Article
Obstetrics & Gynecology
Lauren J. Green, Rebecca Pullon, Lucy H. Mackillop, Stephen Gerry, Jacqueline Birks, Dario Salvi, Shaun Davidson, Lise Loerup, Lionel Tarassenko, Jude Mossop, Clare Edwards, Rupert Gauntlett, Kate Harding, Lucy C. Chappell, Marian Knight, Peter J. Watkinson
Summary: The study aimed to estimate normal ranges for postpartum maternal vital signs, revealing an increase in systolic and diastolic blood pressures from the day of birth to days 5 and 6 postpartum, with a subsequent return to baseline by day 14. Heart rate decreased over the 14-day postpartum period, while oxygen saturation, respiratory rate, and temperature remained stable.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Nutrition & Dietetics
Anouk Tanghe, Elsa Heyman, Elodie Lespagnol, Jan Stautemas, Bert Celie, Jos Op 't Roodt, Ernst Rietzschel, Danusa Dias Soares, Nina Hermans, Emmy Tuenter, Samyah Shadid, Patrick Calders
Summary: This study aimed to assess the effects of a single dose of cocoa flavanols on vascular reactivity in Type 2 diabetes mellitus (T2DM) and non-diabetic subjects, and to investigate whether certain antihypertensive drugs could modulate these effects. However, the results showed that cocoa flavanols did not have any beneficial effects on vascular reactivity parameters in T2DM and non-diabetic participants.
Article
Neurosciences
Emma L. L. Reed, Morgan L. L. Worley, Paul J. J. Kueck, Leonard D. D. Pietrafasa, Zachary J. J. Schlader, Blair D. D. Johnson
Summary: The acute consumption of sugar- and artificially-sweetened beverages may lead to alterations in cerebral vascular function, particularly with a more pronounced effect seen with artificially-sweetened beverages.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Deborah A. Levine, Mellanie Springer, Amy Brodtmann
Summary: High blood pressure has detrimental effects on brain health, contributing to cognitive impairment and dementia. The negative impact of high blood pressure on cognition is present throughout the lifespan and increases the risk of early-onset and late-life dementia. This review focuses on the epidemiology of blood pressure and vascular cognitive impairment, including differences by sex, race, and ethnicity. It also discusses the management and reversibility of blood pressure and vascular cognitive impairment, as well as knowledge gaps and future research directions.
Review
Biochemistry & Molecular Biology
Anna-Sophie Mursch-Edlmayr, Matthias Bolz, Clemens Strohmaier
Summary: Glaucomatous optic neuropathies have long been considered diseases caused by high intraocular pressure, but recent research has shown that vascular factors also play an important role in glaucoma. Advances in the study of ocular vasculature, ciliary circulation, retinal circulation, etc., may bring new breakthroughs in the treatment of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
J. M. Catov, M. F. Muldoon, R. E. Gandley, J. Brands, A. Hauspurg, C. A. Hubel, M. Tuft, M. Schmella, G. Tang, W. T. Parks
Summary: Women with adverse pregnancy outcomes, such as preeclampsia and preterm birth, may have placental vascular lesions that are associated with an adverse cardiovascular profile a decade after delivery. These lesions are characterized by microvascular rarefaction, higher blood pressure, and more atherogenic lipids.
Review
Respiratory System
Olfa Harki, Quentin Boete, Jean-Louis Pepin, Claire Arnaud, Elise Belaidi, Gilles Faury, Charles Khouri, Anne Briancon-Marjollet
Summary: Our meta-analysis has demonstrated that intermittent hypoxia has a significant impact on vascular structure and physiology. The findings support the importance of identifying and treating sleep apnoea in routine cardiac practice.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Obstetrics & Gynecology
Adi Hirshberg, Yifan Zhu, Aaron Smith-McLallen, Sindhu K. Srinivas
Summary: The study aimed to evaluate the association between a remote blood pressure monitoring program and adverse postpartum clinical outcomes in patients with a hypertensive disorder of pregnancy using administrative claims data. The results showed that patients enrolled in the remote monitoring program had a lower rate of adverse outcomes in the first 6 months after delivery compared to the control cohort A. The remote monitoring group had more cardiology visits and fewer postnatal emergency department visits and readmissions.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Peripheral Vascular Disease
Kristen J. Bubb, Owen Tang, Carmine Gentile, Seyed M. Moosavi, Thomas Hansen, Chia-Chi Liu, Belinda A. Di Bartolo, Gemma A. Figtree
Summary: FXYD1 plays a crucial role in protecting eNOS from oxidative stress and contributes to cardiovascular health; FXYD1 regulates oxidative dysregulation within caveolae where it is colocalized; In addition to impacting eNOS function, FXYD1 is closely associated with hypertension and diabetic vascular oxidative stress.
