Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Editorial Material
Plant Sciences
Francisco J. Corpas, Salvador Gonzalez-Gordo, Jose M. Palma
Summary: Nitric oxide is a crucial signaling molecule in plant physiological processes, but the enzymatic generation of nitric oxide in higher plants is still controversial.
TRENDS IN PLANT SCIENCE
(2022)
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Physiology
Katharine L. Bunch, Ammar A. Abdelrahman, Ruth B. Caldwell, R. William Caldwell
Summary: Diabetic retinopathy (DR) and diabetic macular edema (DME) are complications of diabetes that can cause vision loss and reduced quality of life. Current treatments for advanced DR and DME are invasive, expensive, and can have adverse side-effects. Therefore, there is a need for more effective, affordable, and accessible therapies that can target early stage disease. Novel therapies under investigation include erythropoietin-derived peptides, inducers of antioxidant gene expression, activators of nitric oxide/cyclic GMP signaling pathways, and manipulation of arginase activity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Divya Seth, Colin T. Stomberski, Precious J. McLaughlin, Richard T. Premont, Kathleen Lundberg, Jonathan S. Stamler
Summary: The aim of this study was to investigate the interactions between nitric oxide synthase (NOS) isoforms and proteins, as well as the mechanisms by which they mediate S-nitrosylation. The results showed that each NOS isoform interacts with and S-nitrosylates many proteins, but a large proportion of S-nitrosylated proteins are not associated with NOS. Additionally, the interactomes and S-nitrosylomes of individual NOS isoforms are largely unique, indicating specific roles for each isoform in S-nitrosylation.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Horticulture
Sitthisak Intarasit, Bualuang Faiyue, Jamnong Uthaibutra, Kobkiat Saengnil
Summary: The research aimed to investigate the impact of chlorine dioxide (ClO2) on the browning of longan pericarp. The findings indicated that ClO2 fumigation reduced the activities of RNS producing enzymes, resulting in lower nitrosative stress levels and reduced pericarp browning.
SCIENTIA HORTICULTURAE
(2022)
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Dragoslava Djikic, Marijana Kovacic, Juan F. Santibanez, Milica Tosic, Vladan P. Cokic
Summary: In various systems, hydroxyurea has been shown to stimulate the release of nitric oxide or activate nitric oxide synthase. Through inhibiting nitric oxide metabolites, hydroxyurea is able to inhibit the growth of mature erythroid colonies and impact the presence of iNOS immunoreactive CFU-E.
Article
Pharmacology & Pharmacy
Shang Xian Bo, Wang Yan Jie, Cai De Chao, Ma Sai, Wang Zhe, Zhu Ya Kun, Guo Hui Hui, Wang Chen, Ma Xiao, Hu Zhong Yao, Yu Hao Ran, Zhang Ji Sen, Cheng Wen Dan
Summary: The study demonstrated that compound 22o effectively inhibited the inflammatory response and catabolism of chondrocytes, reducing articular cartilage injury in a rat OA model induced by ACLT. The compound showed potential as a disease-modifying OA drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn
Summary: This study found that lipid emulsion enhanced the vasoconstriction induced by dexmedetomidine by inhibiting nitric oxide synthesis, potentially through reducing dexmedetomidine concentration. Dexmedetomidine-induced nitric oxide synthesis may be caused by Src kinase-induced caveolin-1 phosphorylation leading to increased eNOS (Ser1177) phosphorylation and decreased eNOS (Thr495) phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Han-Yan Zhu, Fen-Fang Hong, Shu-Long Yang
