeling and promote cardiomyocyte proliferation after myocardial infarction transplantation.
Article
Cell Biology
Lili Feng, Bowen Li, Yue Xi, Mengxin Cai, Zhenjun Tian
Summary: This study found that aerobic exercise and resistance exercise effectively alleviated skeletal muscle atrophy in MI mice by regulating the IGF-1 pathway. Exercise promoted myogenesis, protein synthesis, reduced protein degradation, and cell apoptosis.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Marcelo Munoz, Cagla Eren Cimenci, Keshav Goel, Maxime Comtois-Bona, Mahir Hossain, Christopher McTiernan, Matias Zuniga-Bustos, Alex Ross, Brenda Truong, Darryl R. Davis, Wenbin Liang, Benjamin Rotstein, Marc Ruel, Horacio Poblete, Erik J. Suuronen, Emilio Alarcon
Summary: This article reports on the development and testing of a sprayable nanotherapeutic that can improve cardiac function and conductivity, reduce infarct size, and increase the number of blood vessels and cardiomyocytes in infarcted myocardium.
Article
Cardiac & Cardiovascular Systems
Ryosuke Sato, Kozo Okada, Eiichi Akiyama, Masaaki Konishi, Yasushi Matsuzawa, Hidefumi Nakahashi, Yugo Minamimoto, Yuichiro Kimura, Nobuhiko Maejima, Noriaki Iwahashi, Kiyoshi Hibi, Masami Kosuge, Toshiaki Ebina, Kouichi Tamura, Kazuo Kimura
Summary: The study found that low appendicular skeletal muscle index (ASMI) and abnormal abdominal fat distribution (increased visceral to subcutaneous fat ratio) are associated with cardiovascular events. Particularly in patients with ST-segment elevation myocardial infarction (STEMI), sarcopenic obesity (SO) pattern may impact long-term outcomes. The correlation of SO pattern with poor prognosis is more prominent in younger-age patients.
Article
Dermatology
Min Zhou, Hao Zhang, Hairen Chen, Baiwen Qi
Summary: This study reveals that adiponectin protects skeletal muscle from ischemia-reperfusion injury through the miR-21/PI3K/Akt signaling pathway by inhibiting inflammatory response, apoptosis, and autophagy.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Weida Liu, Runzhen Chen, Chenxi Song, Chuangshi Wang, Ge Chen, Jun Hao, Yang Wang, Chenxi Yu
Summary: This study analyzed the long-term trajectory of grip strength (GS) using a group-based trajectory model and found that a low GS trajectory was associated with a higher incidence of cardiovascular disease (CVD). Continuous monitoring of GS values could help identify individuals at risk of developing CVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ettore Vanni, Karina Lindner, Anne-Claude Gavin, Christophe Montessuit
Summary: The formation of lipid droplets (LD) is associated with glucose uptake, while the inhibition of diacylglycerol acyltransferases (DGAT) affects glucose uptake under metabolic stress stimulation. This regulation is mediated through the diacylglycerol/triacylglycerol ratio.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Medicine, General & Internal
Jane A. Leopold, Darren B. Taichman
Summary: In patients with acute myocardial infarction complicated by cardiogenic shock, the mortality rate after coronary-artery revascularization procedures is around 50%. Mechanical circulatory support, such as extracorporeal life support with venoarterial extracorporeal membrane oxygenation, can improve perfusion and workload for patients with persistent hemodynamic compromise and organ hypoperfusion.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Rehabilitation
