Review
Pharmacology & Pharmacy
Catia R. Lopes, Vanessa S. Lourenco, Angelo R. Tome, Rodrigo A. Cunha, Paula M. Canas
Summary: The study explores the role of adenosine receptors in the brain, indicating the potential of A1R in neurodegeneration and A2AR in psychiatric conditions. Transgenic mouse experiments reveal the different roles of A2AR in various cell types and brain areas, emphasizing the regulatory role of adenosine in the brain and uncovering potential mechanisms of action.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
P. Boknik, J. Eskandar, B. Hofmann, N. Zimmermann, J. Neumann, U. Gergs
Summary: This review provides an overview of the localization and role of cardiac A(2A)-adenosine receptors, as well as their potential involvement in relevant cardiac pathologies. The review also discusses the cardiac utility of A(2A)-AR as therapeutic targets and identifies gaps in knowledge for future research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Monika Kubacka, Szczepan Mogilski, Marek Bednarski, Krzysztof Pociecha, Artur Swierczek, Noemi Nicosia, Jakub Schabikowski, Michal Zaluski, Grazyna Chlon-Rzepa, Joerg Hockemeyer, Christa E. Mueller, Katarzyna Kiec-Kononowicz, Magdalena Kotanska
Summary: The platelet aggregation inhibitory activity of selected xanthine-based adenosine A(2A) and A(2B) receptor antagonists was investigated, and the compounds were found to act as moderately potent non-selective inhibitors of phosphodiesterases (PDEs). The highest inhibitory activity against PDE3A was observed in TB-42, along with moderate activity against PDE2A and PDE5A. The antiplatelet activity of the compounds may be due to inhibition of PDEs, leading to increased cAMP and/or cGMP concentrations in platelets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Julius R. Herting, Jule H. Koenig, Katarina Hadova, Alexander Heinick, Frank U. Mueller, Paul Pauls, Matthias D. Seidl, Carolina Soppa, Uwe Kirchhefer
Summary: PR72 overexpression in myocardial cells results in mild cardiac hypertrophy and increased contractility. This is accompanied by an increase in the peak amplitude of Ca2+ transients, a shorter decay in intracellular Ca2+ levels, and longer duration and wider width of Ca2+ sparks. Consistent with the contractile data, phosphorylation of phospholamban is also increased in TG hearts, while expression of the Na+/Ca2+ exchanger is decreased.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Daniel Guendel, Thu Hang Lai, Sladjana Dukic-Stefanovic, Rodrigo Teodoro, Winnie Deuther-Conrad, Magali Toussaint, Klaus Kopka, Rares-Petru Moldovan, Peter Boknik, Britt Hofmann, Ulrich Gergs, Joachim Neumann, Peter Brust
Summary: This study aims to investigate the potential use of the PET radiotracer [F-18]FLUDA for non-invasive assessment of A(2A)-AR as a marker for cardiac pathologies. The results show that [F-18]FLUDA exhibits high specific binding to A(2A)-AR and can be used for non-invasive diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Olamide E. Adebiyi, Margaret S. Bynoe
Summary: This study investigates the role of A(1) and A(2A) adenosine receptors in regulating oligodendrocyte precursor cells and myelinating oligodendrocytes in the demyelinated hippocampus. It found that the absence of A(1) and A(2A) adenosine receptors affects spatial learning and memory, and has an impact on hippocampal demyelination and cell apoptosis.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Ana Moreira-de-Sa, Francisco Q. Goncalves, Joao P. Lopes, Henrique B. Silva, Angelo R. Tome, Rodrigo A. Cunha, Paula M. Canas
Summary: Research suggests that administration of A(2A) receptor antagonists can improve motor deficits in an Angelman syndrome mouse model and correct synaptic alterations in the cerebellum and striatum.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Yajia Cheng, Peipei Cao, Chao Geng, Xiaoqi Chu, Yuhao Li, Jianlin Cui
