Review
Pharmacology & Pharmacy
Corrado De Marco, Thierry Charron, Guy Rousseau
Summary: Adenosine has the potential benefits in the treatment of acute myocardial infarction by inhibiting the pathophysiological processes leading to reperfusion injury. However, the heterogenous evidence regarding its effects has resulted in limited uptake in clinical practice. Therefore, studying the dose, route, timing, and site of administration of adenosine is crucial for its efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ting Liu, Andrew G. Howarth, Yinyin Chen, Anand R. Nair, Hsin-Jung Yang, Daoyuan Ren, Richard Tang, Jane Sykes, Michael S. Kovacs, Damini Dey, Piotr Slomka, John C. Wood, Robert Finney, Mengsu Zeng, Frank S. Prato, Joseph Francis, Daniel S. Berman, Prediman K. Shah, Andreas Kumar, Rohan Dharmakumar
Summary: Reperfusion therapy for acute myocardial infarction can lead to myocardial hemorrhage, which increases the size of the infarction. Myocardial hemorrhage drives the expansion of myocardial infarction after reperfusion and compromises myocardial salvage. This has implications for acute care management, risk assessment, and future therapeutics.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
David Adlam, Maciej Zarebinski, Neal G. Uren, Pawel Ptaszynski, Keith G. Oldroyd, Shahzad Munir, Azfar Zaman, Hussain Contractor, Robert Gabor Kiss, Istvan Edes, Joanna Szachniewicz, Gergely Gyorgy Nagy, Mario J. Garcia, Janos Tomcsanyi, John Irving, Andrew S. P. Sharp, Piotr Musialek, Geza Lupkovics, Cheerag Shirodaria, Joseph B. Selvanayagam, Pauline Quinn, Leong Ng, Mark Roth, Michael A. Insko, Ben Haber, Stephen Hill, Lori Siegel, Simon Tulloch, Keith M. Channon
Summary: The study showed that giving FDY-5301 prior to PPCI in first-time STEMI patients increased plasma iodide levels and reduced myocardial damage in some patients after infarction, while also being safe and feasible.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anna Giulia Pavon, Georgios Georgiopoulos, Gabriella Vincenti, Olivier Muller, Pierre Monney, Gregoire Berchier, Chiara Cirillo, Eric Eeckhout, Juerg Schwitter, Pier Giorgio Masci
Summary: Hypocore on T2/T1 maps is the best alternative technique to T2*w for diagnosing and quantifying IMH in post-STEMI patients, showing excellent consistency in quantification of IMH.
EUROPEAN RADIOLOGY
(2021)
Article
Plant Sciences
Sihan Hu, Lan Jiang, Qi Yan, Chenyang Zhou, Xiaochuan Guo, Tong Chen, Siting Ma, Yimiao Luo, Caiyu Hu, Fumin Yang, Lishan Yuan, Xiao Ma, Jinhao Zeng
Summary: Baicalin exhibits positive effects on myocardial ischemia diseases, achieved by regulating key pathological indicators and various signaling pathways. In animal models of myocardial ischemia, reperfusion injury, and myocardial infarction, baicalin can reduce myocardial infarction size, improve cardiac pathological condition, and enhance heart function indicators.
Article
Cardiac & Cardiovascular Systems
Jan Philipp Schuette, Mailin-Christin Manke, Katherina Hemmen, Patrick Muenzer, Barbara F. Schoerg, Gustavo Campos Ramos, Michaela Pogoda, Valerie Dicenta, Sabrina H. L. Hoffmann, Juergen Pinnecker, Ferdinand Kollotzek, Monika Zdanyte, Karin A. L. Mueller, Yogesh Singh, Andreas F. Mack, Bernd Pichler, Florian Lang, Bernhard Nieswandt, Meinrad Gawaz, Katrin G. Heinze, Nicolas Casadei, Oliver Borst
Summary: Platelet-derived miRNAs play a critical role in myocardial inflammation and structural remodeling in response to myocardial ischemia/reperfusion (I/R). In a mouse model with a Dicer gene deletion, disrupted miRNA processing machinery in platelets led to increased myocardial inflammation, impaired angiogenesis, accelerated cardiac fibrosis, and larger infarct size. These findings highlight the importance of platelet-derived miRNA in regulating cellular processes following myocardial I/R.