Article
Critical Care Medicine
Takafumi Ushida, Tomomi Kotani, Kenji Imai, Tomoko Nakano-Kobayashi, Noriyuki Nakamura, Yoshinori Moriyama, Shigeru Yoshida, Mamoru Yamashita, Hiroaki Kajiyama, Fumitaka Kikkawa
Summary: The study evaluated the usefulness of shock index (SI) in detecting postpartum hemorrhage (PPH) in vaginal deliveries using clinical data from 12 primary maternity care units in Japan. The results showed that SI had relatively high accuracy in detecting postpartum hemorrhage, but its sensitivity to larger volumes of bleeding was low.
Article
Cardiac & Cardiovascular Systems
Lei Wang, Megan Rice, Sandra Swist, Thomas Kubin, Fan Wu, Shengpeng Wang, Simone Kraut, Norbert Weissmann, Thomas Boettger, Matthew Wheeler, Andre Schneider, Thomas Braun
Summary: The study revealed that BMP9 and BMP10 act directly on VSMCs for induction and maintenance of their contractile state. The effects of BMP9/10 in VSMCs are mediated by different combinations of BMP type 1 receptors in a vessel bed-specific manner, offering new opportunities to manipulate blood pressure in the pulmonary circulation.
Review
Cell Biology
Megan A. Opichka, Matthew W. Rappelt, David D. Gutterman, Justin L. Grobe, Jennifer J. McIntosh
Summary: Preeclampsia is a life-threatening cardiovascular disorder associated with pregnancy, potentially caused by dysfunction in maternal and placental blood vessels and other factors. Current gaps in knowledge include detailed understanding of its underlying causes and effective treatment options.
Article
Endocrinology & Metabolism
Jillian L. Stobart, Eva Erlebach, Chaim Glueck, Sheng-Fu Huang, Matthew Jp Barrett, Max Li, Sergei A. Vinogradov, Jan Klohs, Yvette Zarb, Annika Keller, Bruno Weber
Summary: This study found that deleting the PDGFB retention motif results in severe pericyte deficiency in the vascular network, leading to reduced cerebral vasodilation capacity and impaired oxygen delivery to the tissue. Pdgfb(ret/ret) mice also showed abnormal blood oxygen extraction, indicating a state of hypoxia. These findings suggest that severe pericyte deficiency can cause vascular abnormalities and altered cerebral blood flow, resembling arteriovenous malformations.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Peripheral Vascular Disease
Joana Lopes Perdigao, Jennifer Lewey, Adi Hirshberg, Nathanael Koelper, Sindhu K. Srinivas, Michal A. Elovitz, Lisa D. Levine
Summary: This study suggests that a short course of postpartum furosemide significantly improves blood pressure control in women with hypertensive disorders of pregnancy, particularly among those without severe disease. The use of furosemide reduced the risk of persistent hypertension at 7 days postpartum and shortened the days to resolution of hypertension, without significant differences in readmissions or need for additional antihypertensive medication between groups.
Article
Peripheral Vascular Disease
Benard O. Ogola, Gabrielle L. Clark, Caleb M. Abshire, Nicholas R. Harris, Kaylee L. Gentry, Shreya S. Gunda, Isabella Kilanowski-Doroh, Tristen J. Wong, Bruna Visniauskas, Dylan J. Lawrence, Margaret A. Zimmerman, Carolyn L. Bayer, Leanne Groban, Kristin S. Miller, Sarah H. Lindsey
Summary: Estrogen may play a protective role in arterial stiffness post-menopause through GPER. Female mice adapt to hypertension by increasing carotid wall thickness, maintaining stiffness, while males show stiffness-related changes in response to blood pressure.
