Article
Cardiac & Cardiovascular Systems
Chengcheng Zhao, Xiangrui Jiang, Liyuan Peng, Yan Zhang, Huihui Li, Qiumeng Zhang, Yinhui Wang, Feipu Yang, Junfang Wu, Zheng Wen, Zuowen He, Jingshan Shen, Chen Chen, Dao Wen Wang
Summary: This study found that the ratio of DHETs/EETs increased in the plasma of heart failure (HF) patients, and the expression of sEH was upregulated in the heart of patients and mice with HF. Cardiomyocyte-specific Ephx2-/- mice showed improved cardiac dysfunction induced by TAC. Mechanistically, AngII enhanced the expression of KLF15, which in turn upregulated sEH. Importantly, glimepiride was identified as a novel sEH inhibitor that attenuated HF by increasing EETs.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaorui Wang, Wenwen Han, Yi Zhang, Yi Zong, Na Tan, Yan Zhang, Li Li, Chang Liu, Limei Liu
Summary: This study investigates the impact of an sEH inhibitor on renovascular endothelial dysfunction in hypertensive rats. The results show that the inhibitor effectively reverses the deleterious effects, such as increased blood pressure and reduced renal blood flow. Additionally, the study reveals the potential role of miR-155-5p in the development of vascular endothelial dysfunction in hypertension.
Article
Cell Biology
Lu Gao, Weixian Chen, Lijun Li, Juanjuan Li, Wenyao Kongling, Yaoyang Zhang, Xueping Yang, Yanrong Zhao, Jie Bai, Fu Wang
Summary: Type H vessels play a role in osteogenesis and Epoxyeicostrioleic acids (EETs) contribute to vascular homeostasis. It is unclear whether increasing EETs with sEH inhibitor TPPU can enhance the coupling of angiogenesis and osteogenesis. In this study, TPPU was found to enhance osteogenic differentiation and promote bone growth and repair. Mechanistically, TPPU promoted cell proliferation and angiogenesis and increased the expression of certain factors involved in endothelial cell function. The results suggest that targeting EETs metabolic pathways can be a promising strategy for bone regeneration and repair.
CELL PROLIFERATION
(2023)
Article
Medicine, Research & Experimental
Zhe Cheng, Xinyu Xiong, Yi Zhou, Fan Wu, Qingqing Shao, Ruolan Dong, Qiong Liu, Lingli Li, Guang Chen
Summary: The study demonstrated that 6-gingerol can alleviate obesity by regulating adipocytokines and the TLR3/IL-6/JAK1/STAT3 axis, inhibiting excessive hyperplasia and hypertrophy of adipocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Laura C. Chambers, Martina Yen, William F. Jackson, Anne M. Dorrance
Summary: Hypertension is a major modifiable risk factor for cerebral small vessel disease. This study aimed to determine the sex differences in young, hypertensive mice to lay a foundation for future research on sex differences at midlife. The results suggest that female sex may provide protection against impaired TRPV4 dilation and cognitive dysfunction during hypertension.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Iwona Baranowska, Olga Gawrys, Agnieszka Walkowska, Krzysztof H. Olszynski, Ludek Cervenka, John R. Falck, Adeniyi M. Adebesin, John D. Imig, Elzbieta Kompanowska-Jezierska
Summary: Numerous studies have shown that metabolites of arachidonic acid, specifically epoxyeicosatrienoic acids (EETs) and 20-Hydroxyeicosatetraenoic acid (20-HETE), play important roles in blood pressure regulation, vascular tone, and renal function control. In this study, the researchers tested the effectiveness of EET-A and AAA in treating spontaneously hypertensive rats (SHR) and found that the combination treatment not only reduced blood pressure but also increased nitric oxide levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Rozenn N. Lemaitre, Paul N. Jensen, Maxwell Zeigler, Julie Denham, Amanda M. Fretts, Jason G. Umans, Barbara V. Howard, Colleen M. Sitlani, Barbara McKnight, Sina A. Gharib, Irena B. King, David S. Siscovick, Bruce M. Psaty, Nona Sotoodehnia, Rheem A. Totah
Summary: This study found no significant association between total EET or DHET levels and incident diabetes among American Indians, but identified a negative association between 14,15-DHET and plasma insulin and glucose levels. Further research is warranted to replicate these findings and explore potential mechanisms.