CIRCULATION RESEARCH
(2023)
Review
Medicine, General & Internal
Mohamed El Farissi, Thomas P. Mast, Mileen R. D. van de Kar, Daimy M. M. Dillen, Jesse P. A. Demandt, Fabienne E. Vervaat, Rob Eerdekens, Simon A. G. Dello, Danielle C. Keulards, Jo M. Zelis, Marcel van 't Veer, Frederik M. Zimmermann, Nico H. J. Pijls, Luuk C. Otterspoor
Summary: The timely revascularization of an occluded coronary artery is crucial in treating patients with STEMI, but it can also cause additional damage known as myocardial reperfusion injury. Unfortunately, there is still no effective treatment for this injury, despite numerous experimental therapies showing promise but failing to demonstrate the same results in human trials.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Antonella Galeone, Maria Grano, Giacomina Brunetti
Summary: Ischemic heart disease, including myocardial infarction, stable angina, and ischemic cardiomyopathy, is a leading cause of death worldwide. Revascularization can reduce myocardial loss and improve clinical outcomes, but it also carries the risk of ischemia-reperfusion injury. This article reviews the role of tumor necrosis factor family members, such as TNF-alpha, CD95L/CD95, TRAIL, and the RANK/RANKL/OPG axis, in myocardial tissue damage and their potential as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Nicholas K. Kawasaki, Tomohiro Suhara, Kyoko Komai, Briana K. Shimada, Naaiko Yorichika, Motoi Kobayashi, Yuichi Baba, Jason K. Higa, Takashi Matsui
Summary: This study demonstrates the crucial role of ferroptosis in causing fibrotic scarring along myofibers in cardiac ischemic injury. By examining cadaveric hearts and using ex vivo experiments, the protective effects of the ferroptosis inhibitor Ferrostatin-1 on ischemia-reperfusion injury were demonstrated.
Article
Cardiac & Cardiovascular Systems
Weihong He, Charlotte S. McCarroll, Katrin Nather, Kristopher Ford, Kenneth Mangion, Alexandra Riddell, Dylan O'Toole, Ali Zaeri, David Corcoran, David Carrick, Mathew M. Y. Lee, Margaret McEntegart, Andrew Davie, Richard Good, Mitchell M. Lindsay, Hany Eteiba, Paul Rocchiccioli, Stuart Watkins, Stuart Hood, Aadil Shaukat, Lisa McArthur, Elspeth B. Elliott, John McClure, Catherine Hawksby, Tamara Martin, Mark C. Petrie, Keith G. Oldroyd, Godfrey L. Smith, Keith M. Channon, Colin Berry, Stuart A. Nicklin, Christopher M. Loughrey
Summary: The study identified that direct cardiac release of cathepsin-L in STEMI patients post-PPCI leads to elevated serum levels, and higher levels in the first 24 hours post-reperfusion are associated with reduced cardiac function and increased infarct size. Preclinical studies showed that inhibiting cathepsin-L release post-reperfusion injury can reduce infarct size and improve cardiac function by limiting abnormal calcium handling and apoptosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Alex Gallinat, Guiomar Mendieta, Gemma Vilahur, Teresa Padro, Lina Badimon
Summary: Cardiovascular diseases, especially acute myocardial infarction (MI), are major causes of death worldwide. DJ-1 protein has been found to play a crucial role in cardioprotection, and systemic administration of recombinant DJ-1 has been shown to reduce infarct size, leukocyte infiltration, apoptosis, and oxidative stress in a mouse model of MI. These effects may be mediated by G-protein-coupled receptor signaling and modulation of immune response. This study provides the first evidence for the extracellular activity of DJ-1 in regulating cardiac injury in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Xiaoguang Wu, Yi Li, Shuchen Zhang, Xiang Zhou
Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.
