Article
Plant Sciences
Nurmila Sari, Yasufumi Katanasaka, Yuga Sugiyama, Yoichi Sunagawa, Yusuke Miyazaki, Masafumi Funamoto, Satoshi Shimizu, Kana Shimizu, Akira Murakami, Kiyoshi Mori, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto
Summary: The study demonstrates that Zerumbone can inhibit the development of cardiac hypertrophy and fibrosis, thereby improving LV function. Both in vitro experiments and mouse models confirmed the effects of Zer on cardiac cells and cardiac fibroblasts.
Article
Cell Biology
Maren Leifheit-Nestler, Miriam A. Wagner, Beatrice Richter, Corinna Piepert, Fiona Eitner, Ineke Boeckmann, Isabel Vogt, Andrea Grund, Susanne S. Hille, Ariana Foinquinos, Karina Zimmer, Thomas Thum, Oliver J. Mueller, Dieter Haffner
Summary: Through experiments using a mouse model with high intra-cardiac Fgf23 synthesis, it was found that chronic exposure to elevated cardiac iFgf23 does not induce LVH in healthy mice, suggesting that Fgf23 excess per se does not affect the heart.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Steve Leu, Kay L. H. Wu, Wei-Chia Lee, You-Lin Tain, Julie Y. H. Chan
Summary: Recent studies have shown that metabolic syndrome and cardiovascular diseases can be influenced by developmental programming, particularly prenatal nutritional and environmental stress. This study used a rat model to investigate the impact of excessive maternal fructose intake during pregnancy and lactation on cardiac development and progression of pressure overload-induced cardiac hypertrophy in offspring. The results indicated that maternal fructose exposure during pregnancy and lactation modulated myocardial gene expression, increased oxidative stress, and exacerbated ventricular pressure overload-induced cardiac remodeling in rat offspring.
Article
Multidisciplinary Sciences
Pankaj Garg, Hosamadin Assadi, Rachel Jones, Wei Bin Chan, Peter Metherall, Richard Thomas, Rob van der Geest, Andrew J. Swift, Abdallah Al-Mohammad
Summary: CMR is helpful for prognostication in patients with HFpEF, where left ventricular fibrosis and hypertrophy are associated with all-cause mortality.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Adam Budai, Ferenc Imre Suhai, Kristof Csorba, Zsofia Dohy, Liliana Szabo, Bela Merkely, Hajnalka Vago
Summary: A machine learning-based model was developed to automatically detect left ventricular hypertrophy in cardiac magnetic resonance images. The model achieved high accuracy and recall by introducing a standardization method. This algorithm has the potential to improve the diagnostic accuracy of left ventricular hypertrophy and has important applications in cardiac magnetic resonance.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Sukka Santosh Reddy, Heena Agarwal, Anant Jaiswal, Kumaravelu Jagavelu, Madhu Dikshit, Manoj Kumar Barthwal
Summary: The study found that macrophage p47phox plays a role in hypertensive cardiac remodeling, with its deficiency potentially leading to worsened cardiac dysfunction, hypertrophy, and increased interstitial fibrosis. Further experiments revealed elevated expression of M2 macrophage markers in KO mice, suggesting a restrictive role of p47phox in anti-inflammatory signaling during cardiac remodeling.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Fiona Eitner, Beatrice Richter, Saskia Schwaenen, Malgorzata Szaroszyk, Isabel Vogt, Andrea Grund, Thomas Thum, Joerg Heineke, Dieter Haffner, Maren Leifheit-Nestler
Summary: Enhanced fibroblast growth factor 23 (FGF23) is associated with left ventricular hypertrophy (LVH) in patients with chronic kidney and heart disease. The synthesis and paracrine role of FGF23 in the heart, as well as its sources within the heart, have been previously unknown. This study reveals that FGF23 is expressed by cardiac myocytes, fibroblasts, and endothelial cells, with cardiac fibroblasts and endothelial cells potentially being important sources of FGF23 in pathological conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Andrew R. Kompa, Fay L. Khong, Yuan Zhang, Cindy Nguyen, Amanda J. Edgley, Owen L. Woodman, Grant McLachlan, Darren J. Kelly
Summary: This study evaluated the efficacy of NP202, a synthetic flavonol, on cardiac remodelling in a chronic model of myocardial infarction (MI). Results showed that NP202 improved left ventricular function and structure, especially at a higher dose. NP202 also reduced hypertrophy and interstitial fibrosis in the non-infarct region of the myocardium.
