Article
Neurosciences
Zhanhao Zhao, Li Li, Chen Xin, Yaqun Yin, Rong Zhang, Jing Guo
Summary: This study used bibliometric analysis to assess the current status and research trends of acupuncture on autonomic function. The results showed that the majority of top-cited articles came from the USA, and neurosciences/neurology was the most studied research area. The study also found an increasing trend in research on the anti-inflammatory effects of acupuncture associated with autonomic function.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Branislav Milovanovic, Vlado Djajic, Dragana Bajic, Aleksandra Djokovic, Tatjana Krajnovic, Sladjana Jovanovic, Antonija Verhaz, Pedja Kovacevic, Miodrag Ostojic
Summary: This study found that autonomic dysfunction, including sympathetic, parasympathetic, or both, may occur in COVID-19 patients in the early phase of infection, with significantly higher proportions in the severe and mild groups compared to healthy controls. Therefore, cardiovascular autonomic neuropathy should be taken into consideration in the assessment of COVID-19 patients.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Monica Ferreira, Sergio Laranjo, Pedro Cunha, Vera Geraldes, Mario Oliveira, Isabel Rocha
Summary: Impairment of the baroreceptor reflex is observed in patients with lone paroxysmal atrial fibrillation (PAF), even at rest. The baroreflex effectiveness index (BEI) may serve as a marker of autonomic dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Denise Guckel, Thomas Eitz, Mustapha El Hamriti, Martin Braun, Moneeb Khalaph, Guram Imnadze, Thomas Fink, Vanessa Sciacca, Christian Sohns, Philipp Sommer, Georg Noelker
Summary: Baroreflex activation therapy (BAT) is an innovative treatment option for advanced heart failure (HFrEF). This therapy has shown positive effects on improving quality of life, left ventricular ejection fraction (LVEF), heart failure hospitalization rates, and NT-proBNP levels. Additionally, combining BAT with sacubitril/valsartan (ARNI) has resulted in more pronounced effects.
Article
Medicine, General & Internal
Anna Katharina Mayr, Victoria Wieser, Georg-Christian Funk, Sherwin Asadi, Irene Sperk, Matthias Helmut Urban, Arschang Valipour
Summary: This study investigated the relationship between pulmonary hyperinflation and baroreceptor reflex sensitivity (BRS) in patients with COPD. The results showed impaired BRS in COPD patients, and hyperinflation may influence BRS through alteration of mechanosensitive vagal nerve activity.
FRONTIERS IN MEDICINE
(2022)
Article
Neurosciences
Tracy L. Johnson, Stefan Clemens
Summary: This study investigated the modulation of dopamine on monosynaptic reflex in different segments of the spinal cord, showing that dopamine leads to facilitation of reflex in segments containing intermediolateral nucleus, while inhibiting in sensorimotor segments. The differential responses observed in autonomic nervous system segments may be due to the presence of gap junctions in the intermediolateral nucleus.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Yung-Jhe Yan, Chien-Nan Chen, Mang Ou-Yang
Summary: The study proposed a pupillary light reflex (PLR) inherent model to demonstrate the dynamic physiological mechanism of PLR and explored PLR abnormalities in diabetic patients, revealing potential pathophysiological mechanisms.
Article
Pharmacology & Pharmacy
Kentaro Kurogochi, Masami Uechi, Kensuke Orito
Summary: Situational syncope, induced by a specific situation, involves disorders of the autonomic nervous system. This study using a rat model suggests that a neurokinin-1 receptor antagonist, fosaprepitant, may suppress the circulatory response to colorectal distension by inhibiting the vagal reflex pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Behavioral Sciences
Nicholas V. Alen, Grant S. Shields, Adele Nemer, Indira A. D'souza, Marcela J. Ohlgart, Camelia E. Hostinar
Summary: Parental socialization may influence the development of children's autonomic nervous system, particularly the parasympathetic nervous system. A meta-analysis revealed that positive parenting is positively associated with higher resting parasympathetic nervous system activity in children. This association is more pronounced in experimental studies and when the sample includes children with a clinical condition.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Engineering, Chemical
Michelle M. Gee, Abraham M. Lenhoff, James S. Schwaber, Babatunde A. Ogunnaike, Rajanikanth Vadigepalli
Summary: This paper developed a computational model that incorporates the intrinsic cardiac nervous system into the computational model of blood pressure regulation. The central and local contributions to the control of heart rate, ventricular functions, and respiratory sinus arrhythmia were studied. The simulations matched the experimental observations and predicted the relative contributions of sensory and motor neuron pathways to heart rate changes. This closed-loop cardiovascular control model is important for evaluating bioelectronic interventions to treat heart failure and renormalize cardiovascular physiology.