Article
Cell Biology
Matthieu Leuillier, Valentin Platel, Ly Tu, Guillaume Feugray, Raphael Thuillet, Deborah Groussard, Hind Messaoudi, Mina Ottaviani, Mustapha Chelgham, Lionel Nicol, Paul Mulder, Marc Humbert, Vincent Richard, Christophe Morisseau, Valery Brunel, Thomas Duflot, Christophe Guignabert, Jeremy Bellien
Summary: Inhibitors of soluble epoxide hydrolase (sEH) present an opportunity for developing oral drugs for cardiovascular and inflammatory diseases. However, the administration of sEH inhibitors may lead to the development of pulmonary hypertension (PH). This study evaluated the impact of chronic oral administration of the sEH inhibitor TPPU on hemodynamics and pulmonary vascular remodeling in rats. The results showed that TPPU did not induce or aggravate PH and RV dysfunction, and may have a potential beneficial effect against pulmonary artery remodeling in humans.
Article
Physiology
Agnieszka Walkowska, Ludek Cervenka, John D. Imig, John R. Falck, Janusz Sadowski, Elzbieta Kompanowska-Jezierska
Summary: The study demonstrated that in spontaneously hypertensive rats, both EET-A and AAA induced renal vasodilation but did not show additive effects. Both agents have a definite therapeutic potential for hypertension and deserve further experimental and clinical testing for novel antihypertensive therapy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xiangyu Zheng, Jennifer Berg Sen, Zhuoxin Li, Mostafa Sabouri, Luaye Samarah, Christina S. Deacon, Joseph Bernardo, Daniel R. Machin
Summary: Excessive salt consumption leads to hypertension and arterial dysfunction in humans, but this phenotype is not observed in genetically identical mouse strains. In this study, researchers investigated the effects of a high-salt diet on blood pressure and arterial function in genetically diverse UM-HET3 mice. Results showed that high-salt diet increased systolic blood pressure and aortic stiffness, while impairing endothelium-dependent dilation. These findings suggest that genetically diverse mice may offer insights into arterial adaptations in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Guillaume Feugray, Tony Pereira, Michele Iacob, Lucile Moreau-Grange, Gaetan Prevost, Valery Brunel, Robinson Joannides, Jeremy Bellien, Thomas Duflot
Summary: This study found that there were no significant differences in ARA metabolite levels between T2D patients and healthy volunteers, but HTN patients showed alterations in ARA metabolite correlation patterns with increased 20-, 19-, 15-, and 8-HETE. Additionally, a decrease in 20-HETE was observed during both hyperglycemic and hyperinsulinemic clamps, suggesting a potential link to glucose tolerance and insulin signaling regulation.
Article
Pharmacology & Pharmacy
Hicham Labazi, Margaret Nilsen, Margaret R. MacLean
Summary: Methamphetamine abuse is associated with the development of pulmonary arterial hypertension (PAH) and right ventricular failure, with female sex being a major risk factor for MA-induced PAH. The study found that methamphetamine caused right ventricular hypertrophy in female mice, but not in males, indicating a potential direct effect of MA on the right ventricle. This may help explain the poor outcomes observed in MA-associated female PAH patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Rozenn N. Lemaitre, Paul N. Jensen, Maxwell Zeigler, Amanda M. Fretts, Jason G. Umans, Barbara Howard, Colleen M. Sitlani, Barbara McKnight, Sina A. Gharib, Irena B. King, David S. Siscovick, Bruce M. Psaty, Nona Sotoodehnia, Rheem A. Totah
Summary: This study investigated the association between total plasma EETs (free + esterified) and diabetes-related cardiovascular diseases, revealing a potential protective role of EETs against myocardial infarction but an increased risk for ischemic stroke. DHETs may play a role in these associations.
Article
Biochemistry & Molecular Biology
Brandon M. Wagner, Jerid W. Robinson, Chastity L. Healy, Madeline Gauthier, Deborah M. Dickey, Siu-Pok Yee, John W. Osborn, Timothy D. O'Connell, Lincoln R. Potter
Summary: Increased phosphorylation-dependent GC-A activity decreases cardiac ERK activity, resulting in smaller male hearts with improved systolic function.
