4.5 Article

Regional differences in the placental levels of oxidative stress markers in pre-eclampsia

期刊

出版社

WILEY
DOI: 10.1016/j.ijgo.2015.03.001

关键词

Catalase; Glutathione peroxidase; Malondialdehyde; Oxidative stress; Placenta; Pre-eclampsia

资金

  1. Department of Science and Technology, Government of India

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Objective: To examine placental malondialdehyde (MDA), catalase, and glutathione peroxidase (GPx) levels in four placental regions among women with and without pre-eclampsia. Methods: A cross-sectional study was conducted among women aged 18-35 years with a singleton pregnancy in Pune, India, between May 3, 2013, and June 16, 2014. Three groups were enrolled: normotensive; pre-eclampsia, delivered at term; and pre-eclampsia, delivered preterm. Samples were collected from the central and peripheral placental regions (maternal and fetal sides) immediately after delivery. Results: A total of 60 women were enrolled (35 normotensive; 11 with pre-eclampsia delivered at term; 14 with pre-eclampsia, delivered preterm). MDA levels were higher in all regions of the placenta among the pre-eclampsia versus normotensive groups (P < 0.01). MDA levels were higher in the central maternal region than in the central fetal region in the preterm pre-eclampsia group (P = 0.023). The MDA levels in the central maternal region were also higher in the preterm than in the term pre-eclampsia group (P = 0.014). Catalase activity was lower in the peripheral maternal (P = 0.036) and fetal (P = 0.050) regions in the preterm pre-eclampsia group versus the normotensive group. The activity of GPx was higher in the peripheral maternal region than in the central fetal region in the normotensive group (P = 0.033). Conclusion: Pre-eclampsia might be characterized by differential placental oxidative stress and antioxidant enzyme activity. (C) 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

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