Article
Cell Biology
Asish K. Ghosh, Anthony A. Kalousdian, Meng Shang, Elizabeth Lux, Mesut Eren, Anna Keating, Lisa D. Wilsbacher, Douglas E. Vaughan
Summary: This study found that cardiomyocyte PAI-1 plays an important role in regulating the transcriptome network involved in the cardiac stress response. The loss of cardiomyocyte PAI-1 may be the underlying cause of cardiac-selective accelerated fibrogenesis in global PAI-1-deficient mice.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Run-Jing Li, Jia-Jia Xu, Zheng-Hao Zhang, Min-Wei Chen, Shi-Xiao Liu, Cui Yang, Yan-Ling Li, Ping Luo, Yi-Jiang Liu, Rong Tang, Zhong-Gui Shan
Summary: The anthraquinone rhein has been found to reduce transverse aortic constriction (TAC)-induced cardiac hypertrophy by inhibiting the molecular function of ERK and downregulating STAT3 and p38 MAPK signaling. Therapeutic doses of rhein have no significant adverse effects on liver and kidney function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xia Wang, Xinxin Zhu, Li Shi, Jingjing Wang, Qing Xu, Baoqi Yu, Aijuan Qu
Summary: Transverse aortic constriction (TAC) is a widely-used animal model to study pressure overload-induced cardiac hypertrophy and heart failure (HF). Most studies use a 27-gauge needle for TAC, resulting in rapid HF but higher mortality. This study focuses on TAC with a 25-gauge needle, which induces mild overload and has low post-operation mortality. The timeline of HF induced by TAC with a 25-gauge needle in C57BL/6 J mice is still unclear. This study provides an optimized method to study mild overload TAC-induced cardiac remodeling from the compensatory period to decompensatory HF in C57BL/6 J mice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ljuba Bacharova, Marta Kollarova, Branislav Bezak, Allan Bohm
Summary: Left ventricular hypertrophy (LVH) refers to the complex rebuilding of the left ventricle, which can lead to heart failure and life-threatening ventricular arrhythmias. Imaging methods such as echocardiography and cardiac magnetic resonance can diagnose the increase in left ventricle size, while other methods can evaluate the functional status and underlying processes of LVH. Molecular and genetic biomarkers offer insights and potential for targeted therapy. This review summarizes the main biomarkers used in LVH evaluation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Shaan Khurshid, Julieta Lazarte, James P. Pirruccello, Lu-Chen Weng, Seung Hoan Choi, Amelia W. Hall, Xin Wang, Samuel F. Friedman, Victor Nauffal, Kiran J. Biddinger, Krishna G. Aragam, Puneet Batra, Jennifer E. Ho, Anthony A. Philippakis, Patrick T. Ellinor, Steven A. Lubitz
Summary: A genome-wide association study on 43,000 UK Biobank participants using cardiac magnetic resonance-derived left ventricular mass index identified 12 associations, including 11 novel ones, related to cardiac contractility and cardiomyopathy. The study demonstrates the association between indexed left ventricular mass and incident cardiomyopathy, as well as implantable cardioverter-defibrillator implant. The findings highlight the importance of cardiac magnetic resonance in assessing cardiovascular risk.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Kimi Sato, Ayman Ayache, Arnav Kumar, Paul C. Cremer, Brian Griffin, Zoran B. Popovic, Christine Jellis, Deborah H. Kwon, Michael Bolen, Jay Ramchand, Michael Chetrit, Muhammad M. Furqan, Douglas Johnston, Allan L. Klein
Summary: Anti-inflammatory therapy may lead to clinical resolution in patients with constrictive pericarditis, with improved constrictive physiology detected by echocardiography markers such as lateral/septal e' and LSlateral/LSseptal. Patients with higher baseline erythrocyte sedimentation rates and greater improvement in these markers were more likely to experience clinical resolution after anti-inflammatory treatment.