Article
Multidisciplinary Sciences
Christian B. Bergmann, Bruce D. Hammock, Debin Wan, Falk Gogolla, Holly Goetzman, Charles C. Caldwell, Dorothy M. Supp
Summary: The study demonstrated that TPPU administration can decrease DHET levels post-burn, leading to reduced IL-6 concentrations. 14,15-DHET was found to modulate neutrophil functionality and mRNA expression, indicating its role in regulating inflammation in burn injury.
SCIENTIFIC REPORTS
(2021)
Article
Rehabilitation
Nandakumar Nagaraja, Alison R. Kraus, Dorian K. Rose, Esther B. Olasoji, Anna Y. Khanna, Alexis N. Simpkins, Christina A. Wilson, Rondalyn R. Dickens, Vishnumurthy Shushrutha Hedna, Carolyn Geis, Teddy Youn, Michelle M. Musalo
Summary: The interdisciplinary stroke clinic identified a significant number of post-acute stroke survivors appropriate for additional rehabilitation. The evaluation scales that most closely correlated with referral for additional therapy were the 10-Meter Walk Test (10MWT) and Short Form-Stroke Impact Scale (SF-SIS).
DISABILITY AND REHABILITATION
(2022)
Editorial Material
Clinical Neurology
Alexis N. Simpkins, Alain Lekoubou
Summary: COVID-19 can lead to acute ischemic stroke (AIS) as a complication beyond respiratory illness. Factors like hypercoagulability, inflammation, cardiac dysfunction, and endothelial inflammation during the infectious phase may cause thrombotic events and cerebral ischemia. Studies on the risk of stroke in COVID-19 have shown substantial variation, with most focusing on AIS incidence in hospitalized patients. The large-scale screening of COVID-19 in both symptomatic and asymptomatic individuals upon hospital admission has made it challenging to determine the true association between COVID-19 and an increased risk of AIS.
Article
Clinical Neurology
Shadi Yaghi, Liqi Shu, Ekaterina Bakradze, Setareh Salehi Omran, James A. Giles, Jordan Y. Amar, Nils Henninger, Marwa Elnazeir, Ava L. Liberman, Khadean Moncrieffe, Jenny Lu, Richa Sharma, Yee Cheng, Adeel S. Zubair, Alexis N. Simpkins, Grace T. Li, Justin Chi Kung, Dezaray Perez, Mirjam Heldner, Adrian Scutelnic, David Seiffge, Bernhard Siepen, Aaron Rothstein, Ossama Khazaal, David Do, Sami Al Kasab, Line Abdul Rahman, Eva A. Mistry, Deborah Kerrigan, Hayden Lafever, Thanh N. Nguyen, Piers Klein, Hugo Aparicio, Jennifer Frontera, Lindsey Kuohn, Shashank Agarwal, Christoph Stretz, Narendra Kala, Sleiman El Jamal, Alison Chang, Shawna Cutting, Han Xiao, Adam de Havenon, Varsha Muddasani, Teddy Wu, Duncan Wilson, Amre Nouh, Syed Daniyal Asad, Abid Qureshi, Justin Moore, Pooja Khatri, Yasmin Aziz, Bryce Casteigne, Muhib Khan, Yao Cheng, Brian Mac Grory, Martin Weiss, Dylan Ryan, Maria Cristina Vedovati, Maurizio Paciaroni, James E. Siegler, Scott Kamen, Siyuan Yu, Christopher R. Leon Guerrero, Eugenie Atallah, Gian Marco De Marchis, Alex Brehm, Tolga Dittrich, Marios Psychogios, Ronald Alvarado-Dyer, Tareq Kass-Hout, Shyam Prabhakaran, Tristan Honda, David S. Liebeskind, Karen Furie
Summary: The study compared the effectiveness of DOACs and warfarin in treating CVT, showing similar outcomes in recurrent venous thrombosis, death, and partial/complete recanalization rates between the two groups, but lower risk of major hemorrhage in the DOACs treatment group.
Meeting Abstract
Clinical Neurology
Niran Vijayaraghavan, Tri Huynh, Hannah Branstetter, Rondalyn Dickens, Justin De Prey, Alexis N. Simpkins
Article
Peripheral Vascular Disease
Fred Stephen Sarfo, Esther Olasoji, Grant P. Banfill, Bruce Ovbiagele, Alexis N. Simpkins
Summary: The prevalence and predictors of hypertension in stroke survivors vary by race and geography. However, the impact of race and geography on treatment-resistant hypertension needs further investigation.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Editorial Material
Medicine, Research & Experimental
John D. Imig
Summary: The SARS-CoV-2 virus's S protein has been found to potentially cause damage to multiple organs through binding to receptors, particularly affecting human cardiac pericytes. Further investigations are needed to evaluate the S protein's impact on pericytes in various organs and explore the efficacy of CD147 receptor-blocking therapies in reducing organ damage.