Article
Biochemistry & Molecular Biology
Yuzo Takayama, Yuka Akagi, Yasuyuki S. Kida
Summary: In this study, key gene clusters and hub genes involved in the induction of autonomic lineages were identified through integrated bioinformatics analysis. The accuracy of this analysis was confirmed by calcium imaging. These findings provide novel insights into the regulatory machinery of autonomic induction and differentiation, contributing to a better understanding and precise control in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Effrosyni Koutsouraki, Koukoulidis Theodoros, Georgiadou Eleni, Kalampouka Marianna, Nikolaidou Areti, Koukoulidou Ariadni, Michmizos Dimitrios
Summary: Multiple sclerosis (MS) is a chronic progressive disease affecting both the central nervous system (CNS) and autonomic nervous system (ANS), leading to a range of urological, sexual, gastrointestinal, cardiovascular, and thermoregulatory disorders as well as increased fatigue. The manifestations of ANS dysfunction in MS are often underestimated due to the non-specificity of symptoms and limited evaluation in clinical practice. The underlying mechanisms causing these disorders have yet to be fully investigated, hindering targeted etiological treatment. Early diagnosis and individualized treatment regimens, incorporating multiple approaches, have shown the best results in managing ANS dysfunction in MS patients.
JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Benedetta Russo, Marika Menduni, Patrizia Borboni, Fabiana Picconi, Simona Frontoni
Summary: This review discusses the role of the autonomic nervous system in obesity and insulin-resistance, highlighting the bi-directional effects of related mechanisms, and exploring the neural, hormonal, and nutritional mechanisms involved. Leptin is emphasized for its crucial role in appetite regulation, glucose homeostasis, and energy expenditure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Mario Lavanga, Elisabeth Heremans, Jonathan Moeyersons, Bieke Bollen, Katrien Jansen, Els Ortibus, Gunnar Naulaers, Sabine Van Huffel, Alexander Caicedo
Summary: This study investigates the development of premature infants' autonomic nervous system through quantitative analysis of heart-rate variability and examines the role of heart-rate drops in relation to sympathovagal indices. The research demonstrates that maturation models based on HRV have comparable performance to other models, with selected features showing predominance in explaining infants' sympathovagal development. Additionally, bradycardias may disrupt the relationship between common temporal indices of the tachogram and the age of the infant and the interpretation of sympathovagal indices.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Hsuan-Yu Wan, Kanokwan Bunsawat, Markus Amann
Summary: The cardiovascular response to exercise is regulated by neurocirculatory control mechanisms, including central command, baroreflex, exercise pressor reflex, and arterial chemoreflex. These mechanisms modulate autonomic nervous system activity, influencing cardiac output and vascular resistance to ensure adequate blood flow to active muscles and organs. The interaction of these mechanisms has recently gained recognition for its impact on circulation, especially in unique environments such as high altitude.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Clinical Neurology
Amanda H. X. Lee, Emmanuel K. Tse, Thomas E. Nightingale, Rahul Sachdeva, Matthias Walter, Andrei Krassioukov
Summary: This study investigated the patterns and perceptions of cannabis use among women with spinal cord injury (SCI), as well as the knowledge of physicians regarding recreational and synthetic cannabinoids. The results showed that some women used cannabis during pregnancy and breastfeeding, mainly for sleep aid and relief of morning sickness. Most physicians had poor knowledge of recreational cannabis products but were more knowledgeable about synthetic cannabinoids.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Rehabilitation