Article
Cardiac & Cardiovascular Systems
Aaisha Ferkh, Catherina Tjahjadi, Luke Stefani, Paul Geenty, Karen Byth, Kasun De Silva, Anita C. C. Boyd, David Richards, Peter Mollee, Dariusz Korczyk, Mark S. S. Taylor, Fiona Kwok, Eddy Kizana, Arnold C. T. Ng, Liza Thomas
Summary: Different echocardiographic parameters can differentiate between different hypertrophic cardiac phenotypes, providing a potential screening tool for further confirmatory testing. LV mass index, LVGLS, E/e', and AMYLI score were found to be useful in distinguishing cardiac amyloidosis and Anderson-Fabry disease from hypertensive heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Toxicology
Joseph A. Cichocki, Yu-Syuan Luo, Shinji Furuya, Abhishek Venkatratnam, Kranti Konganti, Weihsueh A. Chiu, David W. Threadgill, Igor P. Pogribny, Ivan Rusyn
TOXICOLOGICAL SCIENCES
(2019)
Article
Gastroenterology & Hepatology
Pin Wang, Yunshan Wang, Sasha Langley, Yan-Xia Zhou, Kuang-Yu Jen, Qi Sun, Colin Brislawn, Carolina M. Rojas, Kimberly L. Wahl, Ting Wang, Xiangshan Fan, Janet K. Jansson, Susan E. Celniker, Xiaoping Zou, David W. Threadgill, Antoine M. Snijders, Jian-Hua Mao
Article
Genetics & Heredity
Anika C. Bissahoyo, Yuying Xie, Lynda Yang, R. Scott Pearsall, Daekee Lee, Rosemary W. Elliott, Peter Demant, Leonard McMillan, Fernando Pardo-Manuel de Villena, Joe M. Angel, David W. Threadgill
Article
Cell Biology
Adam Price, Atsushi Okumura, Elaine Haddock, Friederike Feldmann, Kimberly Meade-White, Pryanka Sharma, Methinee Artami, W. Ian Lipkin, David W. Threadgill, Heinz Feldmann, Angela L. Rasmussen
Article
Multidisciplinary Sciences
Raena Eldridge, Daniel Osorio, Katia Amstalden, Caitlin Edwards, Colin R. Young, James J. Cai, Kranti Konganti, Andrew Hillhouse, David W. Threadgill, C. Jane Welsh, Candice Brinkmeyer-Langford
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Tiffany A. Garbutt, Kranti Konganti, Thomas Konneker, Andrew Hillhouse, Drake Phelps, Alexis Jones, David Aylor, David W. Threadgill
Article
Endocrinology & Metabolism
Anna C. Salvador, Danny Arends, William T. Barrington, Ahmed M. Elsaadi, Gudrun A. Brockmann, David W. Threadgill
Summary: Genetic mapping revealed QTLs on Chromosome 1, 5, and 7 associated with fat and lean mass gain, as well as a significant QTL on Chromosome 1 linked to serum HDL cholesterol concentration. Causal network analysis showed a connection between HDL cholesterol and fat mass gain with Fmgq1, while strong sex effects were identified at Fmgq2 and Lmgq1, influenced by diet.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Infectious Diseases
Leta Elias, John C. Blazier, Yuliya Rogovska, Kranti Konganti, Jiangli Wang, Shuling Liu, Kelley M. Thieman Mankin, Igor Nebogatkin, David W. Threadgill, Artem S. Rogovskyy
Summary: Recent studies have shown significant differences in the microbiome of Dermacentor reticulatus ticks between different geographical regions and sexes.
