Article
Pharmacology & Pharmacy
Shining Loo, Antony Kam, James P. Tam
Summary: This study demonstrates that the plant-derived EGFR agonist bleogen pB1 can accelerate corneal wound healing and reduce corneal scarring. The agonist decreases inflammatory responses and inhibits myofibroblast accumulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Matan Yampolsky, Ido Bachelet, Yaron Fuchs
Summary: Wound healing is a complex physiological process that can provide valuable insights into genetic modifications and pharmaceutical interventions. In this article, a comprehensive protocol for conducting a skin-wound-healing assay in mice is presented, emphasizing the importance of key aspects in ensuring reliable and reproducible results. The article also discusses the use of lineage-tracing techniques to monitor cell migration and differentiation during the repair process.
Article
Medicine, General & Internal
Guokun Zhang, Dongxu Wang, Jing Ren, Hongmei Sun, Jiping Li, Shengnan Wang, Liyan Shi, Zhen Wang, Mengjie Yao, Haiping Zhao, Chunyi Li
Summary: The study found that paracrine factors released from internal tissues of deer antlers can promote wound healing and reduce scar formation. This effect is achieved by inhibiting the TGF-beta signaling pathway. Therefore, enzymatically digested velvet antler peptides (EVAP) may be a promising candidate for a clinical drug for regenerative wound healing.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Haisheng Lin, Zhihong Zheng, Jianjun Yuan, Chaohua Zhang, Wenhong Cao, Xiaoming Qin
Summary: Marine collagen peptides derived from Sipunculus nudus (SNCP) have been found to promote skin wound healing by reducing inflammation, improving collagen deposition and recombination, and blocking the TGF-β/Smads signaling pathway, thus inhibiting scar formation. The study demonstrated that SNCP accelerates wound healing, induces cell proliferation and migration, and exhibits scar-free healing effects, suggesting potential clinical applications in skin wound repair and scar inhibition.
Article
Biochemistry & Molecular Biology
Aleksandra Malgorzata Siedlar, Tamara Seredenina, Anna Faivre, Yves Cambet, Marie-Jose Stasia, Dominik Andre-Levigne, Marie-Luce Bochaton-Piallat, Brigitte Pittet-Cuenod, Sophie de Seigneux, Karl-Heinz Krause, Ali Modarressi, Vincent Jaquet
Summary: Differentiation of fibroblasts to myofibroblasts is regulated by TGF-beta through redox signaling and ROS generation. NOX4 has been proposed as a target for fibrotic diseases treatment, but this study suggests that NOX4 is dispensable for wound healing and myofibroblast differentiation. Another H2O2-generating flavoprotein may drive this mechanism instead.
Article
Biochemistry & Molecular Biology
Duraisamy Kempuraj, Rajiv R. Mohan
Summary: Autophagy is a crucial cellular mechanism in regulating physiological processes in the cornea, with dysregulation leading to impaired clearance of unwanted substances and dysfunction. The extracellular matrix in the cornea plays a key role in maintaining transparency and wound healing, with dysregulated autophagy impacting this process and potentially causing corneal dysfunction.
Article
Instruments & Instrumentation
Majid Salehi, Arian Ehterami, Saeed Farzamfar, Ahmad Vaez, Somayeh Ebrahimi-Barough
Summary: The alginate/naringenin hydrogel developed in this study showed positive effects on wound healing process, with appropriate porosity and biodegradability, as well as no toxicity to cells. In the rat experiment, the hydrogel containing 20% naringenin demonstrated the best wound closure among other groups.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Hendrik Lintel, Darren B. Abbas, Christopher Lavin, Michelle Griffin, Jason L. Guo, Nicholas Guardino, Andrew Churukian, Geoffrey C. Gurtner, Arash Momeni, Michael T. Longaker, Derrick C. Wan
Summary: Deferoxamine treatment has shown to improve wound healing outcomes in chronically irradiated murine skin. It accelerates wound closure, enhances wound perfusion, upregulates angiogenesis, and improves scar elasticity. Deferoxamine also increases inducible nitric oxide synthase expression and nitric oxide production in early healing wounds.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Luisa A. DiPietro, Traci A. Wilgus, Timothy J. Koh
Summary: Macrophages play a prominent role in skin wound healing, with functions including host defense and support of new tissue growth. However, the exact role of macrophages in wound healing remains elusive, as some wounds can heal well even with limited or no functional macrophages. Recent advances in understanding macrophage phenotypes and cellular plasticity in wounds may provide new insights and paradigms on macrophage function in wounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Xuedong Shu, Jun Shu, Yao Wang, Huan Deng, Junwei Zhang, Jing He, Fang Wu
Summary: This study successfully addresses the challenges of chronic wound repair and excessive scarring by developing a novel multifunctional ROS-scavenging hydrogel, CT-X. This hydrogel effectively removes ROS, promotes wound healing, and reduces scar formation in normal and diabetic wounds.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Ewa A. Burian, Lubna Sabah, Tonny Karlsmark, Klaus Kirketerp-Moller, Christine J. Moffatt, Jacob P. Thyssen, Magnus S. Agren
Summary: This systematic review investigated the association between cytokine levels and the healing of venous leg ulcers (VLUs). The findings suggest that non-healing VLUs may be associated with elevated pro-inflammatory cytokine levels, which decline with healing. TGF-beta 1 levels tended to increase with VLU healing. Further research is needed to explore other cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Yi Li, Hangqi Luo, Yue Li, Peipei Huang, Jie Xu, Jian Zhang, Peihan Cai, Huacheng He, Jiang Wu, Xiaokun Li
Summary: Functional degradable sutures with controlled release of basic fibroblast growth factor (bFGF) were developed to enhance wound healing. The suture showed prolonged bFGF release, improved cell adhesion and proliferation, accelerated wound closure, and facilitated skin mechanical restoration.
MATERIALS & DESIGN
(2023)
Article
Physiology
Guya D. Marconi, Luigia Fonticoli, Thangavelu Soundara Rajan, Paola Lanuti, Ylenia Della Rocca, Sante D. Pierdomenico, Oriana Trubiani, Jacopo Pizzicannella, Francesca Diomede
Summary: After oral mucosal injury, the healing response involves specific steps that require different cell populations, with fibroblasts playing a crucial role in ECM production. The study highlights the role of TGF-beta 1 in promoting the differentiation of gingival fibroblasts into myofibroblasts, as evidenced by changes in specific markers.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Sang Oon Baek, Uk Jang, Jeonghwan Shin, Jun Hyeok Kim, Jie Hyun Kim, Jun Yong Lee
Summary: The authors introduce a novel animal wound model using an internal splint made of nitinol, a shape memory alloy, to effectively impede wound contraction while not affecting the re-epithelialization rate, successfully mimicking the human wound healing mechanism. This model is robust, reliable, and easily reproducible.
BIOMEDICAL MATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Auspreeya Rujirachotiwat, Supaporn Suttamanatwong
Summary: Curcumin upregulated the expression of TGF-beta 1, TGF-beta RI, TGF-beta RII, and VEGF in an in vitro hGF wound healing model. The ERK pathway is required for the induction of TGF-beta RI, TGF-beta RII, and VEGF by curcumin.