Editorial Material
Public, Environmental & Occupational Health
Rondalyn R. Dickens, Tirisham Gyang, Sadie Sanders, Charles Ellis, Alexis N. Simpkins
Summary: Patient-centered research on health care disparities among stroke patients is limited. Existing studies mainly focus on patients' perceptions using validated questionnaires. However, there are several domains that need further investigation, including medication side effects, acceptance of stroke diagnosis, consequences of symptoms, importance of medications for long-term health, and perception of ease of access to equitable health care. The representation of diverse groups in stroke surveys is low. Limited studies have explored health disparities and beliefs of under-represented stroke survivors. Future research should focus on using patient perception questionnaires with underrepresented populations. Improvements in this field can promote patient-centered care and bridge gaps in health care equity.
ETHNICITY & DISEASE
(2022)
Article
Clinical Neurology
Thanh N. Nguyen, Muhammad M. Qureshi, Piers Klein, Hiroshi Yamagami, Mohamad Abdalkader, Robert Mikulik, Anvitha Sathya, Ossama Yassin Mansour, Anna Czlonkowska, Hannah Lo, Thalia S. Field, Andreas Charidimou, Soma Banerjee, Shadi Yaghi, James E. Siegler, Petra Sedova, Joseph Kwan, Diana Aguiar de Sousa, Jelle Demeestere, Violiza Inoa, Setareh Salehi Omran, Liqun Zhang, Patrik Michel, Davide Strambo, Joao Pedro Marto, Raul G. Nogueira
Summary: This study evaluated the impact of the COVID-19 pandemic on CVT hospitalization volume and in-hospital mortality, finding no changes during the first year of the pandemic. However, there was an increase in CVT hospitalization volume and related mortality in the first 5 months of 2021, partially attributable to vaccine-induced immune thrombotic thrombocytopenia.
Article
Neurosciences
Alvin V. Terry Jr, Wayne D. Beck, Ping-Chang Lin, Patrick M. Callahan, R. Daniel Rudic, Mark W. Hamrick
Summary: In this study, a new method using manganese-enhanced magnetic resonance imaging (MEMRI) was developed to measure axonal transport rates in real time in mice. The study evaluated the effects of age and a microtubule-stabilizing agent called Epothilone D on axonal transport rates. The results showed that aging led to decreased axonal transport rates, and treatment with Epothilone D increased axonal transport rates in aged mice. This study provides further evidence for the potential of microtubule-based therapeutic strategies in age-related neurological disorders.
Article
Clinical Neurology
Dennys Reyes, Alexis N. Simpkins, Emi Hitomi, John K. Lynch, Amie W. Hsia, Zurab Nadareishvili, Marie Luby, Lawrence L. Latour, Richard Leigh
Summary: In this study, the National Institutes of Health (NIH) FHV score was developed to quantify the burden of fluid-attenuated inversion recovery hyperintense vessels (FHVs) and investigate its potential as a surrogate for perfusion weighted imaging (PWI). The study found a strong association between the NIH-FHV score and PWI lesion volume, and when combined with diffusion weighted imaging, it may be helpful in determining the presence of a clinically relevant diffusion-perfusion mismatch in situations where perfusion imaging is not available.