TICKS AND TICK-BORNE DISEASES
(2021)
Article
Genetics & Heredity
Carolina Mantilla Rojas, Michael P. McGill, Anna C. Salvador, David Bautz, David W. Threadgill
Summary: This study highlights the discrepancy between pre-clinical efficacy and clinical translation of targeted cancer therapies and the significant impact of genetic background on the response in mouse colorectal cancer models. The genetic background dependency of ERBB3 has implications for polyp growth in the intestines, with implications for the use of ERBB3 inhibitors in colorectal cancer treatment.
Review
Environmental Sciences
Danila Cuomo, Margaret J. Foster, David Threadgill
Summary: Lead poisoning is a significant public health concern in environmental justice communities and developing countries. Individual susceptibility to lead exposure varies due to genetic and epigenetic factors. Current studies have provided inconsistent evidence on the identification of susceptibility genes or early exposure biomarkers.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Hui Yan, Wanbao Yang, Fenghua Zhou, Quan Pan, Kimberly Allred, Clinton Allred, Yuxiang Sun, David Threadgill, David Dostal, Carl Tong, Shaodong Guo
Summary: This study investigates the role of ovaries and ovarian hormone estrogen in cardiac function and energy metabolism. The results show that estrogen can prevent dilated cardiomyopathy, improve cardiac function and energy metabolism, and enhance lifespan. This provides a mechanistic explanation for the gender difference in the incidence of T2D and cardiovascular diseases.
CIRCULATION-HEART FAILURE
(2022)
Article
Microbiology
Kristin Scoggin, Jyotsana Gupta, Rachel Lynch, Aravindh Nagarajan, Manuchehr Aminian, Amy Peterson, L. Garry Adams, Michael Kirby, David W. Threadgill, Helene L. Andrews-Polymenis
Summary: Understanding the molecular mechanisms of resistance and tolerance to pathogen infection can help in developing novel interventions. A study on mice infected with Salmonella Typhimurium found distinct phenotypes of delayed susceptible, tolerant, and resistant strains. Tolerant strains showed lower preinfection core body temperatures, rapid disruption of body temperature postinfection, higher neutrophil levels, and more severe tissue damage compared to resistant strains. Gene analysis identified specific genes associated with tolerance and resistance, particularly fibrinogen genes.
Article
Multidisciplinary Sciences
Luke Gierus, Aysegul Birand, Mark D. Bunting, Gelshan I. Godahewa, Sandra G. Piltz, Kevin P. Oh, Antoinette J. Piaggio, David W. Threadgill, John Godwin, Owain Edwards, Phillip Cassey, Joshua V. Ross, Thomas A. A. Prowse, Paul Q. Thomas
Summary: This study demonstrates a novel gene drive strategy to eradicate invasive rodent populations on islands by leveraging the super-Mendelian transmission of the t haplotype. Transgenic mice were engineered to validate the effectiveness of this approach.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Yeon Sun Kim, Jia Yuan, Amanda Dewar, Jean-Paul Borg, David W. Threadgill, Xiaofei Sun, Sudhansu K. Dey
Summary: HB-EGF recruits VANGL2 for tyrosine phosphorylation through binding to ERBB2 and ERBB3, thereby influencing uterine epithelial cell polarity and regulating the implantation process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Endocrinology & Metabolism
Kebin Zhang, Xiaoqin Guo, Hui Yan, Yuxin Wu, Quan Pan, James Zheng Shen, Xiaopeng Li, Yunmei Chen, Ling Li, Yajuan Qi, Zihui Xu, Wei Xie, Weiping Zhang, David Threadgill, Ling He, Daniel Villarreal, Yuxiang Sun, Morris F. White, Hongting Zheng, Shaodong Guo