Review
Pharmacology & Pharmacy
Yi-Fan Zeng, Qi-Hao Guo, Xin-Yu Wei, Si-Yu Chen, Sheng Deng, Ji-Jia Liu, Ni Yin, Yan Liu, Wen-Jing Zeng
Summary: This meta-analysis aimed to evaluate the efficacy of curcumin for preventing myocardial ischemia/reperfusion (I/R) injury in animal models. The results showed that curcumin treatment significantly improved myocardial infarction size, cardiac function, myocardial injury enzymes, oxidative stress levels, serum inflammatory cytokine levels, and myocardial apoptosis index. However, publication bias was found in some outcome measures. Overall, curcumin has great potential for the treatment of myocardial I/R injury in animal models.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Cajetan Immanuel Lang, Praveen Vasudevan, Piet Doering, Ralf Gaebel, Heiko Lemcke, Tobias Lindner, Gustav Steinhoff, Bernd Joachim Krause, Brigitte Vollmar, Felix G. Meinel, Seyrani Yuecel, Alper Oener, Hueseyin Ince, Robert David
Summary: This study investigated post-infarct remodeling after acute myocardial infarction using mouse models and magnetic resonance imaging. The results showed differences in cardiac remodeling between the permanent ligation (PL) and ischemia reperfusion (I/R) models. Different methods of analysis revealed that PL resulted in significant left ventricle dilation and decreased contractile function, while the effects were less pronounced in the I/R model.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Lejla Medzikovic, Tara Azem, Wasila Sun, Parmis Rejali, Leana Esdin, Shadie Rahman, Ateyeh Dehghanitafti, Laila Aryan, Mansoureh Eghbali
Summary: Mortality from myocardial infarction (MI) has declined due to improved treatment methods, but outcomes of MI with subsequent reperfusion therapy are generally poorer for women compared with men. Further investigation is needed to understand the sex-based differences in disease pathophysiology and treatment response, and develop sex-specific therapeutic methods against myocardial ischemia-reperfusion injury (IRI). This literature review summarizes current knowledge on sex differences in the pathophysiological mechanisms of myocardial IRI, as well as sex differences in the pharmacokinetics, pharmacodynamics, and pharmacogenetics of drugs used to limit myocardial IRI.
Article
Cardiac & Cardiovascular Systems
Max L. Senders, Sophie Hernot, Giuseppe Carlucci, Jan C. van de Voort, Francois Fay, Claudia Calcagno, Jun Tang, Amr Alaarg, Yiming Zhao, Seigo Ishino, Anna Palmisano, Gilles Boeykens, Anu E. Meerwaldt, Brenda L. Sanchez-Gaytan, Samantha Baxter, Laura Zendman, Mark E. Lobatto, Nicolas A. Karakatsanis, Philip M. Robson, Alexis Broisat, Geert Raes, Jason S. Lewis, Sotirios Tsimikas, Thomas Reiner, Zahi A. Fayad, Nick Devoogdt, Willem J. M. Mulder, Carlos Perez-Medina
JACC-CARDIOVASCULAR IMAGING
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Loic Djaileb, Benjamin Dubois, Nicolas de Leiris, Julien Leenhardt, Marjorie Canu, Olivier Phan Sy, Adrien Carabelli, Bastien Boussat, Laurent Dumas, Alexis Broisat, Gerald Vanzetto, Daniel Fagret, Catherine Ghezzi, Gilles Barone-Rochette, Laurent M. Riou
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Oncology
Christopher Montemagno, Laurent Dumas, Pierre Cavailles, Mitra Ahmadi, Sandrine Bacot, Marlene Debiossat, Audrey Soubies, Loic Djaileb, Julien Leenhardt, Nicolas De Leiris, Maeva Dufies, Gilles Pages, Sophie Hernot, Nick Devoogdt, Pascale Perret, Laurent Riou, Daniel Fagret, Catherine Ghezzi, Alexis Broisat
Article
Clinical Neurology
Fanny Cavarec, Philipp Krauss, Tiffany Witkowski, Alexis Broisat, Catherine Ghezzi, Stephanie De Gois, Bruno Giros, Antoine Depaulis, Colin Deransart