Article
Clinical Neurology
Esther B. Olasoji, Daniel K. Uhm, Oluwole O. Awosika, Sylvain Dor, Carolyn Geis, Alexis N. Simpkins
Summary: In the rehabilitation of stroke patients, there has been a shift towards outpatient rehabilitation services, emphasizing its importance as an expanding healthcare resource for reducing stroke-related disabilities.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Liqi Shu, Ekaterina Bakradze, Setareh Salehi Omran, James Giles, Jordan Amar, Nils Henninger, Marwa Elnazeir, Ava Liberman, Khadean Moncrieffe, Jenny Rotblat, Richa Sharma, Yee Cheng, Adeel S. Zubair, Alexis Simpkins, Grace Li, Justin Kung, Dezaray Perez, Mirjam R. Heldner, Adrian Scutelnic, Rascha Von Martial, Bernhard Siepen, Aaron Rothstein, Ossama Khazaal, David Do, Sami Al Kasab, Line Abdul Rahman, Eva A. Mistry, Deborah Kerrigan, Hayden Lafever, Thanh N. Nguyen, Piers Klein, Hugo J. Aparicio, Jennifer A. Frontera, Lindsey Kuohn, Shashank Agarwal, Christoph Stretz, Narendra Kala, Sleiman ElJamal, Allison Chang, Shawna Cutting, Fransisca Indraswari, Adam de Havenon, Varsha Muddasani, Teddy Wu, Duncan Wilson, Amre Nouh, Daniyal Asad, Abid Qureshi, Justin Moore, Pooja Khatri, Yasmin Aziz, Bryce Casteigne, Muhib Khan, Yao Cheng, Brian MacGrory, Martin Weiss, Dylan Ryan, Maria Cristina Vedovati, Maurizio Paciaroni, James Siegler, Scott Kamen, Siyuan Yu, Christopher Leon Guerrero, Eugenie Atallah, Gian Marco De Marchis, Alex Brehm, Tolga Dittrich, Marios Psychogios, Ronald Alvarado-Dyer, Tareq Kass-Hout, Shyam Prabhakaran, Tristan Honda, David Liebeskind, Karen Furie, Shadi Yaghi
Summary: This study aimed to identify predictors of recurrent venous thrombosis in patients with CVT. The study found that Black race, history of VTE, and the presence of one or more positive antiphospholipid antibodies were associated with recurrent venous thrombosis among patients with CVT.
Editorial Material
Clinical Neurology
Alexis N. Simpkins, Susan Cheng
Summary: Most stroke prevention strategies focus on optimizing various aspects of health, but the COVID-19 pandemic has highlighted the increased risk of stroke associated with the infection and vaccination. COVID-19 patients, especially those with severe respiratory manifestations, are more prone to prothrombotic and proinflammatory states, cardiac dysfunction, and stroke. Reports of thrombotic events, such as acute ischemic stroke and cerebral venous thrombosis, have also emerged post-COVID-19 vaccination. As the pandemic continues, it is essential to consider and weigh the risks of stroke from COVID-19 infection and vaccination.
Article
Pharmacology & Pharmacy
John D. Imig, Md Abdul Hye Khan, Anna Stavniichuk, Wojciech K. Jankiewicz, Samaneh Goorani, Michael M. Yeboah, Ashraf El-Meanawy
Summary: The incidence of ureter obstruction is increasing and recovery from this kidney injury can lead to long-term consequences such as an increased risk for salt-sensitive hypertension. A study using a RUUO model found that mice with unilateral ureteral obstruction had elevated blood pressure and decreased sodium excretion, along with renal tubular injury, inflammation, decreased vascular density, and renal fibrosis. These findings highlight the importance of addressing ureter obstruction and its potential impact on sodium excretion and hypertension.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Peripheral Vascular Disease
Michelle L. Gumz, Daichi Shimbo, Marwah Abdalla, Ravi C. Balijepalli, Christian Benedict, Yabing Chen, David J. Earnest, Karen L. Gamble, Scott R. Garrison, Ming C. Gong, John B. Hogenesch, Yuling Hong, Jessica R. Ivy, Bina Joe, Aaron D. Laposky, Mingyu Liang, Eric J. MacLaughlin, Tami A. Martino, David M. Pollock, Susan Redline, Amy Rogers, R. Dan Rudic, Eva S. Schernhammer, George S. Stergiou, Marie-Pierre St-Onge, Xiaoling Wang, Jacqueline Wright, Young S. Oh
Summary: Healthy individuals experience variation in blood pressure over a 24-hour period, with higher levels during wakefulness and lower levels during sleep. Disruption of the blood pressure circadian rhythm has been associated with negative health outcomes such as cardiovascular disease, dementia, and chronic kidney disease. Current approaches to diagnosis and treatment do not adequately consider the circadian rhythmicity of blood pressure. This review summarizes findings from a workshop held by the National Heart, Lung, and Blood Institute to identify knowledge gaps and research opportunities related to the study of blood pressure circadian rhythm and chronotherapy for hypertension.