Yetsa A. Tuakli-Wosornu, Kangxin Wang, Maryam Fourtassi, Catherine Stratton, Laura Paulina Munoz-Velasco, Abderrazak Hajjioui, Rory Cooper, Joseph K. Balikuddembe, Mark Peterson, Uma Pandiyan, Andrei Krassioukov, Deo Rishi Tripathi, Angela Palomba, Bo-Young Hong
Summary: This study aimed to examine the impact of the coronavirus pandemic on the physical and mental health and healthy lifestyle behaviors of people with disabilities living in the community. A web-based global survey was conducted, collecting 3550 responses from 65 countries over a period of 3 months. The results showed that people with disabilities experienced a greater decrease in physical activity levels, reduced intake of fruits and vegetables, and decreased sleep duration compared to those without disabilities.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Review
Clinical Neurology
Katherine Gray, Whitley Sheehan, Laura McCracken, Klaus Krogh, Rahul Sachdeva, Andrei V. Krassioukov
Summary: This systematic review examines the use of local analgesics, specifically lidocaine or bupivacaine, to prevent autonomic dysreflexia (AD) in individuals with spinal cord injury (SCI). The review finds that lidocaine has a beneficial effect on AD in some studies, but the small sample sizes and conflicting results highlight the need for larger, well-monitored clinical trials.
Article
Clinical Neurology
Lauren Rietchel, Andrea L. Ramirez, Shea Hocaloski, Stacy Elliott, Matthias Walter, Andrei Krassioukov
Summary: This study found that autonomic dysreflexia (AD)-associated heart rate changes during penile vibrostimulation (PVS) and urodynamic studies (UDS) appear to be related to the magnitude of systolic blood pressure increases. Highly elevated systolic blood pressure with bradycardia suggests the presence of severe AD. Cardiovascular monitoring and early detection of AD are recommended during PVS and UDS to reduce the risk of life-threatening complications.
Article
Medicine, General & Internal
David P. Darrow, David Young Balser, David Freeman, Eliza Pelrine, Andrei Krassioukov, Aaron Phillips, Theoden Netoff, Ann Parr, Uzma Samadani
Summary: This study aims to assess the effects of chronic SCI patients undergoing spinal cord stimulation on volitional movement and cardiovascular function, and optimize stimulation parameters. The study utilizes a self-controlled trial design, collects data using a mobile application, and analyzes the indirect effects of stimulation on other relevant measures.
Article
Critical Care Medicine
Matthias Walter, Andrea L. Ramirez, Amanda H. X. Lee, Thomas E. Nightingale, Daniel Rapoport, Alex Kavanagh, Andrei V. Krassioukov
Summary: This study demonstrates that fesoterodine can alleviate lower urinary tract symptoms and urinary incontinence in patients with chronic spinal cord injury, improving their quality of life. During the treatment period, patients experienced increased cystometric capacity, decreased maximum detrusor pressure, alleviation of symptoms related to neurogenic detrusor overactivity, as well as a reduction in the severity and frequency of autonomic dysreflexia events.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Rahul Sachdeva, Ali Hosseinzadeh, Aaron Rizzardo, Andrea Maharaj, Michael Berger, Andrei Krassioukov
Summary: This study assessed the effects of oxycodone/naloxone on pain, constipation, and autonomic dysreflexia in spinal cord injury patients. The results showed that oxycodone/naloxone improved pain, bowel function, and severity of autonomic dysreflexia.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Engineering, Biomedical
Rajat Emanuel Singh, Aliya Ahmadi, Ann M. Parr, Uzma Samadani, Andrei V. Krassioukov, Theoden I. Netoff, David P. Darrow