Article
Pharmacology & Pharmacy
Julia Steinmetz-Spah, Samsul Arefin, Karin Larsson, Jabin Jahan, Neja Mudrovcic, Lars Wennberg, Peter Stenvinkel, Marina Korotkova, Karolina Kublickiene, Per-Johan Jakobsson
Summary: This study reveals the vasodilating effects of mPGES-1 inhibition in human microvasculature and suggests the involvement of multiple signaling pathways besides the PGI(2) pathway.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Samsul Arefin, Leah Hernandez, Liam J. Ward, Angelina Schwarz, Peter Barany, Peter Stenvinkel, Karolina Kublickiene
Summary: Individuals with chronic kidney disease are more susceptible to SARS-CoV-2 infection due to altered immune system. This study found that ESKD patients have higher levels of circulating soluble ACE2 and increased ACE2 expression in male vasculature.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Peter M. Barrett, Fergus P. McCarthy, Marie Evans, Marius Kublickas, Ivan J. Perry, Peter Stenvinkel, Karolina Kublickiene, Ali S. Khashan
Summary: The study found that women who experience gestational diabetes (GDM) and subsequently develop type 2 diabetes (T2DM) are at increased risk of chronic kidney disease (CKD) and end-stage kidney disease (ESKD). However, women diagnosed with GDM but never progressing to overt T2DM have a similar risk of future CKD/ESKD compared to those with uncomplicated pregnancies.
Article
Cardiac & Cardiovascular Systems
S. Hobson, S. Arefin, A. Witasp, L. Hernandez, K. Kublickiene, P. G. Shiels, P. Stenvinkel
Summary: The pathophysiology of vascular disease is associated with accelerated biological aging and a combination of various risk factors. Chronic kidney disease (CKD) serves as a valuable model to study the structural, functional, and molecular aspects of arterial aging. The cardiorenal syndrome results from the detrimental interaction between the kidney and the cardiovascular system. Understanding the molecular mechanisms of uremic early vascular aging provides insights into inflammatory pathways and emerging risk factors, offering new prospects for pharmacological and nutritional interventions.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Leah Hernandez, Liam J. Ward, Samsul Arefin, Peter Barany, Lars Wennberg, Magnus Soderberg, Stefania Bruno, Vincenzo Cantaluppi, Peter Stenvinkel, Karolina Kublickiene
Summary: Kidney transplantation (KT) can improve the neurological status of chronic kidney disease (CKD) patients by affecting circulating BBB-specific biomarkers. This study compared the levels of specific biomarkers in kidney-failure patients before and after KT, showing decreased levels of NSE and increased levels of BDNF and NfL at the two-year follow-up. Male patients had higher BDNF levels compared to females. KT can improve the neurological status of CKD patients, as indicated by changes in BBB-specific biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Samsul Arefin, Lars Lofgren, Peter Stenvinkel, Anna B. Granqvist, Karolina Kublickiene
Summary: We investigated the changes in plasma amino acid (AA) metabolism in patients with chronic kidney disease (CKD) and their relationship with endothelial and vascular smooth muscle function. The study found that CKD patients had altered levels of AAs and their metabolites, which were associated with abnormal vascular maintenance. These findings suggest that targeting AA metabolism could be a potential treatment option for CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lorena Cuenca-Bermejo, Alessandro Prinetti, Karolina Kublickiene, Valeria Raparelli, Alexandra M. Kautzky-Willer, Colleen Norris, Louise Pilote, Maria Trinidad Herrero, GOING FWD Consortium
Summary: Brain aging leads to cognitive decline and increased vulnerability to age-related disorders. Lipid metabolism plays a crucial role in brain function, and changes in lipid composition have been linked to aging and neurodegenerative diseases. This study focuses on sex differences in brain lipid changes during aging and in Alzheimer's and Parkinson's diseases. The findings highlight the need to consider sex as an experimental variable in precision medicine research.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Nutrition & Dietetics
Liu L. Yang, Miranda Stiernborg, Elin Skott, Jingjing Xu, Yujiao Wu, Rikard Landberg, Samsul Arefin, Karolina Kublickiene, Vincent Millischer, Ida A. K. Nilsson, Martin Schalling, MaiBritt Giacobini, Catharina Lavebratt
Summary: Synbiotic 2000 reduces comorbid autistic traits and emotion dysregulation in ADHD patients. It affects plasma levels of immune activity markers and SCFAs in both children and adults with ADHD.
Review
Nutrition & Dietetics
Maria del Carmen Macias Ruiz, Lorena Cuenca Bermejo, Nicola Veronese, Emiliano Fernandez Villalba, Ana Maria Gonzalez Cuello, Karolina Kublickiene, Valeria Raparelli, Colleen M. Norris, Alexandra Kautzky-Willer, Louise Pilote, Mario Barbagallo, Ligia Dominguez, Maria Trinidad Herrero
Summary: This article reviews the role of magnesium in health and illness, with emphasis on the elderly population with chronic kidney disease (CKD) and potential sex differences. It is found that magnesium can be used as an adjunctive treatment for CKD patients to improve glomerular filtration, but further research and characterization are needed for its clinical applications. Therefore, well-designed prospective clinical trials are needed to establish guidelines for magnesium supplementation, considering age and sex.
