Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Shanelle R. Shillingford, Anton M. Bennett
Summary: Phosphatases and kinases play crucial roles in maintaining the balance between dephosphorylated and phosphorylated proteins for cellular functions. Imbalance or dysfunction in their activities can lead to unfavorable cellular effects and the development of diseases. Protein tyrosine phosphatases (PTPs) are attractive therapeutic targets due to their involvement in cell signaling and diseases, but they have been challenging in drug development. This article focuses on the progress in small-molecule inhibition of the mitogen-activated protein kinase (MAPK) phosphatases (MKPs), discussing successful strategies and inhibitor discovery tools, as well as the potential future of MKP inhibition.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Cell Biology
Chunxia Li, Jun Dai, Chuanbin Liu, Guanjun Dong, Xin Zhang, Junfeng Zhang, Fenglian Yan, Hui Zhang, Changying Wang, Mingsheng Zhao, Zhaochen Ning, Qun Ma, Hui Shi, Zhihua Li, Huabao Xiong
Summary: This study reveals that PDK2 is involved in the regulation of TLR-mediated inflammation and plays a role in the activation of TLR4 signaling pathway and production of proinflammatory cytokines. Inhibition of PDK2 can significantly reduce the occurrence and pathological damage of endotoxin shock and suppress the production of inflammatory factors. Therefore, PDK2 may be a potential target for the treatment of septic shock.
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Zhenjie Sun, Wenhui Gu, Zezhong Feng, Yaqin Fan, Jianfeng Niu, Guangce Wang
Summary: This study elucidated the expression regulation mechanism of the heat shock protein 70 gene in Neopyropia yezoensis under high temperature stress. The findings showed the involvement of cAMP-dependent protein kinase and activating transcription factors element in the transcription regulation of the gene. In addition, AMPK was also found to play a role in the induction of the gene. Furthermore, posttranscriptional mechanisms were proposed to be involved in the synthesis regulation of the heat shock protein 70-2 protein.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Veterinary Sciences
Rongduo Wen, Hideharu Ochiai, Jumpei Uchiyama, Nanako Osawa, Mami Oba, Yukie Katayama, Kaixin Li, Tsutomu Omatsu, Kenichi Tamukai, Kaoru Suzuki, Hiroo Madarame, Shinji Makino, Tetsuya Mizutani
Summary: The study revealed that African hedgehog adenovirus uses the p38 pathway for replication in infected cells and induces cytopathic effects. Inhibitors of the p38 pathway were effective in suppressing viral replication, but did not inhibit virus-induced cytopathic effects.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Pharmacology & Pharmacy
F. Gao, Ji Hong Yang, Bo Liu, Rui Zhang, Meng Zhang, Y. Geng
Summary: The combination of valproic acid and decitabine can significantly reduce the invasion and metastasis ability of liver cancer cells, increase the expression of E-cadherin protein and the expression level of p53, and inhibit these effects by the p38 mitogen-activated protein kinase activator anisomycin.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Cell Biology
Chang-Ning Fu, Jia-Wen Song, Zhi-Peng Song, Qian-Wen Wang, Wen-Wu Bai, Tao Guo, Peng Li, Chao Liu, Shuang-Xi Wang, Bo Dong
Summary: Statin-induced skeletal injury is mediated by the excessive expression of miR-1a, leading to decreased MAP3K1 gene expression and subsequent apoptosis of skeletal muscle cells.
Article
Chemistry, Multidisciplinary
Guo-Feng Luo, Jun-Long Liang, Di-Wei Zheng, Ping Ji, Jia-Wei Wang, Wei-Hai Chen, Xian-Zheng Zhang
Summary: The combination of stress-activated signal inhibitors and hair-derived nanoparticles enhanced the effectiveness of photothermal therapy by blocking tumor cell growth and invasion.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Jen-Chung Ko, Jyh-Cheng Chen, Jou-Min Hsieh, Pei-Yu Tseng, Chen -Shan Chiang, Li -Ling Liu, Chin-Cheng Chien, I-Hsiang Huang, Qiao-Zhen Chang, Bo-Cheng Mu, Yun-Wei Lin
Summary: This study found that the Hsp90 inhibitor 17-AAG can enhance the cytotoxicity of tamoxifen and erlotinib in NSCLC cells by regulating TP expression.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vikram Jeet Singh, Bharti Sharma, Pooja A. Chawla
Summary: The article focuses on the MAPK signaling pathway and the role of different heterocyclic compounds with nitrogen, sulfur, and oxygen in blocking the MAPK signaling pathway. Heterocyclic compounds are important due to their high potency and selectivity against various targets involved in the MAPK signaling pathway for cancer management. The potential of these compounds in inhibiting MAPK cascade and recent advancements in developing MAPK signaling pathway inhibitors are discussed in detail.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
T. G. Sahana, Ke Zhang
Summary: Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease with multiple genetic and non-genetic risk factors. Cellular stress plays a significant role in ALS conditions, with the MAPK pathway being implicated in the disease pathogenesis and potential drug targeting.
Article
Agriculture, Multidisciplinary
Kai-yuan Ji, Ru-jun Wen, Zheng-zhou Wang, Qian-qian Tian, Wei Zhang, Yun-hai Zhang
Summary: In mammals, miRNAs regulate the expression of target genes and play crucial roles in various biological processes. The expression levels of miR-370-5p differ significantly in sheep with different hair colors, but its function is not clear. This study investigated the roles of miR-370-5p in sheep melanocytes and found that its overexpression significantly inhibited cell proliferation (P<0.01), tyrosinase activity (P=0.001), and melanin production (P<0.001).
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)