Summary: Multiple studies have shown that epidural spinal cord stimulation (eSCS) can restore volitional motor control in participants with motor-complete spinal cord injury (SCI). However, there has been a lack of rigorous quantitative descriptions of muscle coordination. In this study, six participants with chronic SCI underwent a brain motor control assessment (BMCA) to investigate the impact of eSCS on muscle activity complexity and muscle synergies. Results showed that eSCS immediately reduced muscle activity complexity and improved coordination between muscle groups over time. Muscle synergies were also restored with eSCS, supporting the neural hypothesis of muscle synergies.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Medicine, General & Internal
Soshi Samejima, Claire Shackleton, Raza N. Malik, Kawami Cao, Anibal Bohorquez, Tom E. Nightingale, Rahul Sachdeva, Andrei V. Krassioukov
Summary: Spinal cord injury (SCI) leads to severe cardiovascular dysfunction, and autonomic dysreflexia (AD) is one of the causes of high blood pressure in SCI patients. Recently, spinal cord stimulation (SCS) has been considered as a potential intervention to alleviate unstable blood pressure after SCI. This case series demonstrates the real-time effect of epidural SCS (eSCS) at the lumbosacral spinal cord in mitigating AD in individuals with SCI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Matthew C. Dorton, John K. Kramer, Sonja de Groot, Marcel W. M. Post, Victoria E. Claydon
Summary: The study found that poor mental health is an important factor for increased cardiovascular disease risk in individuals with chronic spinal cord injury. There is also a correlation between cardiovascular autonomic function, gender, and the occurrence of neuropathic pain.
Article
Biochemistry & Molecular Biology
Tiev Miller, Dirk Lange, Jayachandran N. Kizhakkedathu, Kai Yu, Demian Felix, Soshi Samejima, Claire Shackleton, Raza N. Malik, Rahul Sachdeva, Matthias Walter, Andrei V. Krassioukov
Summary: Despite the common practice of catheter reuse in individuals with spinal cord injury (SCI), there is a risk of developing catheter-associated urinary tract infections (CAUTI). This study investigated the microbiological burden and surface changes of reused catheters in the short term. The results showed the presence of bacterial biofilm and antibiotic-resistant bacteria on all reused catheter surfaces, as well as asymptomatic bacteriuria in the majority of participants. These findings suggest that short-term catheter reuse may increase the susceptibility to CAUTI in SCI individuals.
Review
Medicine, General & Internal
Fredrika S. Magnuson, Peter Christensen, Andrei Krassioukov, Gianna Rodriguez, Anton Emmanuel, Steven Kirshblum, Klaus Krogh
Summary: Neurogenic bowel dysfunction is a common problem among individuals with spinal cord injury or multiple sclerosis, often resulting in constipation, difficulty with bowel evacuation, and fecal incontinence. The current treatment algorithm does not fully align with clinical practice, calling for an updated version to guide healthcare professionals in treating NBD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Daniel D. Hodgkiss, Gurjeet S. Bhangu, Carole Lunny, Catherine R. Jutzeler, Shin-Yi Chiou, Matthias Walter, Samuel J. E. Lucas, Andrei V. Krassioukov, Tom E. Nightingale
Summary: Spinal cord injury (SCI) often leads to low cardiorespiratory fitness, but exercise can improve it. This study aimed to assess whether certain SCI characteristics and exercise considerations can moderate changes in cardiorespiratory fitness.
Article
Clinical Neurology
Matthew C. Dorton, John K. Kramer, Sonja de Groot, Marcel W. M. Post, Victoria E. Claydon
Summary: This study investigated the relationship between cardiovascular disease (CVD) risk and poor mental health (MH-) and neuropathic pain (NP) in individuals with chronic spinal cord injury (SCI). The results showed that poor mental health was significantly correlated with adverse CVD risk, while neuropathic pain was more prevalent in individuals with better cardiovascular autonomic function. The complex interrelationships between secondary consequences of SCI need further exploration.
Meeting Abstract
Hospitality, Leisure, Sport & Tourism
Cameron Marshall Gee, Adrienne Sinden, Andrei Krassioukov, Kathleen Martin Ginis
JOURNAL OF SPORT & EXERCISE PSYCHOLOGY
(2022)