YiNing Dai, Zhi Liu, HuiMin Zhan, GuoLin Zhang, Ping Wang, ShengQing Zhang, XianYuan Chen, JiYan Chen, PengCheng He, Ling Xue, Lan Guo, Ning Tan, YuanHui Liu
Summary: Inspiratory muscle weakness is associated with an increased risk of pneumonia in acute myocardial infarction (AMI) patients, but does not affect in-hospital mortality and major adverse cardiovascular events (MACEs). Future research could focus on training inspiratory muscles.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Endocrinology & Metabolism
Arata Fukushima, Shintaro Kinugawa, Shingo Takada, Shouji Matsushima, Mochamad Ali Sobirin, Taisuke Ono, Masashige Takahashi, Tadashi Suga, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Tomoyasu Kadoguchi, Takashi Yokota, Koichi Okita, Hiroyuki Tsutsui
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2014)
Article
Cardiac & Cardiovascular Systems
Takashi Yokota, Shintaro Kinugawa, Kagami Hirabayashi, Shouji Matsushima, Naoki Inoue, Yukihiro Ohta, Sanae Hamaguchi, Mochamad A. Sobirin, Taisuke Ono, Tadashi Suga, Satoshi Kuroda, Shinya Tanaka, Fumio Terasaki, Koichi Okita, Hiroyuki Tsutsui
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2009)
Article
Cardiac & Cardiovascular Systems
Sanae Hamaguchi, Shintaro Kinugawa, Mochamad Ali Sobirin, Daisuke Goto, Miyuki Tsuchihashi-Makaya, Satoshi Yamada, Hisashi Yokoshiki, Hiroyuki Tsutsui
CIRCULATION JOURNAL
(2012)
Article
Cardiac & Cardiovascular Systems
Mochamad Ali Sobirin, Shintaro Kinugawa, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Taisuke Ono, Kagami Hirabayashi, Tadashi Suga, Putri Azalia, Shingo Takada, Masaru Taniguchi, Toshinori Nakayama, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui
CIRCULATION RESEARCH
(2012)
Article
Endocrinology & Metabolism
Tadashi Suga, Shintaro Kinugawa, Shingo Takada, Tomoyasu Kadoguchi, Arata Fukushima, Tsuneaki Homma, Yoshihiro Masaki, Takaaki Furihata, Masashige Takahashi, Mochamad A. Sobirin, Taisuke Ono, Kagami Hirabayashi, Takashi Yokota, Shinya Tanaka, Koichi Okita, Hiroyuki Tsutsui
Article
Physiology
Shingo Takada, Shintaro Kinugawa, Kagami Hirabayashi, Tadashi Suga, Takashi Yokota, Masashige Takahashi, Arata Fukushima, Tsuneaki Homma, Taisuke Ono, Mochamad A. Sobirin, Yoshihiro Masaki, Wataru Mizushima, Tomoyasu Kadoguchi, Koichi Okita, Hiroyuki Tsutsui
JOURNAL OF APPLIED PHYSIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Tsuneaki Homma, Shintaro Kinugawa, Masashige Takahashi, Mochamad Ali Sobirin, Akimichi Saito, Arata Fukushima, Tadashi Suga, Shingo Takada, Tomoyasu Kadoguchi, Yoshihiro Masaki, Takaaki Furihata, Masaru Taniguchi, Toshinori Nakayama, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2013)
Article
Physiology
Masashige Takahashi, Shintaro Kinugawa, Shingo Takada, Naoya Kakutani, Takaaki Furihata, Mochamad Ali Sobirin, Arata Fukushima, Yoshikuni Obata, Akimichi Saito, Naoki Ishimori, Kazuya Iwabuchi, Hiroyuki Tsutsui
EXPERIMENTAL PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Hesty Wahyuningsih, Ferdy K. Cayami, Udin Bahrudin, Mochamad A. Sobirin, Farmaditya E. P. Mundhofir, Sultana M. H. Faradz, Ichiro Hisatome
YONAGO ACTA MEDICA
(2017)
Article
Engineering, Biomedical
Sodiqur Rifqi, Safir Sungkar, Mochamad Ali Sobirin, Ilham Uddin, Yoshiyuki Furuse, Mochamad Arif Nugroho, Udin Bahrudin, Ichiro Hisatome
BIOMEDICAL RESEARCH-INDIA
(2017)