Article
Cell Biology
Jonas Laget, Sam Hobson, Karen Muyor, Flore Duranton, Irene Cortijo, Piotr Bartochowski, Bernard Jover, Anne-Dominique Lajoix, Magnus Soderberg, Thomas Ebert, Peter Stenvinkel, Angel Argiles, Karolina Kublickiene, Nathalie Gayrard
Summary: Increased senescent cell burden and dysregulation of the NRF2 pathway play a role in vascular calcification. In vivo and in vitro studies showed increased senescence markers in calcified tissues and VSMCs exposed to uremic serum. NRF2 expression correlated with calcification in vivo but was depleted in vitro. These findings highlight the therapeutic potential of targeting senescence and the NRF2 pathway in the treatment of VC in CKD.
Article
Biology
Lorena Cuenca-Bermejo, Maria Josefa Fernandez-Del Palacio, Valeria de Cassia Goncalves, Victor Bautista-Hernandez, Consuelo Sanchez-Rodrigo, Emiliano Fernandez-Villalba, Karolina Kublickiene, Valeria Raparelli, Alexandra Kautzky-Willer, Colleen M. Norris, Louise Pilote, Maria Trinidad Herrero
Summary: Cardiovascular diseases are a leading cause of death and illness worldwide, with age being an important risk factor. Preclinical models are crucial for understanding cardiac changes related to aging and pathological aspects. In this study, the cardiac electric activity was evaluated in the Octodon degus rodent model during aging, considering differences between males and females. The results showed that both age and sex influence cardiac function and the incidence of arrhythmias, suggesting the potential usefulness of this model for cardiovascular research, including impacts of aging and biological sex.
Article
Medicine, General & Internal
Sam Hobson, Abdul Rashid Qureshi, Jonaz Ripswedan, Lars Wennberg, Henriette de Loor, Thomas Ebert, Magnus Soderberg, Pieter Evenepoel, Peter Stenvinkel, Karolina Kublickiene
Summary: In this study, the pro-calcifying effects of gut-derived uremic toxins trimethylamine N-oxide (TMAO) and phenylacetylglutamine (PAG) were investigated in kidney failure patients. TMAO was found to be independently associated with coronary artery calcification, while PAG was positively associated with 8-hydroxydeoxyguanosine. These findings suggest that targeting TMAO may help reduce cardiovascular mortality in chronic kidney disease.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Sam Hobson, Emmanouil Mavrogeorgis, Tianlin He, Justyna Siwy, Thomas Ebert, Karolina Kublickiene, Peter Stenvinkel, Harald Mischak
Summary: Analyzing the urinary peptidome in CKD patients has identified specific disease progression molecules in early and late stages of the disease. Structural changes may be reversible in the early stage. The results of this study have important implications for guiding patient management.
Review
Peripheral Vascular Disease
Rosa-Maria Bruno, Szabolcs Varbiro, Giacomo Pucci, Janos Nemcsik, Mai Tone Lonnebakken, Karolina Kublickiene, Helena Schluchter, Chloe Park, Ioana Mozos, Andrea Guala, Bernhard Hametner, Ute Seeland, Pierre Boutouyrie
Summary: Blood pressure and vascular ageing trajectories differ between men and women due to sex-related and gender-related factors. Endogenous 17β-estradiol plays a protective role in women's vascular aging, but gender-related factors such as psychological stress and low socioeconomic status have a greater impact on vascular aging in women. On the other hand, men are more susceptible to the adverse effects of alcohol consumption and social deprivation. Unhealthy diet habits and smoking have a disproportional negative effect on women's vascular health. Therefore, future research and prevention strategies should take into account the complex role of gender-related factors.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Rubee Dev, Divine Favour-Ofili, Valeria Raparelli, Hassan Behlouli, Zahra Azizi, Karolina Kublickiene, Alexandra Kautzky-willer, Maria Trinidad Herrero, Louise Pilote, Colleen M. Norris
Summary: There is a rise in cardiovascular diseases in sub-Saharan Africa, and gender-related factors play a role in the development of these diseases. Females have higher prevalence rates of hypertension and overweight/obesity compared to males, resulting in poorer cardiovascular health for females.