Summary: Photoreceptor degeneration is a critical event in various retinal diseases, but there is currently no curative treatment available. This study showed that the A2AR antagonist SCH58261 protected photoreceptors by inhibiting inflammation, apoptosis, and autophagy at the early stage of degeneration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Xiangxu Tang, Chanjuan Zhang, Tian Tian, Xiaomeng Dai, Yun Xing, Yingwei Wang, Duomeng Yang, Hongmei Li, Yiyang Wang, Xiuxiu Lv, Huadong Wang
Summary: DEX posttreatment may aggravate septic cardiomyopathy in the presence of organ dysfunction, possibly through activating the α2A-AR-mediated PKC signal pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Baptiste Maille, Julien Fromonot, Claire Guiol, Marion Marlinge, Florian Baptiste, Suzy Lim, Charlotte Colombani, Marie Charlotte Chaptal, Mohamed Chefrour, Marguerite Gastaldi, Frederic Franceschi, Jean-Claude Deharo, Vlad Gariboldi, Jean Ruf, Giovanna Mottola, Regis Guieu
Summary: The study revealed an association between perioperative atrial fibrillation, high blood adenosine concentration, and increased expression of A(2A)R and A(2B)R, particularly in the left atrium, in patients with underlying structural heart disease after cardiac surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Quanxia Lyu, Shu Gong, Jarmon G. Lees, Jialiang Yin, Lim Wei Yap, Anne M. Kong, Qianqian Shi, Runfang Fu, Qiang Zhu, Ash Dyer, Jennifer M. Dyson, Shiang Y. Lim, Wenlong Cheng
Summary: This study presents a method using a soft resistive force-sensing diaphragm to monitor the contraction forces and beating patterns of cardiac organoids in real-time. The method overcomes the mismatch between the topological complexity and soft tissue properties of organoids and rigid force sensors, providing a new approach for studying the mechanical properties of cardiac tissues.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Nicola Laura Diry, Megan Kay Wood, Taejoon Won, Monica Vladut Talor, Clarisse Lukban, Djahida Bedja, Nadan Wang, Hannah Kalinoski, Abdel Daoud, C. Conover Talbot Jr, Brian Leei Lin, Daniela Cihakova
Summary: Hypereosinophilic syndrome is a progressive disease that leads to organ damage, with cardiac pathology being the main cause of mortality. Understanding the mechanisms of eosinophil-mediated tissue damage can aid in therapeutic development.
Article
Neurosciences
Xiu-Cui Li, Fang-Fang Hong, Yun-Jia Tu, Yuan-Ai Li, Chun-Yan Ma, Chen-Yi Yu, Li Fang, Jia-Yi Chen, Zhi-Lin Li, Shi-Jia Bao, Zi-Long Zhang, Hui-Ya Ying, Adwoa Takyiwaa Gyabaah, Shu-Yun Hu, Guan-Hua Shao, Xiao-Hong Cai
Summary: This study found that the adenosine A(2A) receptor plays a critical role in the impairment of learning and memory in a chronic intermittent hypoxia environment, by accelerating hippocampal neuronal apoptosis and reducing synaptic plasticity.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Canyong Guo, Lingyun Yang, Zhijun Liu, Dongsheng Liu, Kurt Wuthrich
Summary: Eight hundred and twenty-six human G protein-coupled receptors (GPCRs) play a significant role in mediating the actions of hormones, neurotransmitters, and drugs. Studying the structure and dynamics of GPCRs in lipid bilayer environments is crucial for understanding their functionality and developing new drugs. This study incorporates the A(2A) adenosine receptor into lipid nanodiscs, providing a detergent-free environment for structural studies using NMR. The findings demonstrate the stability and mimicry of the lipid nanodisc and LMNG/CHS micelles in preserving the overall fold and local structure of the receptor.
Article
Cardiac & Cardiovascular Systems
Wenwen Zhang, Xinlu Gao, Xiuxiu Wang, Desheng Li, Yiming Zhao, Tingting Zhang, Jingwen Ne, Binbin Xu, Shuainan Li, Zuke Jiang, Hongyue Sun, Wenya Ma, Fan Yang, Benzhi Cai, Baofeng Yang
Summary: The study investigated the effects of LED-Red irradiation on cardiac function in mice with HF, showing that LED-Red has a positive impact on treating HF by improving cardiac function, morphology, reducing pulmonary edema, inhibiting collagen deposition, and attenuating perivascular fibrosis. LED-Red irradiation also promoted calcium transients in cardiomyocytes and increased ATP synthesis, potentially benefiting contractile function in HF mice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