Summary: Vascular dementia is the second most common form of dementia worldwide, caused by cerebrovascular disease. Nitric oxide and nitric oxide synthase play vital roles in the pathogenesis of this disease, with different NOS subtypes having partitioned activities in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Yoshihiro Hata, Masayoshi Iwasaki, Keisuke Fujitaka, Haengnam Park, Daisuke Sato, Chiharu Enoki, Naoki Minato, Keita Horitani, Miyuki Nakano, Hiroshi Kishimoto, Kensaku Wada, Masamichi Koyanagi, Yasushi Adachi, Yoshihiro Yamamoto, Andreas M. Zeiher, Stefanie Dimmeler, Ichiro Shiojima
CIRCULATION JOURNAL
(2018)
Article
Cardiac & Cardiovascular Systems
Daisuke Sato, Hiroki Mani, Yu Makihara, Hiroki Kitajima, Yuji Nishikawa, Seno Keitaro, Yeong-Hwa Chun
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Daisuke Sato, Hajime Otani, Chiharu Enoki, Masanori Fujita, Naoki Minato, Toshiji Iwasaka
CARDIOVASCULAR PATHOLOGY
(2011)
Article
Cardiac & Cardiovascular Systems
Akira Moriguchi, Hajime Otani, Kei Yoshioka, Takayuki Shimazu, Masanori Fujita, Toru Okazaki, Daisuke Sato, Shiori Kyoi, Toshiji Iwasaka
CIRCULATION JOURNAL
(2010)
Article
Cardiac & Cardiovascular Systems
Chiharu Enoki, Hajime Otani, Daisuke Sato, Takayuki Okada, Reiji Hattori, Hiroji Imamura
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2010)
Article
Cardiac & Cardiovascular Systems
Haengnam Park, Hajime Otani, Chihiro Oishi, Mie Fujikawa, Koji Yamashita, Toru Okazaki, Daisuke Sato, Takanao Ueyama, Junji Iwasaka, Yoshihiro Yamamoto, Toshiji Iwasaka
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2011)
Article
Cardiac & Cardiovascular Systems
Hidehira Fukaya, Shinichi Niwano, Hiroe Niwano, Yoshihiko Masaki, Michiro Kiryu, Shoji Hirasawa, Daisuke Sato, Masahiko Moriguchi, Tohru Izumi
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2012)
Article
Cardiac & Cardiovascular Systems
Haengnam Park, Hajime Otani, Teppei Noda, Daisuke Sato, Toru Okazaki, Takanao Ueyama, Junji Iwasaka, Yoshihiro Yamamoto, Toshiji Iwasaka
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Daisuke Satoh, Norihito Inami, Takayuki Shimazu, Takayuki Kajiura, Kohichi Yamada, Toshiji Iwasaka, Shosaku Nomura
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2010)
Article
Cardiac & Cardiovascular Systems
Takayuki Shimazu, Norihito Inami, Daisuke Satoh, Takayuki Kajiura, Kohichi Yamada, Toshiji Iwasaka, Shosaku Nomura
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2009)
Article
Cardiac & Cardiovascular Systems
Daisuke Sato, Hiroki Kitajima, Hiroki Mani, Chang-Hee Park, Yeong-Hwa Chun
JOURNAL OF ARRHYTHMIA
(2013)
Article
Cardiac & Cardiovascular Systems
Masahiro Esato, Yoshitomi Kida, Naoto Nishina, Hiroki Mani, Hiroki Kitajima, Daisuke Sato, YeongHwa Chun
JOURNAL OF ARRHYTHMIA
(2013)
Article
Cardiac & Cardiovascular Systems
Daisuke Sato, Kunihiro Teramoto, Hiroki Kitajima, Naoto Nishina, Yoshitomi Kida, Hiroki Mani, Masahiro Esato, Yeong-Hwa Chun
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Daisuke Sato, Hajime Otani, Masanori Fujita, Takayuki Shimazu, Kei Yoshioka, Chiharu Enoki, Naoki Minato, Toshiji Iwasaka
EXPERIMENTAL & CLINICAL CARDIOLOGY
(2012)
Article
Cardiac & Cardiovascular Systems
Haengnam Park, Hajime Otani, Yoshihiro Yamamoto, Keita Horitani, Chihiro Oishi, Daisuke Sato, Takanao Ueyama, Junji Iwasaka, Toshiji Iwasaka
CARDIOVASCULAR INTERVENTION AND THERAPEUTICS
(2011)