Article
Engineering, Biomedical
Edouard Girard, Gregory Chagnon, Alexis Broisat, Stephane Dejean, Audrey Soubies, Hugo Gil, Tahmer Sharkawi, Francois Boucher, Gael S. Roth, Bertrand Trilling, Benjamin Nottelet
ACTA BIOMATERIALIA
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Laurent Riou, Jakub Toczek, Alexis Broisat, Catherine Ghezzi, Loic Djaileb
JOURNAL OF NUCLEAR CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jessica Bridoux, Sara Neyt, Pieterjan Debie, Benedicte Descamps, Nick Devoogdt, Frederik Cleeren, Guy Bormans, Alexis Broisat, Vicky Caveliers, Catarina Xavier, Christian Vanhove, Sophie Hernot
Review
Biochemistry & Molecular Biology
Christopher Montemagno, Shamir Cassim, Jacques Pouyssegur, Alexis Broisat, Gilles Pages
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Christopher Montemagno, Florian Raes, Mitra Ahmadi, Sandrine Bacot, Marlene Debiossat, Julien Leenhardt, Jean Boutonnat, Francesca Orlandi, Donato Barbato, Mattia Tedesco, Catherine Ghezzi, Pascale Perret, Alexis Broisat
Summary: The study investigates the therapeutic potential of Lu-177 labeled NeoB in tumor therapy, showing promising efficacy and biodistribution in GIST tumors.
Article
Medicine, General & Internal
Marjorie Canu, Lea Margerit, Ismail Mekhdoul, Alexis Broisat, Laurent Riou, Loic Djaileb, Clemence Charlon, Adrien Jankowski, Michele Magnesa, Caroline Augier, Stephanie Marliere, Muriel Salvat, Charlotte Casset, Marion Maurin, Carole Saunier, Daniel Fagret, Catherine Ghezzi, Gerald Vanzetto, Gilles Barone-Rochette
Summary: The study aimed to investigate the prognostic impact of coronary atherosclerotic burden (CAB) in patients with non-ischemic dilated cardiomyopathy (dCMP). The results indicated that high CAB may be a new prognostic factor in dCMP patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Santiago Garcia, Payam Dehghani, Larissa Stanberry, Cindy Grines, Rajan A. G. Patel, Keshav R. Nayak, Avneet Singh, Wah Wah Htun, Ameer Kabour, Nima Ghasemzadeh, Cristina Sanina, Joseph Aragon, M. Chadi Alraies, Catherine Benziger, Brynn Okeson, Ross Garberich, Frederick G. Welt, Laura Davidson, Abdul Moiz Hafiz, Deepak Acharya, Jay Stone, Aditya Mehra, Shy Amlani, Ehtisham Mahmud, Jay Giri, Mehmet Yildiz, Timothy D. Henry
Summary: During the early phase of the COVID-19 pandemic, there have been significant changes in the clinical characteristics and outcomes of STEMI patients with COVID-19 infection. As the pandemic progressed, there was an increase in the proportion of Caucasian patients, patients presented with more typical symptoms, and there was an improvement in treatment outcomes and a decrease in in-hospital mortality. Vaccination played a positive role in reducing mortality among hospitalized patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
V. Muzio, L. Ravasi, L. Sacchetti, L. Fugazza, S. Bacot, M. Debiossat, M. Ahmadi, C. Montemagno, C. Ghezzi, A. Broisat
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
V. Muzio, L. Ravasi, L. Sacchetti, L. Fugazza, S. Bacot, M. Debiossat, M. Ahmadi, C. Montemagno, C. Ghezzi, A. Broisat
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
L. Djaileb, B. Dubois, N. de Leiris, A. Seiller, J. Leenhardt, M. Canu, A. Broisat, G. Vanzetto, D. Fagret, M. Desvignes, C. Ghezzi, L. Riou, G. Barone-Rochette
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
L. Djaileb, A. Seiller, A. Fraguas-Rubio, J. Leenhardt, A. Martin, J. Poujol, A. Broisat, J. Miranda, G. Vanzetto, D. Fagret, M. Desvignes, C. Ghezzi, L. Riou, G. Barone-Rochette
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)